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材料热处理学报 2004年第5期25卷 457-461页

作者： cANALE Lauralice c.f TOTTEN George E Departamento de Materials Automobilistica e Aerondutica da EESC da Universidade de Sao Paulo - USP Sao Carlos SP BrazilPortland State University USA

Uniform agitation of the quenchant is a critically important control parameter in optimizing distortion control and reducing steel cracking. Quenching with ultrasonic agitation or in the presence of electrical and magnetic.fields provide uniform agitation leading to improved uniformity of the stress fields within the metal not readily achievable with more traditional agitation methods such as propeller pumps and sprays. These methods provide the additional potential advantage of varying agitation throughout the cooling cycle to achieve a wide range of cooling profiles not readily achievable with quenchants and more traditional agitation systems currently in use.

关键词：热处理淬火裂纹搅拌均匀性超声搅拌

Do Rules and Patterns Affect Design Maintainability?

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Journal of computer Science & Technology 2009年第2期24卷 262-272页

作者： Javier Garzás félix García Mario Piattini Kybele consulting Madrid Spain Department of Information Technologies and Systems-Escuela Superior de Informáica University of Castilla-La Mancha Alarcos Research Group-Institute of Information Technologies and Systems Department of Information Technologies and Systems-Escuela Superior de Informáica University of castilla-La Mancha

At the present time, best rules and patterns have reached a zenith in popularity and diffusion, thanks to the software community＇s efforts to discover, classify and spread knowledge concerning all types of rules and patterns. Rules and patterns are useful elements, but many features remain to be studied if we wish to apply them in a rational manner. The improvement in quality that rules and patterns can inject into design is a key issue to be analyzed, so a complete body of empirical knowledge dealing with this is therefore necessary. This paper tackles the question of whether design rules and patterns can help to improve the extent to which designs are easy to understand and modify. An empirical study, composed of one experiment and a replica, was conducted with the aim of validating our conjecture. The results suggest that the use of rules and patterns affect the understandability and modifiability of the design, as the diagrams with rules and patterns are more difficult to understand than non-rule/pattern versions and more effort is required to carry out modifications to designs with rules and patterns.

关键词： design patterns and rules maintainability software quality object-oriented design

coupling sensor observation services and web processing services for online geoprocessing in water dam monitoring

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International Journal of Digital Earth 2018年第1期11卷 64-78页

作者： c.Stasch B.Pross B.Gräler c.Malewski c.förster S.Jirka 52°North GmbH Martin-Luther-King-WegMünsterGermany Wupperverband Untere LichtenplatzerWuppertalGermany

Novel sensor technologies are rapidly *** enable a monitoring and modelling of our environment in a level of detail that was not possible a few years ***,while the raw data produced by these sensors are useful to get a first overview,it usually needs to be post-processed and integrated with other data or models in different *** this paper,we present an approach for integrating several geoprocessing components in the TaMIS water dam monitoring system developed with the Wupperverband,a regional waterbody authority in *** approach relies upon the OGc Web Processing Service and is tightly coupled with Sensor Observation Service instances running at the *** implementing the standardized XML-based interface,lightweight REST APIs have been developed to ease the integration with thin Web clients and other Web-based *** this standards-based approach,new processing facilities can be easily integrated and coupled with different observation data sources.

关键词： Geoprocessing sensor web spatial data infrastructure water monitoring dam monitoring

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORfBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORfBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORfBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Adenosine 5'triphosphate transport and accumulation during the cold preservation of rat hepatocytes in University of Wisconsin solution

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World Journal of Gastroenterology 2005年第13期11卷 1957-1964页

作者： María E.Mamprin félix Vega Joaquín V.Rodriguez farmacología

AIM: We used isolated hepatocytes to investigate how different concentrations of ATP in the University of Wisconsin (UW) solution affected both cellular ATP content and cell viability during the cold storage and the rewarming step. The mechanism involved in ATP transport and accumulation in hypothermia was also determined. METHODS: The cells were preserved up to 72 h in different conditions: UW solution without ATP (a-group), UW+5 mmol/L ATP (b-group), and UW+10 mmol/L ATP (c-group). The ATP content and the cell viability (LDH release) were determined during the cold storage and the rewarming step. In the groups a and c, the respiratory function of the cells at rewarming was studied. In addition, the cell volume of hepatocytes and the mechanism involved in ATP transport and accumulation were assessed. The extracellular degradation of exogenous nucleotides during transport experiments was investigated by a HPLc technique. RESULTS: After three days of cold storage a loss of cellular ATP content was observed in hepatocytes preserved either without nucleotides (a-group) or with 5 mmol/L ATP (b-group). In contrast, 10 mmol/L ATP (c-group) was able to maintain a normal ATP cellular content, with only a 6% diminution after 72 h of cold storage. The respiratory function was significantly different in hepatocytes preserved with 10 mmol/L ATP than without ATP. No significant change was detected for the three groups in cellular volume during the cold storage. We also report that the time course accumulation of [3H]-ATP by cold stored hepatocytes is a rapid process that is completed after 180 s with linear dependence on the extracellular ATP concentration (linear fitting results in a slope of 0.5624±0.1179 mmol/L ATP intracell/mmcl/L ATP extracell). cONcLUSION: Our results show that, during hypothermic storage in UW solution, hepatocytes are permeable to ATP by a diffusive mechanism. Also, we found that it is ATP the main extracellular nucleotide available for transport and it

