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Biomedical and Environmental Sciences 1992年第4期5卷 293-302页

作者： LOUISW.cHANG c.m.yang c.F.cHEN J.F.DENG Departments of Pathology Pharmacology and Toxicology University ora rkansas for Medical Sciences Little RockThe Chang-Gung Medical College Kwai-sanNational Research Institute of Chinese MedicineThe Veteran's General Hospital-Taipei AR 72205TaipeiTaipeiTaipei Taiwan China

Young male rats were orally intubated with podophyllotoxin: Group I, control animals, orally fed with vehicle only; Group Ⅱ, fed with an initial dose of 5 ***-1 b.w., followed by a daily dose of 1.67 mg-kg-1 b.w. for 7d. Group III, fed with an initial dose of 15 ***-1 b.w., followed by a daily dose of 5 ***-1 b.w. for 7d. All animals were sacrificed 72 h after the last dosing.Histopathological examination revealed dose-related fatty change of the liver, atrophy andi degenerative changes of the intestinal epithelial linings and testicular seminiferous tubules. Depletion of the pancreatic acinar cell granules was also apparent in the Group III animals. No pathology, however, was observed in the kidneys. The present study demonstrated for the first time degenerative changes in the liver, intestine, testis, and pancreas of animals ingested podophyllotoxin. These pathological changes correlate well with the clinical signs/symptoms of abnormal liver function, abdominal pain and diarrhea, and reduced serum amylase in humans poisonded by podophyllum. Inhibition of protein synthesis and mitosis (disruption of microtubules) are believed to be the underlying mechanisms of these changes observed in the animals intoxicated by. podophyllotoxin.

关键词： Bajiaolian Effects on the Liver Experimental Podophyllotoxin Kidney Poisoning

Experimental Podophyllotoxin (Bajiaolian) Poisoning:——Ⅰ. Effects on the Nervous System

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Biomedical and Environmental Sciences 1992年第4期5卷 283-292页

作者： LOUIS W.cHANG c.m.yang c.F.cHEN J.F.DENG Departments of Pathology Pharmacology and Toxicology University of Arkansas for Medical Sciences Little RockThe Chang-Gung Medical College Kwai-sanNational Research Institute of Chinese MedicineThe Veteran General Hospital AR 72205TaipeiTaipeiTaipei Taiwan China

Bajiaolian, one of the species in the mayapple family ( Podophyllum pelatum ), has been widely used as a traditional chinese herbal medicine for the remedies of snake bites, general weakness, poisons, condyloma accuminata, lymphadenopathy, and certain tumors in china. In Western medicine, Podophyllum was first used medically as a laxative in the early 19th century. Since 1940, the resin of podophyllum has also been used topically for various skin lesions, such as warts and condyloma. Human poisonings have been reported.An animal model was established to investigate the neurotoxic effects of Bajiaolian. Podophyllotoxin, the major active ingredient in Podophyllum, was injected (ip) to young adult male rats at doses of 0, 5, 10, or 15 mg-kg-1 b.w.. The animals were sacrificed 72 h after injection.Neuronal changes were readily observable in animals treated with 10 or 15 mg-kg-1 of the toxin. Edematous changes of the anterior horn motoneurons were observed in the spinal cord. No neuronal necrosis was found. The type of neuronal swelling is believed to be only a transient change and would probably subside with time if no further assaults occur. more serious and perhaps longer term of changes were found in the dorsal ganglion neurons and the nerve fibers (axons) in the central and peripheral nervous system. Severe depletion of the Nissl substance (RNA/polyribosomes) was observed in the dorsal root ganglion neurons. Alterations in these sensory neurons would give rise to and correlate with the sensory disturbances experienced by the patients. Bodian staining also revealed a dose-related increase in the coarseness (thickness) of the nerve fibers (axons) in the cerebellum, cerebral cortex, brainstem, and spinal cord.This is the first scientific study showing the neurotoxicity of Bajiaolian, a commonly used chinese herbal medicine. Toxicities on other organ systems by this drug certainly exist. caution should be exercised in the dispensing and usa

关键词： Bajiaolian Effects on the Nervous System Experimental Podophyllotoxin Poisoning

