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Acquired sensorineural hearing loss,oxidative stress,and microrNAs

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Neural regeneration research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding rNA sequences known as microrNAs(mirNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamirs,""hypoxia,""microrNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** mir-34a and mir-29b levels increase with age in *** mirNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIrT1/P Gc-1α),SIrT

关键词： hearing loss hypoxia microrNAs oxidative stress sensorineural

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAUrABH r.KIrAN D.SINGH r.VAISH V.S.cHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

Bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSDT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the c0finite element method(FEM), and an in-house code is developed in the MATLAB environment to solve it numerically. Various helicoidal layup configurations including helicoidal recursive(Hr), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural regeneration research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Ensuring adequate statistics in particle tracking experiments

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Particuology 2021年第6期19卷 43-54页

作者： c.r.K.Windows-Yule School of chemical Engineering University of BirminghamEdgbastonBirmingham B152TTUnited Kingdom Institute for Multiscale Simulation Engineering of Advanced MaterialsFriedrich-Alexander Universitat Erlangen-NurnbergSchloBplatz 491054 ErlangenGermany

Particle tracking techniques such as magnetic particle tracking,radioactive particle tracking and positron emission particle tracking are widely used in academia and industry to image the dynamics of particulate and multiphase *** techniques can provide detailed data concerning a range of important,whole-field quantities based only on the time-averaged dynamics of a small number of tracer ***,in order for this data to be reliable,the duration over which these time-averages are taken must be suitably ***,the‘minimum averaging time’required to produce good statistics depends sensitively on the system in question and,at present,cannot be determined a priori in advance of an *** this paper,we take a step toward resolving this issue,using discrete element method simulations of a simple vibroﬂuidised granular bed to develop a series of scaling laws relating said minimum averaging time to a variety of key system *** scaling laws developed may be used by future experimentalists to predict the required averaging time for each given system during an experimental campaign,thus improving both the efficiency with which particle tracking techniques may be applied,and the reliability of the data produced thereby.

关键词： Granular Particle tracking Positron emission particle tracking radioactive particle tracking Magnetic particle tracking Particle tracking velocimetry

A framework for building energy management system with residence mounted photovoltaic

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Building Simulation 2021年第4期14卷 1031-1046页

作者： chellaswamy c Ganesh Babu r Vanathi A Department of Electronics and communication Engineering Kings Engineering CollegeChennaiIndia Department of Electronics and communication Engineering SRM TRP Engineering CollegeTiruchirappalliIndia Department of Electronics and communication Engineering Rajalakshmi Institute of TechnologyChennaiIndia

Efficient utilization of a residential photovoltaic (PV) array with grid connection is difficult due to power fluctuation and geographical dispersion. reliable energy management and control system are required for overcoming these obstacles. This study provides a new residential energy management system (rEMS) based on the convolution neural network (cNN) including PV array environment. The cNN is used in the estimation of the nonlinear relationship between the residence PV array power and meteorological datasets. rEMS has three main stages for the energy management such as forecasting, scheduling, and real functioning. A short term forecasting strategy has been performed in the forecasting stage based on the PV power and the residential load. A coordinated scheduling has been utilized for minimizing the functioning cost. A real-time predictive strategy has been used in the actual functioning stage to minimize the difference between the actual and scheduled power consumption of the building. The proposed approach has been evaluated based on real-time power and meteorological data sets.

关键词： building energy management convolution neural network photovoltaic coordinated scheduling

The development and role of microbialhost interactions in gut mucosal immune development

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Journal of Animal Science and Biotechnology 2017年第2期8卷 307-316页

作者： c.r.Stokes School of clinical Veterinary Science University of BristolLangford HouseLangfordNr Bristol BS40 5DUUK

At birth the piglet＇s immune system is immature and it is dependent upon passive maternal protection until *** piglet＇s mucosal immune system develops over the first few weeks but has not reached maturity at weaning ages which are common on commercial farms. At weaning piglets are presented with a vast and diverse range of microbial and dietary/environmental antigens. Their ability to distinguish between antigens and mount a protective response to potential pathogens and to develop tolerance to dietary antigens is critical to their survival and failure to do so is reflected in the high incidence of morbidity and mortality in the post-weaning period. A growing recognition that the widespread use of antibiotics to control infection during this critical period should be controlled has led to detailed studies of those factors which drive the development of the mucosal immune system, the role of gut microbiota in driving this process, the origin of the bacteria that colonise the young piglet＇s intestine and the impact of rearing environment. This review briefly describes how the mucosal immune system is equipped to respond ＂appropriately＂ to antigenic challenge and the programmed sequence by which it develops. The results of studies on the critical interplay between the host immune system and gut microbiota are discussed along with the effects of rearing environment. By comparing these with results from human studies on the development of allergies in children, an approach to promote an earlier maturation of the piglet immune system to resist the challenges of weaning are outlined.

