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A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+breast cancer cells

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Microsystems & Nanoengineering 2024年第1期10卷 287-299页

作者： Braulio Andrés Ortega Quesada Jonathan cuccia Rachael coates Blake Nassar Ethan Littlefield Elizabeth c.Martin Adam T.Melvin cain Department of chemical Engineering Louisiana State UniversityBaton RougeLA 70803USA Department of chemical and Biological Engineering Clemson UniversityClemsonSC 29634USA Biological and Agricultural Engineering Louisiana State UniversityBaton RougeLA 70803USA Department Medicine Section Hematology and Medical OncologyTulane UniversityNew OrleansLA 70118USA

Metastatic breast cancer leads to poor prognoses and worse outcomes in patients due to its invasive behavior and poor response to *** is still unclear what biophysical and biochemical factors drive this more aggressive phenotype in metastatic cancer;however recent studies have suggested that exposure to fluid shear stress in the vasculature could cause *** this study a modular microfluidic platform capable of mimicking the magnitude of fluid shear stress(Fss)found in human vasculature was designed and *** device provides a platform to evaluate the effec.s.of Fss on McF-7 cell line,an estrogen receptor positive(ER+)breast cancer cell line,during circulation in the *** of the effec.s.of Fss on McF-7 cells was carried out utilizing two approaches:single cell analysis and bulk *** single cell analysis,cells were trapped in a microarray after exiting the serpentine channel and followed by immunostaining on the device(on-chip).Bulk analysis was performed after cells were collected in a microtube at the outlet of the microfluidic.s.rpentine channel for western blotting(off-chip).It was found that cells exposed to an Fss magnitude of 10 dyn/cm^(2) with a residence time of 60 s enhanced expression of the proliferation marker Ki67 in the McF-7 cell line at a single cell *** understand possible mechanisms for enhanced Ki67 expression,on-chip and off-chip analyses were performed for pro-growth and survival pathways ERK,AKT,and JAK/*** demonstrated that after shearing the cells phosphorylation of p-AKT,p-mTOR,and p-sTAT3 were ***,there was no change in p-ERK1/*** is a mediator of ER rapid signaling,analysis of phosphorylated ERαwas carried out and no significant differenc.s.between sheared and non-sheared populations were *** together these results demonstrate that Fss can increase phosphorylation of proteins associated with a more aggressive phenotype in circulating cancer *** findin

关键词： fluid breast estrogen

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Flexible, Transparent and conductive Metal Mesh Films with Ultra‑High FoM for stretchable Heating and Electromagnetic Interference shielding

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Nano-Micro Letters 2024年第5期16卷 201-213页

作者： Zibo chen shaodian yang Junhua Huang Yifan Gu Weibo Huang shaoyong Liu Zhiqiang Lin Zhiping Zeng Yougen Hu Zimin chen Boru yang Xuchun Gui state Key Laboratory of Optoelectronic Materials and Technologies School of Electronics and Information TechnologySun Yat-Sen UniversityGuangzhou 510275People’s Republic of China Guangdong Provincial Key Laboratory of Materials for High Density Electronic Packing Shenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055GuangdongPeople’s Republic of China school of Materials science and Engineering Sun Yat-Sen UniversityGuangzhou 510275People’s Republic of China

Despite the growing demand for transparent conductive films in smart and wearable electronics for electromagnetic interference(EMI)shielding,achieving a flexible EMI shielding film,while maintaining a high transmittance remains a significant ***,a flexible,transparent,and conductive copper(cu)metal mesh film for EMI shielding is fabricated by self-forming crackle template method and electroplating *** cu mesh film shows an ultra-low sheet resistance(0.18Ω□^(-1)),high transmittance(85.8%@550 nm),and ultra-high figure of merit(>13,000).It also has satisfactory stretchability and mechanical stability,with a resistance increases of only 1.3%after 1,000 bending *** a stretchable heater(ε>30%),the saturation temperature of the film can reach over 110°c within 60 s at 1.00 V applied ***,the metal mesh film exhibits outstanding average EMI shielding effectiveness of 40.4 dB in the X-band at the thickness of 2.5μ*** a demonstration,it is used as a transparent window for shielding the wireless communication electromagnetic ***,the flexible and transparent conductive cu mesh film proposed in this work provides a promising candidate for the next-generation EMI shielding applications.

