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Bright spots for inland fish and fisheries to guide future hydropower development

Water Biology and Security 2022年第1期1卷 81-99页

作者： William m.Twardek Ian G.cowx Nicolas W.R.Lapointe craig Paukert T.Douglas Beard Elena m.Bennett David Browne Andrew K.carlson Keith D.clarke Zeb Hogan Kai Lorenzen Abigail J.Lynch Peter B.mcIntyre Paulo Pompeu mark Rogers Alexis Sakas William W.Taylor Taylor D.Ward Zeenatul Basher Steven J.cooke Fish Ecology and conservation Physiology Laboratory Department of Biology and Institute for Environmental StudiesCarleton University1125 Colonel By DrOttawaON K1S 5B6Canada Fisheries Institute at the University of Hull Cottingham RdHullHU67RXUnited Kingdom canadian Wildlife Federation 350 Michael Cowpland DrKanataONK2M 2W1Canada U.S.Geological Survey Missouri Cooperative Fish and Wildlife Research UnitUniversity of MissouriColumbiaMO65211United States U.S.Geological Survey National Climate Adaptation Science Center12201 Sunrise Valley DriveMS-516RestonVA20192United States mcGill School of Environment McGill University845 Sherbrooke St WMontrealQuebec H3A 0G4Canada Princeton Environmental Institute and department of Ecology and Evolutionary Biology Princeton UniversityM30 Guyot HallPrincetonNJ08544United States Ecological Sciences Section Science Branch Fisheries and Oceans CanadaCanadaPO Box/CP 5667St.John'sNewfoundland and LabradorA1C 5X1Canada University of Nevada Reno.4505 S Maryland PkwyLas VegasNV89154United States Fisheries and Aquatic Sciences School of Forest Resources and ConservationUniversity of Florida7922 NW 71st StreetGainesvilleFL32653United States department of Natural Resources Cornell UniversityIthacaNY14853United States departamento de Biologia Universidade Federal de LavrasAquenta SolLavrasState of Minas Gerais37200-900Brazil U.S.Geological Survey Tennessee Cooperative Fishery Research UnitTennessee tech UniversityCookevilleTN38505United States The Nature conservancy 6375 Riverside DriveSuite 100DublinOH43017United States michigan State University Department of Fisheries and WildlifeEast LansingMI48823United States

Hydropower production is one of the greatest threats to fluvial ecosystems and freshwater *** that we have entered the Anthropocene,there is an opportunity to reflect on what might constitute a‘sustainable’Anthropocene in the context of hydropower and riverine fish *** elements of existing practices that promote favorable social-ecological outcomes(i.e.,‘bright spots’)is timely given that there are plans to expand hydropower capacity in previously undammed rivers,intensify dam development in some of the world's largest river systems,and re-license existing *** approach this from a pragmatic perspective:for the foreseeable future,hydropower will likely remain an important source of renewable *** offer support for moving toward a more‘sustainable’Anthropocene,we provide syntheses of best practices during the siting,design,construction,operation,and compensation phases of hydropower development to minimize impacts on inland *** each phase,we offer positive examples(or what might be considered‘bright spots’)pertaining to some of the approaches described within our syntheses,acknowledging that these projects may not be viewed as without ecological and(or)societal detriment by all *** findings underscore the importance of protecting critical habitat and free-flowing river reaches through careful site selection and basinscale planning,infrastructure designs that minimize reservoir effects and facilitate safe passage of fish,construction of hydropower plants using best practices that minimize long-term damage,operating guidelines that mimic natural flow conditions,and compensation that is lasting,effective,inclusive,and locally *** from these‘bright spots’may require engagement of diverse stakeholders,professionals,and governments at scales that extend well beyond a given site,river,or even ***,environmental planning that integrates hydropower development into broader discussions

关键词： migration Dams Salmon Hydroelectric Flow Socioecological Fish passage Barriers Ecosystems

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Effect of 4% glycerol and low aeration on result of expression in Escherichia coliof cin3 and three Venturia inaequalisEST’s recombinant proteins

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American Journal of molecular Biology 2013年第1期3卷 1-9页

作者： Taha H. Al-Samarrai William T. Jones Dawn Harvey christopher A. Kirk m. Templtone The Plant and Food Research Institute of New Zealand Ltd. CRI Auckland New Zealand The Plant and Food Research Institute of New Zealand Ltd. CRI Palmerston North New Zealand The University of Samarrai College of Medical Technology Samarra Iraq

