检索结果-南通市图书馆

Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats

引用

chinese Journal of Natural Medicines 2024年第4期22卷 293-306页

作者： YAO Wenhui TAO Rongpin WANG kai DING Xuansheng School of Basic Medicine and clinical Pharmacy China Pharmaceutical UniversityNanjing211198China

Icariin, a flavonoid glycoside, is extracted from Epimedium. This study aimed to investigate the vascular protective effects of icariin in type 1 diabetic rats by inhibiting high-mobility group box 1 (HMGB1)-related inflammation and exploring its potential mechanisms. The impact of icariin on vascular dysfunction was assessed in streptozotocin (STZ)-induced diabetic rats through vascular reactivity studies. Western blotting and immunofluorescence assays were performed to measure the expressions of target proteins. The release of HMGB1 and pro-inflammation cytokines were measured by enzyme-linked immunosorbent assay (ELISA). The results revealed that icariin administration enhanced acetylcholine-induced vasodilation in the aortas of diabetic rats. It also notably reduced the release of pro-inflammatory cytokines, including interleukin-8 (IL-8), IL-6, IL-1β, and tumor necrosis factor-alpha (TNF-α) in diabetic rats and high glucose (HG)-induced human umbilical vein endothelial cells (HUVEcs). The results also unveiled that the pro-inflammatory cytokines in the culture medium of HUVEcs could be increased by rHMGB1. The increased release of HMGB1 and upregulated expressions of HMGB1-related inflammatory factors, including advanced glycation end products (RAGE), Toll-like receptor 4 (TLR4), and phosphorylated p65 (p-p65) in diabetic rats and HG-induced HUVEcs, were remarkably suppressed by icariin. Notably, HMGB1 translocation from the nucleus to the cytoplasm in HUVEcs under HG was inhibited by icariin. Meanwhile, icariin could activate G protein-coupled estrogen receptor (GPER) and sirt1. To explore the role of GPER and Sirt1 in the inhibitory effect of icariin on HMGB1 release and HMGB-induced inflammation, GPER inhibitor and Sirt1 inhibitor were used in this study. These inhibitors diminished the effects of icariin on HMGB1 release and HMGB1-induced inflammation. Specifically, the GPER inhibitor also negated the activation of Sirt1 by icariin. These findings suggest t

关键词： Icariin Diabetes Inflammation Vascular endothelial dysfunction GPER HMGB1

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Hydrologic Response to Future climate change in the Dulong-Irra-waddy River Basin Based on coupled Model Intercomparison Project 6

引用

chinese Geographical Sc.ence 2024年第2期34卷 294-310页

作者： XU Ziyue MA kai YUAN Xu HE Daming Institute of International Rivers and Eco-security Yunnan UniversityKunming 650500China Yunnan Key Laboratory of International Rivers and Transboundary Eco-security Kunming 650500China

Within the context of the Belt and Road Initiative(BRI)and the china-Myanmar Economic corridor(cMEc),the Dulong-Ir-rawaddy(Ayeyarwady)River,an international river among china,India and Myanmar,plays a significant role as both a valuable hydro-power resource and an essential ecological ***,the water resources and security exhibit a high degree of vulnerabil-ity to climate change *** research evaluates climate impacts on the hydrology of the Dulong-Irrawaddy River Basin(DIRB)by using a physical-based hydrologic *** crafted future climate scenarios using the three latest global climate models(GcMs)from coupled Model Intercomparison Project 6(cMIP6)under two shared socioeconomic pathways(SSP2-4.5 and SSP5-8.5)for the near(2025-2049),mid(2050-2074),and far future(2075-2099).The regional model using MIKE SHE based on historical hydrologic processes was developed to further project future streamflow,demonstrating reliable performance in streamflow simulations with a val-idation Nash-Sutcliffe Effic.ency(NSE)of *** showed that climate change projections showed increases in the annual precip-itation and potential evapotranspiration(PET),with precipitation increasing by 11.3%and 26.1%,and PET increasing by 3.2%and 4.9%,respectively,by the end of the century under SSP2-4.5 and *** changes are projected to result in increased annual streamflow at all stations,notably at the basin’s outlet(Pyay station)compared to the baseline period(with an increase of 16.1%and 37.0%at the end of the 21st century under SSP2-4.5 and SSP5-8.5,respectively).Seasonal analysis for Pyay station forecasts an in-crease in dry-season streamflow by 31.3%-48.9%and 22.5%-76.3%under SSP2-4.5 and SSP5-8.5,respectively,and an increase in wet-season streamflow by 5.8%-12.6%and 2.8%-33.3%,***,the magnitude and frequency of flood events are pre-dicted to escalate,potentially impacting hydropower production and food security *** res