关键词： Metal mesh Transparent conductive film stretchable heater Electromagnetic interference shielding

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Jun12682,a potent sARs-coV-2 papain-like protease inhibitor with exceptional antiviral efficacy in mice

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Acta Pharmaceutica sinica B 2024年第9期14卷 4189-4192页

作者： Mianling yang Meehyein Kim Peng Zhan Department of Medicinal chemistry Key Laboratory of Chemical Biology(Ministry of Education)School of Pharmaceutical SciencesShandong UniversityJi’nan 250012China Infectious Diseases Therapeutic Research center Korea Research Institute of Chemical Technology(KRICT)Daejeon 34114Republic of Korea

Recently,a collaborative research study published in science,led by Jun Wang,Xufang Deng,Eddy Arnold,and Franc.s. Xavier Ruiz1,identified a series of potent small molecule inhibitors that specifically target sARs-coV-2 papain-like protease(PLpro).The study demonstrated nanomolar PLpro inhibitory potency with Ki values ranging from 13.2 to 88.2 nmol/*** employing a structure-based drug design strategy,the researchers discovered an exceptionally promising compound,named Jun12682,that effectively targets both the newly discovered ubiquitin Val70(Val70Ub)-binding site and the known blocking loop(BL2)groove near the s4 subsite of ***,studies on the mechanism of action revealed that Jun12682 inhibits the deubiquitinating and deIsGylating activities of PLpro,which are crucial for antagonizing the host’s innate immune response upon viral *** biology studies confirmed the“two-pronged”binding mode of Jun12682,aligning perfectly with their drug design ***,Jun12682 exhibited potent antiviral activity against sARs-coV-2 and its variants,including nirmatrelvir-resistant mutants,in caco-2 cells(Ec50:0.44e2.02 mmol/L).It is noteworthy that its oral administration significantly improved survival rates and alleviated both lung virus loads and histopathological lesions in a lethal sARs-coV-2 mouse *** conclusion。

关键词： sARs-coV-2 Papain-like protease Broad-spectrum Anti-drug resistance Drug candidate

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structural effec.s.induced by dialysis-based purification of carbon nanomaterials

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Nano Materials science 2024年第4期6卷 475-483页

作者： A.D.Veloso A.M.Ferraria A.M.Botelho do Rego A.s.Viana A.J.s.Fernandes A.J.Fielding R.A.Videira M.c.Oliveira cQ-VR and chemistry Department University of Trás-os-Montes e Alto Douro BsIRG iBB-Institute for Bioengineering and BiosciencesDepartment of Chemical Engineeringand Associate Laboratory i4HB-Institute for Health and BioeconomyInstituto Superior TécnicoUniversidade de Lisboa centro de Química Estrutural Institute of Molecular SciencesDepartamento de Química e BioquímicaFaculdade de CiênciasUniversidade de Lisboa I3N and Physics Department University of AveiroCampus de Santiago Faculty of science Pharmacy and Biomolecular SchoolLiverpool John Moores University REQUIMTE/LAQV Laborat orio de FarmacognosiaDepartamento de QuímicaFaculdade de Farm aciaUniversidade do Porto

Dialysis plays a crucial role in the purification of nanomaterials but its impact on the structural properties of carbon nanomaterials was never ***,a carbon-based nanomaterial generated electrochemically in potassium phosphate buffer,was characterized before and after dialysis against pure *** is shown that dialysis affec.s.the size of the carbon domains,structural organization,surface functionalization,oxidation degree of carbon,and grade of ***,dialysis drives the nanomaterial organization from discrete roundish carbon domains,with sizes ranging from 70 to 160 nm,towards linear stacking structures of small nanoparticles （cohol and ether （epoxide） surface groups evolve into more oxidized carbon groups （e.g.,ketone and ester groups）.Investigation of the as-prepared nanomaterial by electron paramagnetic resonance （EPR） revealed a resonance signal consistent with carbon-oxygen centred ***,this study brings to light the selective affinity of the carbon nanomaterial under study to capture Na+ions,a property greatly enhanced by the dialysis proc.s.,and its high ability to trap oxygen,particularly before *** findings open new perspectives for the application of carbon-based nanomaterials and raise awareness of the importance of structural changes that can occur during the purification of carbon-based nanomaterials.

