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When mRNA meets gene editing

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Nano Research 2024年第8期17卷 7337-7356页

作者： Weijie Li chen Wang yuan lu Key Laboratory of Industrial Biocatalysis Ministry of EducationDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Department of chemical engineering Tsinghua UniversityBeijing 100084China

The critical challenge of gene therapy lies in delivering gene editing *** with DNA,while RNA is less stable and more accessible to degrade,it comes with the benefit of lower off-target effects since permanent insertion is not *** review focuses on mRNA-based delivery of gene editing agents,highlighting novel mRNA delivery *** provide context,a comparison is made between three main gene editing agents:programmable nucleases,base editors,and prime *** potential of cas\pi and transposons is also discussed in this ***,a summary of four main barriers to mRNAbased in vivo delivery is ***,this review detailedly introduced different delivery systems,both viral(lentivirus)and non-viral vectors(genome editing via oviductal nucleic acids delivery,lipid nanoparticles,polymer-based nanoparticles,viruslike-particles,extracellular vesicles,and migrasome).Each delivery strategy is assessed by comparing its advantages and disadvantages to offer a comprehensive and objective overview of the delivery ***,we emphasized the vital role of the protein corona as a critical regulator for ***,we concluded the challenges of mRNA-based gene editing strategies(RNA stability,targeting,potential immunogenicity,cytotoxicity,heterogeneity,and rational design).The purpose of this review is to guide further research and provide a comprehensive analysis of mRNA-based in vivo delivery of gene editing agents in this promising field.

关键词： gene editing mRNA delivery viral vectors non-viral vectors cRISPR

cell-free biocatalysis coupled with photo-catalysis and electro-catalysis: Efficient cO2-to-chemical conversion

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Green Energy & Environment 2024年第9期9卷 1366-1383页

作者： Junzhu Yang chi-Kit Sou yuan lu Key Laboratory of Industrial Biocatalysis Ministry of Education Tsinghua University Department of chemical engineering Tsinghua University

The increasing atmospheric carbon dioxide （cO2） concentration has exposed a series of crises in the earth's ecological *** to effectively fix and convert carbon dioxide into products with added value has attracted the attention of many ***-free enzyme catalytic system coupled with electrical and light have been a promising attempt in the field of biological carbon fixation in recent *** this review,the research progresses of photoenzyme catalysis,electroenzyme catalysis and photo-electroenzyme catalysis for converting carbon dioxide into chemical products in cell-free systems are systematically *** focus on reviewing and comparing various coupling methods and principles of photoenzyme catalysis and electroenzyme catalysis in cell-free systems,especially the materials used in the construction of the coupling system,and analyze and point out the characteristics and possible problems of different coupling ***,we discuss the major challenges and prospects of coupling physical signals and cell-free enzymatic catalytic systems in the field of cO2fixation,suggesting possible strategies to improve the carbon sequestration capacity of such systems.

关键词： cO 2 fixation cell-free system Enzyme Photoenzyme catalysis Electroenzyme catalysis

Self-assembled all-oxides three-phase vertically aligned nanocomposite thin film with multifunctionality

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Nano Research 2024年第9期17卷 8226-8232页

作者： Jijie Huang yuan Fang Ping lu Juanjuan lu Haiyan Wang School of Materials Shenzhen Campus of Sun Yat-sen UniversityShenzhen 518107China School of Materials engineering Purdue UniversityWest LafayetteIN 47907USA Sandia National Laboratories AlbuquerqueNew Mexico 87185USA School of Electrical and computer engineering Purdue UniversityWest LafayetteIN 47907USA

Multi-phase vertically aligned nanocomposite(MP-VAN)thin films represent a promising avenue for achieving complex multifunctionality,exploring novel interfacial phenomena,and enabling complex metamaterial designs and *** this study,a novel self-assembled all-oxides three-phase VAN system was conceptualized and fabricated utilizing pulsed laser deposition(PLD)with a single composite *** microstructural analysis reveals the presence of three distinct phases:LiNbO_(3),ceO_(2-x),and LiNbce_(1-x)O_(y)within the MP-VAN ***,ferroelectric,dielectric,optical anisotropy,and magnetic properties were systematically investigated to showcase the multifunctionality inherent in these *** work presents a pioneering approach to designing and realizing MP-VAN systems,and opens up opportunities for tailoring the complex three-dimensional(3D)physical properties and property coupling of VAN films towards diverse device applications.

