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The transcription factor HSFA7b controls thermomemory at the shoot apical meristem by regulating ethylene biosynthesis and signaling in Arabidopsis

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Plant communications 2024年第3期5卷 47-61页

作者： Sheeba John Federico Apelt Amit Kumar Ivan FAcosta Dominik Bents Maria Grazia Annunziata Franziska Fichtner caroline Gutjahr Bernd mueller-Roeber Justyna J.Olas University of Potsdam Institute of Biochemistry and BiologyKarl-Liebknecht-Straße 24-25Haus 2014476 PotsdamGermany Max Planck Institute of Molecular Plant Physiology Am Muehlenberg 114476 PotsdamGermany Laboratory of Molecular Biology Wageningen University6700 AP Wageningenthe Netherlands center of Plant Systems Biology and Biotechnology(cPSBB) 14 St.Knyaz Boris 1 Pokrastitel Str.4023 PlovdivBulgaria Present address:Institute of Plant Biochemistry Heinrich Heine University DusseldorfUniversit€atsstr.140225 DusseldorfGermany Leibniz Institute of Vegetable and Ornamental crops Theodor-Echtermeyer-Weg 114979 GroßbeerenGermany

The shoot apical meristem(SAM)is responsible for overall shoot growth by generating all aboveground *** research has revealed that the SAM displays an autonomous heat stress(HS)memory of a previous non-lethal HS *** the importance of the SAM for plant growth,it is essential to determine how its thermomemory is mechanistically ***,we report that HEAT SHOcK TRAN-ScRIPTION FAcTOR A7b(HSFA7b)plays a crucial role in this process in Arabidopsis,as the absence of functional HSFA7b results in the temporal suppression of SAM activity after *** found that HSFA7b directly regulates ethylene response at the SAM by binding to the promoter of the key ethylene signaling gene ETHYLENE-INSENSITIVE 3 to establish ***,we demonstrated that HSFA7b regulates the expression of ETHYLENE OVERPRODUcER 1(ETO1)and ETO1-LIKE 1,both of which encode ethylene biosynthesis repressors,thereby ensuring ethylene homeostasis at the *** together,these results reveal a crucial and tissue-specic role for HSFA7b in thermomemory at the Arabidopsis SAM.

关键词： ethylene response heat stress adaptation shoot apical meristem SAM thermopriming thermomemory

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应用改良同态滤波方法提高全脊柱MR成像质量——在多发性骨髓瘤中的初步结果

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国际医学放射学杂志 2008年第A6期31卷 525-525页

作者： M.P.Lichy c.mueller-Horvat V.Jellus W.Horger M.Horger c.Pfannenberg 刘庆余 Department of Diagnostic Radiology University of Tuebingen Tuebingen Germany.

评价改良同态滤波方法(BiFic)在临床MR影像后处理中的价值,特别是影像质量及诊断的安全性。23例病人全脊柱检查采用同态滤波方法进行后处理。

关键词：全身MRI 同态滤波信号均匀性影像阅读多发性骨髓瘤

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cachexia and pancreatic cancer: Are there treatment options?

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World Journal of Gastroenterology 2014年第28期20卷 9361-9373页

作者： Tara c.mueller Marc A Burmeister Jeannine Bachmann Marc E Martignoni Department of Surgery University Hospital Rechts der IsarTechnical University of Munich Braun Melsungen AG/Department of Anesthesiology University Hospital Hamburg Eppendorf

cachexia is frequently described in patients with pancreatic ductal adenocarcinoma (PDAc) and is associated with reduced survival and quality of life. Unfortunately, the therapeutic options of this multi-factorial and complex syndrome are limited. This is due to the fact that, despite extensive preclinical and clinical research, the underlying pathological mechanisms leading to PDAc-associated cachexia are still not fully understood. Furthermore, there is still a lack of consensus on the definition of cachexia, which complicates the standardization of diagnosis and treatment as well as the analysis of the current literature. In order to provide an efficient therapy for cachexia, an early and reliable diagnosis and consistent monitoring is required, which can be challenging especially in obese patients. Although many substances have been tested in clinical and preclinical settings, so far none of them have been proven to have a long-term effect in ameliorating cancer-associated cachexia. However, recent studies have demonstrated that multidimensional therapeutic modalities are able to alleviate pancreatic cancer-associated cachexia and ultimately improve patients’ outcome. In this current review, we propose a stepwise and pragmatic approach to facilitate and standardize the treatment of cachexia in pancreatic cancer patients. This strategy consists of nutritional, dietary, pharmacological, physical and psychological methods.

