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Resilience conferred by APOE-R136S:a defense bestowed by nature to combat Alzheimer’s disease

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Signal Transduction and Targeted Therapy 2024年第3期9卷 831-832页

作者： Bin Xiao Joshua Kuruvilla eng-King Tan Department of Neurology National Neuroscience InstituteSingaporeSingapore Neuroscience Academic clinical Program Duke-NUS Medical SchoolSingaporeSingapore Neuroscience and Behavioural Disorders Program Duke-NUS Medical SchoolSingaporeSingapore

In two recent articles published in Nature Neuroscience and cell,Nelson et al.1 and chen et al.2 have shown that a rare APOE3 christchurch(APOE3ch)variant,R136S,has protective effects on neurodegeneration in various Alzheimer’s disease(AD)model systems through attenuating tau pathology and regulating its related neuroimmune *** et *** chen et *** provided evidence that identifying the pathophysiologic clues and potential molecular targets from a protective variant such as APOE R136S,can be an attractive viable approach to develop AD therapeutics.

关键词： protective al. Alzheimer

Tau in the pancreas:understanding the link between type 2 diabetes mellitus and Alzheimer's disease

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Signal Transduction and Targeted Therapy 2024年第1期9卷 6-7页

作者： Wenlu Li Steffen Tiedt eng H.Lo Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolCharlestownMA02129USA consortium International pour la Recherche circadienne sur l’AVc(cIRcA) BostonUSA Institute for Stroke and Dementia Research LMU University HospitalLMU MunichMunichGermany

A recent study published in Molecular Psychiatry proposes a cellular mechanism that may contribute to decreased insulin production in individuals with type 2 diabetes mellitus(T2DM).1 Using a combination of cell culture experiments,animal models and studies in T2DM patients,the authors show that an up-regulation of tau inβ-islet cells can inhibit pancreatic insulin secretion through changes in microtubule assembly.

关键词： T2DM Alzheimer tau

游戏教学法在汉语初级口语课中的应用研究 ——以马来西亚诗巫技职学院为例

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游戏教学法在汉语初级口语课中的应用研究 ——以马来西亚诗巫技...

作者： cHRISTINE SIA cHOU eng（谢周訇）河北大学

学位级别：硕士

人际关系是否融洽,口语交际能力至关重要。如何提升学生的口语表达能力,是汉语作为第二语言教学中要思考的重要问题之一。游戏教学法,寓教于乐,将其应用于汉语口语课堂,可以激发学生学习的兴趣。论文将理论与实践相结合,以作者在马来西... 详细信息

人际关系是否融洽,口语交际能力至关重要。如何提升学生的口语表达能力,是汉语作为第二语言教学中要思考的重要问题之一。游戏教学法,寓教于乐,将其应用于汉语口语课堂,可以激发学生学习的兴趣。论文将理论与实践相结合,以作者在马来西亚诗巫技职学院所执教的2022级四年级烹饪班为研究对象,运用游戏教学法设计了具体的教学方案,并以《汉语》I中第四课的内容为基础进行了教学实践。通过调查问卷和口语测试的方法,对游戏教学法在教学中的效果进行了评估。研究结果表明,游戏教学法在激发学习兴趣、促进同学间关系融洽、丰富教学形式等方面具有显著的帮助效果。这一方法不仅增强了课堂互动,还为汉语教学提供了新思路,对推广汉语作为第二语言教学具有重要价值。但是经过教学实践也发现其应用过程中容易出现游戏目标模糊、时长不易掌控、及游戏类型选择不当等各种问题。针对上述问题,从游戏设计、游戏实施和口语测试三个阶段提出一些建议。教师必须要有精准的时间规划,以确保教学内容能在规定的时间内顺利完成,这包括提前制定游戏规则,并在课堂上清晰地解释,从而节省时间并确保学生能够全面理解游戏的要求和规则。除此之外,教师在实行游戏教学法时应考虑教学目标和内容,这是教师设计游戏时应该特别注意的关键点。这意味着教师需要在设计游戏时明确教学目标,并确保游戏的每个环节都与这些目标紧密相关,使学生在游戏过程中能够获得足够的语言输入和实践机会,并最终达到教学目标。最后,希望此研究可以为职业院校的汉语口语教学提供参考。

