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Journal of Harbin Institute of Technology(New Series) 2021年第2期28卷 1-7页

作者： Yujia e Sen Zhang Bing Dai Jiaqi Zhu Jiecai Han center for composite Materials and Structures Harbin Institute of TechnologyHarbin 150080China

In this paper,a solidly mounted resonator(SMR)was designed with nanocrystalline diamond(NcD)as the high acoustic impedance material of Bragg reflector to improve the *** used Mathcad to investigate the effect of the Bragg reflector on the performance of the SMR,as well as the influence of different materials and the number of layers of Bragg reflector on the quality factor *** show that the Bragg reflector could reduce energy loss effectively,and the higher the impedance of the high acoustic impedance layer,the better the *** parasitic factors of the SMR using two high acoustic impedance materials,tungsten(W)and NcD,were also simulated by an Advanced Design System(ADS)using the.mason *** was found that the parasitic effect caused by metal would significantly decrease the Q factor of the *** the frequency range below 6 GHz,within which the SMR works normally,NcD performed better than ***,NcD is a better choice of high acoustic impedance material in the design of the SMR,with improved quality at high frequency and low *** optimum number of layers of Bragg reflector is 6.

关键词： solidly mounted resonator(SMR) nanocrystalline diamond(NcD) Bragg reflector quality factor(Q) parasitic effect

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全人源抗狂犬病病毒单克隆抗体的制备与鉴定

南京医科大学学报（自然科学版） 2012年第6期32卷 739-744页

作者：张夏玲孙见宇殷珏李明周亦凭刘云成李万波朱进冯振卿 mason Lu 南京医科大学卫生部抗体技术重点实验室江苏南京210029 上海麦柏星生物科技有限公司上海201203 福瑞邦生物科技有限公司黑龙江大庆163316 南京军区军事医学研究所江苏南京210002 University of Texas MD Anderson cancer center HoustonTexas 77030

目的:利用人源IgM转基因小鼠制备全人源抗狂犬病病毒单克隆抗体,并对其进行初步鉴定。方法:以灭活的狂犬病病毒cTN株作为抗原免疫人IgM转基因小鼠。采用杂交瘤技术结合酶联免疫吸附试验(eLISA)高通量交叉筛选技术(HTS)制备全人源抗狂犬... 详细信息

目的:利用人源IgM转基因小鼠制备全人源抗狂犬病病毒单克隆抗体,并对其进行初步鉴定。方法:以灭活的狂犬病病毒cTN株作为抗原免疫人IgM转基因小鼠。采用杂交瘤技术结合酶联免疫吸附试验(eLISA)高通量交叉筛选技术(HTS)制备全人源抗狂犬病病毒单克隆抗体。通过双抗体夹心eLISA鉴定单抗的人源性和抗体型,间接eLISA、斑点杂交(Dot Blot)实验及Western blot检测单抗的特异性,Biacore X-100测定单抗结合抗原的亲和力。结果:建立了2株稳定分泌抗狂犬病病毒人源性单抗的杂交瘤细胞株,分别命名为9e3和9F2。双抗体夹心eLISA结果显示2株单抗均为人源性免疫球蛋白IgM型。间接eLISA、斑点杂交实验结果表明2株单抗均能特异性识别灭活的狂犬病病毒cTN株。Western blot结果显示2株单抗均能与狂犬病病毒糖蛋白特异性结合。2株单抗与狂犬病病毒cTN株抗原结合的亲和力分别为2.62×10-10mol/L、4.06×10-11mol/L。结论:筛选制备了2株特异性、高亲和力的全人源抗狂犬病病毒单克隆抗体。本研究为进一步筛选人源抗狂犬病病毒免疫预防性中和抗体及其免疫治疗的应用奠定了基础。

关键词：人IgM转基因小鼠狂犬病病毒全人源单克隆抗体

Development of a 100 J,10 Hz laser for compression experiments at the High energy Density instrument at the european XFeL

