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Association of accelerometer-measured sleep duration and different intensities of physical activity with incident type 2 diabetes in a population-based cohort study

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Journal of Sport and Health Science 2024年第2期13卷 222-232页

作者： Xinyi Jin Yilin chen Hongliang Feng Mingqing Zhou Joey w.Y.chang Yaping Liu Alice Pik Shan Kong Xiao Tan Yun-Kwok wing Yannis Yan Liang Jihui Zhang Guangdong cardiovascular Institute Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Guangdong Provincial Key Laboratory of coronary Heart Disease Prevention Guangdong Cardiovascular InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510080China School of Medicine South China University of TechnologyGuangzhou 510641China center for Sleep and circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510180China The Second School of clinical Medicine Southern Medical UniversityGuangzhou 510282China Guangdong Mental Health center Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhou 510120China Li chiu Kong Family Sleep Assessment Unit Department of PsychiatryFaculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Psychiatry Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medicine and Therapeutics Faculty of MedicineThe Chinese University of Hong KongHong Kong 999077China Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden Department of Big Data in Health Science Zhejiang University School of Public HealthHangzhou 310058China Key Laboratory of Neurogenetics and channelopathies of Guangdong Province and the Ministry of Education of china Guangzhou 510260China

Purpose:The aim of the current study was to investigate the association of accelerometer-measured sleep duration and different intensities of physical activity(PA)with the risk of incident type 2 diabetes in a population-based prospective cohort ***:Altogether,88,000 participants(mean age=62.2±7.9 years,mean±SD)were included from the UK *** duration(short:ng:>8 h/day)and PA of different intensities were measured using a wrist-won accelerometer over a 7-day period between 2013 and *** was classified according to the median or world Health Organization-recommendation:total volume of PA(high,low),moderate-to-vigorous PA(MVPA)(recommended,not recommended),and light-intensity PA(high,low).Incidence of type 2diabetes was ascertained using hospital records or death ***:During a median follow-up of 7.0 years,1615 incident type 2 diabetes cases were *** with normal sleep duration,short(hazard ratio(HR)=1.21,95%confidence interval(95%cI):1.03-1.41)but not long sleep duration(HR=1.01,95%cI:0.89-1.15)was associated with excessive type 2 diabetes *** increased risk among short sleepers seems to be protected against by *** with normal sleepers with high or recommended PA,short sleepers with low volume of PA(HR=1.81,95%cI:1.46-2.25),not recommended(below the world Health Organization-recommended level of)MVPA(HR=1.92,95%cI:1.55-2.36),or low light-intensity PA(HR=1.49,95%cI:1.13-1.90)had a higher risk of type 2 diabetes,while short sleepers with a high volume of PA(HR=1.14,95%cI:0.88-1.49),recommended MVPA(HR=1.02,95%cI:0.71-1.48),or high light-intensity PA(HR=1.14,95%cI:0.92-1.41)did ***:Accelerometer-measured short but not long sleep duration was associated with a higher risk of incident type 2 diabetes.A higher level of PA,regardless of intensity,potentially ameliorates this excessive risk.

关键词： Light physical activity Sleep duration Triaxial accelerometer Type 2 diabetes UK Biobank

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从机械机器人到智能机器人:人工智能的图像学

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外国文学研究 2024年第3期46卷 1-7页

作者： w.J.T.米切尔韦清琦(译) 美国芝加哥大学东南大学外国语学院

智能机器人将人类带入了自原子弹、电灯或是印刷术以来最伟大的科技革命之中,同时智能机器也能走火入魔这一构思也向来是科幻作品的核心想象。纵观媒体发明的历史长河,对人工智能的恐慌并不新鲜,人们曾认为书写的发明和照相术将扼杀记... 详细信息

