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Traceless photodegradable polymer cocoons for universal protein delivery and light-controlled gene editing

Science china chemistry 2024年第2期67卷 664-676页

作者： Huaibin Yu meron Tsegay Kifle Lili chen Feihong Xiong Yan Zhang Shangbang Gao Wei Hou Shuliang chen Weining Zhao Yuzhou Wu Hubei Engineering Research center for Biomaterials and Medical Protective Materials Hubei Key Laboratory of Bioinorganic Chemistry&Materia MedicaKey Laboratory of Material Chemistry for Energy Conversion and StorageMinistry of EducationSchool of Chemistry and Chemical EngineeringHuazhong University of Science and Technology(HUST)Wuhan430074China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou450000China college of Life Science and Technology Huazhong University of Science and Technology(HUST)Wuhan430074China Institute of Medical Virology School of Basic Medical SciencesWuhan UniversityWuhan430071China college of Pharmacy Shenzhen Technology UniversityShenzhen518118China

Polymer conjugation was found highly valuable in clinic to improve the bioavailability of protein ***,it is still a tremendous challenge to achieve a complete release of original proteins from the conjugated hybrid under external stimulus to recover active proteins in the targeted ***,we report a general light-controlled protein delivery methodology by weaving a photodegradable polymer cocoon around proteins,which could reliably protect them from degradation in the dark while efficiently releasing them under illumination without any residual *** surface charge of the polymer shell is easily tunable to facilitate efficient cell *** versatility of this strategy is demonstrated by the delivery of the cas9/sg RNA complex that realized light-controlled gene editing both in vitro and in vivo,and such repertoire is of particular value in regard to minimizing the off-target toxicity of cRISPR-cas9-based gene therapy.

关键词： photodegradable polymer-protein conjugate protein delivery light control gene editing

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Solar cooling Alternatives for Residential Houses

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Journal of civil Engineering and Architecture 2024年第7期18卷 348-362页

作者： meron Mulatu Mengistu Bahir Dar Institute of Technology Bahir Dar UniversityBahir Dar 26Ethiopia

The energy consumption rate of non-OEcD(non-Organisation for Economic co-operation and Development)countries rises about 2.3 percent per year as compared to the OEcD countries which is 0.6 *** developing countries use energy efficient technology and integrate renewable energy systems in the new building their carbon dioxide emission rate reduces by 25 to 44 ***,even now,renewable energy integrated buildings are hardly considered while constructing *** paper focuses on the study of solar cooling system options for residential house of Bahir Dar city,in *** meet the demand of housing in the city,different types of apartments and villa houses are under *** the analysis case study was made focusing on two types of residential houses,condominium apartment and Impact Real Estate Villa *** results of IDA IcE software show that the average operative temperatures and cooling loads for condominium apartment and Real-estate Vila are 31.8℃ and 30.7℃,5.53 kW and 5.73 kW *** of the residences are not satisfied at this operating *** are different types of solar cooling *** sorption cooling systems are commonly used which can also be classified into absorption,adsorption and desiccant cooling *** adsorption cooling systems are easy to manufacture locally as compared to solar absorption cooling *** do not have moving *** of the working medium pairs used in adsorption cooling system are:activated carbon/ammonia,silica gel/water,zeolite/*** chillier with silica gel/water as a working pair was selected since it can operate at regeneration/desorption temperature as low as 45℃ coming from flat plate *** 75℃ regeneration temperature,the system delivers 9℃ chilled water *** cooling load simulation result direct solar irradiation is the highest source of cooling load for both *** gives an opportunity for passive solar cooling

关键词： Adsorption cooling load condominium impact real-estate IDA IcE

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Important step towards an understanding of the exotic Z_(c)(3900)

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Science china(Physics,Mechanics & Astronomy) 2024年第9期67卷 199-200页

作者： c.Hanhart Institute for Advanced Simulation Forschungszentrum JulichJilich D-52425Germany

