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Thiol-Disulfide Exchange coordinates the Release of Nitric Oxide and Dexamethasone for Synergistic Regulation of Intestinal Microenvironment in colitis

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Research 2024年第2期6卷 285-300页

作者： Junna Lu Tongfei Shi chengxin Shi Fangman chen chao Yang Xiaochun Xie Zheng wang He Shen Jiaqi Xu Kam w.Leong Dan Shao School of Biomedical Sciences and Engineering South China University of TechnologyGuangzhou International CampusGuangzhouGuangdong 510006China National Engineering Research center for Tissue Restoration and Reconstruction South China University of TechnologyGuangdong 510006China Department of Plastic and Aesthetic center The First Affliated Hospital of Zhejiang UniversityHangzhou 310000China Department of Biomedical Engineering Columbia UniversityNew YorkNY 10027USA School of Medicine South China University of TechnologyGuangzhouGuangdong 510006China cAS Key Laboratory of Nano-Bio Interface Suzhou Institute of Nano-Tech and NanoBionicsChinese Academy of SciencesSuzhou 215123China cAS Key Laboratory for Biomedical Efects of Nanomaterials&Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing 100190China Guangdong Provincial Key Laboratory of Biomedical Engineering South China University of TechnologyGuangzhou 510006China Key Laboratory of Biomedical Materials and Engineering of the Ministry of Education South China University of TechnologyGuangzhou 510006China

The cell-specific functions of nitric oxide(NO)in the intestinal microenvironment orchestrate its therapeutic effects in ulcerative *** most biomaterials show promise by eliciting the characteristics of NO,the insufficient storage,burst release,and pro-inflammatory side effects of NO remain as ***,we report the development of thiol-disulfide hybrid mesoporous organosilica nanoparticles(MONs)that improve the storage and sustained release of NO,broadening the therapeutic window of NO-based therapy against *** tailored NO-storing nanomaterials coordinated the release of NO and the immunoregulator dexamethasone(Dex)in the intestinal microenvironment,specifically integrating the alleviation of oxidative stress in enterocytes and the reversal of NO-exacerbated macrophage ***,such a synchronous operation was achieved by a self-motivated process wherein the thiyl radicals produced by NO release cleaved the disulfide bonds to degrade the matrix and release Dex via thiol-disulfide ***,the MON-mediated combination of NO and Dex greatly ameliorated intractable colitis compared with 5-aminosalicylic acid,even after delayed ***,our results reveal a key contribution of synergistic modulation of the intestinal microenvironment in NO-based colitis therapy and introduce thiol-disulfide hybrid nanotherapeutics for the management of inflammatory diseases and cancer.

关键词： sustained release disulfide

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轴重和频率对激光修复316L不锈钢涂层在铁路车轮踏面制动中摩擦学性能的影响

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表面工程与再制造 2024年第2期24卷 51-52页

作者： Li S. Xiao Q. Yang w. Yang c. wang Y. State Key Laboratory of Performance Monitoring and Protecting of Rail Transit Infrastructure East China Jiaotong University Nanchang 330013 China School of Mechatronics and Vehicle Engineering East China Jiaotong University Nanchang 330013 China Railway Industry Key Laboratory of Intelligent Operation and Maintenance of Rolling Stock East China Jiaotong University Nanchang 330013 China

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实... 详细信息

研究复杂制动环境对修复熔覆层服役性能的影响,对提高列车轮轨系统抵御极端恶劣环境的能力具有重要意义。本文针对火车车轮踏面局部损伤问题,利用激光熔覆修复技术在损伤处制备316L不锈钢涂层。采用MS-HT1000高温磨损试验机进行磨损实验。然后,分析不同制动条件对修复试样在室温和高温下摩擦磨损性能的影响。

关键词：激光修复铁路车轮局部损伤磨损实验车轮踏面磨损试验机服役性能踏面制动

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Nickel sulfate solution fluoride separation with hydrous zirconium oxide

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Tungsten 2024年第2期6卷 367-381页

作者： Elbert M.Nigri Ummul K.Sultana André L.A.Santos James w.Vaughan Sonia D.F.Rocha Department of Mining Engineering Federal University of Minas GeraisBelo Horizonte 31270-901Brazil School of chemical Engineering University of QueenslandSt Lucia 4072Australia