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High Power Laser Science and engineering 2018年第4期6卷 133-142页

作者： Paul mason Saumyabrata Banerjee Jodie Smith Thomas Butcher Jonathan Phillips Hauke Hoppner Dominik Moller Klaus ertel Mariastefania De Vido Ian Hollingham ANDrew Norton Stephanie Tomlinson Tinesimba Zata Jorge Suarez Merchan chris Hooker Mike Tyldesley Toma Toncian cristina HernANDez-Gomez chris edwards John collier central Laser Facility STFC Rutherford Appleton LaboratoryDidcotOX11 0QXUK Institute for Radiation Physics Helmholtz-Zentrum Dresden-Rossendorf e.V.D-01328 DresdenGermany

In this paper we review the design and development of a 100 J, 10 Hz nanosecond pulsed laser, codenamed DiPOLe100 X,being built at the central Laser Facility(cLF). This 1 kW average power diode-pumped solid-state laser(DPSSL) is based on a master oscillator power amplifier(MOPA) design, which includes two cryogenic gas cooled amplifier stages based on DiPOLe multi-slab ceramic Yb:YAG amplifier technology developed at the cLF. The laser will produce pulses between 2 and 15 ns in duration with precise, arbitrarily selectable shapes, at pulse repetition rates up to 10 Hz, allowing real-time shape optimization for compression experiments. Once completed, the laser will be delivered to the european X-ray Free electron Laser(XFeL) facility in Germany as a UK-funded contribution in kind, where it will be used to study extreme states of matter at the High energy Density(HeD) instrument.

关键词： cryogenic lasers diode-pumped solid-state laser high energy lasers laser amplifiers Yb:YAG

Myth and Momentum: A critique of environmental Impact Assessments

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Journal of environmental Protection 2013年第8期4卷 72-77页

作者： Andrew J. Wright Sarah J. Dolman Michael Jasny e. c. M. Parsons Doris Schiedek Sharon B. Young 1Department of Bioscience Aarhus University Roskilde Denmark 2Department of environmental Science and Policy George Mason University Fairfax USA Department of Bioscience Aarhus University Roskilde Denmark Department of environmental Science and Policy George Mason University Fairfax USA Natural Resources Defense council Vancouver Canada The Humane Society of the United States Washington USA. Whale and Dolphin conservation Chippenham UK

environmental Impact Assessments (eIAs) are designed to evaluate all reasonably foreseeable environmental consequences of human activities. Appropriate governmental scientists traditionally produced eIAs for management agencies in many countries. However, many eIAs are now contracted out, often to the lowest bidder without due consideration of expertise. Others suffer from limited agency resources. consequently, many eIAs have become insufficiently researched documents that draw heavily from previous eIAs while being rushed to completion to meet legislative deadlines or avoid delaying projects. Habitual treatment of topics often ignores recent scientific literature, perpetuating previous misconceptions and analytical flaws. common problems in eIAs discussing wildlife include: a focus on lethal takes, with little consideration of non-lethal impacts or habitat degradation;a general dismissal of the possibility that non-significant (to the resource) impacts can, when combined, become significant;and the assumption that behavioral habituation in animals represents an end of impact. Incentive to break the cycle is somewhat lacking in this now often commercially competitive environment, where contracts are increasingly awarded by industry, generating potential conflict of interest. We believe investment in thorough, impartially written, scientifically-based and up-to-date eIAs is important for appropriately representing and managing ecosystems and their resources and avoiding potentially expensive litigation.

