检索结果-南通市图书馆

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Multiple sclerosis is at a checkpoint: advancing the program

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ultra‑Transparent and Multifunctional IZVO Mesh Electrodes for Next‑Generation Flexible Optoelectronics

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2025年第1期17卷 293-309页

作者： Kiran A.Nirmal Tukaram D.Dongale Atul c.Khot chenjie Yao Nahyun Kim Tae Geun Kim School of Electrical Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea computational Electronics and Nanoscience Research Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mechanically durable transparent electrodes are essential for achieving long-term stability in flexible optoelectronic ***,they are crucial for applications in the fields of energy,display,healthcare,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide conductors due to their high electrical conductivity,optical transparency,and enhanced mechanical *** this paper,we present a simple method for fabricating an ultra-transparent conducting metal oxide mesh electrode using selfcracking-assisted *** this method,we produced an electrode with ultra-transparency(97.39%),high conductance(Rs=21.24Ωsq^(−1)),elevated work function(5.16 eV),and good mechanical *** also evaluated the effectiveness of the fabricated electrodes by integrating them into organic photovoltaics,organic light-emitting diodes,and flexible transparent memristor devices for neuromorphic computing,resulting in exceptional device *** addition,the unique porous structure of the vanadium-doped indium zinc oxide mesh electrodes provided excellent flexibility,rendering them a promising option for application in flexible optoelectronics.

关键词： Self-cracking template Vanadium-doped indium zinc oxide mesh Organic solar cells Organic light-emitting diodes Flexible transparent memory

Navigating medial patellotibial ligament reconstruction:clinical perspectives and surgical strategies

在线全文

学校读者我要写书评

暂无评论

World Journal of clinical cases 2025年第1期13卷 6-10页

作者： Juan Pablo Zicaro Ignacio garcia-Mansilla Division of Knee Hospital Italiano de Buenos AiresBuenos Aires 1109Argentina

The surgical approach for patellar instability usually refers to reconstruction of the medial patellofemoral ligament associated with an osteotomy of the tibial tuberosity or a trochleoplasty when *** medial patellotibial ligament and the medial patellomeniscal ligament are secondary stabilizers of the *** this,both the medial patellotibial and patellofemoral ligaments aid in patellar rotation and tilt when the knee is flexed beyond 45°.The medial patellotibial ligament plays a particularly important role in the final stages of stretching in extension and between 40 degrees to 90 degrees of *** clinical relevance and surgical indications for medial patellotibial ligament reconstruction associated with medial patellofemoral ligament reconstruction are still *** editorial explores the surgical indications and clinical results for medial patellotibial ligament reconstruction to improve readers’understanding of this technique,especially because reported clinical outcomes have remained sparse.

关键词： Medial patellotibial ligament Patellar instability Reconstruction Surgical

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn J.W.So Konstantin Feinberg Marina Manoraj Jenny cheung Jennifer Zhang Kaveh Mirmoeini JPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

challenges and improvement strategies in the hospitalization of chronic multimorbid patients

在线全文

学校读者我要写书评

暂无评论

World Journal of clinical cases 2025年第3期13卷 35-41页

作者： Andres Fontalba-Navas Francisco Pozo Muñoz Rogelio garcia cisneros Maria Jose garcia Larrosa Maria del Mar callejon Gil Ignacio garcia Delgado Maria Belen Jimenez Martinez Antequera Hospital Northern Málaga Integrated Healthcare AreaAntequera 29200AndalusiaSpain Department of Public Health and Psychiatry University of MálagaMálaga 29010Spain Antequera Hospital Northern Málaga Antequera Integrated Healthcare AreaAntequera 29200MálagaSpain

BAcKGROUND Addressing the growing challenge of hospitalizing chronic multimorbid patients,this study examines the strain these conditions impose on healthcare systems at a local level,focusing on a pilot *** diseases and complex patients require comprehensive management strategies to reduce healthcare burdens and improve patient *** proven effective,this pilot model has the potential to be replicated in other healthcare settings to enhance the management of chronic multimorbid *** To evaluate the effectiveness of the high complexity unit(HcU)in managing chronic multimorbid patients through a multidisciplinary care model and to compare it with standard hospital *** The study employed a descriptive longitudinal approach,analyzing data from the Basic Minimum Data Set(BMDS)to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** The study employed a descriptive longitudinal approach,analyzing data from the BMDS to compare hospitalization variables among the HcU,the Internal Medicine Service,and other services at Antequera Hospital throughout *** HcU,designed for patients with complex chronic conditions,integrates a patient-centered model emphasizing multidisciplinary care and continuity *** This study demonstrates the effectiveness of the HcU in managing patients with complex chronic diseases through a multidisciplinary *** coordinated care provided by the HcU results in improved patient outcomes,reduced unnecessary hospitalizations,and better management of patient *** superiority of the HcU compared to standard care is evident in key outcomes such as fewer readmissions and higher patient satisfaction,reinforcing its value as a model of ca

