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Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease

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World Journal of gastroenterology 2024年第28期30卷 3428-3446页

作者： Aritoshi Koizumi Kosuke Kaji Norihisa Nishimura Shohei Asada Takuya Matsuda Misako Tanaka Nobuyuki Yorioka Yuki Tsuji koh Kitagawa Shinya Sato Tadashi Namisaki Takemi Akahane Hitoshi Yoshiji Department of gastroenterology Nara Medical UniversityKashihara 634-8521Japan

BAcKgROUND Alcohol-associated liver disease(ALD)is a leading cause of liver-related morbidity and mortality,but there are no therapeutic targets and modalities to prevent ALD-related liver *** proliferator activated receptor(PPAR)α and δ play a key role in lipid metabolism and intestinal barrier homeostasis,which are major contributors to the pathological progression of ***,elafibranor(EFN),which is a dual PPARαand PPARδagonist,has reached a phase III clinical trial for the treatment of metabolic dysfunctionassociated steatotic liver disease and primary biliary ***,the benefits of EFN for ALD treatment is *** To evaluate the inhibitory effects of EFN on liver fibrosis and gut-intestinal barrier dysfunction in an ALD mouse *** ALD-related liver fibrosis was induced in female c57BL/6J mice by feeding a 2.5% ethanol(EtOH)-containing Lieber-Decarli liquid diet and intraperitoneally injecting carbon tetrachloride thrice weekly(1 mL/kg)for 8 ***(3 and 10 mg/kg/day)was orally administered during the experimental *** and molecular analyses were performed to assess the effect of EFN on steatohepatitis,fibrosis,and intestinal barrier *** EFN effects on Hepg2 lipotoxicity and caco-2 barrier function were evaluated by cell-based *** The hepatic steatosis,apoptosis,and fibrosis in the ALD mice model were significantly attenuated by EFN *** promoted lipolysis and β-oxidation and enhanced autophagic and antioxidant capacities in EtOH-stimulated Hepg2 cells,primarily through PPARα***,EFN inhibited the Kupffer cell-mediated inflammatory response,with blunted hepatic exposure to lipopolysaccharide(LPS)and toll like receptor 4(TLR4)/nuclear factor kappa B(NF-κB)*** improved intestinal hyperpermeability by restoring tight junction proteins and autophagy and by inhibiting apoptosis and proinflammatory *** protective effect on intestinal bar

关键词： Liver fibrosis Ethanol gut barrier function Apoptosis Autophagy Peroxisome proliferator activated receptor

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Utilizing neural networks to supplant chemical kinetics tabulation through mass conservation and weighting of species depletion

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Energy and AI 2024年第2期16卷 101-110页

作者： Franz M.Rohrhofer Stefan Posch clemens gößnitzer JoséM.garcía-Oliver Bernhard c.geiger Know-center gmbH Sandgasse 36Graz8010StyriaAustria LEc gmbH Inffeldgasse 19Graz8010StyriaAustria Universitat Politècnica de València Camíde VeraValència46022ValènciaSpain

Artificial Neural Networks(ANNs)have emerged as a powerful tool in combustion simulations to replace memory-intensive tabulation of integrated chemical *** reaction mechanisms,however,present a challenge for standard ANN approaches as modeling multiple species typically suffers from inaccurate predictions on minor *** paper presents a novel ANN approach which can be applied on complex reaction mechanisms in tabular data form,and only involves training a single ANN for a complete reaction *** approach incorporates a network architecture that automatically conserves mass and employs a particular loss weighting based on species *** modifications are used to improve the overall ANN performance and individual prediction accuracies,especially for minor species mass *** validate its effectiveness,the approach is compared to standard ANNs in terms of performance and ANN *** distinct reaction mechanisms(H_(2),c_(7)H_(16),c_(12)H_(26),OME_(34))are used as a test cases,and results demonstrate that considerable improvements can be achieved by applying both modifications.

关键词： Neural network approach chemical kinetics Flamelet tabulation Mass conservation Species loss weighting

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Transformed gastric mucosa-associated lymphoid tissue lymphoma originating in the colon and developing metachronously after Helicobacter pylori eradication:A case report

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World Journal of gastrointestinal Oncology 2024年第10期16卷 4281-4288页

作者： Makoto Saito Zen-Ichi Tanei Masumi Tsuda Toma Suzuki Emi Yokoyama Minoru Kanaya koh Izumiyama Akio Mori Masanobu Morioka Takeshi Kondo Blood Disorders center Aiiku HospitalSapporo 064-0804HokkaidoJapan Department of cancer Pathology Faculty of MedicineHokkaido UniversitySapporo 060-8638HokkaidoJapan

