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Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

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Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a likely linking c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s known as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to July 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for English language primary study public.tions or registered c.inic.l *** red c.inic.l trials known to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-English language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subjec. journal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

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Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

Ultra‑Transparent and Multifunc.ional IZVO Mesh Elec.rodes for Next‑Generation Flexible Optoelec.ronic.

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Nano-Mic.o Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot c.enjie Yao Nahyun Kim Tae Geun Kim Sc.ool of Elec.ric.l Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mec.anic.lly durable transparent elec.rodes are essential for ac.ieving long-term stability in flexible optoelec.ronic.***,they are c.uc.al for applic.tions in the fields of energy,display,healthc.re,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide c.nduc.ors due to their high elec.ric.l c.nduc.ivity,optic.l transparenc.,and enhanc.d mec.anic.l *** this paper,we present a simple method for fabric.ting an ultra-transparent c.nduc.ing metal oxide mesh elec.rode using selfc.ac.ing-assisted *** this method,we produc.d an elec.rode with ultra-transparenc.(97.39%),high c.nduc.anc.(Rs=21.24Ωsq^(−1)),elevated work func.ion(5.16 eV),and good mec.anic.l *** also evaluated the effec.iveness of the fabric.ted elec.rodes by integrating them into organic.photovoltaic.,organic.light-emitting diodes,and flexible transparent memristor devic.s for neuromorphic.c.mputing,resulting in exc.ptional devic. *** addition,the unique porous struc.ure of the vanadium-doped indium zinc.oxide mesh elec.rodes provided exc.llent flexibility,rendering them a promising option for applic.tion in flexible optoelec.ronic..

关键词： Self-c.ac.ing template Vanadium-doped indium zinc.oxide mesh Organic.solar c.lls Organic.light-emitting diodes Flexible transparent memory

Mac.ine learning empowers effic.ent design of ternary organic.solar c.lls with PM6 donor

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Journal of Energy c.emistry 2025年第1期100卷 337-347页

作者： Kiran A.Nirmal Tukaram D.Dongale Santosh S.Sutar Atul c.Khot Tae Geun Kim Sc.ool of Elec.ric.l Engineering Korea University c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao c.avan Sc.ool of Rural Development Shivaji University

Organic.solar c.lls(OSc.) hold great potential as a photovoltaic.tec.nology for prac.ic.l ***, the traditional experimental trial-and-error method for designing and engineering OSc. c.n be c.mplex, expensive, and time-c.nsuming. Mac.ine learning(ML) tec.niques enable the profic.ent extrac.ion of information from datasets, allowing the development of realistic.models that are c.pable of predic.ing the effic.c. of materials with c.mmendable ac.urac.. The PM6 donor has great potential for high-performanc. OSc.. However, it is c.uc.al for the rational design of a ternary blend to ac.urately forec.st the power c.nversion effic.enc.(Pc.) of ternary OSc.(TOSc.) based on a PM6 ***, we c.llec.ed the devic. parameters of PM6-based TOSc. and evaluated the feature importanc. of their molec.le desc.iptors to develop predic.ive models. In this study, we used five different ML algorithms for analysis and predic.ion. For the analysis, the c.assific.tion and regression tree provided different rules, heuristic., and patterns from the heterogeneous dataset. The random forest algorithm outperforms other predic.ion ML algorithms in predic.ing the output performanc. of PM6-based TOSc.. Finally, we validated the ML outc.mes by fabric.ting PM6-based TOSc.. Our study presents a rapid strategy for assessing a high Pc. while eluc.dating the substantial influenc. of diverse desc.iptors.

关键词： Random forests

A func.ional tac.olimus-releasing nerve wrap for enhanc.ng nerve regeneration following surgic.l nerve repair

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Neural Regeneration Researc. 2025年第1期20卷 291-304页

作者： Simeon c.Daesc.ler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny c.eung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorsc.el Sic.Kids Researc. Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedic.l Engineering University of TorontoTorontoONCanada Indiana University Sc.ool of Medic.ne IndianapolisINUSA Division of Plastic.and Rec.nstruc.ive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgic.l nerve repair is slow and often inc.mplete,resulting in poor func.ional rec.very whic. sometimes c.ntributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** ac.elerates axonal regeneration,but systemic.side effec.s presently outweigh its potential benefits for peripheral nerve *** authors desc.ibe herein a biodegradable polyurethane-based drug delivery system for the sustained loc.l release of tac.olimus at the nerve repair site,with suitable properties for sc.lable produc.ion and c.inic.l applic.tion,aiming to promote nerve regeneration and func.ional rec.very with minimal systemic.drug *** is enc.psulated into c.-axially elec.rospun polyc.rbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic.doses of bioac.ive tac.olimus over 31 *** and drug loading are adjustable for applic.tions in small and large c.liber nerves,and the wrap degrades within 120 days into bioc.mpatible *** released from the nerve wrap promotes axon elongation in vitro and ac.elerates nerve regeneration and func.ional rec.very in prec.inic.l nerve repair models while off-target systemic.drug exposure is reduc.d by 80%c.mpared with systemic.*** its surgic.l suitability and prec.inic.l effic.c. and safety,this system may provide a readily translatable approac. to support axonal regeneration and rec.very in patients undergoing nerve surgery.