关键词： thin film three-phase vertically aligned nanocomposite multifunctionality ferroelectricity optical anisotropy

Large-scale chiral spherulites with controllable circularly polarized luminescence in liquid crystal block copolymers film

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Aggregate 2024年第1期5卷 427-435页

作者： Jianan yuan Xuemin lu Qinghua lu School of chemistry and chemical engineering Shanghai Jiao Tong UniversityShanghaiChina School of chemical Science and engineering Tongji UniversityShanghaiChina

Macroscopic chiral spherulites prepared by hierarchical self-assembly have attracted considerable attention due to their excellent property as chiroptical ***,preparing controllable chiral spherulites in bulk film remains a challenge due to the absent knowledge of the evolution mechanism from the molecule to macroscopic crystal during chiral *** this contribution,chiral macroscopic spherulites were constructed with controllable circularly polarized luminescence(cPL)using enantiomeric tartaric acid and rhodamine B co-assembled with liquid crystal block copolymers,poly(ethylene oxide)-b-poly(methyl methacrylate)bearing azobenzene group side *** was found that the chiral liquid crystal field induced by exogenous chiral molecules was closely related to the formation of macroscopic chiral ***,the transformation of azobenzene cis-trans isomerization under photo-thermal endows films with adjustable *** facile strategy provides a platform to design large-scale chiral structures for chiroptical switching,encryption,and memory storage materials.

关键词： block copolymer circularly polarized luminescence macroscopic chirality self-assembly

Flower-like cuS/γ-Fe_(2)O_(3) van der Waals heterostructures with highefficient electromagnetic wave absorption

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Nano Research 2024年第4期17卷 3324-3333页

作者： Na lu Jingshen Xu Mengwei yuan Genban Sun Beijing Key Laboratory of Energy conversion and Storage Materials Institution College of ChemistryBeijing Normal UniversityBeijing 100875China center for Advanced Materials Research Beijing Normal UniversityZhuhai 519087China

The escalating electromagnetic(EM)pollution issues and the demand to elevate military stealth technology make it imperative to develop cost-effective and high-performance electromagnetic wave(EMW)absorbing *** this paper,the flower-like cuS/γ-Fe_(2)O_(3) van der Waals(vdW)heterostructures have been synthesized via a facile two-step solvothermal *** flower-like cuS skeleton increases the attenuation path of EMW while reducing the material *** contents ofγ-Fe_(2)O_(3) nanoparticles anchor between the flower-like cuS nanosheets to constitute a heterogeneous structure,which enables dielectric and magnetic loss synergistically to optimize impedance matching and remarkably improve the EMW absorption *** minimum reflection loss(RLmin)is-49.36 dB with a thickness of only 1.6 mm and the effective absorption bandwidth(EAB)reaches 4.64 GHz(13.36–18 GHz).By adjusting the thickness of the absorber,the EAB can cover 96%of the GHz ***,the superior absorption of-61.53 dB at middle frequency band can be obtained by adjusting the amount of Fe_(2)O_(3) *** this study,the adjustment of EM parameters and the optimization of impedance matching have been achieved by constructing a novel vdW heterogeneous structure,which provides fresh ideas and references for the design of high-performance EMW absorbing materials.

关键词： flower-like cuS γ-Fe_(2)O_(3) van der Waals heterostructures impedance matching electromagnetic wave absorption

Multi-Perspective Data Fusion Framework Based on Hierarchical BERT: Provide Visual Predictions of Business Processes

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computers, Materials & continua 2024年第1期78卷 1227-1252页

作者： Yongwang yuan Xiangwei Liu Ke lu School of Mathematics and Big Data Anhui University of Science and TechnologyHuainan232001China School of Economics and Management Anhui University of Science and TechnologyHuainan232001China The Key Laboratory of Embedded System and Service computing Ministry of Education Tongji UniversityShanghai201804China

Predictive Business Process Monitoring(PBPM)is a significant research area in Business Process Management(BPM)aimed at accurately forecasting future behavioral *** present,deep learning methods are widely cited in PBPM research,but no method has been effective in fusing data information into the control flow for multi-perspective process ***,this paper proposes a process prediction method based on the hierarchical BERT and multi-perspective data ***,the first layer BERT network learns the correlations between different category attribute ***,the attribute data is integrated into a weighted event-level feature vector and input into the second layer BERT network to learn the impact and priority relationship of each event on future predicted ***,the multi-head attention mechanism within the framework is visualized for analysis,helping to understand the decision-making logic of the framework and providing visual ***,experimental results show that the predictive accuracy of the framework surpasses the current state-of-the-art research methods and significantly enhances the predictive performance of BPM.

关键词： Business process prediction monitoring deep learning attention mechanism BERT multi-perspective

A solution method for decomposing vector fields in Hamilton energy

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chinese Physics B 2024年第9期33卷 645-653页

作者： Xin Zhao Ming Yi Zhou-chao Wei yuan Zhu lu-lu lu School of Mathematics and Physics China University of GeosciencesWuhan 430074China

Hamilton energy,which reflects the energy variation of systems,is one of the crucial instruments used to analyze the characteristics of dynamical *** we propose a method to deduce Hamilton energy based on the existing *** derivation process consists of three steps:step 1,decomposing the vector field;step 2,solving the Hamilton energy function;and step 3,verifying *** order to easily choose an appropriate decomposition method,we propose a classification criterion based on the form of system state variables,i.e.,type-I vector fields that can be directly decomposed and type-II vector fields decomposed via exterior ***,exterior differentiation is used to represent the curl of low-high dimension vector fields in the process of ***,we exemplify the Hamilton energy function of six classical systems and analyze the relationship between Hamilton energy and dynamic *** solution provides a new approach for deducing the Hamilton energy function,especially in high-dimensional systems.