The Standard Model of particle physics,which contains the field theories for the electro-weak interaction(QED)and the strong interaction(QcD),is an extremely successful theory describing a huge variety of phenomena at... 详细信息

关键词： interaction atomic describing

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Light sheet microscope scanning of biointegrated microlasers for localized refractive index sensing

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Photonics Research 2024年第8期12卷 1673-1680页

作者： ROSS c.cOWIE MARcEL ScHUBERT SUPA School of Physics and AstronomyUniversity of St AndrewsSt AndrewsUK Humboldt centre for Nano and Biophotonics Department of ChemistryUniversity of CologneCologneGermany

Whispering gallery mode(WGM)microlasers are highly sensitive to localized refractive index changes allowing to link their emission spectrum to various chemical,mechanical,or physical *** recently found applications in biological studies within single cells,in three-dimensional samples such as multicellular spheroids,or in ***,detailed studies of biological samples also need to account for the structural heterogeneity of tissues and live animals,therefore requiring a combination of high-resolution microscopy and laser ***,we design and construct a light sheet fluorescence microscope with a coupled spectrometer for use in microlaser studies for combined high-resolution,high-speed imaging and WGM spectral *** light sheet illumination profile and the decoupled geometry of excitation and emission hereby directly affect the lasing and sensing properties,mainly through geometric constraints and by light coupling *** demonstrate the basic working principle of microlaser spectroscopy under light sheet excitation and measure the absolute refractive index within agarose and in zebrafish tail muscle *** further analyze the light coupling conditions that lead to the occurrence of two separate oscillation *** so-called cross modes can be scanned around the entire microlaser surface,which allows to estimate a surface-averaged refractive index profile of the microlaser environment.

关键词： refractive index excitation

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A toast to a zebrafish germ cell induction cocktail

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Science china(Life Sciences) 2024年第6期67卷 1314-1315页

作者： Mary c.Mullins Department of cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGcs)at phenomenal *** major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

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colonic schistosomiasis mimicking cancer,polyp,and inflammatory bowel disease:Five case reports and review of literature

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World Journal of Gastrointestinal Endoscopy 2024年第8期16卷 472-482页

作者： Sebhatleab T Mulate Abdulsemed M Nur Abel T Tasamma Rodas T Annose Esmael M Dawud Kinfe W Ekubazgi Hailemichael D Mekonnen Hidaya Y Mohammed meron B Hailemeskel Shimelis A Yimer Department of Internal Medicine Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Internal Medicine Division of Gastroenterology and HepatologyAddis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Internal Medicine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 9086Ethiopia Department of Internal Medicine Hawassa UniversityHawassa PO Box 05Ethiopia Department of Internal Medicine St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia Department of Pathology Addis Ababa UniversityCollege of Health ScienceAddis Ababa 9086Ethiopia Department of Pathology St Paul’s Hospital Millennium Medical CollegeAddis Ababa 1271Ethiopia Department of Pathology Ethio Tebib General HospitalAddis Ababa 1111Ethiopia

BAcKGROUND Schistosomiasis,officially named as a neglected tropical disease by The World Health Organization,is a serious parasitic disease caused by trematode flukes of the genus *** is a common infectious disease,endemic in more than 78 *** disease can involve various organs and poses far-reaching public health *** SUMMARY Here,we present a series of five patients with variable presentations:an asymptomatic patient who was diagnosed with colonic schistosomiasis upon screening colonoscopy;2 patients with clinical suspicion of colonic cancer;and 2 patients with a clinical diagnosis of inflammatory bowel *** patients were subsequently confirmed to have colonic schistosomiasis after colonoscopy and histopathologic *** clinical manifestations,colonoscopy features and histologic findings of the patients are *** of the patients showed significant clinical improvement following administration of oral *** Intestinal schistosomiasis can present with features mimicking other gastrointestinal *** disease should be a diagnostic consideration in patients who live in or have traveled to endemic areas.