关键词： High complexity unit chronic multimorbidity Patient-centered care Integrated care Healthcare management

A new strategy for corrosion protection of porous stainless steel using polypyrrole films

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 2020年第2期37卷 85-95页

作者： c.garcia-cabezon c.garcia-Hernandez M.L.Rodriguez-Mendez F.Martin-Pedrosa Materials Engineering E.I.I.Universidad de Valladolid47011 ValladolidSpain UVASENS E.I.I.Universidad de Valladolid47011 ValladolidSpain

In this work,a method to improve the protection against corrosion of porous sintered stainless steel is *** is based on the electrodeposition of polypyrrole(PPy)layers doped with a large size counterion such as dodecylbenzenesulphonic acid(DBSA),a conducting polymer with high corrosion resistance and good *** efficacy of PPy coating depends on the adequate adhesion between the metal substrate and the coating *** protection against corrosion has been tested using 316 L stainless steel(SS)powder sintered at different conditions to evaluate the effect of the sintering atmosphere(nitrogen and vacuum)and cooling rates(furnace and water)on corrosion resistance,while wrought 316 L SS has been used as reference *** addition,two electrochemical deposition techniques have been tested to select the most *** circuit potential evolution,anodic polarization measurements and electrochemical impedance spectra have been used to evaluate corrosion protection in phosphate buffer saline *** has been evidenced that a more homogeneous and stable coating was obtained in the case of porous stainless *** corrosion potential shifted to nobler values and the anodic polarization branch became more *** porous samples have a good passivation performance with a lower stable passive current density and a higher breakdown *** transfer electronic resistance and the impedance module increase more than one order of ***,the porosity of sintered stainless steel is seen as an advantage for the improvement of the adherence of the PPy *** best corrosion protection is found for samples sintered in nitrogen and water-cooled.

关键词： Stainless steel Powder metallurgy Protection corrosion Electrodeposited films Polymer coatings

Self-Healing concrete with crystalline Admixture——A Review

在线全文

学校读者我要写书评

暂无评论

Journal of Wuhan University of Technology(Materials Science) 2019年第5期34卷 1143-1154页

作者： A Ravitheja dr T chandra Sekhara Reddy dr c Sashidhar JNTU college of Engineering AnantapurAPIndia civil Engineering GPR Engineering CollegeKurnoolAPIndia civil Engineering JNTU College of EngineeringAnantapurAPIndia

The scope of the present paper is to understand the effects of crystalline admixture on the selfhealing capacity of the cementitious composites. Previous studies were examined and a conclusion was drawn to the effect that different additives to crystalline admixture tend to improve self-healing of concrete for larger cracks. It is recommended that initial treatment with chemical admixture can stimulate and heal further cracks and it has the better repeatability trend in mixing with the concretes and mechanical recovery is possible even under repetitive preloading. Effective self-healing with chemical admixtures even under open-air exposure, leads to study the importance of a service ability design parameter including the maximum allowable crack width by repeatability analysis as a function of the exposure with the concept of sealable crack width.

关键词： crystalline admixture permeability reducer admixture cracking

Stepwise assembly to construct stable copper(I) cluster-based circularly polarized luminescent MOFs

在线全文

学校读者我要写书评

暂无评论

Science china chemistry 2025年

作者： Jing-Wen Xie Meng-Ting Wang Yan Jin Si Li Jian-Hua Qin Shuang-Quan Zang Tomas c.W.Mak college of chemistry Henan Key Laboratory of Crystalline Molecular Functional Materials Zhengzhou University college of chemistry and chemical Engineering Luoyang Normal University Department of chemistry The Chinese University of Hong Kong

circularly polarized luminescence （cPL） materials have been extensively studied in recent years owing to their widespread applications in 3D display,optical storage,optical anti-counterfeiting,and biological imaging,***（I） clusters have emerged as a promising candidate for cPL materials,driven by their cost-effectiveness,superior luminescent properties,precise structure,and low ***,the poor environmental stability of copper（I） clusters renders their synthesis and preservation challenging,thereby significantly impeding their ***,we have designed and synthesised a chiral double-coordinated ligand in order to construct copper（I） cluster nodes that can be further *** anticipated,by utilizing stepwise assembly strategy,a cu4cluster node co-modified by chiral alkynyl ligands and triphenylphosphine was further assembled with cd2+ions to obtain 2D layers structure,L/*** L/D-cu4-cd exhibits excellent stability and optical properties,including bright yellow emission,solvent-responsive luminescence,and cPL activity with a maximum glumup to 2.0×10-3,which shows potential applications in the WLED and *** interestingly,the material also exhibits deflection ability towards different wavelengths of linearly polarized light,showing certain potential in the preparation of circular polarizer.

关键词：