The phytopathogenic fungus Venturia inaequalis causes scab of apple. Once this fungus penetrates the plant surface, it forms a specialized body called a stroma between the inner cuticle surface and the epidermal cell wall. A novel Venturia inaequalis 5704 (cin3) and three expressed sequence tags (ESTs);38, 6987, and 4010 are strongly up-regulated in the early stages of infection. The cIN3 and three ESTs using two vectors pmAL-c2 and pET 21 were expressed in Escherichia coli. Recombinant proteins expression, solubility and yields were analyzed. 38, 5704 (cin3) and 6987 re- combinant proteins were expressed in soluble form and while 4010 was expressed in inclusion bodies. Re- solution on native-PAGE, the recombinant proteins;38, 5704 (cin3), 6987 were shown to be present in dimmer, tetramer and polymer. A method was de- veloped, consisting of induction of expression at va- rious temperatures, and using enriched broth with 4% glycerol together with slow shaking, led to a decrease in concentration of nascent polypeptide and production of soluble recombinant proteins of;38, 5704 (cin3), 6987 and 4010. Resolution on native- PAGE, the recombinant proteins were shown to be present as monomer.

关键词： Venturia inaequalis Expressed Sequence Tag (ESTs) Phytopathogenic Fungus Appressorium A Stroma

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视力良好的重型糖尿病视网膜病变患者行全视网膜光凝后视功能障碍

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 4-5页

作者： Shimura m Yasuda K Nakazawa T Tamai m 杨秀梅 department of Ophthalmology NTT East Japan Tohoku Hospital 2- 29- 1 Yamato Wakabayashi Sendai Miyagi 984- 8560 Japan.Dr.

PURPOSE: To compare macular thickness and best-corre-cted visual acuity (Bcva) before and after panretinal photocoagulation (PRP) in patients with severe diabetic retinopathy and good visual acuity (va) to identify factors that predict post-operative visual function. deSIGN: Prospective, non-comparative, interventional case series. mETHODS: Sixty-four consecutive patients with severe non-proliferative diabetic retinopathy or with non-high-risk proliferative diabetic retinopathy whose va was 20/20 or better before PRP were studied. Sixty-four eyes of 64 patients underwent scatter PRP in four sessions every other week. macular thickness was measured by optical coherence tomography (OcT), and va was measured before and periodically after PRP. RESULTS: During the 24- week observation period, patients were classified into three groups according to changes in vaduring the post-operative period. In groupA, va was maintained at pre-operative levels in 54 (84% ) eyes during the 24 weeks after PRP. In group B, va initially decreased in three eyes but subsequently recovered to baseline during the observation period; in group c, va did not recover during follow-up in seven eyes. There was no significant difference in pre-operative foveal thicknesses among the three groups, but parafoveal thickness was m in group A, ranged from 270 to 280 μ m in group B, and was > 300 μ m in group c. cONcLUSION: For eyes with severe diabetic retinopathy and good va, PRP did not affect post-operative va in more than 80% of patients. Patients whose pre-operative parafoveal thickness was > 300 μ m had a worse visual prognosis.

关键词：全视网膜光凝视功能障碍中心凹干预性定期测量预测术病例研究预后差基线水平

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Heat shock protein 90 inhibition by 17-DmAG lessens disease in the mRL/Ipr mouse model of systemic lupus erythematosus

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cellular & molecular Immunology 2012年第3期9卷 255-266页

作者： Samuel K Shimp III cristen B chafin Nicole L Regna Sarah E Hammond molly A Read David L caudell marissa Nichole Rylander christopher m Reilly Virginia Tech-Wake Forest School of Biomedical Engineering and Science Virginia Polytechnic Institute and State University Blacksburg VA USA department of Biomedical Sciences and Pathobiology Virginia-Maryland Regional College of Veterinary Medicine Blacksburg VA USA Edward Via college of Osteopathic medicine Blacksburg VA USA department of mechanical Engineering Virginia Polytechinc Institue and State University Blacksburg VA USA

Elevated expression of heat shock protein 90 （HSP90） has been found in kidneys and serum of systemic lupus erythematosus （SLE） patients and mRLImp-FasIprIFasJpr（mRLIIpr） autoimmune mice. We investigated if inhibition of HSP90 would reduce disease in mRL/ Ipr mice. In vitro, pretreatment of mesangial cells with HSP90 inhibitor Geldanamycin prior to immune-stimulation showed reduced expression of IL-6, IL-12 and NO. In vivo, we found HSP90 expression was elevated in mRL/Ipr kidneys when compared to c57BL/6 mice and mRIJIpr mice treated with HSP90 inhibitor 17-DmAG. mRIJIpr mice treated with 17-DmAG showed decreased proteinuria and reduced serum anti-dsDNA antibody production. Glomerulonephritis and glomerular IgG and c3 were not significantly affected by administration of 17-DmAG in mRIJIpr. 17-DmAG increased cD8＋ T cells, reduced double-negative T cells, decreased the cD4/cD8 ratio and reduced follicular B cells. These studies suggest that HSP90 may play a role in regulating T-cell differentiation and activation and that HSP90 inhibition may reduce inflammation in lupus.