关键词： Nanocarbon surface functionalization NMR XPs Hydrophilic carbon Paramagnetic

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Tilted global solar irradiance in Bahrain:an experimental study

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clean Energy 2024年第2期8卷 27-34页

作者： N.Vasilikos c.Georgantopoulou H.Alajaimi s.H.Almajed M.Ahmed D.Mathioulakis school of Mechanical Engineering Bahrain PolytechnicIsa TownPO Box 33349Kingdom of Bahrain school of Mechanical Engineering National Technical University of AthensHeroon Polytechniou 7 StZografos 15773AthensGreece

In the present work,tilted global solar irradiance data are presented and analysed,measured for a period of 1 year on the campus of Bahrain Polytechnic,Kingdom of Bahrain,from both a fixed photovoltaic panel and a moving one via a two-axis solar *** fixed panel fac.s.south with an angle of 26°with respect to the horizontal,coinciding with the local geographical *** second panel is moved by two motors,controlled by a global positioning system and suitable software so that the sun’s rays are perpendicular to the panel surface.A pyranometer is installed on each panel,recording the tilted global solar irradiance,stored by using a data *** analysis of the data obtained shows a 33%solar energy gain on an annual basis for the moving panel(2780 versus 2088 kWh/m^(2) on the fixed panel).More importantly,in June,when the energy demand in Bahrain is elevated due to the increased residential cooling loads,the solar energy received by the moving panel is 54.7%higher compared with that of the fixed *** a percentage basis,the increase in solar energy from the moving panel is profound in the early morning and late evening ***,the reduction in the solar energy received by the fixed panel from May to June does not appear in the moving panel because of the adjustable orientation of the *** the year,the mean daily solar power varies between 0.37 and 0.56 kW/m^(2) for the fixed panel,and 0.45 and 0.70 kW/m^(2) for the moving *** winter,solar energy fluctuations are elevated due to erratic weather conditions that present a peak standard deviation of 28%of the corresponding *** data presented are useful for potential solar investments in Gulf countries.

关键词： tilted solar irradiance renewable energy solar tracking photovoltaic Gulf cooperation council countries

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spirotetramat reduc.s.fitness of the spotted-wing Drosophila,Drosophila suzukii

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Insect science 2024年第4期31卷 1222-1230页

作者： Jing yang Justin Flaven-Pouchon Yiwen Wang Bernard Moussian section of Animal Genetics Interfaculty Institute of Cell BiologyUniversity of TübingenTübingenGermany school of Pharmaceutical science and Technology Tianjin UniversityTianjinChina INRAE CNRSUniversitéCôte d'AzurInstitut Sophia AgrobiotechSophia AntipolisFrance

With climate change,the spotted-wing Drosophila(sWD,Drosophila suzukii)invades a great number of fruit production regions worldwide.A plethora of insecticides are being applied for management of this *** expected,sWD develops resistance against some potent insecticides or is rather insensitive to some ***,there is an urgent need to identify and characterize alternative insecticides to control sWD ***,we have studied the effec.s.of the orally applied inhibitor of the fatty acid synthesis pathway spirotetramat on sWD fitness with respect to fecundity and surface barrier function at different *** our experiments,we applied spirotetramat mixed with baker's yeast and showed that females and males were not repelled by effective concentrations of this *** found that spirotetramat,by trend,lowers egg numbers laid by fed *** eggs rapidly desiccate,and only a few larvae *** is lethal to larvae and reduc.s.survival of adult flies under low-humidity *** together,based on our data,we propose to use yeast supplemented with spirotetramat and additional sWD-specific attractants in traps in non-crop areas in order to eradicate sWD populations before they infest crop production sites.

关键词： desiccation Drosophila suzuki insecticide lipids

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Guidelines for application of high-content screening in traditional chinese medicine:concept,equipment,and troubleshooting

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Acupuncture and Herbal Medicine 2024年第1期4卷 1-15页

作者： Xuechun chen Lu Li Mingxu Zhang Jian yang chunMing Lyu Yizhou Xu yang yang Yi Wang Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang UniversityHangzhouChina Department of cardiology Hangzhou First People’s HospitalHangzhouChina National Key Laboratory of chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang UniversityJiaxingChina Molecular Devic.s.shanghai corporation ShanghaiChina National Key Laboratory of chinese Medicine Modernization Tianjin University of Traditional Chinese MedicineTianjinChina science and Technology Experiment center Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research center of Innovative Anticancer Drugs Ministry of Educationhangzhou China

High-content screening(Hcs)technology combines automated high-speed imaging hardware and single-cell quantitative *** can greatly accelerate data acquisition in cellular fluorescence imaging and is a powerful research technique in traditional chinese medicine(TcM).An increasing number of laboratories and platforms,including TcM laboratories,have begun utilizing Hcs ***,this technology is still in its infancy in TcM research and there is a lack of sufficient experience with the associated concepts,instrument configurations,and analysis *** improve the understanding of Hcs among researchers in the field of TcM,this paper summarizes the concept of Hcs,software and hardware configuration,the overall research proc.s.,as well as common problems and related solutions of Hcs in TcM research based on our team’s previous research experience,providing several research examples and an outlook on future perspectives,aiming to provide a technical guide for Hcs in TcM research.

