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Associations between Hormonal and Mechanical Factors of Knee Osteoarthritis in Women—A preliminary Study

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Open Journal of Rheumatology and Autoimmune Diseases 2013年第2期3卷 79-85页

作者： David S. Mandeville Gretc.en A. casazza Andrea c. Alvarez Julia Sheremet Brandee l. Waite Brian A. Davis Department of Kinesiology and Health Sc.ence California State University Sacramento USA Department of physical Therapy California State University Sacramento USA Sports Medicine program University of California Davis Health System Sacramento USA

The purpose of this study was to determine the associations between urinary estradiol (E2) metabolite concentration and medial knee loading with radiographic disease severity in middle aged women with initial stage knee osteoarthritis (OA). Women presenting with knee pain were recruited into a cross-sectional correlation study (KOA, n = 9, age = 52 ± 4 yrs). Self report menstrual history, the Modified Baecke Questionnaire and the Knee Injury and Osteoarthritis Outcome Score (KOOS) subjective data were collected. A fasting blood sample (follicle stimulating hormone (FSH) and Tumor Necrosis Factor-α (TNF-α)), and urine catch (16α-hydroxyestrone and 2-hydroxyestrone) were collected. Gait analysis using an 8-camera motion analysis system assessed internal knee varus moment and foot progression angle. pearson product moments tested for associations between urinary 16α-hydroxyestrone and 2-hydroxyestrone, TNF-α, medial knee loading, and radiographic disease severity (Kellgren/lawrence (K/l) radiographic score). Significant correlations were found within the hormonal biomarkers (r = 0.94, p p p = 0.31). No correlations were found for radiographic disease severity or TNF-α. The lack of association between hormonal and biomechanical variables could be due to large variability of the E2 metabolites seen in the menopause transition and the limited structural changes of initial staged knee OA.

关键词： Knee Osteoarthritis 2-Hydroxyestrone Follicle Stimulating Hormone Gait Analysis Medial Knee loading Tumor Necrosis Factor-α

Self-configuring Two Types of Neural Networks by MpcA

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Journal of Mechanics engineering and Automation 2015年第2期5卷 112-120页

作者： Juliana A. Anochi Haroldo F. campos Velho Helaine c.M. Furtado1 Eduardo F.p. luz computing and Applied Mathematics laboratory INPE (National Institute for Space Research) Sao Jose dos Campos 12227-01O Brazil Institute of engineering and Geology UFOPA (Federal University of Western PardO Santarem 68040-470 Brazil cEMADen (National center for Monitoring and Early Warning of Natural Disasters) Sao Jose dos Campos 12247-016 Brazil

ANN （artificial neural network） is a technique successfully employed in many applications on several research fields. An appropriate configuration for neural networks is a tedious task, and it often requires the knowledge of an expert on the application. In this paper, a technique for automatic configuration for two types of neural networks is presented. The multilayer perceptron and recurrent Elman are the neural networks used here. The determination of optimal parameters for the neural network is formulated as an optimization problem, solved with the use of meta-heuristic MpcA （multiple particle collision algorithm）. The self-configuring networks are applied to perform data assimilation.

关键词： Neural networks MpcA data assimilation.

Drucker-prager准则在拉剪区的修正

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岩石力学与工程学报 2010年第A1期29卷 3029-3033页

作者：李平恩殷有泉中国地震局地球物理研究所北京100081 北京大学力学与工程科学系北京100871

针对在岩石塑性力学领域广泛应用的Drucker-prager准则(简称D-p准则)是一个压剪屈服准则,在拉剪受力状态下不适用的情况,提出在拉剪区修正D-p准则的2种可行性方案。第一种方案是在压剪区,仍采用D-p准则的锥面式,而在拉剪区及其邻近,采... 详细信息

针对在岩石塑性力学领域广泛应用的Drucker-prager准则(简称D-p准则)是一个压剪屈服准则,在拉剪受力状态下不适用的情况,提出在拉剪区修正D-p准则的2种可行性方案。第一种方案是在压剪区,仍采用D-p准则的锥面式,而在拉剪区及其邻近,采用一个球形屈服面代替原来的锥顶附近的锥面。第二种方案是使用一个双曲旋转面近似地代替D-p圆锥面。将这2种方法定义的新的修正的D-p准则简称为D-p-Y准则,它是一个三参数准则,不仅在压剪区符合三轴压缩实验结果,而且在拉剪区也可拟合抗拉强度的资料。同时,它还是一个在全区域处处光滑的正则函数,可以使用经典的正交法则和一致性条件建立本构关系,而不必做任何奇异点的处理,这给应用和编程都带来方便,具有广泛的应用前景。特别地,对于双曲型的D-p-Y准则,当相关参数取0时,可分别退化为D-p准则和Mises准则,因此,在编程中可只编入D-p-Y准则。

