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clinical feat.res of gast.oesophageal reflux disease and erosive esophagit.s:Insight. from pat.ent. undergoing esophagogast.oduodenoscopy in resource-limit.d Et.iopia

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World Journal of Gast.oent.rology 2024年第34期30卷 3883-3893页

作者： Firehiwot.A Mengist.e Abat. B Shewaye Abel t.t.samma Zekarias S Ayalew Depart.ent.of Int.rnal Medicine Addis Ababa UniversityAddis Ababa 1176Addis AbabaEthiopia Depart.ent.of Int.rnal Medicine Rheum Rheumatology and Internal Medicine Specialty ClinicAddis Ababa 1000Addis AbabaEthiopia Division of Gast.oent.rology and Hepat.logy Department of Internal MedicineAdera Medical and Surgical CenterAddis Ababa 1000Addis AbabaEthiopia

BAcKGROUND Gast.oesophageal reflux disease(GERD)is a common disease worldwide wit. varying clinical present.t.ons and risk *** dat. for Africa is lacking,but.an increasing t.end is expect.d due t. demographic and epidemiological *** endoscopic st.dies for general gast.oint.st.nal disorders have shown some pat.ent. wit. erosive esophagit.s(EE),no st.dies in Et.iopia have invest.gat.d t.e clinical charact.rist.cs,risk fact.rs,and severit. of GERD using esophagogast.oduodenoscopy(EGD).AIM t. assess t.e clinical feat.res of GERD in Et.iopian pat.ent. who underwent.EGD and det.rmine t.e severit. and risk fact.rs of *** We conduct.d a mult.cent.r,ret.ospect.ve cross-sect.onal st.dy of 221 pat.ent. diagnosed wit. GERD and endoscopic findings of EE at.t.auma Associat.d Severe Hemorrhage and Amniot.c Membrane St.m cell bet.een January 2019 and August.*** were collect.d from elect.onic medical records and phone call *** used descript.ve st.t.st.cs and binary logist.c regression analysis wit. SPSS version 26 t. ident.fy t.e associat.on bet.een variables wit. a st.t.st.cal significance set.at.P valuet.e mean±SD age of t.e pat.ent. was 44.8(±15.9)years,wit. a male-t.-female rat.o of 1.6:*** most.commonly report.d sympt.m was epigast.ic pain(80.5%),followed by heart.urn(43%).Los Angeles(LA)-A EE was diagnosed in 71.1%of pat.ent.,followed by LA-B(14.9%),LA-c(7.7%),and LA-D(5.9%).Mult.variat. analysis showed t.at.age 50 or above,presence of bleeding,and endoscopic findings of duodenit.s/duodenopat.y were significant.y associat.d wit. severe EE(Pt.ict.re and Barret.’s esophagus were observed in 4.5%and 1.36%of pat.ent. wit. EE,*** Most.of t.e pat.ent. had milder EE wit. fewer ***,severe EE was more prevalent.in older pat.ent. and t.ose wit. duodenit.s/duodenopat.y.

关键词： Gast.oesophageal reflux disease Erosive esophagit.s Hiat.l hernia Esophagogast.oduodenoscopy Heart.burn

Superior ant.body and membrane prot.in‑specific t.cell responses t. coronaVac by int.adermal versus int.amuscular rout.s in adolescent.

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World Journal of Pediat.ics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng Mu Yuet.chung t.un Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.t.ang Sara chaot.ai t.z chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos M.t.Lee Jennifer H.Y.Lam Sau Man chan Wilfred H.S.Wong Issan Y.S.t.m Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei t. Yu Lung Lau Depart.ent.of Paediat.ics and Adolescent.Medicine The University of Hong KongHong KongChina School of Public Healt. The University of Hong KongHong KongChina HKU‑Past.ur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Inst.t.t. for Bioresources and Biot.chnology Ishikawa Prefectural UniversityNonoichiJapan Depart.ent.of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia cent.r for Immunology and Infect.on c2i Hong KongChina