关键词： climate change hydrologic response coupled Model Intercomparison Project 6(cMIP6) MIKE SHE(Système Hydrologique Europeén) Dulong-Irrawaddy River Basin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

contrasts of bimodal tropical instability waves(TIWs)-induced wind stress perturbations in the Pacific Ocean among observations,ocean models,and coupled climate models

引用

Journal of Oceanology and Limnology 2024年第1期42卷 1-23页

作者： kai MA chuanyu LIU Junli XU Fan WANG School of Mathematics and Physics Research Institute for Mathematics and Interdisciplinary SciencesQingdao University of Science and TechnologyQingdao 266100China Key Laboratory of Ocean circulation and Waves Institute of OceanologyChinese Academy of SciencesQingdao 266071China Pilot National Laboratory for Marine Sc.ence and Technology(Qingdao) Qingdao 266237China

The coupling between wind stress perturbations and sea surface temperature(SST)perturbations induced by tropical instability waves(TIWs)in the Pacific Ocean has been revealed previously and proven crucial to both the atmosphere and ***,an overlooked fact by previous studies is that the loosely defined“TIWs”actually consist of two modes,including the Yanai wave-based TIW on the equator(hereafter eTIW)and the Rossby wave-based TIW off the equator(hereafter vTIW).Hence,the individual feedbacks of the wind stress to the bimodal TIWs remain *** this study,individual coupling relationships are established for both eTIW and v TIW,including the relationship between the TIW-induced SST perturbations and two components of wind stress perturbations,and the relationship between the TIW-induced wind stress perturbation divergence(curl)and the downwind(crosswind)TIW-induced SST *** show that,due to different distributions of eTIW and vTIW,the coupling strength induced by the eTIW is stronger on the equator,and that by the vTIW is stronger off the *** results of any of eTIW and vTIW are higher than those of the loosely defined *** further investigated how well the coupling relationships remained in several widely recognized oceanic general circulation models and fully coupled climate ***,the coupling relationships cannot be well represented in most numerical ***,we confirmed that higher resolution usually corresponds to more accurate ***,the coupling models established in this study are complementary to previous research and can be used to refine the oceanic and coupled climate models.

关键词： bimodal tropical instability waves mesoscale air-sea interaction coupled models Yanai wave

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exciton Bose–Einstein condensation in Transition Metal Dichalcogenide Monolayer under In-Plane Magnetic Fields

引用

chinese Physics Letters 2024年第8期41卷 69-76页

作者： Dengfeng Wang Yingda c.en Zhi-chuan Niu Wen-kai Lou kai chang SKLSM Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China college of Materials Sc.ence and Opto-electronic Technology Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China School of Physics Zhejiang UniversityHangzhou 310027China

Based on the Gross–Pitaevskii equation,we theoretically investigate exciton Bose–Einstein condensation(BEc)in transition metal dichalcogenide monolayers(TMDc-MLs)under in-plane magnetic *** observe that the in-plane magnetic fields exert a strong influence on the exciton BEc wave functions in TMDc-MLs because of the mixing of the bright and dark exciton states via Zeeman *** leads to the brightening of the dark exciton BEc *** competition between the dipole–dipole interactions caused by the long-range coulomb interaction and the Zeeman effect induced by the in-plane magnetic fields can effectively regulate dark exciton BEc *** findings emphasize the utility of TMD-MLs as platforms for investigating collective phenomenon involving excited states.

