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International Journal of mining Science and Technology 2015年第4期25卷 537-543页

作者： Kurnia Jundika c. Sasmito Agus P. Hassani Ferri P. mujumdar Arun S. mechanical Engineering Department Universiti Teknologi PETRONAS Department of mining and materials Engineering McGill University

A proper control and management of dust dispersion is essential to ensure safe and productive underground working environment. Brattice installation to direct the flow from main shaft to the mining face was found to be the most effective method to disperse dust particle away from the mining face. However,it limits the movement and disturbs the flexibility of the mining fleets and operators at the tunnel. This study proposes a hybrid brattice system- a combination of a physical brattice together with suitable and flexible directed and located air curtains- to mitigate dust dispersion from the mining face and reduce dust concentration to a safe level for the working operators. A validated three-dimensional computational fluid dynamic model utilizing Eulerian–Lagrangian approach is employed to track the dispersion of dust particle. Several possible hybrid brattice scenarios are evaluated with the objective to improve dust management in underground mine. The results suggest that implementation of hybrid brattice is beneficial for the mining operation: up to three times lower dust concentration is achieved as compared to that of the physical brattice without air curtain.

关键词： Dust dispersion Hybrid brattice Underground mine Ventilation

Unsupervised learning on scientific ocean drilling datasets from the South china Sea

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Frontiers of Earth Science 2019年第1期13卷 180-190页

作者： Kevin c.TSE Hon-chim cHIU man-Yin TSANG Yiliang LI Edmund Y.LAm Department of Earth Sciences The University of Hong KongPokfulamHong KongChina Department of Geography and centre for Geo-computation Studies Hong Kong Baptist UniversityKowloon TongHong KongChina Department of Earth Sciences University of TorontoTorontoON M5S 2M8Canada Department of Electrical and Electronic Engineering The University of Hong KongPokfulamHong KongChina

Unsupervised learning methods were applied to explore data patterns in multivariate geophysical datasets collected from ocean floor sediment core samples coming from scientific ocean drilling in the South china *** to studies on similar datasets,but using supervised learning methods which are designed to make predictions based on sample training data,unsupervised learning methods require no a priori information and focus only on the input *** this study,popular unsupervised learning methods including K-means,self-organizing maps,hierarchical clustering and random forest were coupled with different distance metrics to form exploratory data *** resulting data clusters were externally validated with lithologic units and geologic time scales assigned to the datasets by conventional methods. compact and connected data clusters displayed varying degrees of correspondence with existing classification by lithologic units and geologic time scales.K-means and self-organizing maps were observed to perform better with lithologic units while random forest corresponded best with geologic time *** study sets a pioneering example of how unsupervised machine learning methods can be used as an automatic processing tool for the increasingly high volume of scientific ocean drilling data.

关键词： machine learning unsupervised learning ODP IODP clustering

Recent advancements in the B7/cD28 immune checkpoint families:new biology and clinical therapeutic strategies

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cellular & molecular Immunology 2023年第7期20卷 694-713页

作者： marc c.Pulanco Anne T.madsen Ankit Tanwar Devin T.corrigan Xingxing Zang Department of microbiology and Immunology Albert Einstein College of MedicineNew YorkNY10461USA Department of Urology Albert Einstein College of MedicineNew YorkNY10461USA Department of Oncology Albert Einstein College of MedicineNew YorkNY10461USA Department of medicine Albert Einstein College of MedicineNew YorkNY10461USA

The B7/cD28 families of immune checkpoints play vital roles in negatively or positively regulating immune cells in homeostasis and various *** basic and clinical studies have revealed novel biology of the B7/cD28 families and new therapeutics for cancer *** this review,we discuss the newly discovered KIR3DL3/TmIGD2/HHLA2 pathways,PD-1/PD-L1 and B7-H3 as metabolic regulators,the glycobiology of PD-1/PD-L1,B7x(B7-H4)and B7-H3,and the recently characterized PD-L1/B7-1 *** also cover the tumor-intrinsic and-extrinsic resistance mechanisms to current anti-PD-1/PD-L1 and anti-cTLA-4 immunotherapies in clinical ***,we review new immunotherapies targeting B7-H3,B7x,PD-1/PD-L1,and cTLA-4 in current clinical trials.

关键词： B7 family immune checkpoints metabolic regulators glycobiology therapy resistance

Thermal stability of nanocrystalline mg-based alloys prepared via mechanical alloying

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Transactions of Nonferrous metals Society of china 2016年第2期26卷 398-405页

作者： m.RAJABI R.m.SEDIGHI S.m.RABIEE Department of material Science and Engineering Faculty of Mechanical EngineeringBabol Noshirvani University of Technology

Thethermal stability and the kinetics of grain growth of nanocrystalline mg-6Al-1Zn and mg-6Al-1Zn-1Si alloys prepared via mechanical alloying were investigated. It started with elemental powders, using a variety of analytical techniques including differential scanning calorimetry （DSc）, X-ray diffraction （XRD）, scanning electron microscopy （SEm）, transmission electron microscopy （TEm） and energy dispersive spectrometry. The kinetics of grain growth in isothermal annealing was investigated. The XRD results show that, although the grain sizes of both material systems increase as the annealing temperature rises, the Si-containing system displays a relatively smaller grain size, i.e., 60 nm compared with 72 nm in mg-6Al-1Zn system, after being exposed to 350 ℃ for 1 h. The second-phase intermetallic particle mg2Si formed during the isothermal annealing of mg-6Al-1Zn-1Si system could influence not only the activation energy but also the exponent of kinetic equation. Higher hardness values obtained in the Si-containing system would be due to the formation of mg2Si intermetallic phase.

