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Regulator of G protein signaling 6 mediates exercise-induced recovery of hippocampal neurogenesis,learning,and memory in a mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2969-2981页

作者： Mackenzie M.spicer Jianqi Yang Daniel Fu Alison N.DeVore Marisol Lauffer Nilufer s.Atasoy Deniz Atasoy Rory A.Fisher Department of Neuroscience and Pharmacology University of Iowa Carver College of MedicineIowa CityIAUSA Iowa Neuroscience Institute University of Iowa Carver College of MedicineIowa CityIAUSA Interdisciplinary Graduate Program in Molecular Medicine University of Iowa Carver College of MedicineIowa CityIAUSA Neural circuits and Behavior core University of Iowa Carver College of MedicineIowa CityIAUSA

Hippocampal neuronal loss causes cognitive dysfunction in Alzheimer’s *** hippocampal neurogenesis is reduced in patients with Alzheimer’s *** stimulates adult hippocampal neurogenesis in rodents and improves memory and slows cognitive decline in patients with Alzheimer’s ***,the molecular pathways for exercise-induced adult hippocampal neurogenesis and improved cognition in Alzheimer’s disease are poorly ***,regulator of G protein signaling 6(RGs6)was identified as the mediator of voluntary running-induced adult hippocampal neurogenesis in ***,we generated novel RGs6fl/fl;APP_(sWE) mice and used retroviral approaches to examine the impact of RGs6 deletion from dentate gyrus neuronal progenitor cells on voluntary running-induced adult hippocampal neurogenesis and cognition in an amyloid-based Alzheimer’s disease mouse *** found that voluntary running in APP_(sWE) mice restored their hippocampal cognitive impairments to that of control *** cognitive rescue was abolished by RGs6 deletion in dentate gyrus neuronal progenitor cells,which also abolished running-mediated increases in adult hippocampal *** hippocampal neurogenesis was reduced in sedentary APP_(sWE) mice versus control mice,with basal adult hippocampal neurogenesis reduced by RGs6 deletion in dentate gyrus neural precursor ***6 was expressed in neurons within the dentate gyrus of patients with Alzheimer’s disease with significant loss of these RGs6-expressing ***,RGs6 mediated voluntary running-induced rescue of impaired cognition and adult hippocampal neurogenesis in APP_(sWE) mice,identifying RGs6 in dentate gyrus neural precursor cells as a possible therapeutic target in Alzheimer’s disease.

关键词： adult hippocampal neurogenesis Alzheimer’s disease dentate gyrus exercise learning/memory neural precursor cells regulator of G protein signaling 6(RGs6)

Melanopsin expression is an indicator of the well-being of melanopsin-expressing retinal ganglion cells but not of their viability

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Neural Regeneration Research 2016年第8期11卷 1243-1244页

作者： Marta Agudo-Barriuso Francisco M.Nadal-nicolás María H.Madeira Giuseppe Rovere Beatriz Vidal-Villegas Manuel Vidal-sanz Departamento de Oftalmologia Facultad de Medicina Universidad de Murcia and Instituto Murciano de Investigacion Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca) Murcia Spain Institute for Biomedical Imaging and Life sciences (IBILI) Faculty of Medicine University of Coimbra Coimbra Portugal cNc.IBILI University of Coimbra Coimbra Portugal

Light is an electromagnetic stimulus that in mammals is sensed by specialized neurons in the *** physiological response to light encompasses two fundamental and different functional outputs：image-forming and non-imag... 详细信息

关键词： RGcs retina specialized physiological expressing ganglion viability tracing Figure unpublished

TENsILE cREEP DEFORMATION AND DAMAGE BEHAVIOR IN A NIcKEL-BAsE sUPERALLOY AT 900℃

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Acta Metallurgica sinica(English Letters) 2004年第4期17卷 606-611页