BAcKgROUND Helicobacter pylori(***)eradication treatment for primary gastric mucosaassociated lymphoid tissue(MALT)lymphoma has already been ***,t(11;18)(q21;q21)/API2-MALT1 translocation-positive lesions are a type of primary gastric MALT lymphoma in which a response to eradication treatment is difficult to *** addition,trisomy 18 may be associated with diffuse large B-cell lymphoma(DLBcL)transformation of gastric MALT *** SUMMARY A 66-year-old man was diagnosed with MALT lymphoma in the ascending colon by colonoscopy and *** years later,esophagogastroduodenoscopy revealed chronic atrophic gastritis that was positive for ***,and eradication treatment was *** years and nine months later(at the age of 70),a new ulcerative lesion suggestive of MALT lymphoma appeared in the gastric body,and six months later,a similar lesion was also found in the *** year later(4 years and 3 months after *** eradication),at the age of 72,the lesion in the gastric body had become deeper and had propagated.A biopsy revealed a pathological diagnosis of *** MALT lymphoma lesions in the ascending colon and DLBcL lesions in the stomach were positive for the t(11;18)(q21;q21)/API2-MALT1 translocation,and trisomy 18q21 was also *** 6 courses of R-cHOP(rituximab,cyclophosphamide,doxorubicin,vincristine and prednisone)chemotherapy,all of the above lesions disappeared[complete remission(cR)],and cR has been maintained for more than 3 *** addition,both the colonic and gastric lesions were proven to have the same *** Because the patient had a MALT1 translocation with trisomy 18q21,it was thought that this gastric MALT lymphoma developed independently of *** infection and progressed.

关键词： gastric mucosa-associated lymphoid tissue lymphoma Transform Diffuse large B-cell lymphoma colonic mucosa-associated lymphoid tissue lymphoma Helicobacter pylori eradication MALT1 translocation case report

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High mobility group box 1 in the central nervous system:regeneration hidden beneath inflammation

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Neural Regeneration Research 2025年第1期20卷 107-115页

作者： Hanki Kim Bum Jun Kim Seungyon koh Hyo Jin cho Xuelian Jin Byung gon Kim Jun Young choi Department of Brain Science Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Ajou University Graduate School of MedicineSuwonSouth Korea Department of Neurology Ajou University School of MedicineSuwonSouth Korea Department of geriatrics The Affiliated Suqian First People’s Hospital of Nanjing Medical UniversitySuqianJiangsu ProvinceChina

High-mobility group box 1 was first discovered in the calf thymus as a DNA-binding nuclear protein and has been widely studied in diverse fields,including neurology and ***-mobility group box 1 in the extracellular space functions as a pro-inflammatory damage-associated molecular pattern,which has been proven to play an important role in a wide variety of central nervous system disorders such as ischemic stroke,Alzheimer’s disease,frontotemporal dementia,Parkinson’s disease,multiple sclerosis,epilepsy,and traumatic brain *** drugs that inhibit high-mobility group box 1 as a damage-associated molecular pattern,such as glycyrrhizin,ethyl pyruvate,and neutralizing anti-high-mobility group box 1 antibodies,are commonly used to target high-mobility group box 1 activity in central nervous system *** it is commonly known for its detrimental inflammatory effect,high-mobility group box 1 has also been shown to have beneficial pro-regenerative roles in central nervous system *** this narrative review,we provide a brief summary of the history of high-mobility group box 1 research and its characterization as a damage-associated molecular pattern,its downstream receptors,and intracellular signaling pathways,how high-mobility group box 1 exerts the repair-favoring roles in general and in the central nervous system,and clues on how to differentiate the pro-regenerative from the pro-inflammatory *** targeting high-mobility group box 1 in the central nervous system may benefit from differentiating between the two functions rather than overall suppression of high-mobility group box 1.

关键词： central nervous system damage-associated molecular pattern ethyl pyruvate glycyrhizzin high mobility group box 1 inflammation neural stem cells neurodevelopment oligodendrocyte progenitor cells redox status regeneration

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SiP的模块化发展趋势

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电子与封装 2024年第7期24卷 21-28页

作者： William koh Pacrim Technology Inc. IrvineCA 92602

系统级封装(SiP)技术已广泛应用于移动设备、可穿戴设备、健康和医疗设备、人工智能(AI)、物联网(IoT)和汽车电子。SiP采用异构集成的方式,将各种芯片和元件集成到一个封装中,以实现特定功能,并具有节省电路板空间、简化布局设计和降低... 详细信息

系统级封装(SiP)技术已广泛应用于移动设备、可穿戴设备、健康和医疗设备、人工智能(AI)、物联网(IoT)和汽车电子。SiP采用异构集成的方式,将各种芯片和元件集成到一个封装中,以实现特定功能,并具有节省电路板空间、简化布局设计和降低制造成本等优势。随着电子组件的小型化发展方向不断持续,一些SiP已经发展成为模块或系统级模块(SiM),可以直接连接并安装到器件中。回顾了SiP从多芯片模块(McM)、多芯片封装(McP)到高级芯粒封装和共封装光学器件(cPO)的演变。未来几年,更多的SiP将变成SiM,直接连接器件或系统。