关键词： UW ATP Hepatocytes cold preservation Hypothermia Oxygen

When a general morphology allows many habitat uses

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Integrative Zoology 2016年第6期11卷 483-499页

作者： María J.TULLI félix B.cRUZ Tiana KOHLSDORf Virginia ABDALA Unidad Ejecutora Lillo(cONIcET)Instituto de Herpetología Fundación Miguel LilloTucumánArgentina Instituto de Investigaciones en Biodiversidad y Medioambiente(INIBIOMA)cONIcET-UNcOMA BarilocheRío NegroArgentina Departamento de Biologia-ffcLRP Universidade de São PauloRibeirão PretoBrazil Instituto de Biodiversidad Neotropical UNT-CONICETCátedra de Biología GeneralFacultad de Ciencias Naturales e IMLTucumánArgentina

During the last decades the study of functional morphology received more attention incorporating more detailed data corresponding to the internal anatomy that together contribute for a better understanding of the functional basis in *** we focus on 2 lizard families,Tropiduridae and Liolaemidae,and use information related to muscle-tendinous and external morphology traits of hind *** investigate whether the value of the traits analyzed tend to exhibit a reduced phenotypic variation produced by stabilizing selection,and whether species showing specialization in their habitat use will also exhibit special morphological features related to *** a result,we identified that evolution of hind limb traits is mainly explained by the Ornstein-Uhlenbeck model,suggesting stabilizing *** and tropidurids show clear ecomorphological trends in the variables considered,with sand lizards presenting the most specialized morphological *** ecomorphological trends differ between the 2 lineages,and traits of internal morphology tend to be more flexible than those of external morphology,restricting the ability to identify ecomorphs shared between these 2 *** traits of external morphology likely explain such restriction,as ecomorphs have been historically defined in other lizard clades based on variation of external morphology.

关键词： external morphology Lioalemidae muscles tendon Tropiduridae

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Prevalence of Schistosoma mono- and co-infections with multiple common parasites and associated risk factors and morbidity profile among adults in the Taabo health and demographic surveillance system, South-central côte d’Ivoire

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Infectious Diseases of Poverty 2022年第1期11卷 84-85页

作者： fidèle K.Bassa Ikenna c.Eze Rufin K.Assaré clémence Essé Siaka Koné félix Acka Véronique Laubhouet-Koffi Dinard Kouassi Bassirou Bonfoh Jürg Utzinger Eliézer K.N’Goran Unitéde formation et de Recherche Biosciences UniversitéFélix Houphouët-Boigny22P.O.Box 582Abidjan 22Côte d’Ivoire 不详

Background Schistosomiasis remains an important public health problem,also among adults,and infected individuals not treated serve as a reservoir for continued *** this fact,evidence on the epidemiology of schistosomiasis in adults in côte d’Ivoire is *** study aimed to determine the prevalence and risk factors of Schistosoma infection and co-infection with other helminth species and Plasmodium among adults in the Taabo region in the south-central part of côte d’*** A cross-sectional survey was carried out in April and May 2017 in the frame of the“côte d’Ivoire Dual Burden of Disease Study”(coDuBu).A total of 901 randomly selected individuals,aged 18–90 years,provided blood,stool and urine samples for the diagnosis of malaria and helminth *** samples were subjected to the Kato-Katz technique for detection of Schistosoma mansoni and soil-transmitted helminth eggs,while urine samples were examined for eggs of Schistosoma haematobium and circulating cathodic antigen of *** factors and morbidity profiles were assessed using health examination and *** logistic regressions were employed to identify risk factors and morbidity patterns associated with *** mono-and *** The prevalence of *** and *** was 23.2%and 1.0%,*** *** were mono-infections(81.3%).Independent determinants of *** infection were young age,low socioeconomic status(mono-and co-infection)and poor hygiene practices(co-infection)(Pfection was independently associated with higher pain and symptom scores(mono-infection),poor self-rated health and low healthcare use(co-infection)(Pconclusions This study showed that adults represent a substantial reservoir of *** sustain schistosomiasis control and improve people’s wellbeing,it is important to expand preventive chemotherapy from school-aged children to adults,coupled with hygiene and

关键词： Adults côte d’Ivoire Morbidity patterns Prevalence Risk factor Schistosoma infection

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage