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Operational adaptations of the trachoma pre-validation surveillance strategy employed in Ghana:a qualitative assessment of successes and challenges

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Infectious Diseases of Poverty 2019年第4期8卷 104-105页

作者： Laura Senyonjo Agatha Aboe Robin bailey David Agyemang Benjamin Marfo Seth Wanye Elena Schmidt James Addy Karl Blanchet Research team SightsaversHaywards HeathUK clinical Research Department London School of Hygiene&Tropical MedicineLondonUK 不详

Background:In 2009 Ghana began to design a trachoma pre-validation surveillance plan,based on then-current WHO *** plan aimed to identify active trachoma resurgence and identify and manage trichiasis cases,through both active and passive surveillance *** paper outlines and reviews the adaptations made by Ghana between 2011 and *** assessment will provide a learning opportunity for a number of countries as they progress towards elimination ***:A mixed methods approach was taken,comprising in-depth interviews and documents *** January and April 2016,20 in-depth interviews were conducted with persons involved in the operationalisation of the trachoma surveillance system from across all levels of the health system.A three-tier thematic coding framework was developed using a primarily inductive approach but also allowed for a more iterative approach,which drew on aspects of grounded ***:During the operationalisation of the Ghana surveillance plan there were a number of adaptations(as compared to the WHO recommendations),these included:(i)Inclusion of surveillance of active trachoma in the passive surveillance approach,as compared to trichiasis *** with case identification,challenges in implementation coverage and a non-specific reporting structure hampered effectiveness;(ii)Random selection and increase in number of sites selected for the active surveillance *** likely lacked the spatiotemporal power to be able to identify recrudescence in a timely manner;(iii)Targeted trichiasis door-to-door case searches,led by ophthalmic *** effective methodology to identify trichiasis cases but resource intensive;(iv)A buddy system between ophthalmic nurses to support technical skills in an elimination setting where it is difficult to attain diagnostic and surgical skills,due to a lack of *** strategy did not take into account the loss of proficiency within experienced ***

关键词： Trachoma Pre-validation Surveillance Elimination case-finding Surveillance strategy Adaptation

Finite element analysis of the effect of interlayer on interfacial stress transfer in layered graphene nanocomposites

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Journal of Materials Science & Technology 2019年第6期35卷 1147-1152页

作者： c.c.Roach Y.c.Lu Department of Mechanical Engineering University of Kentucky

Understanding the roles of interlayers in reinforcement efficiencies by layered graphene is very important in order to produce strong and light graphene based nanocomposites. The present paper uses the finite element method to evaluate the interfacial strain transfers and reinforcement efficiencies in layered graphene-polymer composites. Results indicate that the presence of compliant interlayers in layered graphene plays significant roles in the transfers of strain/stress from matrix to graphene and subsequently the reinforcement effectiveness of layered graphene. In general, the magnitude of shear strain transferred onto the rigid graphene decreases as the thickness of the interlayer increases. This trend becomes insignificant as the graphene becomes sufficiently large(s>25,000). The shear strain at the interface of graphene-matrix is also greatly influenced by the interlayer modulus. A stiffer interlayer would result in a higher shear strain transferred on the graphene. The performance of the interlayers is further affected by the property of the composite and the architecture of the layered graphene stack. If a composite contains more graphene phase, the efficiency of reinforcement by a layered graphene becomes improved. If a graphene stack contains more interlayers, the effectiveness of reinforcement at the edges of the graphene becomes negatively affected.

关键词： Interlayer Layered graphene Nanocomposites Interfacial stress transfer Finite element method

Analytical modeling of effect of interlayer on effective moduli of layered graphene-polymer nanocomposites

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Journal of Materials Science & Technology 2017年第8期33卷 827-833页

作者： c.c.Roach Y.c.Lu Department of Mechanical Engineering University of KentuckyLexingtonKY 40506-0503USA

Nanocomposites enhanced with two-dimensional, layered graphene fillers are a new class of engineering materials that exhibit superior properties and characteristics to composites with conventional ***, the roles of ＂interlayers＂ in layered graphene fillers have yet to be fully explored. This paper examines the effect of interlayers on mechanical properties of layered graphene polymer *** an effective filler, the fundamental properties（in-plane Young＇s modulus E（L1）, out-of-plane Young＇s modulus E（L2）; shear modulus G（L12）, major Poisson＇s ratio V（L12）） of the layered graphene were computed by using the Arridge＇s lamellar model. The effects of interlayers on effective moduli of layered graphene epoxy composites were examined through the Tandon-Weng model. The properties of the interlayer show noticeable impact on elastic properties of the composites, particular the out-of-plane properties（Young＇s modulus E2 and shear modulus G（12））. The interlayer spacing is seen to have much great influence on properties of the composites. As the interlayer spacing increases from 0.34 nm to 2 nm, all elastic properties of the composites have been greatly decreased.