智能机器人将人类带入了自原子弹、电灯或是印刷术以来最伟大的科技革命之中,同时智能机器也能走火入魔这一构思也向来是科幻作品的核心想象。纵观媒体发明的历史长河,对人工智能的恐慌并不新鲜,人们曾认为书写的发明和照相术将扼杀记忆和绘画,现在又照例指责数码正在毁灭模拟技术的独一性。人类应该冷静下来,采取对症下药的态度。有必要解构关于人与机器之差异的想象,而毋需躲避与智能机器人的交互谈话。人类物种虽然在作茧自缚,但同时又以进化与生态智能为基础,努力建设可持续全球体系。图像学研究的图像和文字同时包括了机器和人类的作品,因而相关的研究者应明确自己的任务:就文字与图像和智能机器人展开对话,在上述人类的生存努力中谋求与智能机器人携手合作。

关键词：智能机器人人工智能机器图像学传媒人文

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综述杂豆酚类化合物多样性的影响因素

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中国食品学报 2024年第1期24卷 390-406页

作者：李昱昊宋萧萧聂少平 cui Steve w. 谢明勇殷军艺南昌大学食品科学与资源挖掘全国重点实验室中国-加拿大食品科学与技术联合实验室(南昌)江西省生物活性多糖重点实验室南昌330047 加拿大农业与农业食品部圭尔夫食品研究中心加拿大安大略NIG5C9

杂豆酚类化合物种类繁多,并影响杂豆的外观、感官特征及营养特性。杂豆酚类化合物多样性是杂豆营养特性研究的重点。本文总结杂豆酚类化合物多样性的影响因素,发现合理的提取与分析方法有利于酚类化合物提取的完整性以及表征的正确性。... 详细信息

杂豆酚类化合物种类繁多,并影响杂豆的外观、感官特征及营养特性。杂豆酚类化合物多样性是杂豆营养特性研究的重点。本文总结杂豆酚类化合物多样性的影响因素,发现合理的提取与分析方法有利于酚类化合物提取的完整性以及表征的正确性。在此基础上,指出种属与产地、生长与贮藏及加工过程影响杂豆酚类化合物的合成、溶出与释放,并促使酚类化合物多样性的形成。最后介绍杂豆酚类化合物多样性的代谢组学技术在杂豆多样性研究方面的贡献与优势,提出今后工作的重点与挑战,以期为杂豆酚类化合物的变化机制、加工利用及育种等提供参考。

关键词：杂豆酚类化合物多样性提取方法定性与定量影响因素

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Ion migration in 3D metal halide perovskite field effect transistors

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Electron 2024年第2期2卷 85-97页

作者： Jinghai Li Yanyan Gong william w.Yu School of chemistry and chemical Engineering Shandong UniversityJinanChina Shandong Provincial Key Laboratory for Science of Material creation and Energy conversion Science Center for Material Creation and Energy ConversionInstitute of Frontier and Interdisciplinary ScienceShandong UniversityQingdaoChina State Key Laboratory of Biobased Material and Green Papermaking Qilu University of Technology(Shandong Academy of Sciences)JinanChina

3D perovskite materials are advancing rapidly in the field of photovoltaics and light-emitting diodes,but the development in field effect transistors(FETs)is limited due to their intrinsic ion *** migration in perovskite FETs can screen the electric field of the gate and affect its modulation,as well as influence the charge carriers transport,leading to non-ideal device characteristics and lower device ***,we provide a concise review that explains the mechanism of ion migration,summarizes the strategies for suppressing ion migration,and concludes with a discussion of the future prospects for 3D perovskite FETs.