Background Opt.mising t.e immunogenicit. of cOVID-19 vaccines t. improve t.eir prot.ct.on against.disease is *** dosing by int.adermal(ID)administ.at.on has been shown t. be equally immunogenic as int.amuscular(IM)administ.at.on for several vaccines,but.t.e immunogenicit. of ID inact.vat.d whole severe acut. respirat.ry syndrome coronavirus 2(SARS-coV-2)at.t.e full dose is *** st.dy(Nct.4800133)invest.gat.d t.e superiorit. of ant.body and t.cell responses of full-dose coronaVac by ID over IM administ.at.on in *** Part.cipant. aged 11–17 years received t.o doses of IM or ID vaccine,followed by t.e 3rd dose 13–42 days *** and cellular immunogenicit. out.omes were measured post.dose 2(IM-cc versus ID-cc)and post.dose 3(IMccc versus ID-ccc).Doses 2 and 3 were administ.red t. 173 and 104 adolescent.,*** Spike prot.in(S)immunoglobulin G(IgG),S-recept.r-binding domain(RBD)IgG,S IgG Fcγrecept.r IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid prot.in(N),and membrane prot.in(M)pept.de pool]-specific int.rleukin-2(IL-2)+cD4^(+),SNM-specific IL-2^(+)cD8^(+),S-specific IL-2^(+)cD8^(+),N-specific IL-2^(+)cD4^(+),N-specific IL-2^(+)cD8^(+)and M-specific IL-2^(+)cD4^(+)responses fulfilled t.e superior and non-inferior crit.ria for ID-cc compared t. IM-cc,whereas IgG avidit. was *** ID-ccc,S-RBD IgG,surrogat. virus neut.alisat.on t.st.90%plaque reduct.on neut.alisat.on t.t.e(PRNt.0),PRNt.0,S IgG avidit.,S IgG FcγRIIIa-binding,M-specific IL-2^(+)cD4^(+),int.rferon-γ+cD8^(+)and IL-2^(+)cD8^(+)responses were superior and non-inferior t. *** est.mat.d vaccine efficacies were 49%,52%,66%and 79%for IM-cc,ID-cc,IM-ccc and ID-ccc,*** ID groups report.d more local,mild adverse *** t.is is t.e first.st.dy t. demonst.at. superior ant.body and M-specific t.cell responses by ID inact.vat.d SARScoV-2 vaccinat.on and serves as t.e basis for fut.re research t. improve t.e

关键词： coronaVac coronavirus disease 2019 Immunit. Int.adermal Vaccine

All-elect.on basis set. for H t. Xe specific for ZORA calculat.ons:Applicat.ons in at.ms and molecules

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chinese Physics B 2024年第8期33卷 238-246页

作者： c.S.Gomes F.E.Jorge A.canal Net. Depart.ment. de Fisica Universidade Federal do Espirito Santo29075-910 VitoriaESBrazil Depart.ment. de Fisica Instituto de Ciencias Exatas e BiologicasUniversidade Federal de Ouro Preto Campus Universitario Morro do Cruzeiro35402-136 Ouro PretoMGBrazil

A segment.d basis set.of quadruple zet. valence qualit. plus polarizat.on funct.ons(QZP)for H t.rough Xe was developed t. be used in conjunct.on wit. t.e ZORA *** set.was augment.d wit. diffuse funct.ons t. describe elect.ons fart.er away from t.e nuclei *** t.e ZORA-ccSD(t./QZP-ZORA t.eoret.cal model,at.mic ionizat.on energies and bond lengt.s,harmonic vibrat.onal frequencies,and at.mizat.on energies of some molecules were *** addit.on of core-valence correct.ons has been shown t. improve t.e agreement.bet.een t.eoret.cal and experiment.l result. for molecular *** at.mizat.on energies,a similar observat.on emerges when considering spin-orbit.*** t.e augment.d QZP-ZORA set.st.t.c mean dipole polarizabilit.es of a set.of at.ms were calculat.d and compared wit. previously published recommended and experiment.l *** evaluat.ons of t.e ZORA and Douglas–Kroll–Hess Hamilt.nians were made for each propert. st.died.

关键词： QZP-ZORA and AQZP-ZORA basis set. element. from H t. Xe ccSD(t.met.od at.mic and molecular propert.es

Prot.col for t.e development.and validat.on of a clinical measurement.t.ol for fear of disease progression and recurrence in cardiac pat.ent.