关键词： Geldanamycin heat shock protein 90 mRUIpr systemic lupus erythematosus 17-DmAG

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成功治疗银屑病可改善银屑病患者的特异心理因素,但对患者的一般心理因素无显著改善

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世界核心医学期刊文摘（皮肤病学分册） 2005年第5期1卷 16-16页

作者： Fortune D.G. Richards H.L. Kirby B. et al. c.E.m. Griffiths 牛新武 dermatology centr e Univ. of Manchester Sch. of Medicine Hope Hospital Salford Manchester M6 8 HD UnitedKingdom

Background:Psoriasis has a detrimental effect on patients’quality of life. H owever, there is a relative dearth of information on which aspects of a patient ’s well-being are affected by successful treatment. Objectives:To investigate whether, and to what extent, improvement in the clinical severity of psoriasis induced by photochemotherapy with psoralen plus ultraviolet A (PUva) translates into meaningful changes in beliefs about psoriasis, coping, stress, distress or disability. methods:In a prospective study, 72 patients were assessed before PU va therapy and again when they had achieved clearance of their psoriasis. Result s:Patients demonstrated significant reductions in psoriasis-related disability , psoriasis-related stress or daily hassles and in the frequency of psoriasis- related symptoms. By comparison, there were no significant differences in levels of anxiety, depression or worrying. Similarly, patients’perceptions about cure , potential chronicity, causes, consequences and coping also remained unchanged. conclusions:These results suggest that while clearance of psoriasis produces a significant reduction in factors specific to psoriasis (disability and stress), it does not impact upon psychological distress, on patients’beliefs about psor iasis or on coping. This observation highlights the complex features of patients ’psychological experience of psoriasis and may provide further impetus for inte gration of psychological interventions into standard care protocols.

关键词：银屑病心理因素心理适应劳动能力丧失皮损消退补骨脂素临床改善长波紫外线生活质量无显著性差异

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Adjuvants derived from Neisseria meningitidisSerogroup B Induce a cross Reactive Response against Neisseria gonorrhoeaein mice

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Open Journal of Immunology 2020年第3期10卷 47-58页

作者： Laura m. Reyes miriam Lastre maribel cuello Osmir cabrera Yusnaby Borrego Raúl Ramos Pupo Steve Black Oliver Pérez department of Immunology Instituto de Ciencias Básicas y Preclínicas “Victoria de Girón” Universidad de Ciencias Médicas de la Habana Havana Cuba Facultad de Ingenierías Universidad Técnica “Luis Vargas Torres” de Esmeraldas Esmeralda Ecuador Biomedical Research Institute (BIOmED). Faculty of medicine and Life Sciences Hasselt University Hasselt Belgium cincinnati children’s Hospital Cincinnati USA

Introduction: Neisseria is a large genus of bacteria that colonize mucosal surfaces. Of the 11 species that colonize humans, only two are pathogens, N. meningitidis and N. gonorrhoeae. Both are obligate human pathogens;the last is causal agent of gonorrhea disease. Although curable with timely antibiotic treatment, an annual incidence of more than 62 million cases is estimated by the World Health Organization and there are no successful vaccines available. In contrast, several prophylactic vaccine options for Neisseria meningitidis meningitis do exist. Of note, there is trace of cross parenteral response induced between N. meningitidis and N. gonorrhoeae, and Proteoliposome (PL, also named outer membrane vesicles, OmV) vaccine has shown high impact on this response. Objective: To determine effect of vamENGOc-Bc? and its derivates (AFPL1 and AFco1) at mucosal and systemic level and possible cross response against Neisseria gonhorroeae in Balb/c and c57Bl/6 mice. methods: We evaluated cross response against N. gonorrhoeae in mouse serum IgG and saliva IgA after mucosal immunization with va-mENGOc-Bc or its derivatives (AF, Adjuvant Finlay PL1 or AFco (cochleate) 1). Results: Immunizations with AFPL1 or AFco1 induce anti N. gonorrhoeae at saliva IgA and serum IgG responses similar to va-mENGOc-Bc? vaccine. conclusions: Such data confirms a new possible window of prime-boost vaccination strategy against gonorrhea and extends our knowledge regarding the effect of PL vaccines on cross responses.