关键词： Policy Management environmental Impact Assessment errors cumulative Impact Assessment

比较crohn病肠壁血供的超声检测、组织学表现和病变的活动性

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国际医学放射学杂志 2009年第4期32卷 410-411页

作者： B.H.Drews T.F.e.Barth M.M.H?nle A.S.Akinli R.A.mason R.Muche 李鹏(译) 刘筠(校) Department of Internal Medicine 1 Center for Internal MedicineUniversity Medical Center UlmAlbert-Einstein-Allee 2389081 UlmGermany 不详

本研究目的回顾性比较crohn病病人能量多普勒超声半定量测量肠壁血供、内镜组织病理学改变和疾病的活动性。在1332例经组织活检证实的crohn病病人中，32例（18例女性，14例男性；平均年龄38．8岁）符合下述标准：5d内进行回结肠内镜活... 详细信息

本研究目的回顾性比较crohn病病人能量多普勒超声半定量测量肠壁血供、内镜组织病理学改变和疾病的活动性。在1332例经组织活检证实的crohn病病人中，32例（18例女性，14例男性；平均年龄38．8岁）符合下述标准：5d内进行回结肠内镜活检和能量多普勒超声测量肠壁血供，以评估病变活动性。超声测量肠壁血供是基于半定量评分。内镜肠壁活检采用自行开发的炎症评分来评价。crohn病活动性是依靠计算crohn病活动性指数（cDAI）来确定。

关键词： crohn病疾病活动性超声肠壁血供

Molecular phylogenetic analysis of Leibnitzia cass.(Asteraceae:Mutisieae:Gerbera-complex),an Asian-North American disjunct genus

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Journal of Systematics and evolution 2010年第3期48卷 161-174页

作者： Kristen e.BAIRD Vicki A.FUNK Andrea WeeKS Department of environmental Science and Policy George Mason University US National Herbarium Smithsonian InstitutionMRC 166P.O.Box 371012WashingtonDC 20013-7012USA

Leibnitzia comprises six species of perennial herbs that are adapted to high elevation conditions and is one of only two Asteraceae genera known to have an exclusively disjunct distribution spanning central to eastern Asia and North *** phylogenetic analysis of Leibnitzia and other Gerbera-complex members indicates that Leibnitzia is monophyletic,which is in contrast with our expectation that the American Leibnitzia species L. lyrata and *** would be more closely related to another American member of the Gerbera-complex,namely *** area reconstructions show that the historical biogeography of the Gerbera-complex mirrors that of the entire Asteraceae,with early diverging lineages located in South America that were followed by transfers to Africa and eurasia and,most recently,to North *** transfer of Leibnitzia appears to have been directed from Asia to North *** calibrations of nuclear(ribosomal DNA internal transcribed spacer region)and chloroplast(trnL-rpl32 intron)DNA sequence data using relaxed clock methods and either mean rate or fossil-based priors unanimously support Miocene and younger divergence times for Gerbera-complex *** ages are not consistent with most Gondwanan vicariance episodes and,thus,the global distribution of Gerbera-complex members must be explained in large part by long-distance *** species of Leibnitzia are estimated to have diverged from their Asian ancestor during the Quaternary(ca.2 mya)and either migrated overland to North America via Beringia and retreated southwards along high elevation corridors to their present location in southwestern North America or were dispersed long distance.

关键词： Beringia biogeography Gerbera-complex Mutisieae.

Identification of conserved Regulatory elements in Mammalian Promoter Regions:A case Study Using the PcK1 Promoter

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Genomics, Proteomics & Bioinformatics 2008年第3期6卷 129-143页

作者： George e. Liui Matthew T. Weirauch curtis P. Van Tassell Robert W. Li Tad S. Sonstegard LakshmiK. Matukumal erin e. connor Richard W. Hanson Jianqi Yang Bovine Functional Genomics Laboratory Beltsville Agricultural Research Center Beltsville MD 20705 USA Department of Biomolecular engineering University of California Santa Cruz Santa Cruz CA 95064 USA Department of Bioinformatics and computational Biology George Mason University Manassas VA 20110 USA Department of Biochemistry Case Western Reserve University School of Medicine Cleveland OH 44106 USA.