关键词： Interlayer Layered graphene Nanocomposite Effective moduli

Deleterious effects of electron beam irradiation on development and reproduction of tomato/potato psyllids, Bactericera cockerelli

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Insect Science 2020年第6期27卷 1311-1321页

作者： Jiaxin Lei Jia Meng Ivy Wchen Weining cheng Andrea L.Beam Md-Sajedul Islam Woodward D.bailey Suresh Pillai Keyan Zhu-Salzman Department of Entomology Texas A&M UniversityCollege StationTXUSA Institute for Plant Genomics&Biotechnology Texas A&M UniversityCollege StationTXUSA Key Laboratory of Integrated Pest Management on crops in Northwestern Loess Plateau Ministry of AgricultureNorthwest A&F UniversityYanglingShaanxiChina USDA-APHIS-PPQ-S&T-cPHST MiamiFLUSA National center for Electron Beam Research Texas A&M UniversityCollege StationTXUSA

The potato/tomato psyllid Bactericera cockerelli causes serious damage to several solanaceous crops by direct feeding and vectoring candidatus Liberibacter solanacearum,a bacterial *** beam(eBeam)irradiation is an environmentally friendly,chemical-free alternative method that is increasing in use for disinfestation of insect *** hypothesize that this irradiation technology will have detrimental effects on potato psyllid and thus impede its disease *** this end,we explored the effects of eBeam treatment ranging from 50 to 500 Gy on survival,development and reproduction of this *** on psyllids was apparently *** irradiated at 350 Gy,eggs could not hatch,1st instar nymphs failed to emerge,and although a small portion of irradiated 5th instar nymphs survived,the emerged adults were mostly *** in eclosed adults suggests harmful effects of eBeam on *** was seriously impaired when female psyllids were exposed to eBeam at the 5th instar nymphal or young adult stage,presumably due to inability to form *** addition,reciprocal crosses between irradiated and untreated psyllids indicated that female psyllids were more radiosensitive than males to *** together,these findings indicate that eBeam negatively impacted potato psyllid development and reproduction,which would inevitably compromise its disease transmission capacity.A dose of 350 Gy can be considered as a reference dose for effective control of potato psyllids.

关键词： Bactericera cockerelli development electron beam(eBeam) irradiation reproductive system

Abdominal Wall Endometriomas at cesarean Section Scars: A case Series

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Open Journal of Obstetrics and Gynecology 2017年第8期7卷 815-823页

作者： Kathryn Wampler bailey Harwager Kimberly Michael University of Nebraska Medical center Omaha NE USA

Endometriosis, a common gynecological condition, is defined as the presence of functioning endometrial tissue outside the uterine cavity. It often presents as a cyclic, hormonally stimulated pain in women during their reproductive years. While endometriosis is usually located within the pelvis, it may also occur at intraperitoneal, intestinal, perineal, and distant ectopic sites. Although often diffuse, a localized, focal mass of endometrial tissue is termed as an endometrioma. In rare occurrences, an endometrioma will present superficially to the peritoneum within the abdominal wall following gynecologic or obstetric surgery. The presence of an abdominal wall endometrioma within a cesarean section scar may pose a diagnostic dilemma, which is often misdiagnosed, and results in surgery referrals for treatment. The clinical symptoms and sonographic appearance of abdominal wall endometriomas occurring at cesarean section scars are highlighted in this case series.

关键词： Endometriosis Endometrioma Abdominal Wall Endometrioma cesarean Section Scar Sonography

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二甲双胍和非胰岛素依赖型糖尿病

国外医学（内科学分册） 1993年第4期20卷 162-164,166页

作者： bailey c J 严励

二甲双胍为双胍类抗高血糖药物,一般不引起乳酸性酸中毒,不导致临床低血糖,不增加血胰岛素水平及体重,可降低血清甘油三酯浓度。它作为实用的口服降糖药正广泛地单独或与磺脲类联合治疗非胰岛素依赖型糖尿病病人。

关键词：二甲双胍糖尿病非胰岛素依赖型

Effect of administration of phenylephrine immediately after low dose insemination on pregnancy rates in mares

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Open Journal of Obstetrics and Gynecology 2013年第10期3卷 722-726页

作者： Theresa Beachler Renan Sper c. Scott bailey James Shewmaker c. Nick Buchanan Anne Josson-Schramme Michael Whitacre college of Veterinary Medicine North Carolina State University Raleigh USA School of Veterinary Medicine Ross University Basseterre Saint Kitts and Nevis

There is considerable pressure on equine veterinarians to achieve good pregnancy rates with very small doses of semen. Phenylephrine administration in the rabbit increased numbers of oviductal, uterine, and cervical sperm, myometrial contractions, and fertilized ova after low dose insemination. The use of phenylephrine to enhance uterine contractility and fertility has not been investigated in the mare. Thus, the objective of this study was to determine if phenylephrine administration would result in clinically acceptable pregnancy rates in mares bred by low dose insemination. The hypothesis (Ha) was that pregnancy rates would be significantly higher in mares receiving phenylephrine compared to saline controls. Six pony mares and eight horse mares were enrolled in this study. Mares were inseminated within 24 hours of ovulation with 30 million progressively motile spermatozoa from a single fertile stallion. Immediately following insemination, mares were administered either phenylephrine (0.06 mg/kg) or 1mL of saline via IV injection. Pregnancy status was determined 14 days following ovulation via transrectal ultrasonography. Pregnancy rates in phenylephrine treated mares were 44% (4/9) while 22% (2/9) in saline-treated mares (P > 0.05).