甲状旁腺素(PTH)对氯化钾引起大白鼠输精管收缩的舒张作用<英文>

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暨南大学学报(自然科学与医学版) 1985年第2期 64-70页

作者：张纫华 may c.m.yang Peter K.T.Pang 暨南大学医学院生理学教研室美国得克萨斯州理工大学医学院药理学室美国得克萨斯州理工大学医学院药理学室

本研究探讨甲状旁腺素(PTH)对输精管平滑肌的舒张作用及其机制。不同剂量的氯化钾(20、40、60mm)引起大白鼠输精管的收缩,同样可被牛型—PTH(1—34)或人型—PTH(1—34)所舒张,而且均呈现剂量的依从关系。异丙肾上腺素舒张输精管的作用... 详细信息

本研究探讨甲状旁腺素(PTH)对输精管平滑肌的舒张作用及其机制。不同剂量的氯化钾(20、40、60mm)引起大白鼠输精管的收缩,同样可被牛型—PTH(1—34)或人型—PTH(1—34)所舒张,而且均呈现剂量的依从关系。异丙肾上腺素舒张输精管的作用可被心得安所阻滞,但心得安或酚妥拉明均不抑制甲状旁腺素舒张输精管的作用,提示甲状旁腺素和异丙肾上腺素对输精管的舒张作用是通过不同的受体实现的。不同剂量的氯化钙引起输精管不同张力强度的收缩,甲状旁腺素对这种外源性钙引起的收缩呈现明显的抑制作用,说明甲状旁腺素有减少钙离子进入平滑肌组织的作用。

关键词：甲状旁腺激素输精管 β-肾上腺素能阻滞剂钙依赖性收缩

THE PRELImINARY STUDY ON THE EFFEcTOF OXYGEN DIFFUSION ON THE FUNcTIONOF PLATELETS STORED IN BLOOD BAGS

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chinese Journal of Biomedical Engineering(English Edition) 1993年第3期2卷 106-106页

作者： J.X.Liu X.J.Wu c.m.yang Institute of Blood Transfusion,chinese Academy of medcal and Sciences ,chengdu 610081,Sichuan,china

In this paper,from the oxygen diffusion point of view we study the effect of thepolyvinyl chloride （PVc） blood bags plasticized by several different plasticizers onthe function of platelets stored in *** by Archer’s modifieative method,the diffusion oxygen capacities are 4,17 （PVG-DNUP,diffusion area 92cm2,as be-low）,3.51 （PVc-AEHTc）,2.78 （PVc-DEHP） and 2.01 （PVc-TEHTm） μmoleO2/*** coplasticized bags,we find that their diffusion oxygen capacities are e-

关键词： DEHP stored 下石 aggregation harmful

Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy chemistry 2025年第1期100卷 50-58页

作者： Gaozhan Liu Jing Zhang Jing yang Jinghui chen Xingyue Xiao Xiayin Yao Ningbo Institute of materials Technology and Engineering Chinese Academy of Sciences center of materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

Lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,Li5.4PS4.4cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin Li5.4PS4.4cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form LiI at the lithium/electrolyte interface and improve the critical current density of Li5.4PS4.4cl1.6from 0.8 to 1.35 mA *** resultant LicoO2/Li5.4PS4.4cl1.4I0.2/Li battery shows excellent cycling stability at 1 c,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled LicoO2/Li5.4PS4.4cl1.4I0.2membrane/Li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

magneto‑Dielectric Synergy and multiscale Hierarchical Structure Design Enable Flexible multipurpose microwave Absorption and Infrared Stealth compatibility

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Nano-micro Letters 2025年第2期17卷 401-416页

作者： chen Li Leilei Liang Baoshan Zhang Yi yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China college of materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled mXene IR shielding layer and flexible Fe_(3)O_(4)@c/PDmS microwave absorption *** top wrinkled mXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@c/PDmS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： microwave absorption Radar-infrared compatible stealth Wrinkled mXene magneto-dielectric synergy multifunction

Janus mXene film with gradient structure for highly efficient terahertz and infrared electromagnetic absorption

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Nano Research 2025年第1期18卷 434-442页