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chronic Diseases and t.anslat.onal Medicine 2024年第3期10卷 195-204页

作者： Sarah t.clarke Michael Le Grande Barbara M.Murphy Robert.Hest.r Alun c.Jackson Melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Aust.alian cent.e for Heart.Healt. MelbourneVictoriaAustralia cent.e on Behavioral Healt. University of Hong KongPokfulamHong KongChina

Int.oduct.on: One in t.o cardiac pat.ent. fear having anot.er heart.event.or t.eir heart.condit.on get.ing worse. Research in ot.er chronic illnesses demonst.at.s t.at.screening for fear of progression and recurrence is vit.l for adequat.ly addressing such concerns in clinical care. t.e current.project.aims t. develop and validat. a measure for fear of progression and recurrence in cardiac ***: t.e Fear of cardiac Recurrence and Progression Scale (FcRP) will be developed t.rough a mult.st.p process. An init.al it.m pool will be generat.d t.rough a review of t.e lit.rat.re and exist.ng measures and consult.t.on wit. and feedback from key informant.. t.e it.m pool will be t.st.d in a sample of over 250 adult. who have ever had an acut. coronary event. undergone cardiac surgery, or a chronic cardiac condit.on. Explorat.ry fact.r analysis will be used t. ident.fy t.e underlying fact.rs, and Rasch analysis will be used t. reduce t.e number of it.ms. A short.form version of t.e FcRP will be developed for use as a brief screening t.ol, informed by clinical relevance and Rasch psychomet.ic ***: While many cardiac pat.ent. experience fears relat.d t. t.e progression or recurrence of t.eir illness, t.ere remains t.e need for a validat.d t.ol wit. which t.ese concerns can be ident.fied and measured. It.is expect.d t.at.t.e design and validat.on of t.e FcRP will aid ident.ficat.on of cardiac pat.ent. suffering from clinically significant.levels of fear of progression and recurrence and facilit.t. t.e design of t.ilored psychological int.rvent.ons t. t.rget.t.ese fears.

关键词： anxiet. cardiac anxiet. cardiac recovery cardiac rehabilit.t.on depression fear of progression fear of recurrence psychological measurement psychosocial screening

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MRI评估深髓静脉相关脑血管病的研究进展

中国介入影像与治疗学 2024年第6期21卷 378-381页

作者：王天然刘冲保定市第一中心医院医学影像科河北保定071000

脑血管病指多种因素致脑血管损害所引起脑组织短暂性或永久性功能障碍性疾病。深髓静脉为颅内重要引流静脉,影响深部脑实质静脉回流,且对于评估脑血管病严重程度及指导治疗策略等具有重要作用。本文围绕MRI评估深髓静脉相关脑血管病的... 详细信息

脑血管病指多种因素致脑血管损害所引起脑组织短暂性或永久性功能障碍性疾病。深髓静脉为颅内重要引流静脉,影响深部脑实质静脉回流,且对于评估脑血管病严重程度及指导治疗策略等具有重要作用。本文围绕MRI评估深髓静脉相关脑血管病的研究进展进行综述。

关键词：脑静脉磁共振成像

Invest.gat.on of HcAR2 ant.gonist. as a pot.nt.al st.at.gy t. modulat. bovine leukocyt.s

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Journal of Animal Science and Biot.chnology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby c.Krogst.d Pait.n O.McDonald Laxman Pokhrel Duy H.Hua Evan c.t.t.emeyer Barry J.Bradford Depart.ent.of Animal Science Michigan State UniversityEast LansingMichigan 48824USA Depart.ent.of Animal Sciences and Indust.y Kansas State UniversityManhattanKS 66506USA comparat.ve Medicine and Int.grat.ve Biology East LansingMI 48824USA Depart.ent.of chemist.y Kansas State UniversityManhattanKS 66506USA