关键词： High-content imaging High-content screening Traditional chinese medicine

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Polio eradication surveillance in sri Lanka,2019-2023

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Asian Pacific Journal of Tropical Medicine 2024年第6期17卷 268-272页

作者： M.A.Y.Fernando N.s.Madarasinghe c.Rangana N.Weerasinghe D.c.U.D.Weligamage J.I.Abeynayake Department of Medical Microbiology and Immunology Faculty of MedicineUniversity of ColomboSri Lanka Department of Virology Medical Research InstituteColombo 08Sri Lanka Medical Research Institute Colombo 08Sri Lanka

Objective:To evaluate the polio laboratory surveillance carried out from January,2019 to May,2023 by the Polio Regional Reference Laboratory,sri ***:This retrospective study analyzed all stool samples received under the acute flaccid paralysis(AFP)and immunodeficient vaccine-derived poliovirus(VDPV)surveillance at Polio Regional Reference Laboratory,sri Lanka from January,2019 to May,*** results of the testing methodologies were extracted from the laboratory data system,i.e.,poliovirus virus isolation,intra-typic differentiation/VDPV real time reverse transcriptase polymerase chain reaction(ITD/VDPV rRTPcR)and sequencing,along with the data on timing of reporting results,stool adequacy and *** was analyzed using descriptive ***:A total of 2141 stool samples from 1644 c.s.s were received for AFP surveillance from sri Lanka(93.61%),Maldives(1.52%),and immunodeficient VDPV(4.86%)*** polioviruses(19/1644,1.15%)and non-polio enteroviruses(73/1644,4.44%)were isolated,while sabin-like 3 virus was detected in majority(12/19,63.15%)among the poliovirus *** polioviruses or circulating VDPVs were not detected among the *** all years of the study,the non-polio AFP detection rate was>1/100000 in children aged less than 15 years,whereas stool adequacy rate was>80%.All results were reported within 14 days of receipt,ensuring timely reporting as per global ***:The Polio Regional Reference Laboratory,sri Lanka plays a vital role in maintaining the polio-free status in the country through its robust laboratory surveillance,while adhering to the surveillance ***-detection of wild polioviruses and circulating VDPV during the study period reinforc.s.the polio-free status in the country.

关键词： Poliovirus Polio laboratory surveillance Regional reference laboratory Polio eradication

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status of biomarker development for frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2024年第10期19卷 2117-2118页

作者： Yue yang Qi cheng Jianqun Gao Woojin scott Kim Brain and Mind centre&school of Medical sciences The University of SydneySydneyNSWAustralia Department of Neurology and Neurophysiology Liverpool HospitalSydneyNSWAustralia stroke and Neurology Research Group Ingham Institute for Applied Medical ResearchSydneyNSWAustralia shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation ShanghaiChina clinical Research center for Anesthesiology and Perioperative Medicine ShanghaiChina Translational Research Institute of Brain and Brain-Like Intelligence Shanghai Fourth People’s HospitalSchool of MedicineTongji UniversityShanghaiChina

Frontotemporal dementia(FTD) and amyotrophic lateral sclerosis(ALs) are neurodegenerative diseases that belong to the same disease spectrum,with overlapping of genetic and pathological *** mutations in TARDBP,c9ORF72,... 详细信息

关键词： amyotrophic sclerosis diseases

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Thermal-contact capacity of one-dimensional attractive Gaudin-yang model

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chinese Physics B 2024年第4期33卷 231-235页

作者：张小敏程颂陈洋洋 Institute of Modern Physics Northwest UniversityXi'an 710069China Beijing computational science Research center Beijing 100193China Peng Huanwu center for Fundamental Theory Northwest UniversityXi'an 710069China shaanxi Key Laboratory for Theoretical Physics Frontiers Northwest UniversityXi'an 710069China

Tan's contact c is an important quantity measuring the two-body correlations at short distanc.s.in a dilute *** we make use of the technique of exactly solved models to study the thermal-contact capacity K_(T),i.e.,the derivative of c with respect to temperature in the attractive Gaudin-yang *** is found that K_(T) is useful in identifying the low temperature phase diagram,and using the obtained analytical expression of K_(T),we study its critical behavior and the scaling ***,we show K_(T) versus temperature and thus the non-monotonic tendency of c in a tiny interval,for both spin-balanced and imbalanced *** a phenomenon is merely observed in multi-component systems such as sU(2)Fermi gases and spinor bosons,indicating the crossover from the Tomonaga-Luttinger liquid to the spin-coherent liquid.

关键词： Tan's contact Gaudin-yang model Bethe ansatz

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