作者： H.c.Yu s.s.Xie H.c.Yang Beijing Institute of Aeronautical Materials Beijing 100095 ChinaR & D Center Baosteel Co. Ltd. Shanghai 201900 ChinaCollege of Materials and Metallurgy Northeastern University Shenyang 110004 China

The tensile creep deformation and damage evolution in a Ni-base superalloy at 900℃/170MPa were investigated. At the first creep stage, abnormal creep occured due to the resolution of fine particles, and the deformation initiated from grain boundary areas. It is evident that nearly all of the dislocations were in γ matrix channels in form of dislocation pairs and the dislocations were impeded at γ/γ' interfaces, thus the dislocation networks developed deformation. At the steady creep stage, impeded dislocations atγ/γ' interfaces climbed over γ' phases by diffusion-dominant mechanism. At the last creep stage, voids were formed around carbides at grain boundary which leaded to accumulated damage and caused creep rate accelerated. With the dislocation networks being broken, the voids connected and grew into micro-cracks gradually. Finally the cracks propagated along grain boundary area and resulted in failure.

关键词： creep deformation and damage dislocation microstructure su-peralloy

convergence,scalarization and continuity of Minimal solutions in set Optimization

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Journal of the Operations Research society of china 2024年第3期12卷 773-793页

作者： Karuna c.s.Lalitha Department of Mathematics University of DelhiDelhiDelhi110007India Department of Mathematics University of Delhi South CampusNew DelhiDelhi110021India

The paper deals with the study of two different aspects of stability in the given space as well as the image space,where the solution concepts are based on a partial order relation on the family of bounded subsets of a real normed linear *** first aspect of stability deals with the topological set convergence of families of solution sets of perturbed problems in the image space and Painlevé–Kuratowski set convergence of solution sets of the perturbed problems in the given *** convergence in the given space is also established in terms of solution sets of scalarized perturbed *** second aspect of stability deals with semicontinuity of the solution set maps of parametric perturbed problems in both the spaces.

关键词： Topological convergence Painlevé-Kuratowski convergence Upper semicontinuity Lower semicontinuity stability scalarization

Temperature correction for Thickness Measurements of Hot Rolled steel Plates

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Journal of Iron and steel Research International 2010年第12期17卷 23-29页

作者： c Gheorghies s condurache-Bota Faculty of sciences Dunarea de Jos University

Measuring the thickness of steel plates during the hot rolling process Is crucial tor getnng me necessary feedback to obtain the desired values at room temperature. The dilatation and the phase transformations of steel occur during heating and subsequent cooling and rolling strongly influences the results of thickness measurements. The radiometrie method provides the necessary means for making real-time and fully automatized measurements of steel thickness during rolling, if only the temperature correction is precisely known and taken into consideration. This article proves that the experimental results concerning the relative variation of steel thickness and corresponding massthickness variation can be correctly explained by means of the theory of metal dilatation correlated with the theory of nuclear radiation absorption when passing through a metal or metallic alloy, such as steel.

关键词： hot rolling dilatation phase transformation temperature correction attenuation

sources and Deficiency Diseases of Mineral Nutrients in Human Health and Nutrition:A Review

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Pedosphere 2014年第1期24卷 13-38页

作者： U.c.GUPTA s.c.GUPTA Agriculture and Agri-canada canada Crops and Livestock Research Centre The Department of Plastic surgery Loma Linda University

Mineral nutrients are fundamentally metals and other inorganic compounds. The life cycle of these mineral nutrients begins in soil, their primary source. soil provides minerals to plants and through the plants the minerals go to animals and humans; animal products are also the source of mineral nutrients for humans. Plant foods contain almost all of the mineral nutrients established as essential for human nutrition. They provide much of our skeletal structure, e.g., bones and teeth. They are critical to countless body processes by serving as essential co-factors for a number of enzymes. Humans can not utilize most foods without critical minerals and enzymes responsible for digestion and absorption. Though mineral nutrients are essential nutrients, the body requires them in small, precise amounts. We require them in the form found in crops and they can be classified into three different categories： major, secondary, and micro or trace minerals. This classification is based upon their requirement rather than on their relative importance. Major minerals such as potassium （K） and phosphorus （P） are required in amounts of up to 10 g d-1. The daily requirement of secondary and micro minerals ranges from 400 to 1 500 mg d-1 and 45 ~tg d-1 to 11 mg d-1, respectively. To protect humans from mineral nutrient deficiencies, the key is to consume a variety of foods in modest quantities, such as different whole grains, low fat dairy, and different meats, vegetables and fruits. For insurance purposes, a supplement containing various mineral nutrients can be taken daily.

