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A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.w.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

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Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

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Science china chemistry 2025年

作者： Jing-wen Xie Meng-Ting wang Yan Jin Si Li Jian-Hua Qin Shuang-Quan Zang Tomas c.w.Mak college of chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University college of chemistry and chemical Engineering Luoyang Normal University Department of chemistry The Chinese University of Hong Kong

circularly polarized luminescence （cPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for cPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with cd2+ions to obtain 2D layers structure,L/*** L/D-cu4-cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and cPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the wLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

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Effect of different water supply on morphology, growth and physiological characteristics of Salix psammophila seedlings in Maowusu sandland, china

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Journal of Environmental Sciences 2001年第4期13卷 411-417页

作者： Xiao, c.-w. Lab. Quantitative Vegetation Ecol. Institute of Botany Chinese Academy of Sciences Beijing 100093 China

Response pattern was investigated for seedlings of Salix psammophila, a dominant shrub in Maowusu sandland, to the simulated precipitation change by artificially controlling water supply at four levels. The growth characters, in terms of plant height, stem diameter, total branch number, total leaf number and area, total bifurcation ratio, total branch lenght and branch number, branch lenght, leaf number and leaf area of each branch order, and leaf, branch and root biomass significantly increased when water supply increased. That water supply had significant effect on biomass allocation showed different investment pattern of biomass resource of the seedlings grown under different water supply treatments. Stomatal density of abaxial leaf surface decreased, and stomatal apparatus length and width of adaxial and abaxial leaf surface increased with the increase of water supply, while Stomatal density of adaxial leaf surface was not affected by water supply. water supply obviously affected the diumal changes of photosynthetic rate, and the photosynthetic rate of the seedlings showed strongly midday depression grown under the 157.5 mm water supply, but not grown under higher water supply. Additionally the assimilation-light response curves and flourescence efficiency more showed that water supply improve photosynthesis capacity. Finally, S. psammophila seedlings stood out by their slow growth and relatively high investments in root growth in order to reduce tissue losing rate and consumption of water resource for keeping water balance under water stress. The seedlings that grown under rich water supply did by their fast growth and relatively high investments in branch and leaf growth in order to improve the power of capturing light energy for higher photosynthesis.

关键词： Biomass Fluorescence Morphology Photosynthesis Physiology Plants (botany) Precipitation (chemical) Seed Tissue

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Measurement and Prediction of Insertion Force for the Mosquito Fascicle Penetrating into Human Skin

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Journal of Bionic Engineering 2009年第2期6卷 143-152页

作者： X Q Kong c w wu State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering MechanicsDalian University of Technology

Mosquitoes are exceptional in their ability to pierce into human skin with a natural ultimate painless microneedle, named fascicle. Here the structure of the Aedes albopictus mosquito fascicle is obtained using a Scanning Electron Microscope (SEM), and the whole process of the fascicle inserting into human skin is observed using a high-speed video imaging technique. Direct measurements of the insertion force for mosquito fascicle to penetrate into human skin are reported. Results show that the mosquito uses a very low force (average 18 μN) to penetrate into the skin. This force is at least three orders of magnitude smaller than the reported lowest insertion force for an artificial microneedle with an ultra sharp tip to insert into the human skin. In order to understand the piercing mechanism of mosquito fascicle tip into human multilayer skin tissue, a numerical simulation is conducted to analyze the insertion process using a nonlinear finite element method. A good agreement occurs between the numerical results and the experimental measurements.

关键词： biomimetic microneedle mosquito fascicle mechanics penetration

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Effect of suction change on water content and total volume of an expansive clay

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 699-706页

作者： ZHAN Liang-tong cHEN Ping NG c.w.w. ~ Department of civil Engineering Zhejiang University Hangzhou 310027 China Department of civil Engineering Zhejiang Sci- Tech University Hangzhou 310018 China Department of civil Engineering Hong Kong University of Science and Technology Hong Kong China

A laboratory study was carried out on both natural and compacted specimens to investigate the complex soil-water interaction in an unsaturated expansive clay. The laboratory study includes the measurement of soil-water characteristic curves, 1D free swelling tests, measurement of swelling pressure and shrinkage tests. The test results revealed that the air-entry value of the natural specimen was quite low due to cracks and fissures present. The hydraulic hysteresis of the natural specimen was relatively insignificant as compared with the compacted specimen. within a suction range 0 to 500 kPa, a bilinear relationship between free swelling strain (or swelling pressure) and initial soil suction was observed for both the natural and compacted specimens. As a result of over-consolidation and secondary structures such as cementation and cracks, the natural specimens exhibited significant lower swelling (or swelling pressure) than the compacted specimen. The change of matric suction exerts a more significant effect on the water phase than on the soil skeleton for this expansive clay.

关键词： Expansive soil water content Suction Swelling Shrinkage

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Is a nanorod (or nanotube) with a lower Young’s modulus stiffer? Is not Young’s modulus a stiffness indicator?

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Science china(Physics,Mechanics & Astronomy) 2010年第4期53卷 712-724页

作者： Lim c. w. Department of Building and construction City University of Hong Kong

It has been a known fact in classical mechanics of materials that Young’s modulus is an indicator of material stiffness and materials with a higher Young’s modulus are stiffer. At the nanoscale, within the scope and under specific circumstances described in this paper, however, a nanorod (or a nanotube) with a smaller Young’s modulus (smaller stress-strain rate) is stiffer. In such a scenario, Young’s modulus is not a stiffness indicator for nanostructures. Furthermore, the nonlocal stress-strain rate is dependent on types of load, boundary conditions and location. This is likely to be one of the many possible reasons why numerous experiments in the past obtained significantly varying values of Young’s modulus for a seemingly identical nanotube, i.e. because the types of loading and/or boundary conditions in the experiments were different, as well as at which point the property was measured. Based on the nonlocal elasticity theory and within the scope of material and geometric linearity, this paper reports the strange and hitherto unrealized effect that a nanorod (or a nanotube) with a lower Young’s modulus (smaller stress-strain rate) indicates smaller extension in tensile analysis. Similarly, it is also predicted that a nanorod (or a nanotube) with a lower Young’s modulus results in smaller bending deflection, higher critical buckling load, higher free vibration frequency and higher wave propagation velocity, which are at all consequences of a stiffer nanostructure.

关键词： nanorod nanotube nonlocal stress nonlocal elasticity stiffness tensile Young’s modulus

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