关键词： mg-based alloys thermal stability grain growth mechanical alloying

magmatism during continental collision, subduction, exhumation and mountain collapse in collisional orogenic belts and continental net growth: A perspective

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Science china Earth Sciences 2015年第7期58卷 1284-1304页

作者： SONG ShuGuang WANG mengJue WANG cao NIU YaoLing mOE Key Laboratory of Orogenic Belt and crustal Evolution School of Earth and Space SciencesPeking University Department of Earth Sciences Durham University Institute of Oceanology Chinese Academy of Sciences

continental orogens on Earth can be classified into accretionary orogen and collisional *** in orogens occurs in every periods of an orogenic cycle,from oceanic subduction,continental collision to orogenic *** collision requires the existence of prior oceanic subduction *** is generally assumed that the prerequisite of continental deep subduction is oceanic subduction and its drag force to the connecting passive-margin continental lithosphere during continental *** subduction and collision lead to the thickening and uplift of crust,but the formation time of the related magmatism in orogens depends on the heating mechanism of *** accretionary orogens,on the other hand,have no strong continental collision,deep subduction,no large scale of crustal thrusting,thickening and uplift,and no UHP eclogite-facies metamorphic rocks related to continental deep *** though arc crust could be significantly thickened during oceanic subduction,it is still doubtful that syn-or post-collisional magmatism would be *** collisional orogens,due to continental deep subduction and significant crustal thickening,the UHP metamorphosed oceanic and continental crusts will experience decompression melting during exhumation,generating syn-collisional *** the orogen unrooting and collapse,post-collisional magmatism develops in response to lithosphere extension and upwelling of asthenospheric mantle,marking the end of an orogenic ***,magmatism in orogens can occur during the continental deep subduction,exhumation and uplift after detachment of subducted oceanic crust from continental crust,and extensional *** time span from continental collision to collapse and erosion of orogens(the end of orogenic cycle)is 50–85 *** orogens are the key sites for understanding continental deep subduction,exhumation,uplift and orogenic *** in collisional orogens plays impo

关键词： collisional orogeny continental deep subduction orogen unrooting and collapse magmatism continental net growth

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Injectable mechanical pillows for attenuation of load-induced post-traumatic osteoarthritis

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Regenerative Biomaterials 2019年第4期6卷 211-219页

作者： Derek T.Holyoak Tibra A.Wheeler marjolein c.H.van der meulen Ankur Singh meinig School of Biomedical Engineering Cornell UniversityIthacaNY 14853USA Sibley School of mechanical and Aerospace Engineering Cornell UniversityIthacaNY 14853USA Research Division Hospital for Special SurgeryNew YorkNY 10021USA Englander Institute for Precision medicine Weill Cornell Medical CollegeCornell UniversityNew YorkNY 10021USA

Osteoarthritis(OA)of the knee joint is a degenerative disease initiated by mechanical stress that affects millions of *** disease manifests as joint damage and synovial ***-traumatic osteoarthritis(PTOA)is a specific form of OA caused by mechanical trauma to the *** progression of PTOA is prevented by immediate post-injury therapeutic ***-articular injection of anti-inflammatory therapeutics(***)is a common treatment option for OA before end-stage surgical ***,the efficacy of intra-articular injection is limited due to poor drug retention time in the joint space and the variable efficacy of ***,we endeavored to characterize a four-arm maleimide-functionalized polyethylene glycol(PEG-4mAL)hydrogel system as a‘mechanical pillow’to cushion the load-bearing joint,withstand repetitive loading and improve the efficacy of intra-articular injections of nanoparticles containing dexamethasone,an anti-inflammatory ***-4mAL hydrogels maintained their mechanical properties after physiologically relevant cyclic compression and released therapeutic payload in an on-demand manner under in vitro inflammatory ***,the on-demand hydrogels did not release nanoparticles under repetitive mechanical loading as experienced by daily *** dexamethasone had minimal protective effects on OA-like pathology in our studies,the PEG-4mAL hydrogel functioned as a mechanical pillow to protect the knee joint from cartilage degradation and inhibit osteophyte formation in an in vivo load-induced OA mouse model.