A systematic phylogenetic footprinting approach was performed to identify conserved transcription factor binding sites （TFBSs） in mammalian promoter regions using human, mouse and rat sequence alignments. We found that the score distributions of most binding site models did not follow the Gaussian distribution required by many statistical methods. Therefore, we performed an empirical test to establish the optimal threshold for each model. We gauged our computational predictions by comparing with previously known TFBSs in the PcK1 gene promoter of the cytosolic isoform of phosphoenolpyruvate carboxykinase, and achieved a sensitivity of 75% and a specificity of approximately 32% Almost all known sites overlapped with predicted sites, and several new putative TFBSs were also identified. We validated a predicted SP1 binding site in the control of PcK1 transcription using gel shift and reporter assays. Finally, we applied our computational approach to the prediction of putative TFBSs within the promoter regions of all available RefSeq genes. Our full set of TFBS predictions is freely available at http：//***/tfbsconsSites.

关键词： phylogenetic footprinting phosphoenolpyruvate carboxykinase transcription factor binding sites mammalian gene promoters

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放疗与替莫唑胺联合治疗胶质母细胞瘤

世界核心医学期刊文摘（神经病学分册） 2005年第9期1卷 6-7页

作者： Stupp R. mason W.P. Van Den Bent M.J. 黄卫东 Multidisciplinary Oncology center Ctr. Hospitaller Univ. Vaudois 46 rue du Bugnon CH-1011 Laus anne SwitzerlandDr.

BAcKGROUND: Glioblastoma, the most common primary brain tumor in adults, is us ually rapidly fatal. The current standard of care for newly diagnosed glioblasto ma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy p lus temozolomide, given concomitantly with and after radiotherapy, in terms of e fficacy and safety. MeTHODS: Patients with newly diagnosed, histologically confi rmed glioblastoma were randomly assigned to receive radiotherapy alone (fraction ated focal irradiation in daily fractions of 2 Gy given 5 days per week for 6 we eks, for a total of 60 Gy) or radiotherapy plus continuous daily temozolomide (7 5 mg per square meter of body-surface area per day, 7 days per week from the fi rst to the last day of radiotherapy), followed by six cycles of adjuvant temozol omide (150 to 200 mg per square meter for 5 days during each 28-day cycle). The primary end point was overall survival. ReSULTS: A total of 573 patients from 8 5 centers underwent randomization. The median age was 56 years, and 84 percent o f patients had undergone debulking surgery. At a median follow-up of 28 months, the median survival was 14.6 months with radiotherapy plus temozolomide and 12. 1 months with radiotherapy alone. The unadjusted hazard ratio for death in the r adiotherapy-plus-temozolomide group was 0.63 (95 percent confidence interval, 0.52 to 0.75; P e log-rank test). The two-year survival rate was 26.5 percent with radiotherapy plus temozolomide and 10.4 percent with radiother apy alone. concomitant treatment with radiotherapy plus temozolomide resulted in grade 3 or 4 hematologie toxic effects in 7 percent of patients. cONcLUSIONS: T he addition of temozolomide to radiotherapy for newly diagnosed glioblastoma res ulted in a clinically meaningful and statistically significant survival benefit with minimal additional toxicity.

关键词：替莫唑胺胶质母细胞瘤原发性脑肿瘤组织学检查标准治疗方法单纯放疗组局部放疗中位生存时间随机研究毒副作用

Miniature gastrointestinal endoscopy: Now and the future

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World Journal of Gastroenterology 2019年第30期25卷 4051-4060页

作者： John J McGoran Mark e McAlindon Prasad G Iyer eric J Seibel Rehan Haidry Laurence B Lovat Sarmed S Sami Digestive Diseases centre Leicester Royal InfirmaryLeicester LE1 5WWUnited Kingdom Department of Gastroenterology Royal Hallamshire HospitalSheffield S10 2JFUnited Kingdom Division of Gastroenterology and Hepatology Mayo Clinic RochesterMN 55905United States Department of Mechanical engineering University of Washington4000 Mason StSeattleWA 98195United States Division of Surgery and Interventional Science University College LondonLondon WC1E 6BTUnited Kingdom

