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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

creeping fat and gut microbiota in crohn’s disease

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World Journal of Gastroenterology 2025年第1期31卷 16-23页

作者： Ana EV Quaglio Daniéla O Magro Marcello Imbrizi Ellen cS De Oliveira Luiz c Di Stasi Ligia Y Sassaki Verum Ingredients Botucatu Technology ParkBotucatu 18605-525São PauloBrazil Department of Surgery Faculty of Medical SciencesState University of CampinasCampinas 13083-970São PauloBrazil Department of Gastroenterology Faculty of Medical SciencesUniversity of CampinasCampinas 13083-970São PauloBrazil Department of Internal Medicine Medical SchoolSão Paulo State UniversityBotucatu 18618-686São PauloBrazil Department of Biophysics and Pharmacology Institute of BiosciencesSão Paulo State UniversityBotucatu 18618-689São PauloBrazil

In this article,we explored the role of adipose tissue,especially mesenteric adipose tissue and creeping fat,and its association with the gut microbiota in the pathophysiology and progression of crohn’s disease(cD).cD is a form of inflammatory bowel disease characterized by chronic inflammation of the gastrointestinal tract,influenced by genetic predisposition,gut microbiota dysbiosis,and environmental *** microbiota plays a crucial role in modulating immune response and intestinal inflammation and is associated with the onset and progression of ***,visceral adipose tissue,particularly creeping fat,a mesenteric adipose tissue characterized by hypertrophy and fibrosis,has been implicated in cD pathogenesis,inflammation,and *** bacteria from the gut microbiota may translocate into mesenteric adipose tissue,contributing to the formation of creeping fat and influencing cD *** creeping fat may be a protective barrier against bacterial invasion,its expansion can damage adjacent tissues,leading to *** gut microbiota through interventions such as fecal microbiota transplantation,probiotics,and prebiotics has shown potential in managing ***,more research is needed to clarify the mechanisms linking gut dysbiosis,creeping fat,and cD progression and develop targeted therapies for microbiota modulation and fat-related complications in patients with cD.

关键词： creeping fat Mesenteric adipose tissue Gut microbiota crohn’s disease Inflammatory bowel disease

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

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Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Serological surveillance for SARS-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： Marcos G Pinheiro Gabriela G O Alves Maria Eduarda R conde Sofia L costa Regina c S Sant’Anna Isa M F Antunes Mônica c carneiro Fabio S Ronzei Julia c Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio c Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele c Alexandre Karla c de Paula Márcio Watanabe Antonio claudio L da Nóbrega Jackeline christiane P Lobato Fabio Aguiar-Alves Laboratory of Molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-coV-2),which led to the outbreak of coronavirus disease 2019(cOVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-coV-2 antibodies could indicate the immunoreactive profile during the cOVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-coV-2 antibodies in individuals within a university setting during the cOVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from March 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)M and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of IgM or IgG and age[odds ratio(OR)=1.16,95%cI:1.02-1.31](Pcontact with a cOVID-19-positive case(OR=3.49,95%cI:2.34-5.37)(Pceived the cOVID-19 vaccine(OR=2.33,95%cI:1.61-3.35)(Pcial isolation(OR=0.59,95%cI:0.41-0.84)(P<0.004).The likelihood of sho

关键词： Serological surveillance SARS-coV-2 antibodies cOVID-19 Serological rapid test Risk factors for cOVID-19

Virtual reality based apps are the future of patient:counseling

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World Journal of clinical cases 2025年第6期13卷 58-60页

作者： Ranjan K Behera Arvind K Morya Parul c Gupta Arshi Singh Department of Ophthalmology MMIMSR Mullana AmbalaAmbala 133207HaryānaIndia Department of Ophthalmology All India Institute of Medical SciencesHyderabad 508126TelanganaIndia Department of Ophthalmology Post Graduate Institute of Medical Education and ResearchChandigarh 160012PunjabIndia Department of Ophthalmology Guru Nanak Eye CentreNew Delhi 110001New DelhiIndia

The use of virtual reality to educate preoperative patients has a positive impact on nurses as well as patients undergoing *** can help improve patient satisfaction and improve favorable outcomes by reducing patient anxiety and proving adequate knowledge about the procedure and possible outcomes to the *** also reduces burden on nursing staff and *** and more diverse cohort studies will help us understand the wider application of this tool on the patient *** may be difficult to apply this tool on elderly patients with failing eyesight,multiple physical ***,there may be reduced acceptance of this modality by older nursing staff and practitioners who may prefer the traditional verbal version for *** will benefit from a combined approach of using virtual reality apps with tradition one-on-one counselling to help alleviate patient concerns and improve patient and healthcare professional satisfaction.