关键词： 3D metal halide perovskite field effect transistors ion migration

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Gas Exchange Rates of Texas Persimmon (Diospyros texana) in central Texas woodlands

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American Journal of Plant Sciences 2024年第5期15卷 329-348页

作者： Matthew B. Grunstra Oscar w. Van Auken Department of Integrative Biology University of Texas at San Antonio San Antonio TX USA

Diospyros texana (Texas persimmon) is a secondary species in most Juniperus ashei/Quercus fusiformis woodlands in central Texas. It has high density, but plants are mostly in the community understory. Light response curves at ambient and elevated levels of cO2 and temperature were measured for D. texana. The Anet (photosynthetic rate) increased significantly as both light level and cO2 levels increased but not temperature. The Amax (maximum photosynthetic rate) of D. texana in full sun at elevated levels of cO2 was increased for all treatments. Stomatal conductance increased with levels of cO2 but only if the interaction was removed from the model. Intercellular levels of cO2 increased with both temperature and cO2 treatments as did water use efficiency (wUE). Furthermore, light saturation (Lsat) increased with cO2 treatments and light compensation (Lcp) increased with temperature. The dark respiration (Rd) increased with both temperature and cO2 treatments. Markov population models suggested D. texana populations would remain ecologically similar in the future. However, sub-canopy light levels and herbivory should be considered when examining population projections. For example, Juniperus ashei juveniles are not recruited into any canopy unless there are high light levels. Herbivory reduces the success of Quercus juveniles from reaching the canopy. These factors do not seem to be a problem for D. texana juveniles which would allow them to reach the canopy without need of a high light gap and are not prevented by herbivory. Thus, Juniperus/Quercus woodlands will change in the future to woodlands with D. texana a more common species.

关键词： Replacement Dynamics Ecological Succession cO2 concentrations Temperature Levels Photosynthetic Rates Drought Tolerance Herbivory Species Replacement Encroachment Juniper

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The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

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Bone Research 2024年第2期12卷 289-301页

作者： Heeseog Kang Amy L.Strong Yuxiao Sun Lei Guo conan Juan Alec c.Bancroft Ji Hae choi chase A.Pagani Aysel A.Fernandes Michael woodard Juhoon Lee Sowmya Ramesh Aaron w.James David Hudson Kevin N.Dalby Lin Xu Robert J.Tower Benjamin Levi center for Organogenesis Regeneration and TraumaDepartment of SurgeryUniversity of Texas SouthwesternDallasTX 75390USA Section of Plastic Surgery Department of SurgeryUniversity of MichiganAnn ArborMI 48109USA Quantitative Biomedical Research center Peter O’Donnell Jr.School of Public HealthUniversity of Texas SouthwesternDallasTX 75390USA Department of Orthopedics and Sports Medicine University of WashingtonSeattleWA 98195USA Division of chemical Biology and Medicinal chemistry College of PharmacyUniversity of Texas at AustinAustinTX 78712USA Department of Pathology Johns Hopkins UniversityBaltimoreMD 21218USA

while hypoxic signaling has been shown to play a role in many cellular processes,its role in metabolism-linked extracellular matrix(EcM)organization and downstream processes of cell fate after musculoskeletal injury remains to be ***(HO)is a debilitating condition where abnormal bone formation occurs within extra-skeletal *** andhypoxia-inducible factor 1α(HIF-1α)activation have been shown to promote ***,the underlying molecular mechanisms bywhich the HIF-1αpathway in mesenchymal progenitor cells(MPcs)contributes to pathologic bone formation remain to ***,we used a proven mouse injury-induced HO model to investigate the role of HIF-1αon aberrant cell ***-cell RNA sequencing(scRNA-seq)and spatial transcriptomics analyses of the HO site,we found that collagen EcM organizationis the most highly up-regulated biological process in *** mesenchymal cell-specific deletion of Hif1α(Hoxa11-creER^(T2);Hif1a^(fl/fl))significantly mitigated HO in ***-seq analysis of these Hoxa11-creER^(T2);Hif1a^(fl/fl)mice identified the PLOD2/LOXpathway for collagen cross-linking as downstream of the HIF-1αregulation of ***,our scRNA-seq data and mechanisticstudies further uncovered that glucose metabolism in MPcs is most highly impacted by HIF-1α*** a translational aspect,a pan-LOX inhibitor significantly decreased HO.A newly screened compound revealed that the inhibition of PLOD2 activity in MPcssignificantly decreased osteogenic differentiation and glycolytic *** suggests that the HIF-1α/PLOD2/LOX axis linked tometabolism regulates HO-forming MPc *** results suggest that the HIF-1α/PLOD2/LOX pathway represents a promisingstrategy to mitigate HO formation.