关键词：岩石力学 D—p准则拉剪区修正球形屈服面双曲旋转面修正的D-p准则正则函数

"Reaction principle" as applied to certain Mineral Transformations in Migmatitic Rocks

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地质学报 1940年第2期 113-119页

作者： Y.c.c.enG Geological Survey of china

The application of N. l. Bowen’s reaction-principle (2’, pp.177-198; 3 p.60) tothe study of certain igneous textures and the crystallisation and cooling of magmas hasbeen widely accepted. The plagioclase series ranging from the calcic.end-to the sodicis the best example of a continuous reaction series, while the olivine-pyroxene-amphibole-biotite series-the existence of which can be easily convinced by the presence of coronastructure in certain gabbroic rock-is a discontinuous series of frequent *** his study of the mixed rocks-migmatites-of a portion of an injection-complexin North Sutherland. Scotland (5), the writer has found certain mineral changes whichmay be interpreted in the light of Bowen’s reaction-principle. Such changes, as aredifferent from those occurred in the course of the cooling of a magma, were takingplace in a solid rock-system under high temperature, strong stress and the dominantinfluence of certain chemically active. fluids related to a granitic magma.

关键词： Reaction principle

REVIEW OF NUclEAR pOWER REAcTOR cOOlANT SYSTEM lEAKAGE EVenTS AND lEAK DETEcTION REQUIREMenTS

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REVIEW OF NUCLEAR POWER REACTOR COOLANT SYSTEM LEAKAGE EVENT...

Black-Scholes Option pricing Model Modified to Admit a Miniscule Drift can Reproduce the Volatility Smile

第十八届国际反应堆结构力学大会

作者： N.c. chokshi M. Srinivasan D. S. Kupperman p. Krishnaswamy U.S. Nuclear Regulatory commission U.S. Nuclear Regulatory commission Argonne National laboratory eng. Mechanics corporation of columbus

＜正＞ In response to the vessel head event at the Davis-Besse reactor, the U.S. Nuclear Regulatory commission （NRc） formed a lessons learned Task Force （llTF）. Four action plans were formulated to respond to the recommendations of the llTF. The action plans involved efforts on barrier integrity, stress corrosion cracking （Scc）, operating experience, and inspection and program management. One part of the action plan on barrier integrity was an assessment to identify potential safety benefits from changes in requirements pertaining to

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Applied Mathematics 2012年第6期3卷 597-605页

作者： Matthew c. Modisett James A. powell Department of Mathematics and Statistics Utah State University Logan USA Financial Guard ltd. London UK

This paper develops a closed-form solution to an extended Black-Scholes (EBS) pricing formula which admits an implied drift parameter alongside the standard implied volatility. The market volatility smiles for vanilla call options on the S&p 500 index are recreated fitting the best volatility-drift combination in this new EBS. Using a likelihood ratio test, the implied drift parameter is seen to be quite significant in explaining volatility smiles. The implied drift parameter is suffic.ently small to be undetectable via historical pricing analysis, suggesting that drift is best considered as an implied parameter rather than a historically-fit one. An overview of option-pricing models is provided as background.

关键词： Option pricing Black-Scholes Volatility Smile

Exposure of Kenyan population to aflatoxins in foods with special reference to Nandi and Makueni counties

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Food Quality and Safety 2017年第2期1卷 131-137页

作者： E.K.Kang’ethe M.Gatwiri A.J.Sirma E.O.Ouko c.K.Mburugu-Musoti p.M.Kitala G.J.Nduhiu J.G.Nderitu J.K.Mungatu V.Hietaniemi V.Joutsjoki H.J.Korhonen Department of public Health Pharmacology and ToxicologyNairobiKenya Jomo Kenyatta University of Agriculture and Technology NairobiKenya Ministry of Agriculture livestock and Fisheries Veterinary Laboratories KabetePrivate Bag KabeteNairobiKenya Natural Resources Institute Finland LUKEJokioinenFinland