关键词： Gut microbiota Intestine Mucosal immune development Pig rearing environment

Microspheres give improved resolution in nondestructive examination of semiconductor devices

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Light(Science & Applications) 2022年第3期11卷 13-14页

作者： r.c.Woods college of Engineering University of South AlabamaMobileALUSA

The minimum spatial resolution of typical optical inspection systems used in the microelectronics industry is generally governed by the classical relations of Ernst *** et *** in a new Light:Science and Applications a... 详细信息

关键词： optical resolution governed

Transient Thermal Management comparison of a Microprocessor Using PcMs in Various configurations

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Journal of Thermal Science 2011年第6期20卷 516-520页

作者： Thenmozhi r Sharmeela c Natarajan P Velraj r Ganthipathy Tulsis' Engineering college AUIndia Anna University ChennaiIndia Bharathidasan Engineering college AUIndia

There has been a strong interest in the use of Phase change Materials (PcMs) for the transient thermal abatement of high powered *** paper presents a set of transient computational analysis for selected Ic packages with the purpose of calibrating the merits of PcM in different *** transient analysis of high powered microprocessors with heat sinks was performed as a benchmark for comparison with the same microprocessors fitted with PcM in the following configurations:a) PcM imbedded into the finned region of the heat sink,b) PcM mounted between the microprocessor and heat sink,c) sealed PcM underfill to the microprocessor and d) PcM fitted to the underside of the printed circuit board directly beneath the *** analysis was performed using a commercial cFD tool together with an approximation to the phase change mechanism using the slope *** indicate the merit of each configuration.

关键词： Phase change Materials cFD Thermal Management Transient Latent heat

Scalable Ir-Doped NiFe₂O₄/TiO₂ Heterojunction Anode for Decentralized Saline Wastewater Treatment and H₂ Production

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NANO-MIcrO LETTErS 2025年第1期17卷 1-18页

作者： Hong, Sukhwa Kim, Jiseon Park, Jaebeom Im, Sunmi Hoffmann, Michael r. cho, Kangwoo Pohang Univ Sci & Technol POSTEcH Div Environm Sci & Engn Pohang 790784 South Korea cALTEcH Linde Labs Pasadena CA 91125 USA Yonsei Univ Int campus Inst Convergence Res & Educ Adv Technol I CREATE Incheon 21983 South Korea

Wastewater electrolysis cells (WEcs) for decentralized wastewater treatment/reuse coupled with H-2 production can reduce the carbon footprint associated with transportation of water, waste, and energy carrier. This study reports Ir-doped NiFe2O4 (NFI, similar to 5 at% Ir) spinel layer with TiO2 overlayer (NFI/TiO2), as a scalable heterojunction anode for direct electrolysis of wastewater with circumneutral pH in a single-compartment cell. In dilute (0.1 M) Nacl solutions, the NFI/TiO2 marks superior activity and selectivity for chlorine evolution reaction, outperforming the benchmark IrO2. robust operation in near-neutral pH was confirmed. Electroanalyses including operando X-ray absorption spectroscopy unveiled crucial roles of TiO2 which serves both as the primary site for cl- chemisorption and a protective layer for NFI as an ohmic contact. Galvanostatic electrolysis of NH4+-laden synthetic wastewater demonstrated that NFI/TiO2 not only achieves quasi-stoichiometric NH4+-to-N-2 conversion, but also enhances H-2 generation efficiency with minimal competing reactions such as reduction of dissolved oxygen and reactive chlorine. The scaled-up WEc with NFI/TiO2 was demonstrated for electrolysis of toilet wastewater.

关键词： Wastewater electrolysis cell Ir-doped NiFe2O4 reactive chlorine species Decentralized H-2 production On-site wastewater treatment