Fluoride is an impurity in nickel sulfate production,which is required for electric vehicle *** zirconium oxide(HZO)was evaluated for removing fl uoride from nickel sulfate *** fluoride removal occurred at pH value 4 and optimal pH value is 4–5,considering Zr *** availability decreases with pH due to hydrogen fluoride and zirconium fluoride aqueous *** removal is initially rapid,with 50 wt.%removal in 7 min,followed by slow removal up to 68 wt.%after 72 h and follows second order rate *** removal was dominated by an ion exchange mechanism and resulting Zr–F bonds were observed using Fourier-transform infrared *** presence of nickel sulfate decreased loading capacity compared to a salt-free *** maintained adsorption capacity through five cycles of loading and regeneration.

关键词： Hydrous zirconium oxide Nickel sulfate Fluoride Adsorption Anion exchange

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Effect of suction change on water content and total volume of an expansive clay

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2007年第5期8卷 699-706页

作者： ZHAN Liang-tong cHEN Ping ng c.w.w. ~ Department of civil Engineering Zhejiang University Hangzhou 310027 China Department of civil Engineering Zhejiang Sci- Tech University Hangzhou 310018 China Department of civil Engineering Hong Kong University of Science and Technology Hong Kong China

A laboratory study was carried out on both natural and compacted specimens to investigate the complex soil-water interaction in an unsaturated expansive clay. The laboratory study includes the measurement of soil-water characteristic curves, 1D free swelling tests, measurement of swelling pressure and shrinkage tests. The test results revealed that the air-entry value of the natural specimen was quite low due to cracks and fissures present. The hydraulic hysteresis of the natural specimen was relatively insignificant as compared with the compacted specimen. within a suction range 0 to 500 kPa, a bilinear relationship between free swelling strain (or swelling pressure) and initial soil suction was observed for both the natural and compacted specimens. As a result of over-consolidation and secondary structures such as cementation and cracks, the natural specimens exhibited significant lower swelling (or swelling pressure) than the compacted specimen. The change of matric suction exerts a more significant effect on the water phase than on the soil skeleton for this expansive clay.

关键词： Expansive soil water content Suction Swelling Shrinkage

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Development of a Proof-of-concept Multi-Method computer Simulation to Support Rural Healthcare Disaster Preparedness Planning

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International Journal of Disaster Risk Science 2024年第3期15卷 346-358页

作者： Thomas A.Berg Kristina w.Kintziger Julie Suzuki crumly Scott A.Lawson carole R.Myers Tracey T.Stansberry college of Nursing University of Tennessee Knoxville Department of Environmental Agricultural and Occupational Health University of Nebraska Medical Center Public Health and Healthcare Oak Ridge Associated Universities

Due to a lack of resources, rural communities often face challenges when planning catastrophic events. This project involved applying systems thinking and model-based systems engineering to develop a proof-of-concept, multi-method computer simulation and then determining whether the simulation could be used to assess the efficacy of disaster planning approaches on health outcomes in rural communities, as a function of primary healthcare. The project focus was a rural or non-urban healthcare system experiencing a natural hazard. Both system dynamics and discrete event models were incorporated to represent subsystem operations, crucial disaster responses, as well as three key response systems: public health, emergency management, and healthcare. The subsystem models included several components: policies/procedures, communications,resources, exercises/drills/training, healthcare space and staff, and the flow of affected people into and through the *** combined simulation can serve as a first step to a more comprehensive approach to helping rural communities achieve more efficient and effective healthcare planning for disaster responses.

关键词： computer simulation Disaster preparedness Model-based systems engineering Rural healthcare System dynamics model Systems thinking

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Application of AcP Nonlinear Math in Analyzing Arithmetic and Radiation Transmission Data (Application 1 & 2) [4-21-2024, 820P] (V)

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Journal of Applied Mathematics and Physics 2024年第6期12卷 2302-2319页

作者： Ralph w. Lai Melisa w. Lai-Becker Grace cheng-Dodge 28 cornerstone ct. Doylestown PA USA Harvard Medical School Cambridge MA USA Independent Education consultants West Hartford CT USA