关键词： hydrogel osteophyte biomaterials drug delivery cartilage inflammation

多能源混合电动汽车控制策略的模糊预测研究(英文)

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系统仿真学报 2008年第9期20卷 2416-2422页

作者：余群明喻伟雄周健王耀南 *** c.Ament H.Seizer 湖南大学汽车车身先进设计制造国家重点实验室长沙410082 德国不来梅大学工业技术与虚用工程科学学院 D-28359

为了使混合电动汽车获得较大的加速度和较长的续驶里程,同时改善整车的动力性能,提出了一种多能源混合动力系统结构。高能量、大功率的多能源混合动力系统必须配备一个能量智能管理系统,才能达到合理分配功率的目的。为此,建立在前向推... 详细信息

为了使混合电动汽车获得较大的加速度和较长的续驶里程,同时改善整车的动力性能,提出了一种多能源混合动力系统结构。高能量、大功率的多能源混合动力系统必须配备一个能量智能管理系统,才能达到合理分配功率的目的。为此,建立在前向推理结构模型的基础上,提出了一种能量管理系统的模糊预测控制策略。它主要由电池荷电状态预测控制器、充电控制器和功率分配控制器组成。仿真结果表明:与简单分配控制策略(查表法)相比,采用模糊预测控制策略的混合电动汽车在续驶里程、燃油经济性和整车效率等方面均有较大提高。下一步将采用快速控制原型dSPAcE系统完成该模糊预测控制的实车实现。

关键词：模糊逻辑控制策略锌空气电池镍氢电池超级电容

桐柏-红安造山带的构造演化：从大洋俯冲／增生到陆陆碰撞

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中国科学：地球科学 2015年第9期45卷 1088-1108页

作者：刘晓春李三忠江博明中国地质科学院地质力学研究所、国土资源部古地磁与古构造重建重点实验室北京100081 中国海洋大学海洋地球科学学院青岛266100 台湾大学地质科学系中国台北106

桐柏-红安造山带位于秦岭与大别-苏鲁造山带之间，因其完好地保存了古生代增生造山体系和古生代末坤生代碰撞造山体系而成为了解华北-华南陆块之间构造演化的关键地区．近20年来的可利用研究资料表明，桐柏-红安造山带显生宙的总体构造... 详细信息

桐柏-红安造山带位于秦岭与大别-苏鲁造山带之间，因其完好地保存了古生代增生造山体系和古生代末坤生代碰撞造山体系而成为了解华北-华南陆块之间构造演化的关键地区．近20年来的可利用研究资料表明，桐柏-红安造山带显生宙的总体构造演化框架包括以下4个主要阶段：（1）早古生代（490—420ma）大洋俯冲、岛弧增生与弧陆碰撞，从而于早古生代末在华北陆块南缘形成一个新的安第斯型大陆边缘；（2）晚古生代（340～310ma）大洋俯冲与增生，进而在商丹-松扒断裂南侧形成变质时代相同，但变质作用类型不同的“双变质带”，即被分割的武关．龟山中级变质杂岩带和熊店高压榴辉岩带；（3）晚古生代末-早中生代（255～200ma）大陆俯冲与陆陆碰撞，通过华南大陆岩板东深西浅的俯冲和多层次拆离／折返形成桐柏高压变质地体和红安高压／超高压变质地体；（4）晚中生代（140～120ma）伸展、大规模岩浆侵位与构造挤出，造成桐柏-红安-大别高压／超高压变质地体最终出露地表及东宽西窄的构造格局．然而，对每一构造演化阶段的具体细节以及早期地质历史的认识方面还存在着诸多争议和（或）难以解释的问题．未来的研究除在桐柏．红安造山带继续开展深入细致的工作外，还需与西部“软碰撞”的秦岭造山带和东部“硬碰撞”的大别．苏鲁造山带的研究紧密结合，以期建立适合于整个秦岭．桐柏．红安-大别-苏鲁造山带从古生代到中生代的经典构造演化模型．

关键词：大洋俯冲增生大陆俯冲碰撞桐柏-红安造山带

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六、美国和缅甸:合作对付毒品的威胁

南洋资料译丛 1976年第3期 40-41页

作者： m.c.滕舟

毒品的生产和走私仍然是美国和缅甸两国面临的一个严重问题。臭名昭著的“金三角”位于缅甸、老挝和泰国边境的交界处,系种植鸦片的山区,面积有六万平方英里。因为“金三角”也有一部分在缅甸境内,所以鸦片和诸如玛啡、海洛因等衍生物... 详细信息

毒品的生产和走私仍然是美国和缅甸两国面临的一个严重问题。臭名昭著的“金三角”位于缅甸、老挝和泰国边境的交界处,系种植鸦片的山区,面积有六万平方英里。因为“金三角”也有一部分在缅甸境内,所以鸦片和诸如玛啡、海洛因等衍生物就从“金三角”经过缅甸运往其它目的地—一主要是美国。缅甸一直在采取强有力的措施,禁止种植鸦片并截捕出入该国的鸦片和海洛因的走私者。为了帮助缅甸进行这项工作,美国已经提供了两架直升飞机,并且答应再给十架。其中有一架直升飞机参加了最近对靠近泰缅边界的城镇孟萨的一家海洛因制造厂的成功的袭击,有两百个叛军在这家工厂里从事海洛因的制作。

关键词：缅甸出口进口美利坚合众国北美洲美国缅元

Advanced Pull Test to Determine Adhesion Properties of Thin Surfaces for Pavement

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Advanced Pull Test to Determine Adhesion Properties of Thin ...