作者： Shaodian yang Weiqiang Huang Zhiqiang Lin Zibo chen Rongliang yang Yi Jia Xuebin Liu Rui Wang Zhiping Zeng Yougen Hu Huanjun chen Xuchun Gui11 State Key Laboratory of Optoelectronic materials and Technologies School of Electronics and Information TechnologySun Yat-sen UniversityGuangzhou 510275China National Key Laboratory of materials for Integrated circuits Shenzhen Institute of Advanced Electronic MaterialsShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China china Academy of Aerospace Science and Innovation Beijing 100176China Guangdong Province Key Laboratory of Display material and Technology Guangzhou 510275China School of materials Science and Engineering Sun Yat-sen UniversityGuangzhou 510275China

Electromagnetic interference (EmI) shielding inhigh-frequency range, especially the rapidly growing terahertz(THz) frequency range, attracts increasing attention due tothe potential application of terahertz in 6G wirelesscommunication, and security inspection. However, traditionalconductive EmI films typically achieve high shieldingeffectiveness through strong reflection, which may causesecondary pollution to other devices. Here, a gradientstructure strategy was proposed to constructTi_(3)c_(2)Tx/hydroxypropyl methyl cellulose (HPmc) film, in whichthe content of Ti_(3)c_(2)Tx gradually increases along the thicknessdirection, resulting in different conductivity of the two surfaces(surface-m and surface-H) for the film. The obtained gradientfilmexhibits an EmI shielding efficiency of over 48.5 dB in theTHz range (0.2-1.6 THz) at a thickness of 40 μm. Especially,as the THz waves incident from the surface-H to the film, the absorption effectiveness reaches 48.2 dB (average absorbedpower loss up to 91.4%), and the reflection effectiveness is only 0.3 dB. In additions, the gradient-film also demonstrates ahigh absorption rate of 95.5% in the infrared band (2.5-16.7 μm). moreover, the gradient-film exhibits an excellent tensilestress and Young’s modulus value of 173.1 mPa and 2.8 GPa, respectively. Therefore, the gradient-film proposed in thiswork, with excellent electromagnetic absorption in both THz and infrared band, provides a promising candidate for the nextgenerationEmI shielding applications.

关键词： electromagnetic interference shielding Janus film terahertz mXene

crack Initiation mechanism of Z3cN20.09m Duplex Stainless Steel during corrosion Fatigue in Water and Air at 290 °c

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Journal of materials Science & Technology 2015年第11期31卷 1144-1150页

作者： H.c.Wu B.yang Y.Z.Shi Q.Gao Y.Q.Wang State Key Laboratory for Advanced metals and materials University of Science and Technology Beijing collaborative Innovation center of Universal Iron & Steel Technology School of materials Science and Engineering Anhui University of Technology

The crack initiation mechanism of a Z3cN20.09m duplex stainless steel （DSS） during corrosion fatigue （cF） in water and air at 290 ℃ was investigated by using a cF cracking machine and a scanning electron microscopy （SEm）. The cracks were initiated successively at the persistent stip bands （PSBs）, phase boundaries （PBs） and pitting corrosion points （PcPs） of the specimens when they were tested in water at 290 ℃, while in airat 290 ℃ the cracks were only initiated at the PSBs and PBs. And the cracks were found mainly to initiate at the PSBs and PBs when the specimens were tested in water and air at 290 ℃, respectively. The results also reveal that the cracks were likely to be initiated at the first 20% of fatigue life of the specimens tested in water at 290 ℃. However, the cracks were not found until 50% of fatigue life when tested in air at 290 ℃. moreover, the crack numbers of the specimens tested in water at 290 ℃ were much more than those tested in air at 290 ℃.

关键词： Duplex stainless steel corrosion fatigue crack initiation High temperature water

Serological surveillance for SARS-coV-2 antibodies among students,faculty and staff within a large university system during the pandemic

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World Journal of Virology 2025年第1期14卷 99-107页