In this study, we explore the application of AcP (asymptotic curve based and proportionality oriented) Alpha Beta (αβ) Nonlinear Math to analyze arithmetic and radiation transmission data. Specifically, we investigate the relationship between two variables. The novel approach involves collecting elementary “y” data and subsequently analyzing the asymptotic cumulative or demulative (opposite of cumulative) Y data. In part I, we examine the connection between the common linear numbers and ideal nonlinear numbers. In part II, we delve into the relationship between X-ray energy and the radiation transmission for various thin film materials. The fundamental physical law asserts that the nonlinear change in continuous variable Y is negatively proportional to the nonlinear change in continuous variable X, expressed mathematically as dα = −Kdβ. Here: dα {Y, Yu, Yb} represents the change in Y, with Yu and Yb denoting the upper and baseline asymptote of Y. dβ {X, Xu, Xb} represents the change in X, with Xu and Xb denoting the upper and baseline asymptote of X. K represents the proportionality constant or rate constant, which varies based on equation arrangement. K is the key inferential factor for describing physical phenomena.

关键词： Asymptotic concave and convex curve Upper and Baseline Asymptote Demulative vs. cumulative coefficient of Determination Proportionalityand Position constant Skewed Bell and Sigmoid curve

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用于单片集成传感系统的多晶硅级联自发光器件研究

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光子学报 2024年第5期53卷 180-188页

作者：唐宇罗谦刘斯扬 SNYMAN Lukas w 徐开凯电子科技大学电子薄膜与集成器件全国重点实验室成都611731 东南大学国家ASIc工程中心无锡214000 南非大学电子工程系南非比勒陀利亚0001

针对全硅光电生物传感器的硅基单片集成应用需求,提出了基于多晶硅级联自发光器件的单片集成传感器,对其中作为关键部分的多晶硅光源进行了试制,采用标准0.35μm的cMOS工艺对该光源进行了流片验证,并设计了适配的全硅波导检测结构。结... 详细信息

针对全硅光电生物传感器的硅基单片集成应用需求,提出了基于多晶硅级联自发光器件的单片集成传感器,对其中作为关键部分的多晶硅光源进行了试制,采用标准0.35μm的cMOS工艺对该光源进行了流片验证,并设计了适配的全硅波导检测结构。结果表明,多晶硅光源发光特征峰为635 nm、700 nm和785 nm,该特征峰作为波导入射光源时,设计的全硅波导检测结构能够实现检测目的。

关键词：单片集成硅基光源氮化硅波导生物传感器折射率传感

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Implementation of Fuzzy Logic control into an Equivalent Minimization Strategy for Adaptive Energy Management of A Parallel Hybrid Electric Vehicle

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Journal of Transportation Technologies 2024年第1期14卷 88-118页

作者： Jared A. Diethorn Andrew c. Nix Mario G. Perhinschi w. Scott wayne Department of Mechanical and Aerospace Engineering West Virginia University Morgantown WV USA

As government agencies continue to tighten emissions regulations due to the continued increase in greenhouse gas production, automotive industries are seeking to produce increasingly efficient vehicle technology. Hybrid electric vehicles (HEVs) have been introduced to mitigate problems while improving fuel economy. HEVs have led to the demand of creating more advanced controls software to consider multiple components for propulsive power in a vehicle. A large section in the software development process is the implementation of an optimal energy management strategy meant to improve the overall fuel efficiency of the vehicle. Optimal strategies can be implemented when driving conditions are known a prior. The Equivalent consumption Minimization Strategy (EcMS) is an optimal control strategy that uses an equivalence factor to equate electrical to mechanical power when performing torque split determination between the internal combustion engine and electric motor for propulsive and regenerative torque. This equivalence factor is determined from offline vehicle simulations using a sensitivity analysis to provide optimal fuel economy results while maintaining predetermined high voltage battery state of charge (SOc) constraints. when the control hierarchy is modified or different driving styles are applied, the analysis must be redone to update the equivalence factor. The goal of this work is to implement a fuzzy logic controller that dynamically updates the equivalence factor to improve fuel economy, maintain a strict charge sustaining window of operation for the high voltage battery, and reduce computational time required during algorithm development. The adaptive algorithm is validated against global optimum fuel economy and charge sustaining results from a sensitivity analysis performed for multiple drive cycles. Results show a maximum fuel economy improvement of 9.82% when using a mild driving style and a 95% success rate when maintaining an ending SOc within 5% of th