关键词：游戏教学法马来西亚技职学院初级汉语口语课

边境民族地区中小学国家安全教育地方课程建设研究

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中国教育学刊 2024年第7期 45-49页

作者：曾煜姜琪云南师范大学继续教育学院云南昆明650092 云南省腾冲市教育教师发展中心云南腾冲679100

建设边境民族地区中小学国家安全教育地方课程是国家安全教育的一项重点工作,其目的是以课程的适切性和针对性回应维护边境民族地区国家安全的特殊需求,提升中小学国家安全教育的有效性。开展此项工作要坚持适度理论性与突出实践性相协... 详细信息

建设边境民族地区中小学国家安全教育地方课程是国家安全教育的一项重点工作,其目的是以课程的适切性和针对性回应维护边境民族地区国家安全的特殊需求,提升中小学国家安全教育的有效性。开展此项工作要坚持适度理论性与突出实践性相协同、规范性安排与灵活性实施相结合的基本原则,在实施过程中建议着重开展以下三个方面的探索和努力:党委政府主导,以行政力量与专业力量的协同重点推进;体系化建构,以清晰的课程边界实现纵向与横向衔接;强化引领示范,以有力正向引导持续不断优化课程。

关键词：边境民族地区国家安全教育地方课程建设

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岭南猪肉卷章加工及其安全风险研究进展

肉类研究 2024年第4期38卷 70-76页

作者：徐青怡 PHUAH eng-Tong 董浩曾晓房白卫东李光辉仲恺农业工程学院轻工食品学院广东省岭南特色食品科技重点实验室农业农村部岭南特色食品绿色加工与智能制造重点实验室广东广州510225 文莱科技大学应用科学与数学学院文莱斯里巴加湾BE1410

猪肉卷章(肉卷)是我国岭南地区著名的传统美食,以猪后腿肉和腐皮为主要原料,制卷并经油炸制作而成。目前,猪肉卷章面临高饱和脂肪、高盐及热加工中伴随危害物产生等问题,具有引发心血管疾病、肥胖、糖尿病等风险。因此,低盐、低脂和营... 详细信息

猪肉卷章(肉卷)是我国岭南地区著名的传统美食,以猪后腿肉和腐皮为主要原料,制卷并经油炸制作而成。目前,猪肉卷章面临高饱和脂肪、高盐及热加工中伴随危害物产生等问题,具有引发心血管疾病、肥胖、糖尿病等风险。因此,低盐、低脂和营养健康是猪肉卷章的研究方向。本文围绕岭南特色卷章的研究现状及发展趋势进行综述,指出岭南特色卷章的加工方法及其潜在的食品安全风险,提出Pickering乳液替代脂肪、减盐策略及危害物预防控制的解决方案,并对其后续脂肪替代、营养健康和市场前景等方面进行展望,旨在为营养健康的新型卷章在食品工业中的应用提供理论依据。

关键词：猪肉卷章 Pickering乳液脂肪替代营养

A toast to a zebrafish germ cell induction cocktail

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Science china(Life Sciences) 2024年第6期67卷 1314-1315页

作者： Mary c.Mullins Department of cell and Developmental Biology University of Pennsylvania Perelman School of MedicinePhiladelphia 19104USA

The zebrafish field is ringing in the new year with a publication from Yonghua Sun's laboratory(Wang et al.,2023)of a cocktail of germline factors that can induce all cells of the zebrafish embryo into primordial germ cells(PGcs)at phenomenal *** major advance is not only of great interest to germ cell biologists,but it has important applications to the entire zebrafish field,as shown in Wang et al.(2023).