关键词： cachexia Pancreatic neoplasms Nutritional support Gastrointestinal neoplasms

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Pharmacological blockage of cYP2E1 and alcohol-mediated liver cancer: is the time ready?

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chinese Journal of cancer Research 2013年第3期25卷 269-271页

作者： Sebastian mueller Department of Medicine and Alcohol Research center Salem Medical Center University of Heidelberg

chronic alcohol consumption is a major risk factor worldwide affecting significantly both mortality and years of life lost （YLL）（1）. ca. 5% of the western world show risky alcohol consumption and in some countries such as china a regional yearly increase of alcohol consumption of over 400% has been observed recently （2,3）. The liver is the major target organ of alcohol. According to the recently published ＇Global Burden of Disease Study 2010, liver cirrhosis and liver cancer are ranked at position 12 and 16 in the global deaths statistics （1）. Thus, in 2010, ca. 1 million people died from liver cirrhosis with one third directly attributable to alcohol. This is a considerable number when comparing with coronary heart disease with 7 million deaths and the leading cause of mortality. In central Europe, liver cirrhosis even ranks at the fourth position in YLL. Hepatocellular cancer （Hcc） is now the most common fatal complication of patients with alcoholic cirrhosis. Moreover, it shows the second fastest increase of all tumors worldwide after kidney tumors and alcohol-associated Hcc ranks on third position after Hccs caused by viral hepatitis B and c.

关键词： cYP Pharmacological blockage of cYP2E1 and alcohol-mediated liver cancer is the time ready time

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Enterprise applications of semantic technologies for business process management

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Journal of Zhejiang University-Science c(computers and Electronics) 2012年第4期13卷 308-310页

作者： Ralf mueller Oracle BPM Product Development

1 Introduction Today’s business process management (BPM)systems have evolved to provide rich and sophisticated tooling and runtime support for subject

关键词：业务流程管理信息技术企业应用程序语义 Web本体语言 PM系统流程模型基础设施

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Stem cell treatment and cerebral palsy: Systemic review and meta-analysis

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World Journal of Stem cells 2019年第10期11卷 891-903页

作者： Simone Eggenberger céline Boucard Andreina Schoeberlein Raphael Guzman Andreas Limacher Daniel Surbek Martin mueller Department of Obstetrics and Gynaecology InselspitalUniversity Hospital BernBern 3010Switzerland Department for BioMedical Research University of BernBern 3008Switzerland Department of Neurosurgery University Hospital of BaselBasel 4056Switzerland cTU Bern University of BernBern 3012Switzerland

BAcKGROUND Perinatal complications may result in life-long morbidities,among which cerebral palsy(cP)is the most severe motor *** developed,cP is a nonprogressive disease with a prevalence of 1-2 per 1000 live births in developed *** demands an extensive and multidisciplinary ***,it is a challenge for our health system and a burden for patients and their ***,stem cell therapy emerged as a promising treatment option and raised hope in patients and their *** The aim is to evaluate the efficacy and safety of stem cell treatment in children with cP using a systematic review and meta-analysis METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials(RcT)investigating the effect of stem cell transplantation in children with *** the review,we performed a randomeffects meta-analysis focusing on the change in gross motor function,which was quantified using the gross motor function *** calculated the pooled standardized mean differences of the 6-and/or 12-mo-outcome by the method of *** quantified the heterogeneity using the I-squared *** We identified a total of 8 RcT for a qualitative *** the initially selected trials,5 met the criteria and were included in the ***’population ranged from 0.5 up to 35 years(n=282).We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95(95%confidence interval:0.13-1.76)favoring the stem cell group and a high heterogeneity(I2=90.1%).Serious adverse events were rare and equally distributed among both intervention and control *** Stem cell therapy for cP compared with symptomatic standard care only,shows a significant positive effect on the gross motor function,although the magnitude of the improvement is ***-term safety is present and further highquality RcTs are needed.

关键词： cerebral palsy Perinatal brain injury Stem cells Umbilical cord blood Mesenchymal stem/stromal cells Gross motor function Meta-analysis

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Alcoholic liver disease and hepatitis c:A frequently underestimated combination

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World Journal of Gastroenterology 2009年第28期15卷 3462-3471页

作者： Sebastian mueller Gunda Millonig Helmut K Seitz Department of Medicine and center for Alcohol Research Live Disease and Nutrition Salem Medical Center University of Heidelberg Zeppelinstraβe 11-33 69121 Heidelberg Germany

Alcoholic liver disease(ALD) and hepatitis c virus(HcV) infection represent, either alone or in combination, more than two thirds of all patients with liver disease in the Western *** review discusses the epidemiology and combined impact of ALD and HcV on the progres sion of liver *** and HcV affect the progres sion of liver disease to liver cirrhosis and hepatocellular carcinoma(Hcc) in a synergistic ***, the risk for Hcc increases f ive times with a daily alcohol con sumption of 80 g;in the presence of HcV it is increased 20fold, and a combination of both risk factors leads to a more than 100fold risk for Hcc *** consumption also decreases the response to interferon treatment which is probably due to a lack of compliance than a direct effect on HcV *** molecu lar mechanisms are discussed that could explain the synergistic interaction of alcohol and HcV on disease *** include modulation of the immune response and apoptosis, increased oxidative stress via induction of cYP2E1 and the hepatic accumulation of ***, both HcV and alcohol independently cause hepatic iron accumulation in > 50% of patients probably due to suppression of the liversecreted systemic iron hormone hepcidin.A better understanding of hepcidin regulation could help in developing novel therapeutic approaches to treat the chronic disease in the *** now, it can be generally concluded that HcVinfect ed patients should abstain from alcohol and alcoholicsshould be encouraged to participate in detoxification programs.

关键词： Alcoholic liver disease chronic hepatitis c Steatosis Steatohepatitis Fibrosis cirrhosis Reactiveoxygen species Hepatocellular carcinoma Iron accu-mulation

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Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice

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World Journal of Gastroenterology 2011年第8期17卷 968-975页

作者： cécile Bastard Matteo R Bosisio Michèle chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian mueller Laurent Sandrin Laurent Sandrin Echo-sens Research and Development Department INSERM U930 cNRS ERL3106 Univ Franois Rabelais UPMc Univ Paris 06 UMR 7623 LIP cNRS UMR 7623 Laboratoire d'Imagerie Paramétrique INSERM U872 Centre de Recherche des Cordeliers Equipe 4 UPMc Univ Paris 06 UMR S 872 Equipe 4 Univ Paris Descartes UMR S 872 Equipe 4 EPHE Laboratoire de Pharmacologie Cellulaire Et Moléculaire INSERM U1016 Institut Cochin cNRS UMR8104 Univ Paris Descartes Department of Medicine and center for Alcohol Research Liver Disease and Nutrition Salem Medical Center University of Heidelberg

AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in ***:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm *** novel probe was validated in a classical fibrosis model(ccl4) and in a transgenic murine model of systemic ***:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with ccl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P ch higher LS values were obtained,reaching maximum values of > 150 *** significantly correlated with the amyloidosis index(0.93,P concentration of mutant hapoA-□(0.62,P cONcLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS.

关键词： Transient elastography Micro-elastography Liver stiffness Liver Mice Amyloidosis Fibrosis Ultrasound

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每核子14.6和60GeV能量下氧离子诱发核反应的带电粒子谱

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高能物理与核物理 1989年第10期13卷 865-869页