关键词： Nurse Patient Virtual reality counselling Healthcare

Hepatocellular carcinoma recurrence after liver transplant:An Australian single-centre study

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World Journal of Transplantation 2025年第1期15卷 105-114页

作者： Matthew G Garas Luis calzadilla-Bertot Briohny W Smith Luc Delriviere Byron Jaques Lingjun Mou Leon A Adams Gerry c MacQuillan George Garas Gary P Jeffrey Michael c Wallace Medical School University of Western AustraliaNedlands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Surgery Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia

BAcKGROUND Hepatocellular carcinoma(Hcc)is a leading cause of cancer-related deaths *** transplantation(LT)offers the most effective *** recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for *** rate of Hcc recurrence is generally reported as 8%-20%in the *** predictors of Hcc have already been researched,however,to our knowledge there are no published studies on this topic using Australian *** To determine the rate and identify predictors of Hcc recurrence in a contemporary Western Australian LT *** We performed a retrospective cohort study of all liver transplants in patients with Hcc at Sir charles Gairdner Hospital between 2006 and *** was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of *** survival of Hcc patients post-LT,stratified for recurrence,was calculated by Kaplan Meier *** and multivariate cox regression was used to determine predictors of Hcc recurrence *** Between 1/1/2006 and 12/31/2021,119 patients were transplanted with Hcc.8.4%of subjects developed recurrent Hcc after LT with median follow-up time of 5.4 *** median time to recurrence was 2.9 years±0.75 *** comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(P=0.001),vascular invasion(P=0.003)and poorly differentiated Hcc(P=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with Hcc recurrence compared to those without Hcc recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank PcONcLUSION Hcc recurrence was low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT *** studies are requir

关键词： Liver cancer Recurrence Liver transplantation Hepatocellular carcinoma Predictors Post-transplant survival Australian data

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

Solid-state NMR of vulcanized natural rubber/butadiene rubber blends:Local organization and cross-linking heterogeneities This article is part of the virtual special issue“Solid-state NMR studies on polymers and biological solids”

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Magnetic Resonance Letters 2024年第4期4卷 49-61页

作者： Pierre Daniel c.istina c.elho-diogo Valérie Gaucher Grégory Stoclet clément Robin cédric Lorthioir Sorbonne Université CNRSLaboratoire de Chimie de la Matière Condensée de ParisLCMCPUMR 757475005 ParisFrance Sorbonne Université CNRSFédération Chimie et Matériaux de Paris-CentreFR 248275005 ParisFrance Univ.Lille CNRSINRAECentrale LilleUnitéMatériaux et TransformationsUMETUMR 820759000 LilleFrance Hutchinson Research and Innovation center 45120 Châlette-sur-LoingFrance

Elastomer blends,among which natural rubber(NR)and butadiene rubber(BR),are involved in many components of the automotive/tire industry.A comprehensive understanding of their mechanical behavior requires,among other features,a detailed description of the crosslink density in these *** the case of vulcanized immiscible blends,the distribution of the cross-link density within each of the NR-and BR-rich domains is key information,but difficult to determine using the conventional approaches used for one-component crosslinked *** this study,the vulcanization within NR/BR blends is investigated using a robust^(1)H double-quantum(DQ)MAS recoupling experiment,*** kinds of cross-linked NR/BR blends were considered with two different microstructures for the BR *** bulk organization of the resulting blends was first probed by analyzing the^(1)H spin-lattice relaxation *** a second step,BaBa-xy16 was used to investigate,in a selective way,the cross-link heterogeneities within NR/BR *** particular,for immiscible NR/BR mixtures,the distribution of the cross-link density between both phases was compared and the observed differences were discussed.

关键词： Rubbers Blends cross-linking 1H solid-state NMR Relaxation Double-quantum NMR Dipolar recoupling