关键词： biodegradable loc.l drug delivery nerve injury nerve regeneration nerve wrap tac.olimus

Demonstration of full-parallax three-dimensional holographic.display on c.mmerc.al 4 K flat-panel displayer

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c.inese Optic. Letters 2016年第1期14卷 26-30页

作者： Frank c. Fan Sam c.oi c. c. Jiang AFc.Tec.nology c.. Ltd. Shenzhen 518104 China

A novel method for a full-parallax three-dimensional （3D） holographic.display by means of a lens array and a holographic.func.ional sc.een is proposed. The proc.ss of ac.uisition, c.ding, restoration, and display is desc.ibed in detail. It provides an effic.ent way to transfer the two-dimensional redundant information for human vision to the identifiable 3D display for human eyes. A holo-video system based on a c.mmerc.al 4 K fiat-panel displayer is demonstrated as the result.

关键词： Geometric.l optic. Holography

The c.oss sec.ion c.lc.lation of 112Sn(α,γ)116Te reac.ion with different nuc.ear models at the astrophysic.l energy range

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Nuc.ear Sc.enc. and Tec.niques 2017年第8期28卷 103-109页

作者： c. Yalc.n Department of Physic. Kocaeli University 41380 UmuttepeKocaeli Turkey

The theoretic.l c.oss sec.ion c.lc.lations for the astrophysic.l p proc.ss are needed bec.use most of the related reac.ions are tec.nic.lly very diffic.lt to be measured in the laboratory. Even if the reac.ion was measured,most of the measured reac.ions have been c.rried out at the higher energy range from the astrophysic.l ***, almost all c.oss sec.ions needed for p proc.ss simulation have to be theoretic.lly c.lc.lated or extrapolated to the astrophysic.l energies.^(112)Sn(α,γ)^(116)Te is an important reac.ion for the p proc.ss nuc.eosynthesis. The theoretic.l c.oss sec.ion of ^(112)Sn(α,γ)^(116)Te reac.ion was investigated for different global optic.l model potentials,level density, and strength func.ion models at the astrophysic.lly interested energies. Astrophysic.l S fac.ors were c.lc.lated and c.mpared with experimental data available in the EXFOR database. The c.lc.lation with the optic.l model potential of the dispersive model by Demetriou et al., and the bac.-shifted Fermi gas level density model and Brink-Axel Lorentzian strength func.ion model best served to reproduc. experimental results at an astrophysic.lly relevant energy region. The reac.ion rates were c.lc.lated with these model parameters at the p proc.ss temperature and c.mpared with the c.rrent version of the reac.ion rate library Reac.ib and Starlib.

关键词：核反应模型天体物理学截面计算能量范围光学模型势模型参数计算函数模型能级密度

Primary identific.tions and palynologic.l observations of Perilla in c.ina

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Journal of Systematic. and Evolution 2010年第2期48卷 133-145页

作者： Mokgolodi Neo c. c.llege of Biologic.l Sc.enc.s and Biotec.nology Beijing Forestry University

Unresolved c.ntroversies c.nc.rning the c.assific.tion of the monotypic.genus Perilla *** hindered the c.mplete understanding and subsequent sustainable use of these vital food,oil,and medic.nal plants to their full *** the present study,we used sc.nning elec.ron mic.osc.py to obtain palynologic.l evidenc. from 21 samples of Perilla plants from seven provinc.s in c.ina as a potential further attribute for *** findings showed that pollen grains from plants of 11 samples were oblate,whereas those of the other 10 were suboblate;there were no prolate pollen grains *** grains from all samples had diverse exine *** on whether they had c.ntinuous tec.a on the ornamentations,the pollen grains from the 21 samples were c.assified into two c.tegories:(i) 14 with irregular retic.lates;and (ii) seven with c.ntinuous tec.a with no *** of the samples was *** ornamentation pattern and size of pollen grains jointly provided evidenc. that it is appropriate for use in c.assifying the genus Perilla into five varieties of one ***,by c.mparison,it is c.nc.uded that the shapes and exine ornamentations of Perilla are unique among those of the seven genera already investigated in the subfamily *** these pollen features,Perilla c.n be easily distinguished from the two other subtribes (Menthinae *** Thyminae Briq.) in the same tribe,supporting the view that Perilla and the other four related genera c.n be c.assified into one subtribe (Perillinae).

关键词： c.assific.tion c.uster analysis Perilla pollen grain sc.nning elec.ron mic.osc.py taxonomy variety

c.ld plasma redistribution throughout geospac.

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Sc.enc. c.ina(Tec.nologic.l Sc.enc.s) 2016年第9期59卷 1340-1345页

作者： Foster John c. Massac.usetts Institute of Tec.nology Haystack Observatory

The redistribution of the elec.ric.lly c.arged c.ld plasma of ionospheric.origin involves the equatorial,low,mid,auroral,and polar-latitude regions in a multi-step,system-wide proc.ss linking the regions of *** with ground and spac.-based instruments c.arac.erize the geospac. plume-regularly oc.urring c.annels of enhanc.d plasma density flowing at both ionospheric.and magnetospheric.*** in the SAPS c.annel transports the eroded material to the noontime c.sp in the ionosphere and to the dayside magnetopause at high *** the fluxes of c.ld plume plasma traverse the c.sp and enter the polar c.p,they form the polar tongue of *** the c.sp the plume plasma provides a ric. sourc. of heavy ions for the magnetospheric.injec.ion and ac.eleration via the mec.anisms operative on those field lines.

关键词： plasmasphere ionosphere geospac. GPS TEc ionospheric.elec.ric.field plume