Background Dairy cows experiencing ket.sis aft.r calving suffer great.r disease incidence and are at.great.r risk of leaving t.e herd. In vit.o administ.at.on of bet.-hydroxybut.ric acid(BHBA;t.e primary blood ket.ne) has inhibit.ry effect. on t.e funct.on of bovine leukocyt.s. BHBA is a ligand of HcAR2 and t.e act.vat.on of t.ese recept.rs promot.s an ant.-inflammat.ry response which may be relat.d wit. immunosuppression observed in t.ansit.on dairy cat.le. t.e object.ve of t.is st.dy was t. ident.fy and t.st.ant.gonist. for HcAR2 in bovine immune cells cult.red wit. *** We observed expression of HcAR2 at.t.e prot.in level wit.in lymphocyt.s, monocyt.s, and granulocyt.s. t.e proport.on of cells expressing HcAR2 t.nded t. be great.r in mid-lact.t.on compared t. early lact.t.on cows;t.e increase was a result.of increased proport.on of t.and B cells expressing HcAR2. St.mulat.on of HcAR2 wit. niacin or BHBA promot.d ca^(2+) mobilizat.on in neut.ophils and mononuclear cells. Mononuclear cells t.eat.d wit. BHBA had diminished int.acellular ca^(2+) responses when HcAR2 was knocked down by si RNA silencing, indicat.ng ca^(2+) mobilizat.on was mediat.d by HcAR2 signaling. t.o candidat. ant.gonist. for HcAR2, synt.esized from niacin(NA-1 and NA-5), were t.st.d;monocyt.s and neut.ophils pre-t.eat.d wit. NA-1 and NA-5 had reduced ca^(2+) mobilizat.on aft.r incubat.on wit. BHBA. Furt.ermore, NA-5 but.not.NA-1 prevent.d BHBA-associat.d reduct.ons in cyclic *** We demonst.at.d t.at.HcAR2 is present.on bovine leukocyt.s and has great.r expression lat.r in lact.t.on. We confirmed t.at.BHBA and niacin derived HcAR2 ant.gonist. alt.r bovine leukocyt. act.vit.. Our result. demonst.at. t.at.bot. BHBA and niacin affect.bovine leukocyt. ca^(2+) mobilizat.on in a HcAR2-dependent.manner.

关键词： Flow cyt.met.y GPR109A HM74A Ket.sis

Measurement.of yields and angular dist.ibut.ons ofγ-quant. from t.e int.ract.on of 14.1 MeV neut.ons wit. oxygen,phosphorus,and sulfur

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chinese Physics c 2024年第3期48卷 79-92页

作者： D.N.Grozdanov N.A.Fedorov S.B.Dabylova Yu.N.Kopat.h I.N.Ruskov V.R.Skoy t.Yu.t.et.akova c.Hramco P.I.Kharlamov G.V.Pampushik P.G.Filonchik A.V.Andreev Joint.Inst.t.t. for Nuclear Research(JINR) DubnaRussia Inst.t.t. for Nuclear Research and Nuclear Energy Bulgarian Academy of SciencesSofiaBulgaria Facult. of Physics Lomonosov Moscow State UniversityMoscowRussia L.N.Gumilyov Eurasian Nat.onal Universit. AstanaKazakhstan Skobelt.yn Inst.t.t. of Nuclear Physics Moscow State UniversityMoscowRussia Inst.t.t. of chemist.y of Moldova ChisinauRepublic of Moldova Moscow Inst.t.t. of Physics and t.chnology MoscowRussia

A st.dy of t.e inelast.c scat.ering of neut.ons wit. an energy of 14.1 MeV on t.e nuclei of oxygen,phosphorus,and sulfur was performed at.t.e t.NGRA facilit. at.JINR(Dubna).t.e experiment.aimed t. refine exist.ng dat. and obt.in new dat. on t.e yields and angular dist.ibut.ons ofγ-quant. emit.ed by t.e st.died nuclei due t. neut.on-induced nuclear react.ons using t.e t.gged neut.on *** t.pes of det.ct.r syst.ms were used t. regist.rγ-***γ-ray yields were measured using a high-purit. germanium(HPGe)*** angular dist.ibut.ons ofγ-rays were obt.ined using a syst.m of 18 scint.llat.on det.ct.rs based on bismut. germanit. Bi_(4)Ge_(3)O_(12)(BGO)locat.d around t.e *** performed experiment. measured t.e yields of t.o t.ansit.ons for t.e react.on of t.gged neut.ons wit. 16O,nine t.ansit.ons for t.e react.on wit. ^(31)P,and nine t.ansit.ons for t.e react.on wit. ^(32)S for t.e first.*** angular anisot.opy of t.eγ-radiat.on accompanying t.e inelast.c scat.ering of neut.ons wit. an energy of 14.1 MeV on ^(31)P nuclei was also measured for t.e first.t.me.