Aflatoxins cause acute and chronic health and production effects in humans and animals,*** study reports on the exposure of the Kenyan population to the two mycotoxins in two counties(Nandi and Makueni)using children younger than 5 years as the proxy.A questionnaire was administered,which captured knowledge of the incidences of acute aflatoxin poisoning,food consumption *** of aflatoxin in samples of urine,breast milk,maize,sorghum,and millet was done using cElISA and *** and sorghum are used in the weaning formula of *** difference in consumption of maize-and sorghum-based diets in children between younger than 1 and between 1 and 5 years was significant with p=0.037 and p=0.002,respectively,in Nandi and *** children younger than 5 years,the consumption of maize ranged from 0.1 to 0.25 kg per person per day in Nandi and Makueni with an aflatoxin exposure rate of 0.011 and 0.49μg per kg body weight(bwt)per day,*** exposure to aflatoxin through milk for children younger than 5 years was 4×10^(−4) and 1×10^(−4)μg per kg bwt per day in Makueni and Nandi,*** exposure of nursing children through breast milk was 6×10^(−3) and 1×10^(−6)μg per kg bwt per day in Makueni and Nandi,*** younger than 30 months in Makueni had 1.4 times higher levels of aflatoxin M1(AFM1)in urine than those of the same age in *** stunting and severe stunting rates in Makueni and Nandi were 28.7%,18.5%and 30.7%,16.5%,***,there is need for urgent mitigation measures,a constant surveillance program,strict regulations,and awareness creation directed at poor households to reduce dietary exposure to mycotoxins.

关键词： Aflatoxins contamination Exposure Kenya.

Ultrasound curriculum taught by first-year medical students： A four-year experience in Tanzania

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World Journal of Emergency Medicine 2018年第1期9卷 33-40页

作者： Scan p. Denny William B. Mintccr Rcccc T.H. Fcnning Sahil Aggarwal Dcbora H. lee Shclla K. Raja Kaavya R. Raman Allison O. Farfcl priya A. patcl Marklicbcr Mcgan E. Bcrnstcin Shadi lahham John c. Fox School of Medicine University of California Irvine Orange California 92868 USA Department of EmergencyMedicine University of California Irvine Orange California 92868 USA

BAcKGROUND: Diagnostic imaging is an integral aspect of care that is often insuffic.ent, if not altogether absent, in rural and remote regions of low to middle income countries(lMIcs) such as Tanzania. The introduction of ultrasound can significantly impact treatment in these countries due to its portability, low cost, safety, and usefulness in various medical assessments. This study reviews the implementation of a four-week ultrasound course administered annually from 2013–2016 in a healthcare professional school in Mwanza, Tanzania by first-year allopathic US medical ***: participants(n=582, over 4 years) were recruited from the Tandabui Institute of Health Sc.ences and Technology to take the ultrasound course. Subjects were predominantly clinical officer students, but other participants included other healthcare professional students, practicing healthcare professionals, and school employees. Data collected includes pre-course examination scores, post-course examination scores, course quiz scores, demographic surveys, and postcourse feedback surveys. Data was analyzed using two-tailed t-tests and the single factor analysis of variance(ANOVA).RESUlTS: For all participants who completed both the pre-and post-course examinations(n=229, 39.1% of the total recruited), there was a significant mean improvement in their ultrasound knowledge of 42.5%, pcal students can effectively teach a point of care ultrasound course to healthcare professional students within four weeks in Tanzania. Future investigation into the level of long-term knowledge retention, impact of ultrasound training on knowledge of human anatomy and diagnostic capabilities, and how expansion of an ultrasound curriculum has impacted access to care in rural Tanzania is warranted.

关键词： point of care ultrasound Ultrasound education Tanzania

Quantitative Estimation of coastal changes Along Selected locations of Karnataka, India: A GIS and Remote Sensing Approach

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International Journal of Geosc.ences 2011年第4期2卷 385-393页

作者： p. Vinayaraj Glejin Johnson G. Udhaba Dora c. Sajiv philip V. Sanil Kumar R. Gowthaman 不详

Qualitative and quantitative studies on changes of coastal geomorphology and shoreline of Karnataka, India have been carried out using toposheets of Survey of India and satellite imageries (IRS-p6 and IRS-1D). changes during 30 years period are studied at each station. Significant morphological changes in landforms like spit, channel Island, coastal plain, tidal flat, lateritic plain, alluvial plain and sand bar within and adjcent to estuarine river mouths of Kali, Sharavathi, Kollur-chakkara - Haladi and Udyavara Rivers are observed. The study indicates that gradual erosion is observed at i) Karwar spit along the northern side of the Kali river mouth, ii) the spit at the southern side of the Sharavathi river mouth and iii) at some regions of Kundapur.

关键词： coastal Geomorphology Shoreline coastal zone Erosion Accretion Beach