关键词： N. meningitidis N. gonorrhoeae vaccine cross Reactivity

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慢性肾病患者的心血管死亡风险:传统危险因素和新危险因素的比较

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 25-26页

作者： Shlipak m. G. Fried L. F. cushman m. 杜媛 General Internal medicine Section VA Medical Center(111A1) 4150 Clement St San Francisco CA 94121 United States Dr.

context: Elderly persons with chronic kidney disease have substantial risk for cardiovascular mortality, but the relative importance of traditional and novel risk factors is unknown. Objective: To compare traditional and novel risk factors as predictors of cardiovascular mortality. design, Setting, and Patients: A total of 5808 community-dwelling persons aged 65 years or older living in 4 communities in the United States participated in the cardiovascular Health Study cohort. Participants were initially recruited from 1989 to June 1990; an additional 687 black participants were recruited in 1992-1993. The average length of follow-up in this longitudinal study was 8.6 years. main Outcome measures: cardiovascular mortality among those with and without chronic kidney disease. chronic kidney disease was defined as an estimated glomerular filtration rate of less than 60 mL/min per 1.73 m2. Results: Among the participants, 1249(22%) had chronic kidney disease at baseline. The cardiovascular mortality risk rate was 32 deaths/1000 person-years among those with chronic kidney disease vs 16/1000 person-years among those without it. In multivariate analyses, diabetes, systolic hypertension, smoking, low physical activity, nonuse of alcohol, and left ventricular hypertrophy were predictors of cardiovascular mortality in persons with chronic kidney disease(all P valuesmong the novel risk factors, only log c-reactive protein(P=.05) and log interleukin 6(Pciated with the outcome as linear predictors. Traditional risk factors were associated with the largest absolute increases in risks for cardiovascular deaths among persons with chronic kidney disease: for left ventricular hypertrophy, there were 25 deaths per 1000 person-years; current smoking, 20 per 1000 person-years; physical inactivity, 15 per 1000 person-years; systolic hypertension, 14 per 1000 personyears; diabetes, 14 per 1000 person-years; and nonuse of alcohol, 11 per 1000 person-years vs 5 dea

关键词：慢性肾病患者传统危险因素死亡风险肾小球滤过率心血管健康收缩期高血压左室肥大体力活动心血管风险生活方式干预

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美国放射学院适宜性标准:肩关节置换术后影像学检查(续)

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中华肩肘外科电子杂志 2017年第4期5卷 299-304页

作者：张晓萌陈建海 Soterios Gyftopoulos Zehava S.Rosenberg catherine c.Roberts Jenny T.Bencardino marc Appel Steven J.Baccei R.carter cassidy Eric Y.chang michael G.Fox Bennett S.Greenspan mary G.Hochman Jon A.Jacobson Douglas N.mintz Joel S.Newman Nehal A.Shah Kirstin m.Small Barbara N.Weissman 北京大学人民医院创伤骨科 100044 纽约大学医疗中心纽约市纽约关节病医院纽约市梅奥诊所亚利桑那州凤凰城纽约大学医学院纽约市 James J.Peters va医疗中心纽约市马萨诸塞大学医疗中心伍斯特英国医疗脊柱和全关节服务列克星敦 va圣地亚哥医疗系统圣地亚哥弗吉尼亚卫生系统夏洛茨维尔奥古斯塔大学佐治亚州医学院奥古斯塔贝斯以色列女执事医疗中心波士顿密歇根大学医疗中心安娜堡纽约特种外科医院纽约市新英格兰浸信会医院波士顿布列根和妇女医院波士顿

过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分... 详细信息

过去的20年里,在美国实施的肩关节置换术的数量迅速增长,其中包括部分或全肱骨头表面置换术、半肩置换术、全肩关节置换术和反式全肩关节置换术。影像学检查在诊断这些肩关节置换术引起的并发症方面起到了重要作用。本综述分为两个部分。第一部分阐述了对各种影像学检查模式的总体探讨,包括X线片、计算机断层扫描、核磁共振成像、超声、核医学以及它们提供有益的以治疗为导向的信息时所发挥的作用。第二部分重点研究最佳影像学方法的选择,用于肩关节置换术的并发症,包括无菌性松动、感染、骨折、肩袖肌腱撕裂和神经损伤。在本报告中所提供的美国放射学院适宜性标准循证指南,是通过广泛分析来自同行评审期刊的现有医学文献,并应用行之有效的方法学而完成的(兰德/加州大学洛杉矶分校的适宜性方法以及推荐评价、发展和评估分级),它们用于特殊临床情况下的影像学检查和治疗措施的适宜性评价。多学科专家小组对指南进行了进一步的分析和审查。由于用于推荐合适成像算法的数据会出现不足或模棱两可,在这种情况下,专家意见可能对现有证据进行补充。为此,将美国《放射学院适宜性标准:肩关节置换术后影像学检查》翻译成中文,供同道参考。