关键词：系统级封装系统级模块多芯片模块

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Nitrogen mineralization in the oldest climax communities in the eastern Mediterranean region

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Journal of Forestry Research 2024年第1期35卷 213-228页

作者： Fatma Selcen Sakar gürcan güleryüz Department of Biology Section Ecology GörükleGraduate School of Natural and Applied ScienceUniversity of Bursa Uludağ16059 NilüferBursaTurkey Department of Biology Section Ecology GörükleFaculty of Science and ArtsUniversity of Bursa Uludağ16059 NilüferBursaTurkey

In this study,we investigated how tree species affect N mineralization in connection to some soil properties and seconder metabolite levels of litter,in the soil of the old-est native forest *** the oldest pure communi-ties of Pinus nigra(PN),Fagus orientalis(FO),and Abies bornmuelleriana(AB)in the mountain range of Mount Uludağ,Bursa,Turkey,annual net yield and N mineraliza-tion in the 0-5-and 5-20-cm soil layers were determined in a field incubation study over 1 *** locations were chosen from 1300 to 1600 m a.s.l.,and moisture content(%),pH,water-holding capacity(%),organic c,total N,and c/N ratio,and annual net mineral N yield of the soil and hydro-lyzed tannic acid and total phenolic compounds in litter were compared for these forest *** had the highest annual net Nmin yield(43.9±4.8 kg ha^(-1) a^(-1)),*** the lowest(30.5±4.2 kg ha^(-1) a^(-1)).Our findings show that in the oldest forest ecosystems,the seasonal soil moisture content and tree species play an essential role in N cycling and that hydrolyzed tannic acids and total phenolic compounds effectively control N *** acid and total phenolics in the litter were found to inhibit nitrification,but total phenolics were found to stimulate ammonification.

关键词： Oldest forest communities Nitrogen mineralization Nitrification Tannic acid Total phenolic Litter

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Assessment of cO_(2)storage prospect based on physical properties of Rio Bonito Formation rock units

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Energy geoscience 2024年第1期5卷 321-330页

作者： Richardson M.Abraham-A Stephanie San Martín cañas Isabella F.S.Miranda colombo c.g.Tassinari Institute of Energy and Environment(IEE) University of São Paulo(USP)Brazil Research centre for greenhouse gas Innovation(RcgI) University of Sãao Paulo(USP)Brazil

The physical properties of the rock units associated with the Rio Bonito Formation are presented in this study with the focus on modelling reservoir quality based on petrophysics-derived parameters to evaluate cO_(2)storage *** involves the modelling of the reservoir depths,thicknesses,flow zone indicators(FZI),and effective permeability(Keff)and presenting the cO_(2)storage efficiency factors peculiar to the rock units of the study *** results presented by this study for the stated objectives are not quite common in the *** values range from 200 mD to higher than 2000 mD,and FZI values are generally above 1.0 mm and up to 13.0 mm within the portions covered by the drilled *** sandstone units recorded are up to 20 m thick in some *** Keff and FZI models indicate the sandstone reservoirs as permeable units to support the injection and circulation of cO_(2)within the potential reservoir units of the Rio Bonio Formation across São Paulo *** from some points in the southeastern part of the study location,where the Rio Bonito are delineated at depths less than 800 m(minimum cO_(2)storage depth based on best practices),other portions are deeper,ranging from 950 m to 3500 ***-bedded layers will affect the integrity of the rocks as cO_(2)storage tanks or reservoir seals/traps/overburden within the *** bed thicknesses are up to 20 m in some ***,hybrid cO_(2)reservoir units are feasible,especially in portions where thin siltstone layers are sandwiched between sandstone units to provide considerable thicknesses based on cO_(2)storage *** current study shows that useable areas considering reservoir thickness,depth,and other physical qualities will significantly control the cO_(2)storage efficiency of the study *** studies featuring a detailed geophysical exploration of the site to confirm the availability and saturations of preexisting fluid(hydrocarbon and water)are encouraged

关键词： Rio Bonito Effective permeability Fluid transmissibility cO_(2)storage prospect Reservoir quality Overburden integrity Flow zones

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Photoionisation detection of a single Er3+ ion with sub-100-ns time resolution

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National Science Review 2024年第4期11卷 38-45页