关键词： Artificial Insemination Low Dose Insemination Equine Phenylephrine

7-亚甲基-2-甲基-1,4,6-三氧螺[4,4]壬烷聚合反应机理的研究

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高分子学报 1989年第1期 18-24页

作者：潘才元王寅 William J.bailey 中国科学技术大学应用化学系美国马里兰大学化学系

本文报道了一种新的不饱和螺环原酸酯——7-亚甲基-2-甲基-1,4,6-三氧螺[4,4]壬烷的合成,研究了它的自由基聚合,反应。结果说明在本体聚合时,聚合物由半开环结构单元(Ⅶ)组成;当溶液聚合时,得到结构单元(Ⅶ)和(Ⅷ)、(Ⅸ)的共聚物。根据... 详细信息

本文报道了一种新的不饱和螺环原酸酯——7-亚甲基-2-甲基-1,4,6-三氧螺[4,4]壬烷的合成,研究了它的自由基聚合,反应。结果说明在本体聚合时,聚合物由半开环结构单元(Ⅶ)组成;当溶液聚合时,得到结构单元(Ⅶ)和(Ⅷ)、(Ⅸ)的共聚物。根据聚合物的结构,对聚合反应机理进行了讨论。

关键词：螺环原酸酯自由基引发剂聚合

Skeletal muscle-specific Bambi deletion induces hypertrophy and oxidative switching coupling with adipocyte thermogenesis against metabolic disorders

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Science china Life Sciences 2025年

作者： Xiangping Yao Xudong Mai Ye Tian Yifan Liu Guanghui Jin Ze Li Shujie chen Xiaoshuang Dai Liujing Huang Zijing Fan Guihua Pan Xiaohan Pan Xiangmin Li Michael c Yu Jia Sun Jingxing Ou Hong chen Liwei Xie college of Life and Health Sciences Guangdong Industry Polytechnic Department of Endocrinology and Metabolism Zhujiang Hospital Southern Medical University State Key Laboratory of Applied Microbiology Southern china Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application Guangdong Open Laboratory of Applied MicrobiologyInstitute of Microbiology Guangdong Academy of Sciences Institute of Aging Research Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics School of Medical Technology Guangdong Medical University Department of Hepatic Surgery and Liver transplantation center of the Third Affiliated Hospital Organ Transplantation Institute Sun Yat-sen University Organ Transplantation Research Center of Guangdong ProvinceGuangdong province engineering laboratory for transplantation medicine Guangdong Provincial Key Laboratory of Liver Disease Research School of Public Health Xinxiang Medical University BGI Institute of Applied Agriculture BGI-Shenzhen Department of Applied Biology and chemical Technology The Hong Kong Polytechnic University Department of Biological Sciences State University of New York at Buffalo Department of Internal Medicine Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan) Guangdong Medical University

Skeletal muscle plays a significant role in both local and systemic energy metabolism. The current investigation aims to explore the role of the Bambi gene in skeletal muscle, focusing on its implications for muscle hypertrophy and systemic metabolism. We hypothesize that skeletal muscle-specific deletion of Bambi induces muscle hypertrophy, improves metabolic performance, and activates thermogenic adipocytes via the reprogramming of progenitor of i WAT, offering potential therapeutic strategies for metabolic syndromes. Leveraging the chromatin immunoprecipitation(chIP)-seq and bioinformatics analysis, Bambi gene is shown to be a direct target of HIF2α, which is further confirmed by chIP-qPcR and promoter luciferase assay. Skeletal muscle-specific Bambi deletion led to significant muscle hypertrophy and improved metabolic parameters, even under high-fat diet conditions. This deletion induced metabolic reprogramming of stromal vascular fractions(SVFs) into thermogenic adipocytes, contributing to systemic metabolic improvements, potentially through the secretory ***, mice with skeletal muscle-specific Bambi deletion demonstrate resistance to high-fat diet-induced metabolic disorders, highlighting a potential therapeutic pathway for metabolic syndrome management. Thus, skeletal muscle-specific deletion of Bambi triggers muscle growth, enhances metabolic performance, and activates thermogenic adipocytes. These findings suggest Bambi as a novel therapeutic target for metabolic syndromes, providing new insights into the interaction between muscle hypertrophy and systemic metabolic improvement. The study underscores the potential of manipulating muscle physiology to regulate whole-body metabolism, offering a novel perspective on treating metabolic disorders.

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