关键词： metabolism skeletal aberrant

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Prevalence and risk factors of depression among patients with perianal fistulizing crohn’s disease

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world Journal of Psychiatry 2024年第5期14卷 715-725页

作者： Jing Li wing-Yi ng Li-chao Qiao Fen Yuan Xing Lan Li-Bei Zhu Bo-Lin Yang Zhong-Qiu wang Department of Radiology Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of Acupuncture and Rehabilitation Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Department of colorectal Surgery Jiangsu Province Hospital of Chinese Medicine Affiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029Jiangsu ProvinceChina

BAcKGROUND Psychological distress,especially depression,associated with perianal fistulizing crohn’s disease(PFcD)is widespread and ***,there is a surprising paucity of studies to date that have sought to identify the prevalence and risk factors of depression associated with *** To estimate the prevalence of depressive symptoms and investigate the depression-related risk factors in patients with *** The study was conducted in the form of survey and clinical data collection via questionnaire and specialized medical *** symptoms,life quality,and fatigue severity of patients with PFcD were assessed by Patient Health Questionnaire-9,Inflammatory Bowel Disease Patient Quality of Life Questionnaire(IBDQ),and Inflammatory Bowel Disease(IBD)Fatigue Patient Self-assessment *** basic demographic information,overall disease features,perianal clinical information,and laboratory inflammation indicators were also *** regression analysis was ultimately used to ascertain the risk factors of depression associated with *** A total of 123 patients with PFcD were involved,and 56.91%were suffering from *** to multivariate logistic regression analysis,Perianal Disease Activity Index(PDAI)score[odds ratio(OR)=0.69,95%confidence interval(cI):0.50 to 0.95],IBDQ score(OR=0.93,95%cI:0.88 to 0.97),modified Van Assche index(OR=1.24,95%cI:1.01 to 1.53),and IBD Fatigue score(OR=1.72,95%cI:1.23 to 2.42)were independent risk factors of depression-related prevalence among patients with PFcD(Pcreasing perianal modified Van Assche index(βvalue=0.166,95%cI:0.02 to 0.31)and decreasing IBDQ score(βvalue=-0.116,95%cI:-0.14 to-0.09)were independently associated with the severity of depression(PcONcLUSION Depressive symptoms in PFcD patients have significantly high *** score,modified Van Assche index,quality of life,and fatigue severity

关键词： crohn’s disease Fistula Depression Inflammatory bowel diseases Risk factors

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Severe acute respiratory syndrome coronavirus-2-related and imputable deaths in children:results from the French pediatric national registry

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world Journal of Pediatrics 2024年第6期20卷 611-620页

作者： Marguerite Lockhart-Bouron Noemie Vanel Michael Levy Anais R.Briant Etienne Javouhey Sophie Breinig Julia Dina Marion caseris Francois Angoulvant Stephane Leteurtre Morgan Recher David w.Brossier Univ.Lille CHU LilleULR 2694-METRICS:Evaluation Des Technologies de Sante Et Des Pratiques Medicales59000LilleFrance Pediatric Intensive care Unit CHU de MarseilleMarseilleFrance Pediatric Intensive care Unit CHU Robert-DebreAssistance Publique Hopitaux de ParisParisFrance UniversitéParis-cite ParisFrance Biostatistics and clinical Research Unit CHU de Caen Normandie14000CaenFrance Pediatric Intensive care Hospices Civils de LyonLyonFrance Neonatal andPediatric Intensivecare Unit Children's HospitalToulouseFrance Virology Department INSERM U1311 DynamicureUniv CAEN NormandieCHU de Caen14000 CaenFrance Medical School Universite Caen Normandie14000 CaenFrance Department of Pediatrics CHU Robert-DebréAssistance Publique Hopitaux de ParisParisFrance Department women-Mother-child Service of PediatricsLausanne University Hospital(CHUV)LausanneSwitzerland Pediatric Intensive care Unit Réanimation Et Soins Intensifs PéediatriquesCHU de CAENAvenue de La Cote de Nacre14000 CaenFrance cHU Sainte Justine Research center MontréalCanada