关键词： effect Einstein dipole

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Design of a Bio-inspired,Two-winged,Flapping-wing Micro Air Vehicle with High-lift Performance

引用

Journal of Bionic.engineering 2024年第3期21卷 1191-1207页

作者： kai Hu Huichao Deng Shengjie Xiao Gongyu Yang Yuhong Sun Space Robot Laboratory The School of Mechanical EngineeringBeihang UniversityBeijing100191China

In this paper,we present the development of our latest flapping-wing micro air vehicle(FW-MAV),named Explobird,which features two wings with a wingspan of 195 mm and weighs a mere 25.2 g,enabling it to accomplish vertical take-off and hover *** devised a novel gear-based mechanism for the flapping system to achieve high lift capability and reliability and conducted extensive testing and analysis on the wings to optimise power matching and lift *** Explobird can deliver a peak lift-to-weight ratio of 1.472 and an endurance time of 259 s during hover flight powered by a single-cell LiPo *** the inherent instability of the prototype,we discuss the derivatives of its longitudinal system,underscoring the importance of feedback control,position of the centre of gravity,and increased *** demonstrate the effect of damping enhancement on stability,we also designed a passive stable ***,the vehicle is actively stabilised in roll by adjusting the wing root bars and in pitch through high-authority tail control,whereas yaw is passively *** a series of flight tests,we successfully demonstrate that our prototype can perform vertical take-off and hover flight under wireless *** promising results position the Explobird as a robust vehicle with high lift capability,paving the way towards the use of FW-MAVs for carrying load equipment in multiple tasks.

关键词： Flapping wing Biologically inspired robots Mechanical design Flight dynamics Damping enhancement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Link Prediction Method Fusion with Local Structural entropy for Directed Network

引用

chinese Journal of Electronics 2024年第1期33卷 204-216页

作者： Shuxin LIU Hongchang c.en Lan WU kai WANG Xing LI People’s Liberation Army Strategic Support Force Information engineering University

Link prediction utilizes accessible network information to complement or predict the network *** is an important prerequisite for link prediction which means links more likely occurs between two similar nodes. Existing methods utilize the similarity of nodes but neglect of network structure. However the link direction leads to a far more complex structure and contains more information useful than the undirected networks. Most classic methods are difficult to depict the distribution of the network structure with incidental direction so the similarity characteristics of the network structure itself are lost. In this respect, a new method of local structure entropy is proposed to depict the directed structural distribution characteristics, which can be used to evaluate the degree of local structural similarity of nodes and then applied to link prediction methods. Experimental results on 8 real directed networks show that this method is effective for both area under the receiver operating characteristic curve(AUc)and ranking-score measures, and improved predictive capacity of the baseline methodology.

关键词： correlation current measurement Area measurement Prediction methods Receivers Benchmark testing entropy

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Jellyfish bio-inspired Fe@cNT@cuNc derived from ZIF-8 for cathodic oxygen reduction

引用

Nano Research 2024年第4期17卷 2352-2359页

作者： kai c.eng Zequan Liu Demin Jiang Min Song Yuqiao Wang Research center for Nano Photoelectrochemistry and Devices School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing 211189China Yangtze River Delta carbon Neutrality Strategy Development Institute Southeast UniversityNanjing 210096China School of energy and environment Southeast UniversityNanjing 210096China

Biomimetics provides guidance to design and synthesize advanced catalysts for oxygen reduction reaction in microbial fuel cells(MFcs).Herein,jellyfish-inspired Fe clusters on carbon nanotubes connected with cuNc(Fe@cNT@cuNc)were designed and prepared by using zeolitic imidazolate framework(ZIF)-8 precursors to imitate the organic texture and function of *** antibacterial effect of cu^(+)ions depressed the growth of cathode biofilm to ensure rapid mass *** clusters and cuNc connected by cNTs accelerated the electron transfer from Fe to *** optimization of oxygen adsorption was caused by electron redistribution between sites of Fe and ***-like catalysts achieved a half-wave potential of 0.86 V and onset potential of 0.95 V *** hydrogen electrode(RHE).MFcs gained the maximum power density of 1600 mW·m^(-2) after 500 h *** work provides insights into the special design of advanced catalysts based on bio-inspiration and biomimetics.