关键词： deficiency diseases deficiency symptoms origin recommended daily dose toxicity

The race towards quantum computational advantage:milestone photonic experiment

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science Bulletin 2021年第7期66卷 637-639页

作者： Fabio sciarrino nicolòspagnolo Quantum Information Laboratory Dipartimento di FisicaSapienza Universitàdi Roma

In recent years,much work has been directed to the development of technologies to enable the long-term goal of scalable,universal quantum *** effort is motivated by the promise of quantum computational speed-up in tasks such as integer factoring,quantum simulation,and solving systems of linear *** the tremendous advances in quantum technologies reported in the last few years,the implementation of a large-scale universal quantum computer is still far from our current capabilities.

关键词： equations. 量子计算 quantum

Inverse methodology as applied to reconstruct local textile features from measured pressure field

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Journal of Materials science & Technology 2021年第12期71卷 241-247页

作者： s.Bancora c.Binetruy s.Advani comas-cardona Ecole centrale de Nantes Research Institute in Civil Engineering and Mechanics(GeM)UMR CNRS 618344321 Nantes Cedex 3France Department of Mechanical Engineering University of DelawareNewarkDelaware 19716USA

One can compute the final deformation of a known geometry under specific boundary conditions using the constitutive laws of mechanics that describe their stress strain *** such cases the initial geometry is known,and all operators mapping the deformation are defined on the reference ***,there are situations in which the final configuration of a deformation might be known but not the *** inverse formulation allows one to determine the initial geometry of a domain,given its final deformation state,the material behavior law and a set of boundary *** the present work we propose a method to reconstruct the mesoscale geometry of a textile based on its mechanical response during *** do so,stress boundary conditions are acquired by means of a pressuresensitive *** adopting an appropriate material law,the thickness and width information of the yarns are deduced from the pressure field experienced by the compacted *** 3 D scanning techniques such as-cT,the proposed method can be applied on any domain size,allowing long-range variability to be *** the best of the authors’knowledge,there are no previous works that use a pressure-sensitive film on a large domain to capture the input data for a shape *** example application serves as a demonstration of a methodology which could be applied to other classes of materials.

关键词： Textiles Pressure sensors Inverse method Digital twin Geometry reconstruction Hyperelasticity

Pore size Distribution of High Performance Metakaolin concrete

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Journal of Wuhan University of Technology(Materials science) 2002年第1期17卷 42-46页

作者： c.s.Poon s.c.Kou L.Lam Department of civil and structural Engineering The Hong Kong Polytechnic University Hong Kong China

The compressive strength, porosity and pore size distribution of high performance metakaolin (MK) concrete were investigated. concretes containing 0,5% , 10% and 20% metakaolin were prepared at a water / cementitious material ratio ( W/c) of 0. 30. In parallel, concrete mixtures with the replacement of cement by 20% fly ash or 5 and 10% silica fume were prepared for comparison. The specimens were cured in water at 27℃ for 3 to 90 days. The results show that at the early age of curing (3 days and 7 days), metakaolin replacements increase the compressive strength, but silica fume replacement slightly reduces the compressive strength. At the age of and after 28 days , the compressive strength of the concrete with metakaolin and silica fume replacement increases. A strong reduction in the total porosity and average pore diameter were observed in the concrete with MK 20% and 10% in the first 7 days.

关键词： high performance concrete metakaolin pore size distribution