关键词：全肩关节置换术美国放射学院影像学检查适宜性标准核磁共振成像计算机断层扫描循证指南

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2型糖尿病患者血清超敏c-反应蛋白的表达特性

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现代医院 2005年第3期5卷 47-48页

作者：王维黄志锋邓穗德广州市第一人民医院广东广州510180

目的　探讨 2型糖尿病患者血清超敏c -反应蛋白 (hs-cRP)的表达特性。方法　利用胶乳增强免疫比浊法定量检测健康对照组 10 0例、2型糖尿病患者 130例 (其中糖尿病无大血管并发症 75例 ,有大血管并发症 5 5例 )的血清hs -cRP和脂蛋白 (a... 详细信息

目的　探讨 2型糖尿病患者血清超敏c -反应蛋白 (hs-cRP)的表达特性。方法　利用胶乳增强免疫比浊法定量检测健康对照组 10 0例、2型糖尿病患者 130例 (其中糖尿病无大血管并发症 75例 ,有大血管并发症 5 5例 )的血清hs -cRP和脂蛋白 (a) (Lp(a) ) ,酶法检测总胆固醇Tc ,高、低密度脂蛋白胆固醇(HDL -c、LDL -c)。结果　①hs-cRP在健康对照组为 (0 . 78± 0 .5 5 )mg/L ,糖尿病无大血管病变组为 (3 .0 5±1 .2 1)mg/L ,糖尿病并发大血管病变组为 (4 6 5± 1 .0 3)mg/L ,与健康对照组比较不论有无大血管并发症差异均有显著性差异 (P c和Lp(a)比健康对照组均明显增高 (P c、Lp(a)和hs-cRP浓度与糖尿病无大血管病变组之间的差异也有显著意义 (P cRP对糖尿病患者发生大血管意外预测和预防具有重要意义。

关键词： hs-cRP 对照组大血管病变 2型糖尿病患者血清 LDL-c 结论健康重要意义

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甲磺酸帕珠沙星注射液人体药动学研究

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中国抗生素杂志 2006年第11期31卷 679-682页

作者：沈奇梁德荣苗佳余勤梁茂植徐楠郑莉罗柱吴松泽四川大学华西医院国家药品临床研究基地成都610041

目的研究单次及多次静脉滴注甲磺酸帕珠沙星注射液的药动学特点。方法筛选健康受试者12名,q12h静脉滴注甲磺酸帕珠沙星注射液每次500m g,连续5d,共9次;用反向高效液相色谱-紫外法测定血药浓度,用DA Sver1.0软件拟合药动学参数。结果受... 详细信息

目的研究单次及多次静脉滴注甲磺酸帕珠沙星注射液的药动学特点。方法筛选健康受试者12名,q12h静脉滴注甲磺酸帕珠沙星注射液每次500m g,连续5d,共9次;用反向高效液相色谱-紫外法测定血药浓度,用DA Sver1.0软件拟合药动学参数。结果受试者静脉滴注甲磺酸帕珠沙星注射液后体内过程符合二室模型;单次给药后的药动学参数:Tm ax为(0.47±0.09)h,cm ax为(13.71±1.81)m g/L,AUc0-t为(24.60±4.15)m g.h/L,t1/2为(1.46±0.64)h,m RT、cL和Vd分别为(2.14±0.33)h、(0.09±0.04)L/(***)和(0.17±0.03)L/kg。q12h静脉滴注帕珠沙星500m g连续5d(共9次),第2、3、4、5d晨测得谷浓度分别为0.13、0.16、0.17和0.14m g/L,提示血药浓度已达稳态。末剂给药后的药动学参数:Tm ax为(0.48±0.10)h,cm ax为(15.41±1.67)m g/L,AUc0-t为(28.42±4.90)m g.h/L,t1/2为(1.33±0.49)h,cL为(0.09±0.06L/)h,(css)av为(2.34±0.43)m g/L,DF为(99.48±0.38)%,以上参数与单次给药比较除cm ax外均无统计学差异,且累积系数小,说明本品多次给药无体内蓄积。女性和男性受试者主要药动学参数比较均无统计学差异。受试者给药期间未出现严重不良反应。结论500m g q12h静脉滴注,在人体内可达到有效血药浓度,可以作为临床应用的推荐方案。

关键词：甲磺酸帕珠沙星反向高效液相色谱-紫外法药动学

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