关键词： bio-inspiration oxygen reduction reaction antibacterial ability microbial fuel cells density functional theory(DFT)rational design

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Microstructure and Internal Friction Behavior of Laser 3D Printed Fe-Based Amorphous composites

引用

Acta Metallurgica Sinica(english Letters) 2024年第1期37卷 196-204页

作者： Shuilong huang Qingjun c.en Li Ji Kan Wang Guosheng huang School of Material Sc.ence and engineering Nanchang Hangkong UniversityNanchang330063China State Key Laboratory for Marine corrosion and Protection Luoyang Ship Material Research Institute(LSMRI)Qingdao266237China

Laser 3D printing,also known as laser additive manufacturing(LAM),is favored for its ability to form bulk metallic glass(BMG)and its composite materials(BMGcs)with freeform *** this work,two different kinds of Fe_(41)co_(7)cr_(15)Mo_(14)c_(15)B_(6)Y_(2)amorphous coatings(A and B)were prepared by using LAM technology under air-and water-cooled conditions,respectively;meanwhile,to reduce the cracks generated due to the residual thermal stresses,coating c obtained by air-sweep annealing of B with a low energy-density *** morphology and amorphous content and microstructure of the coatings were investigated,the results show many cracks in coating B deposited under water-cooled conditions,and its microstructure shows an amorphous-crystal-nanocrystalline mixed *** was suppressed in coating c,obtained by air-sweep annealing based on coating B,but the amorphous content was reduced from 32.6 to 13.4%.And the hardness and corrosion resistance of the coating will increase with the increase in the amorphous ***,the internal friction behavior of a BMGcs was prepared on the basis of the process of sample c is compared with that of as-cast amorphous *** results show that the low temperature internal friction behavior of BMGcs is affected by the defects produced during printing,and the high temperature internal friction behavior is affected by the precipitated hard phase.

关键词： Laser 3D printing Amorphous coating Microstructure corrosion resistance Internal friction behavior

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data complexity-based batch sanitization method against poison in distributed learning

引用

Digital communications and Networks 2024年第2期10卷 416-428页

作者： Silv Wang kai Fan Kuan Zhang Hui Li Yintang Yang State Key Laboratory of Integrated Service Networks Xidian UniversityXi'an710126China Department of Electrical and computer engineering University of Nebraska-LincolnLincolnNE68588USA Key Lab.of the Minist.of Educ.for Wide Bandgap Semiconductor Materials and Devices Xidian UniversityXi'an710071China

The security of Federated Learning(FL)/Distributed Machine Learning(DML)is gravely threatened by data poisoning attacks,which destroy the usability of the model by contaminating training samples,so such attacks are called causative availability indiscriminate *** the problem that existing data sanitization methods are hard to apply to real-time applications due to their tedious process and heavy computations,we propose a new supervised batch detection method for poison,which can fleetly sanitize the training dataset before the local model *** design a training dataset generation method that helps to enhance accuracy and uses data complexity features to train a detection model,which will be used in an effic.ent batch hierarchical detection *** model stockpiles knowledge about poison,which can be expanded by retraining to adapt to new *** neither attack-specific nor scenario-specific,our method is applicable to FL/DML or other online or offline scenarios.

关键词： Distributed machine learning security Federated learning Data poisoning attacks Data sanitization Batch detection Data complexity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Sound event localization and detection based on deep learning

引用

Journal of Systems engineering and Electronics 2024年第2期35卷 294-301页

作者： ZHAO Dada DING kai QI Xiaogang c.en Yu FenG Hailin School of Mathematics and Statistics Xidian UniversityXi’an 710071China Sc.ence and Technology on Near-Surface Detection Laboratory Wuxi 214035China

Acoustic source localization(ASL)and sound event detection(SED)are two widely pursued independent research *** recent years,in order to achieve a more complete spatial and temporal representation of sound field,sound event localization and detection(SELD)has become a very active research *** paper presents a deep learning-based multioverlapping sound event localization and detection algorithm in three-dimensional ***-Mel spectrum and generalized cross-correlation spectrum are joined together in channel dimension as input *** features are classified and regressed in parallel after training by a neural network to obtain sound recognition and localization results *** channel attention mechanism is also introduced in the network to selectively enhance the features containing essential information and suppress the useless ***,a thourough comparison confirms the effic.ency and effectiveness of the proposed SELD *** experiments show that the proposed algorithm is robust to reverberation and environment and can achieve higher recognition and localization accuracy compared with the baseline method.

关键词： sound event localization and detection(SELD) deep learning convolutional recursive neural network(cRNN) channel attention mechanism

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：