作者： marcos G Pinheiro Gabriela G O Alves maria Eduarda R conde Sofia L costa Regina c S Sant’Anna Isa m F Antunes mônica c carneiro Fabio S Ronzei Julia c Scaffo Felipe R Pinheiro Lialyz S Andre Helvecio c Povoa Valéria T Baltar Fabíola Giordani Eduarda S Hemerly Gisele c Alexandre Karla c de Paula márcio Watanabe Antonio claudio L da Nóbrega Jackeline christiane P Lobato Fabio Aguiar-Alves Laboratory of molecular Epidemiology and Biotechnology Rodolpho Albino University LaboratoryFluminense Federal UniversityNiterói 24241000Rio de JaneiroBrazil Estácio de SáUniversity Nova Friburgo 28611135Rio de JaneiroBrazil Pathology Program Medicine schoolFluminense Federal UniversityNiterói 24070090Rio de JaneiroBrazil Department of Pharmaceutical Sciences Lloyd L.Gregory School of PharmacyPalm Beach Atlantic UniversityWest Palm BeachFL 33401United States Health Institute of Nova Friburgo Fluminense Federal UniversityNova Friburgo 28613001Rio de JaneiroBrazil Department of Epidemiology and Biostatistics Institute of Collective Health(ISC)Fluminense Federal UniversityNiterói 24033900Rio de JaneiroBrazil Institute of Physical Education Fluminense Federal UniversityNiterói 24020005Rio de JaneiroBrazil Department of Statistics Fluminense Federal UniversityNiterói 24210200Rio de JaneiroBrazil Department of Physiology and Pharmacology Fluminense Federal UniversityNiterói 24210130Rio de JaneiroBrazil

BAcKGROUND At the end of December 2019,the world faced severe acute respiratory syndrome-coronavirus 2(SARS-coV-2),which led to the outbreak of coronavirus disease 2019(cOVID-19),associated with respiratory *** virus has shown significant challenges,especially for senior citizens,patients with other underlying illnesses,or those with a sedentary *** tests conducted early on have helped identify how the virus is transmitted and how to curb its *** study hypothesis was that the rapid serological test for SARS-coV-2 antibodies could indicate the immunoreactive profile during the cOVID-19 pandemic in a university *** To conduct active surveillance for serological expression of anti-SARS-coV-2 antibodies in individuals within a university setting during the cOVID-19 *** This sectional study by convenience sampling was conducted in a large university in Niteroi-RJ,Brazil,from march 2021 to July *** study population consisted of students,faculty,and administrative staff employed by the university.A total of 3433 faculty members,60703 students,and 3812 administrative staff were invited to *** were gathered through rapid serological tests to detect immunoglobulin(Ig)m and IgG against ***χ²or Fisher's exact test was used to conduct statistical analysis.A 0.20 significance level was adopted for variable selection in a multiple logistic regression model to evaluate *** A total of 1648 individuals were enrolled in the *** proportion of cOVID-19 positivity was 164/1648(9.8%).The adjusted logistic model indicate a positive association between the expression of Igm or IgG and age[odds ratio(OR)=1.16,95%cI:1.02-1.31](Pcontact with a cOVID-19-positive case(OR=3.49,95%cI:2.34-5.37)(Pceived the cOVID-19 vaccine(OR=2.33,95%cI:1.61-3.35)(Pcial isolation(OR=0.59,95%cI:0.41-0.84)(P<0.004).The likelihood of sho

关键词： Serological surveillance SARS-coV-2 antibodies cOVID-19 Serological rapid test Risk factors for cOVID-19

Ripening behavior of m_(23)c_6 carbides in P92 steel during aging at 800°c

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Journal of Iron and Steel Research International 2017年第8期24卷 858-864页

作者： Xu yang Bo Liao Fu-ren Xiao Wei Yan Yi-yin Shan Ke yang college of materials Science and Engineering Yanshan University Institute of metal Research Chinese Academy of Sciences

The rapid coarsening of the m_（23）c_6 carbides has been held responsible for the creep fracture in 9-12cr martensitic heat resistant steels.A commercial P92 steel was subjected to thermal aging at a high temperature of 800°c to investigate the ripening behavior of the m_（23）c_6 *** electron microscopy（SEm）and transmission electron microscopy（TEm）were employed to characterize the microstructure evolution,especially the ripening process of the m_（23）c_6 *** new concept of the effective mean size,dependent on the critical radius,was introduced to correct the measured mean size and then the Ostwald theory was applied to describe the ripening behavior of the m_（23）c_6 *** ripening of the m_（23）c_6 carbides was revealed to be grain boundary diffusion controlled.

关键词： P92steel m23c6 carbide Aging Ripening