作者： Yangbo Zhang Wenda Fan Jiliang Yang Hao guan Qi Zhang Xi Qin changkui Duan gabriele g.de Boo Brett c.Johnson Jeffrey c.Mc callum Matthew J.Sellars Sven Rogge chunming Yin Jiangfeng Du cAS Key Laboratory of Microscale Magnetic Resonance and School of Physical Sciences University of Science and Technology of China cAS center for Excellence in Quantum Information and Quantum Physics University of Science and Technology of China Hefei National Laboratory University of Science and Technology of China centre of Excellence for Quantum computation and communication Technology School of Physics University of New South Wales centre of Excellence for Quantum computation and communication Technology School of Engineering RMIT University centre of Excellence for Quantum computation and communication Technology School of Physics University of Melbourne centre of Excellence for Quantum computation and communication Technology Research School of Physics and Engineering Australian National University

Efficient detection of single optical centres in solids is essential for quantum information processing, sensing and single-photon generation *** this work,we use radio-frequency（RF） reflectometry to electrically detect the photoionisation induced by a single Er3+ion in *** high bandwidth and sensitivity of the RF reflectometry provide sub-100-ns time resolution for the photoionisation *** this technique,the optically excited state lifetime of a single Er3+ion in a Si nano-transistor is measured for the first time to be 0.49±0.04μ*** results demonstrate an efficient approach for detecting a charge state change induced by Er excitation and *** approach could be used for fast readout of other single optical centres in solids and is attractive for large-scale integrated optical quantum systems thanks to the multi-channel RF reflectometry demonstrated with frequency multiplexing techniques.

关键词： single optical centres erbium ions RF reflectometry photoionisation detection

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Shell-model representations of the microscopic version of the Bohr-Mottelson collective model

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communications in Theoretical Physics 2024年第8期76卷 79-90页

作者： H g ganev Joint Institute for Nuclear Research DubnaRussia Institute of Mechanics Bulgarian Academy of SciencesSofiaBulgaria

The structure of the irreducible collective spaces of the group Sp(12,R),which many-particle nuclear states are classified according to the chain Sp(12,R)⊃U(6)⊃SO(6)⊃SU_(pn)(3)⊗SO(2)⊃SO(3)of the proton-neutron symplectic model(PNSM),is considered in *** chain of the PNSM was recently shown to correspond to a microscopic shell-model version of the Bohr-Mottelson collective *** construction of the relevant shell-model representations of the Sp(12,R)group along this chain is considered for three nuclei with varying collective properties and from different mass *** is shown that the SU_(pn)(3)basis states of the Sp(12,R)representations belonging to the SO(6)irreps with seniorityυ≥υ0,withυ0 denoting the maximal seniority SO(6)irrep contained in the Sp(12,R)bandhead,are always Pauli allowed,but organized in a different way into different SO(6)*** is in contrast to the case of filling the levels of the standard three-dimensional harmonic oscillator and using the plethysm *** the SU_(pn)(3)multiplets withinυcard *** results obtained in the present work are important for the practical application of the microscopic version of the Bohr-Mottelson collective model.

关键词： microscopic shell-model version of the Bohr-Mottelson model proton-neutron symplectic model Sp(12,R)dynamical algebra shell-model representations

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A Preliminary comparative Study on the centering Algorithms for cassiniISS NAc Images

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Research in Astronomy and Astrophysics 2024年第10期24卷 58-65页

作者： T.Liang Q.-F.Zhang g.-M.Liu W.-H.Zhu c.-S.Wang Department of computer Science Jinan UniversityGuangzhou 510632China Sino-French Joint Laboratory for Astrometry Dynamics and Space ScienceJinan UniversityGuangzhou 510632China School of computer Science Guangdong University of EducationGuangzhou 510303China

Obtaining high precision is an important consideration for astrometric studies using images from the Narrow Angle camera(NAc)of the cassini Imaging Science Subsystem(ISS).Selecting the best centering algorithm is key to enhancing astrometric *** this study,we compared the accuracy of five centering algorithms:gaussian fitting,the modified moments method,and three point-spread function(PSF)fitting methods(effective PSF(ePSF),PSFEx,and extended PSF(x PSF)from the cassini Imaging central Laboratory for Operations(cIcLOPS)).We assessed these algorithms using 70 ISS NAc star field images taken with cL1 and cL2 filters across different stellar *** ePSF method consistently demonstrated the highest accuracy,achieving precision below 0.03 pixels for stars of magnitude *** to the previously considered best,the modified moments method,the e PSF method improved overall accuracy by about 10%and 21%in the sample and line directions,***,the xPSF model provided by cIcLOPS had lower precision than the ***,the ePSF exhibits an improvement in measurement precision of 23%and 17%in the sample and line directions,respectively,over the *** discrepancy might be attributed to the xPSF focusing on photometry rather than *** findings highlight the necessity of constructing PSF models specifically tailored for astrometric purposes in NAc images and provide guidance for enhancing astrometric measurements using these ISS NAc images.

关键词： methods:analytical techniques:image processing stars:imaging astrometry

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