Since its original application,gastrointestinal(GI)endoscopy has undergone many innovative transformations aimed at expanding the scope,safety,accuracy,acceptability and cost-effectiveness of this area of clinical *** method of achieving this has been to reduce the caliber of endoscopic *** propose the collective term“Miniature GI endoscopy”.In this Opinion Review,the innovations in this field are explored and *** progress and clinical use of the three main areas of miniature GI endoscopy(ultrathin endoscopy,wireless endoscopy and scanning fiber endoscopy)are *** opportunities presented by these technologies are set out in a clinical context,as are their current *** of the positive aspects of miniature endoscopy are clear,in that smaller devices provide access to potentially all of the alimentary canal,while conferring high patient *** must be balanced with the costs of new technologies and recognition of device specific *** on future application are also considered and the efforts being made to bring new innovations to a clinical platform are *** devices demonstrate that miniature GI endoscopy has a valuable place in investigation of symptoms,therapeutic intervention and *** technologies give promise that the potential for enhancing the investigation and management of GI complaints is significant.

关键词： Ultrathin endoscopy capsule endoscopy Single fiber endoscopy

Phylogenetic insights resolve Dacampiaceae(Pleosporales)as polyphyletic:Didymocyrtis(Pleosporales,Phaeosphaeriaceae)with Phoma-like anamorphs resurrected and segregated from Polycoccum(Trypetheliales,Polycoccaceae ***.)

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Fungal Diversity 2015年第5期74卷 53-89页

作者： Damien ertz Paul Diederich James D.Lawrey Franz Berger colin e.Freebury Brian coppins Alain Gardiennet Josef Hafellner Department Bryophytes-Thallophytes(BT) Botanic Garden MeiseNieuwelaan 38B-1860 MeiseBelgium Musée national d’histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg Department of Biology George Mason University4400 University DriveFairfaxVA 22030USA Raiffeisenweg 130 A-4794 KopfingAustria canadian Museum of Nature PO Box 3443Stn.BDOttawaOntarion K1P 6P4Canada Royal Botanic Garden edinburgh 20A Inverleith RowEdinburgh EH35LRUK 14 rue Roulette F-21260 VéronnesFrance Institute for Plant Sciences NAWI GrazKarl-Franzens-University GrazHolteigasse 6A-8010 GrazAustria

A phylogenetic analysis of nuLSU and ITS sequences representing genera previously included in Dacampiaceae indicates that the family is strongly polyphyletic and that the type species of Dacampia is placed in *** genus Munkovalsaria *** placed in Didymosphaeriaceae(Pleosporales).Polycoccum *** two species of clypeococcum are shown to form a new lineage sister to the Trypetheliaceae in Trypetheliales and described here as *** members of Polycoccum *** included in the Pleosporales and are closely related to lichenicolous Phoma-like species of the family *** genus Didymocyrtis is resurrected for these species and for lichenicolous species previously assigned to Diederichia,Diederichomyces,Leptosphaeria and *** genera Diederichia and Diederichomyces are synonymized with *** new combinations Didymocyrtis bryonthae,***,***,***,***,***,***,***,*** and *** are made,and the new name *** is introduced for Phoma *** anamorph-teleomorph relationships are resolved,such as Didymocyrtis ramalinae–Phoma ficuzzae and Didymocyrtis consimilis–Phoma caloplacae,the phylogenetic results being supported by single ascospore cultures that lead to the asexual stage producing pycnidia and conidia in *** by host switching is assumed to be important in the genus *** identification key to Didymocyrtis species is provided.

关键词： Dothideomycetes Leptosphaeria Diederichia Diederichomyces Lichenicolous fungi Phylogeny