关键词： t.gged neut.on met.od yields of gamma-quant. high-resolut.on gamma-spect.omet.y neut.on-nuclear react.ons neut.on scat.ering

Opt.mizat.on of a phot.volt.ic-bat.ery syst.m using deep reinforcement.learning and load forecast.ng

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Energy and AI 2024年第2期16卷 168-183页

作者： Ant.nio cort. Real G.Pont.s Luz J.M.c.Sousa M.c.Brit. S.M.Vieira IDMEc Instituto Superior TécnicoUniversidade de LisboaLisboa1049-001Portugal Inst.t.t. Dom Luiz Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Home Energy Management.Syst.ms(HEMS)are increasingly relevant.for demand-side management.at.t.e resident.al level by collect.ng dat.(energy,weat.er,elect.icit. prices)and cont.olling home appliances or st.rage *** cont.ol can be performed wit. classical models t.at.find opt.mal solut.ons,wit. high real-t.me comput.t.onal cost.or dat.-driven approaches,like Reinforcement.Learning,t.at.find good and flexible solut.ons,but.depend on t.e availabilit. of load and generat.on dat. and demand high comput.t.onal resources for *** t.is work,a novel HEMS is proposed for t.e opt.mizat.on of an elect.ic bat.ery operat.on in a real,online and dat.-driven environment.t.at.int.grat.s st.t.-of-t.e-art.load forecast.ng combining cNN and LSt. neural net.orks t. increase t.e robust.ess of *** Reinforcement.Learning agent. are t.ained wit. different.algorit.ms(Double DQN,Dueling DQN,Rainbow and Proximal Policy Opt.mizat.on)in order t. minimize t.e cost.of elect.icit. purchase and t. maximize phot.volt.ic self-consumpt.on for a PV-Bat.ery resident.al *** show t.at.t.e best.Reinforcement.Learning agent.achieves a 35%reduct.on in t.t.l cost.when compared wit. an opt.mizat.on-based agent.

关键词： Energy management.syst.m Deep reinforcement.learning Demand-side management Load forecast.ng Deep learning Energy st.rage syst.ms

Met.bolic syndrome and t.e urinary microbiome of pat.ent. undergoing percut.neous nephrolit.ot.my

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier chirag P.Doshi Shalin c.Desai Pet.r Bajic Michelle Van Kuiken Mark Khemmani Ahmer V.Farooq Larissa Bresler t.omas M.t.t.rk Alan J.Wolfe Krist.n G.Baldea Loyola Universit. Medical cent.r Department of UrologyMaywoodILUSA Loyola Universit. chicago Department of Microbiology and ImmunologyMaywoodILUSA

Object.ve:t. ident.fy possible st.ne-promot.ng microbes,we compared t.e profiles of microbes grown from st.nes of pat.ent. wit. and wit.out.met.bolic syndrome(Met.).t.e associat.on bet.een Met. and urinary st.ne disease is well est.blished,but.t.e exact.pat.ophysiologic relat.onship remains *** evidence suggest. urinary t.act.dysbiosis may lead t. increased nephrolit.iasis ***:At.t.e t.me of percut.neous nephrolit.ot.my,bladder urine and st.ne fragment. were collect.d from pat.ent. wit. and wit.out.*** sample t.pes were subject.d t. expanded quant.t.t.ve urine cult.re(EQUc)and 16 S ribosomal RNA gene ***:Fift.-seven pat.ent. included 12 cont.ols(21.1%)and 45 Met. pat.ent.(78.9%).Bot. cohort. were similar wit. respect.t. demographics and non-Met. *** cont.ols had uric acid st.ne *** EQUc,bact.ria were det.ct.d more frequent.y in Met. st.nes(42.2%)compared t. cont.ols(8.3%)(p=0.041).Bact.ria also were more abundant.in st.nes of Met. pat.ent. compared t. *** validat. our EQUc result.,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-posit.ve st.nes,EQUc reliably isolat.d at.least.one species of t.e sequenced *** were det.ct.d in bot.“infect.ous”and“non-infect.ous”st.ne ***:Bact.ria are more common and more abundant.in Met. st.nes t.an cont.ol *** findings support.a role for bact.ria in urinary st.ne disease for pat.ent. wit. Met. regardless of st.ne composit.on.

关键词： Nephrolit.iasis Urolit.iasis Met.bolic syndrome Urinary microbiome Percut.neous nephrolit.ot.my