作者： M.I.Adamovich M.M.A■■arwal R.Arora Y.A.Alexandrov S.A.Azimov S.K.Badyal E.Basova K.B.Bhalla A.Bhasin V.S.Badyal R.A.Bomadarenko T.H.Burnett 蔡(冒力) L.P.chernova M.M.chernyavski B.Dressel E.M.Friedlander S.I.Gerassimov E.R.Ganssau■e S.Garpman S.G.Gerassimov A.Gill J.Grote K.G.Gulamov V.G.Gulyamov V.K.Gupta S.Hackel H.H.Heckman B.Jakobsson B.Judek S.Katroo F.G.Kadyrov H.Kallies L.Karlsson G.L.Kaul M.Kaur S.P.Kharlamov J.Kohli V.Kumar P.Lal V.G.Larinova P.J.Lindstrom 刘连寿 S.Lokanathan J.Lord N.S.Lukicheva L.K.Man■otra N.V.Maslennikova I.S.Mitta E.Monnand S.Moolerjee c.mueller S.H.Nasyrov V.S.Nvtny G.I.Orlova I.Otterlund N.G.Peresadko S.Persson N.V.Petrov 钱琬燕 R.Raniwala S.Raniwana N.K.Rao J.Y.Rhee N.Shaidkhanov N.G.Salmanova W.Schulz F.Schussler V.S.Shukla D.Skeldin■ K.Soderstrom E.Stanlund R.S.Storey 孙君芬 L.N.Svechnilova M.I.Tretyakova T.P.Trofimova 王海桥翁智群 R.J.Wilkes 许国发张东海郑蒲英周代翠周景晨列比切夫研究所旁加贝大学物理技术研究所查漠大学拉加斯坦大学核物印研究所华盛顿大学华中师范大学菲利浦斯大学劳伦斯-伯克利实验室隆德大学国家研究委员会原子能研究中心 )列比切夫研究所山西师范大学高能物理研究所

本文给出了每核子14.6和60GeV能量下氧离子诱发核反应的带电粒子多重数分布和赝快度分布.实验数据取自EMU-01乳胶叠,并与Lund Monte carlo模型(FRITIOF)作了比较.

关键词：氧离子诱发核反应带电粒子谱

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Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells

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Nano Research 2016年第11期9卷 3437-3452页

作者： Wolfram c. Poller Evelyn Ramberger Philipp Boehm-Sturm Susanne mueller Konstantin Moller Norbert Lowa Frank Wiekhorst Susanne Wagner Matthias Taupitz Eyk Schellenberger Gert Baumann Karl Stangl Verena Stangl Antje Ludwig Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charite-Universitatsmedizin Berlin Campus Mitte Chariteplatz 1 10117 Berlin Germany Abteilung fur Experimentelle Neurologie Center for Stroke Research Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany charite core Facility '7 T experimental MRIs' Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Physikalisch-Technische Bundesanstalt Abbestr. 2-12 10587Berlin Germany Institut fur Radiologie Charite-Universitatsmedizin Berlin Campus Mitte Charit@platz 1 10117 Berlin Germany DZHK (German centre for cardiovascular Research) partner site Berlin 10115 Berlin Germany Berlin Institute of Health (BIH) 10117 Berlin Germany

Very small superparamagnetic iron oxide nanoparticles （VSOPs） rapidly accumulate in atherosclerotic lesions, thereby enabling plaque visualization by magnetic resonance imaging （MRI）. This study was performed to identify the uptake mechanisms of VSOPs into atherosclerotic plaques. Low-density lipoprotein receptor-deficient （LDLR^-/-） mice with advanced atherosclerosis were analyzed using MRI and transmission electron microscopy （TEM） at various time points after intravenous administration of VSOPs. Post-mortem MRI detected VSOP labeling of atherosclerotic plaques 10 min after injection, and the signal increased over the first 3 h. TEM revealed that the intensive plaque labeling was mediated by accelerated transcytosis of VSOPs through endothelial cells overlaying atherosclerotic lesions. Experiments with endocytosis inhibitors and small interfering RNA （siRNA） revealed a dynamin-dependent mechanism involving both clathrin- and caveolin-mediated processes. In cell culture experiments, endothelial VSOP uptake was enhanced under proatherogenic flow and TNFα stimulation, conditions that are both present in plaque areas. Our study demonstrates that VSOPs enable non-invasive MRI assessment of accelerated endothelial transcytosis, an important pathomechanism in atherosclerotic plaque formation.

关键词： atherosclerosis,unstable plaques,magnetic resonanceimaging decreased endothelial barrier function,superparamagnetic ironoxide nanoparticles

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