关键词： fish zebra field

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Performance of evolutionary optimized machine learning for modeling total organic carbon in core samples of shale gas fields

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Petroleum 2024年第1期10卷 150-164页

作者： Leonardo Goliatt c.M.Saporetti L.c.Oliveira E.Pereira Department of computational and Applied Mechanics Federal University of Juiz de Fora Department of computational Modeling Polytechnic Institute Rio de Janeiro State University Petrobras Department of Stratigraphy and Paleontology Rio de Janeiro State University

Rock samples' TOc content is the best indicator of the organic matter in source rocks. The origin rock samples' analysis is used to calculate it manually by specialists. This method requires time and resources because it relies on samples from many well intervals in source rocks. Therefore, research has been done to aid this effort. Machine learning algorithms can estimate total organic carbon instead of well logs and stratigraphic studies. In light of these efforts, the current work present a study on automating the total organic carbon estimation using machine learning approaches improved by an evolutionary methodology to give the model flexibility and precision. Genetic algorithms, differential evolution, particle swarm optimization, grey wolf optimization, artificial bee colony, and evolution strategies were used to improve machine learning models to predict TOc. The six metaheuristics were integrated into four machine learning methods: extreme learning machine, elastic net linear model, linear support vector regression, and multivariate adaptive regression splines. core samples from the YuDong-Nan shale gas field, located in the Sichuan basin, were used to evaluate the hybrid strategy. The findings show that combining machine learning models with an evolutionary algorithms in a hybrid fashion produce flexible models that accurately predict TOc. The results show that, independent of the metaheuristic used to guide the model selection, optimized extreme learning machines attained the best performance scores according to six metrics. Such hybrid models can be used in exploratory geological research,particularly for unconventional oil and gas resources.

关键词： Total organic carbon Hybrid models Automated machine learning Evolutionary algorithms Geology

Recent advances on bismuth oxyhalides for photocatalytic cO_(2)reduction

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Journal of Environmental Sciences 2024年第6期140卷 183-203页

作者： Liangpang Xu Jimmy c.Yu Ying Wang Department of chemistry The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China

Photocatalytic conversion of cO_(2)into fuels such as cO,cH_(4),and cH_(3)OH,is a promising approach for achieving carbon *** oxyhalides(BiOX,where X=cl,Br,and I)are appropriate photocatalysts for this purpose due to the merits of visible-light-active,efficient charge separation,and easy-to-modify crystal structure and surface *** practical applications,multiple strategies have been proposed to develop high-efficiency BiOX-based *** review summarizes the development of different approaches to prepare BiOX-based photocatalysts for efficient cO_(2)*** the review,the fundamentals of photocatalytic cO_(2)reduction are ***,several widely used modification methods for BiOX photocatalysts are systematacially discussed,including heterojunction construction,introducing oxygen vacancies(OVs),Bi-enrichment,heteroatom-doping,and morphology ***,the challenges and prospects in the design of future BiOX-based photocatalysis for efficient cO_(2)reduction are examined.

关键词： Bismuth oxyhalides Photocatalysis cO_(2)reduction Modification methods

Exercise immunology:Novel insights

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Journal of Sport and Health Science 2024年第3期13卷 277-279,I0001页

作者： David c.Nieman Human Performance Laboratory Appalachian State UniversityNorth Carolina Research CampusKannapolisNC 28081USA

The coronavirus disease 2019(cOVID-19)pandemic heightened worldwide attention on the influence of exercise on the immune *** were raised about whether regular moderate-to-vigorous physical activity(MVPA)could help prevent cOVID-19 or mitigate symptoms when *** MVPA bolster immunity among those most prone to cOVID-19 including the elderly,obese,and immunocompromised patients?Does regular MVPA dampen systemic inflammation,thereby lessening the cOVID-19 cytokine storm?

关键词： immunity inflammation thereby