Background Severe acute respiratory syndrome coronavirus-2(SARS-coV-2)is responsible for an important mortality rate *** aimed to evaluate the actual imputability of SARS-coV-2 on the mortality rate associated with SARS-coV-2-related illnesses in the pediatric intensive care unit(PIcU).Secondary objectives were to identify risk factors for *** This national multicenter comparative study comprised all patients under 18 years old with positive SARS-coV-2 polymerase chain reactions(PcRs)[acute corona virus disease 2019(cOVID-19)or incidental SARS-coV-2 infection]and/or pediatric inflammatory multisystem syndrome(PIMS)recorded in the French PIcU registry(PIcURe)between September 1,2021,and August 31,*** patients were classified and compared according to their living status at the end of their PIcU *** patients were evaluated by four experts in the field of pediatric infectiology and/or pediatric intensive *** imputability of SARS-coV-2 as the cause of death was classified into four categories:certain,very probable,possible,or unlikely,and was defined by any of the first three *** There were 948 patients included of which 43 died(4.5%).From this,26 deaths(67%)could be attributed to SARS-coV-2 infection,with an overall mortality rate of 2.8%.The imputability of death to SARS-coV-2 was considered certain in only one case(O.1%).Deceased patients suffered more often from comorbidities,especially heart disease,neurological disorders,hematological disease,cancer,and *** of the deceased patients were admitted for pediatric inflam-matory multisystem syndrome(PIMS).Mortality risk factors were male gender,cardiac comorbidities,cancer,and acute respiratorydistress *** SARS-coV-2 mortality in the French pediatric population was *** though the imputability of SARS-cov-2 on mortality was considered in almost two-thirds of cases,this imputability was considered certain in only one case.

关键词： Death Pediatric intensive care unit SARS-coV-2

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Positive health:An integrated quantitative approach in patients with chronic gastrointestinal and hepato-pancreatico-biliary disorders

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world Journal of Gastroenterology 2024年第28期30卷 3418-3427页

作者： Anja H w M Lemlijn-Slenter Karolina AP wijnands Gijs van der Hamsvoort Luuk P van Iperen Nico wolter Angelique E de Rijk Ad AM Masclee Department of Social Medicine Faculty of HealthMedicine and Life sciencesCare and Public Health Research Institute Maastricht UniversityMaastricht 6200 MDLimburgNetherlands Division of Gastroenterology and Hepatology Department of Internal MedicineSchool of Nutrition and Translational Research in MetabolismMaastricht 6200 MDLimburgNetherlands Social Medical Affairs Employee Insurance Agency(UWV)Heerlen 6400 ACLimburgNetherlands Department of Research Academic Knowledge Center Work and Health South-East Netherlands(AKAG-ZON)Heerlen 6400 ACLimburgNetherlands