关键词： Hamilton energy dynamical systems vector field exterior differentiation

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Photonic neuromorphic architecture for tens-of-task lifelong learning

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Light(Science & Applications) 2024年第3期13卷 519-530页

作者： yuan c.eng Jianing Zhang Tiankuang Zhou Yuyan Wang Zhihao Xu Xiaoyun yuan lu Fang Sigma Laboratory Department of Electronic EngineeringTsinghua UniversityBeijing 100084China Beijing National Research center for Information Science and Technology(BNRist) Beijing 100084China Institute for Brain and cognitive Science Tsinghua University(THUIBCS)Beijing 100084China

Scalable,high-capacity,and low-power computing architecture is the primary assurance for increasingly manifold and large-scale machine learning *** electronic artificial agents by conventional power-hungry processors have faced the issues of energy and scaling walls,hindering them from the sustainable performance improvement and iterative multi-task *** to another modality of light,photonic computing has been progressively applied in high-efficient neuromorphic ***,we innovate a reconfigurable lifelong-learning optical neural network(L2 ONN),for highly-integrated tens-of-task machine intelligence with elaborated algorithm-hardware *** from the inherent sparsity and parallelism in massive photonic connections,L2 ONN learns each single task by adaptively activating sparse photonic neuron connections in the coherent light field,while incrementally acquiring expertise on various tasks by gradually enlarging the *** multi-task optical features are parallelly processed by multi-spectrum representations allocated with different *** evaluations on freespace and on-chip architectures confirm that for the first time,L2 ONN avoided the catastrophic forgetting issue of photonic computing,owning versatile skills on challenging tens-of-tasks(vision classification,voice recognition,medical diagnosis,etc.)with a single ***,L2 ONN achieves more than an order of magnitude higher efficiency than the representative electronic artificial neural networks,and 14×larger capacity than existing optical neural networks while maintaining competitive performance on each individual *** proposed photonic neuromorphic architecture points out a new form of lifelong learning scheme,permitting terminal/edge AI systems with light-speed efficiency and unprecedented scalability.

关键词： life neural versatile

Severe liver injury and clinical characteristics of occupational exposure to 2-amino-5-chloro-N,3-dimethylbenzamide: A case series

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 186-194页

作者： Meng-Xiao Feng Hua Zou yuan-Qiang lu Department of Emergency Medicine The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Key Laboratory for Diagnosis and Treatment of Aging and Physic-chemical Injury Diseases of Zhejiang Province Hangzhou 310003China Occupational Health and Radiation Protection Institute Zhejiang Provincial Center for Disease Control and PreventionHangzhou 310051China

Background:The 2-amino-5-chloro-N,3-dimethylbenzamide is a key intermediate in the synthesis of pesticides and ***,no literature currently exists on 2-amino-5-chloro-N,3-dimethylbenzamide poisoning in *** study aimed to reveal the health hazard of this chemical for humans and summarize the clinical characteristics of patients with occupational 2-amino-5-chloro-N,3-dimethylbenzamide ***:This observational study included four patients with 2-amino-5-chloro-N,3-dimethylbenzamide poisoning from June 2022 to July *** entire course of the incidents was described in *** 2-amino-5-chloro-N,3-dimethylbenzamide concentrations were detected by a mass ***-toxylin and eosin staining was performed to assess liver injury,and immunofluorescence was used to evaluate hepatic ***:The 2-amino-5-chloro-N,3-dimethylbenzamide powder(99%purity)entered the human body mainly via the skin and respiratory tract due to poor personal protective *** typical course of 2-amino-5-chloro-N,3-dimethylbenzamide poisoning was divided into latency,rash,fever,organic dam-age,and recovery phases in accordance with the clinical *** and fever may be the important premonitory symptoms for further organ *** chemical was detected in the blood of all patients and caused multiple organ injuries,predominantly liver injury,including kidney,myocardium,and *** patients recovered smoothly after comprehensive treatments,including artificial liver therapy,continuous renal replacement therapy,glucocorticoids,and other symptomatic and supportive *** patient survived by liver *** postoperative pathological findings of the removed liver showed acute liver failure,and immunofluorescence staining confirmed the abundance of mitophagy in residual ***:This study is the first to elaborate the clinical characteristics of patients with 2-amino-5-chloro-N,

关键词： 2-amino-5-chloro-N,3-dimethylbenzamide Poisoning clinical characteristics Liver injury

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