关键词： Hybrid Electric Vehicle Fuzzy Logic Adaptive control charge Sustainability

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Predictors of survival in autoimmune liver disease overlap syndromes

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world Journal of Hepatology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis calzadilla-Bertot Malik Janjua Bastiaan de Boer John Joseph wendy cheng Simon Hazeldine Briohny w Smith Gerry c MacQuillan Michael c wallace George Garas Leon A Adams Gary P Jeffrey Medical School University of Western AustraliaNed-lands 6009Western AustraliaAustralia Department of Hepatology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Department of Anatomical Pathology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Department of Gastroenterology and Hepatology Royal Perth HospitalPerth 6000Western AustraliaAustralia Department of Gastroenterology and Hepatology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medical School University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BAcKGROUND Survival in patients with autoimmune liver disease overlap syndromes(AILDOS)compared to those with single autoimmune liver disease is *** To investigate the survival of patients with AILDOS and assess the accuracy of non-invasive serum models for predicting liver-related *** Patients with AILDOS were defined as either autoimmune hepatitis and primary biliary cholangitis overlap(AIH-PBc)or autoimmune hepatitis and primary sclerosing cholangitis overlap(AIH-PSc)and were identified from three tertiary centres for this cohort ***-related death or transplantation(liver-related mortality)was determined using a population-based data linkage *** scores for liver-related death were compared for accuracy[including liver outcome score(LOS),Hepascore,Mayo Score,model for end-stage liver disease(MELD)score and MELD incorporated with serum sodium(MELD-Na)score].RESULTS Twenty-two AILDOS patients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hepascore was 1(range,0.07-1).At five years post enrolment,57%of patients remained free from liver-related mortality(74%AIH-PBc,27%AIH-PSc).There was no significant difference in survival between AIH-PBc and *** was a significant predictor of liver-related mortality(Pwith AIH-PBc(n=14)but not AIH-PSc(n=8).A LOS cut-point of 6 discriminated liver-related mortality in AIH-PBc patients(P=0.012,log-rank test,100%sensitivity,77.8%specificity)(Harrell's c-statistic 0.867).The MELD score,MELD-Na score and Mayo Score were not predictive of liver-related mortality in any *** Survival in the rare,AILDOS is *** current study supports the LOS as a predictor of liver-related mortality in AIH-PBc *** trials investigating predictors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap syndromes Liver outcome score Liver-related death Hepascore Autoimmune hepatitis Primary biliary cholangitis Primary sclerosing cholangitis

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Microstructures and mechanical properties of laser-directed energy deposited crcoNi medium-entropy alloy

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Rare Metals 2024年第7期43卷 3286-3300页

作者： wen-Jie Zhao chang-Yu Liu Peng-cheng che Zhi-Liang Ning Hong-Bo Fan Jian-Fei Sun Yong-Jiang Huang Alfonso H.w.ngan National Key Laboratory for Precision Hot Processing of Metals Harbin Institute of TechnologyHarbin 150001China Space Environment Simulation Research Infrastructure Harbin Institute of TechnologyHarbin 150001China Department of Mechanical Engineering The University of Hong KongHong Kong 999077China

The distinctive intrinsic heat treatment(IHT)originating from cyclic reheating in the laser-directed energy deposition(LDED) has attracted growing attention in recent *** this investigation,simulations and experimental characterizations were performed to examine the impact of IHT on the micros true ture and mechanical properties of LDED-fabricated crcoNi medium-entropy alloy(MEA).The results show that the intensity of the IHT is proportional to the utilized laser energy density(LED).As the LED increased,significant dynamic recrystallization and grain refinement occurred within the alloy due to the enhanced intensity of ***,the high LED leads to severe hot cracking within the as-built MEA,resulting in inferior *** decreasing LED,the hot cracking was effectively ***,low LED weakened the intensity of IHT and consequently inhibited kinetic conditions of dynamic recrystallization,resulting in a heterogeneous grain structure characterized by multi-scale-sized *** structure provides significant hetero-deformation-induced hardening during plastic deformation,enabling the alloy to have a sustainable work-hardening *** expect that this work will have implications in taking full advantage of the unique IHT of the LDED process to fabricate ME As with excellent metallurgical quality and mechanical performance.

关键词： Intrinsic heat treatment Laser-directed energy deposition crcoNi MEA Dynamic recrystallization Heterogeneous grain structure

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