BAcKGROUND The concept of positive health(PH)supports an integrated approach for patients by taking into account six dimensions of *** approach is especially relevant for patients with chronic *** gastrointestinal and hepatopancreatico-biliary(GI-HPB)disorders are among the top-6 of the most prevalent chronically affected organ *** impact of chronic GI-HPB disorders on individuals may be disproportionally high because:(1)The affected organ system frequently contributes to a malnourished state;and(2)persons with chronic GIHPB disorders are often younger than persons with chronic diseases in other organ *** To describe and quantify the dimensions of PH in patients with chronic GI-HPB *** Prospective,observational questionnaire study performed between 2019 and 2021 in 235 patients with a chronic GIHPB disorder attending the Outpatient Department of the Maastricht University Medical *** questionnaires and data from patient files were used to quantify the six dimensions of *** consistency was tested with McDonald’s ***-order Pearson correlations and t-tests were used to assess associations and differences.A P valuewas considered *** The GI-HPB patients scored significantly worse in all dimensions of PH compared to control data or norm scores from the general *** quality of life,participation and daily functioning,GI-HPB patients scored in the same range as patients with chronic disorders in other organ systems,but depressive symptoms(in 35%)and malnutrition(in 45%)were more frequent in patients with chronic GI-HPB *** scores between the six dimensions were only very weak to weak,forcing us to quantify each domain *** All six dimensions of PH are impaired in the GI-HPB *** and depressive symptoms are more prevalent compared to patients with chronic disorders in other organ systems.

关键词： Positive health chronic gut disorders Gastrointestinal disorders Hepato-pancreatico-biliary disorders Integrated care

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Mapping the global research landscape on nonalcoholic fatty liver disease and insulin resistance:A visualization and bibliometric study

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world Journal of Hepatology 2024年第6期16卷 951-965页

作者： Sa'ed H Zyoud Omar E Hegazi Samer O Alalalmeh Muna Shakhshir Faris Abushamma Shadi Khilfeh Samah w Al-Jabi Department of clinical and community Pharmacy College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine clinical Research center An-Najah National University HospitalNablus 44839Palestine college of Pharmacy and Health Sciences Ajman UniversityAjman 346United Arab Emirates Department of Nutrition An-Najah National University HospitalNablus 44839Palestine Department of Medicine College of Medicine and Health SciencesAn-Najah National UniversityNablus 44839Palestine Department of Urology An-Najah National University HospitalNablus 44839Palestine Department of Gastroenterology Hepatology and EndoscopyAn-Najah National University HospitalNablus 44839Palestine

BAcKGROUND Nonalcoholic fatty liver disease(NAFLD)is a liver condition that is prevalent worldwide and associated with significant health risks and economic *** it has been linked to insulin resistance(IR),this study aimed to perform a bibliometric analysis and visually represent the scientific literature on IR and *** To map the research landscape to underscore critical areas of focus,influential studies,and future directions of NAFLD and *** This study conducted a bibliometric analysis of the literature on IR and NAFLD indexed in the SciVerse Scopus database from 1999 to *** search strategy used terms from the literature and medical subject headings,focusing on terms related to IR and *** software was used to visualize research trends,collaborations,and key thematic *** analysis examined publication type,annual research output,contributing countries and institutions,funding agencies,journal impact factors,citation patterns,and highly cited *** This analysis identified 23124 documents on NAFLD,revealing a significant increase in the number of publications between 1999 and *** search retrieved 715 papers on IR and NAFLD,including 573(80.14%)articles and 88(12.31%)*** most productive countries were china(n=134;18.74%),the United States(n=122;17.06%),Italy(n=97;13.57%),and Japan(n=41;5.73%).The leading institutions included the Universitàdegli Studi di Torino,Italy(n=29;4.06%),and the consiglio Nazionale delle Ricerche,Italy(n=19;2.66%).The top funding agencies were the National Institute of Diabetes and Digestive and Kidney Diseases in the United States(n=48;6.71%),and the National Natural Science Foundation of china(n=37;5.17%).The most active journals in this field were Hepatology(27 publications),the Journal of Hepatology(17 publications),and the Journal of clinical Endocrinology and Metabolism(13 publications).The main research hotspots were“therapeutic approaches for IR and NAFLD”and“inflamma

关键词： Nonalcoholic fatty liver disease Insulin resistance Bibliometric Visualization

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