关键词： Schistosomiasis Schistosoma colon Polyp Ethiopia case report

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convergence,Scalarization and continuity of Minimal Solutions in Set Optimization

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Journal of the Operations Research Society of china 2024年第3期12卷 773-793页

作者： Karuna c.S.Lalitha Department of Mathematics University of DelhiDelhiDelhi110007India Department of Mathematics University of Delhi South CampusNew DelhiDelhi110021India

The paper deals with the study of two different aspects of stability in the given space as well as the image space,where the solution concepts are based on a partial order relation on the family of bounded subsets of a real normed linear *** first aspect of stability deals with the topological set convergence of families of solution sets of perturbed problems in the image space and Painlevé–Kuratowski set convergence of solution sets of the perturbed problems in the given *** convergence in the given space is also established in terms of solution sets of scalarized perturbed *** second aspect of stability deals with semicontinuity of the solution set maps of parametric perturbed problems in both the spaces.

关键词： Topological convergence Painlevé-Kuratowski convergence Upper semicontinuity Lower semicontinuity Stability Scalarization

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Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.M.Saporetti L.c.Oliveira E.Pereira Department of computational and Applied Mechanics Federal University of Juiz de ForaJuiz de ForaBrazil Department of computational Modeling Polytechnic InstituteRio de Janeiro State UniversityNova FriburgoBrazil Petrobras Rio de JaneiroBrazil Department of Stratigraphy and Paleontology Rio de Janeiro State UniversityRio de JaneiroBrazil

Rock samples'TOc content is the best indicator of the organic matter in source *** origin rock samples’analysis is used to calculate it manually by *** method requires time and resources because it relies on samples from many well intervals in source ***,research has been done to aid this *** learning algorithms can estimate total organic carbon instead of well logs and stratigraphic *** light of these efforts,the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and *** algorithms,differential evolution,particle swarm optimization,grey wolf optimization,artificial bee colony,and evolution strategies were used to improve machine learning models to predict *** six metaheuristics were integrated into four machine learning methods:extreme learning machine,elastic net linear model,linear support vector regression,and multivariate adaptive regression *** samples from the YuDong-Nan shale gas field,located in the Sichuan basin,were used to evaluate the hybrid *** findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict *** results show that,independent of the metaheuristic used to guide the model selection,optimized extreme learning machines attained the best performance scores according to six *** hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

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A perspective on utilizing the minority stress model for HIV and mental health care for men who have sex with men

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 333-334页

作者： Rowalt c.Alibudbud Department of Sociology and Behavioral Sciences De La Salle UniversityManilaPhilippines

In 2022,the Joint United Nations Programme on HIV/AIDS(UNAIDS)and the World Health Organization(WHO)called upon global,regional,national,and local stakeholders to embrace a holistic approach to person-centered HIV prevention,treatment,and care[1].This approach emphasizes integrating mental health and psychosocial support services into existing frameworks[1].It recognizes the critical role these services play in addressing mental distress and improving the overall well-being and quality of life for people living with HIV[1].In light of men who have sex with men(MSM)remaining a key population affected by HIV[1],it becomes imperative to delve into the shared factors that influence their HIV care and mental health,among which minority stress stands out as a critical consideration.

关键词： prevention distress stress

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Exercise immunology:Novel insights

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Journal of Sport and Health Science 2024年第3期13卷 277-279,I0001页

作者： David c.Nieman Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The coronavirus disease 2019(cOVID-19)pandemic heightened worldwide attention on the influence of exercise on the immune *** were raised about whether regular moderate-to-vigorous physical activity(MVPA)could help prevent cOVID-19 or mitigate symptoms when *** MVPA bolster immunity among those most prone to cOVID-19 including the elderly,obese,and immunocompromised patients?Does regular MVPA dampen systemic inflammation,thereby lessening the cOVID-19 cytokine storm?

关键词： immunity inflammation thereby

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