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Exogenous testosterone therapy on choroid in androgen deficiency

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international Journal of Ophthalmology(English edition) 2024年第8期17卷 1489-1494页

作者： Volkan Yeter Nurullah Koçak merve Kalyoncu Ramazan Aşçi Nurşen Aritürk Department of Ophthalmology Ondokuz Mayıs UniversitySamsun 55139Turkey Department of Urology Ondokuz Mayıs UniversitySamsun 55139Turkey

Aim:To investigate the effects of exogenous testosterone treatment on the choroidal parameters in patients with androgen ***:Right eyes of 24 patients with androgen deficiency and 31 healthy volunteers were included in the *** eyes were scanned for subfoveal choroidal thickness(SFcT),choroidal vascularity index(cVi),choroidstromal area(c-SA),choroid-luminal area(c-LA),choroidstromal to luminal area ratio(cSLR),and the choroidal parameters within central 1500μm of the macula(cVi1500,c-LA1500,c-SA1500,and cSLR1500)by enhanced-depth imaging optical coherence tomography(EDi-OcT)at baseline,6th and 18th weeks of the exogenous testosterone ***:The mean SFcT values of the androgen deficient groups and healthy controls were 307.7±27.0 and 303.2±37.2μm(P=0.8).However,cVi,c-SA,cSLR,cVi1500,c-LA1500,and cSLR1500 were significantly different between the groups(all Pisit after exogenous testosterone treatment,SFcT,cVi,c-LA,and c-SA were significantly decreased,and these parameters returned to baseline levels at the 18th-week visit(all P>0.05).However,cVi1500 and LA1500 significantly increased at the end of the follow-up period(PcONcLUSiON:cVi is lower in androgen-deficient patients than in healthy *** alterations in the choroid during the testosterone peak are transient in the treatment of patients with androgen ***,the increase in cVi within the central 1500μm of the macula persists even after 4mo.

关键词： testosterone androgen deficiency choroid vascularity index

The ccD instrument background of the SmiLE SXi

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Earth and Planetary Physics 2024年第1期8卷 15-24页

作者： m.W.J.Hubbard O.Hetherington D.J.Hall T.W.Buggey S.Parsons T.Arnold A.Holland c.Pagani S.Sembay centre for Electronic imaging The Open UniversityMilton KeynesMK76AAUK X-ray and Observational Astronomy Group Department of Physics&AstronomyUniversity of LeicesterLE17RHUK

The ESA and cAS SmiLE mission orbit is highly elliptical and will pass through multiple radiation *** Soft X-ray imager(SXi)instrument aboard has a radiation shutter door designed to close when the surrounding radiation flux is *** shutter door will close when passing below an altitude threshold to protect against trapped particles in the Earth’s Van Allen ***,two radiation environments can be approximated based on the shutter door position:open and *** instrument background for the ccDs(charge-coupled Devices)that form the focal plane array of the SXi were evaluated for the two *** to the correlation of the space environment with the solar cycle,the solar minima and maxima,the background was also evaluated at these two *** results demonstrated that the highest instrument background will occur during solar minima due to the main contributing source being Galactic cosmic Rays(GcRs).it was also found that the open background was highest for solar minima and that the closed background was highest during solar *** is due to the radiation shutter door acting as a scattering centre and the changes in the energy flux distribution of the GcRs between the two solar extremes.

关键词： instrument background X-ray astronomy space radiation

comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

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Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： melissa A.Stephen chris R.Burke Jennie E.Pryce Nicole m.Steele Peter R.Amer Susanne meier claire V.c.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae centre for Genetics and Breeding-massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： cattle Gibbs sampler markov-chain monte carlo(mcmc) Puberty

Pair of dyon production near magnetized dyonic Reissner-Nordstrom black holes

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chinese Physics c 2024年第5期48卷 257-271页

作者： Haryanto m.Siahaan Jurusan Fisika Universitas Katolik ParahyanganJalan Ciumbuleuit 94Bandung 40141Indonesia

We investigate the phenomenon of pair production of massive scalar particles with magnetic charge near the horizon of a magnetized dyonic Reissner-Nordstrom black *** intrinsic symmetry between the electric and magnetic quantities in the Einstein-maxwell equations suggests that the pair can be generated through Hawking radiation and the Schwinger effect,provided that the Dirac quantization condition is satisfied.

关键词： Dyon pair production black hole

一种评估非接触水下爆炸对海军复合船体影响的设计方法

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哈尔滨工程大学学报（英文版） 2024年第2期23卷 316-326页

作者： F.mannacio F.Di marzo m.Gaiotti c.m.Rizzo m.Venturini italian Navy Naval Support and Experimentation CentreCSSN Viale S.Bartolomeo40019126 La Spezia(Italy) University of Genova Polytechnic SchoolDITEN Via Montallegro116145 Genova(Italy).

Despite the non-contact underwater explosion phenomena(UNDEX)have been studied for decades and several numerical methods have been proposed in literature,its effects on military structures,especially composite ones,are even nowadays matter of *** early design phases,it is not always possible to verify the shock resistance of hull structures modelling the whole phenomenon,in which fluid,gas and solid properties must be properly set in a fully coupled fluid-structure interaction(FSi)numerical *** ones are extremely complex to set,computationally demanding and certainly not suitable for everyday design *** this paper,a simplified finite element(FE)model,easy to use in an early design phase,is ***,the structure and the fluid are *** this approximation,the fluid behaviour is simplified,using special finite elements,available in a commercial software *** choice reduces the computational time and numerical efforts avoiding the problem of combining computational fluid dynamics(cFD)and FE domains and equations in a fully coupled fluid-structure interaction model.A typical parallel body block of a minesweeper is modelled,using two-dimensional multi-layered shell elements to properly account for the composite materials *** the fluid instead,three dimensional volumetric elements,directly coupled to the structural elements,are *** addition,the same calculation is performed,modelling separately fluid in the cFD environment and structures in the finite element ***,realizing a fully coupled fluid-structure interaction *** results obtained by applying both numerical models are compared with the structural response measured on board of a composite ship during a full-scale shock *** simplified proposed procedure provides results in satisfactory agreement with experiments,allowing the validation of the *** are discussed and differences with the real phenomenon and fully coupled cFD+

关键词： Underwater explosions Shock resistance composites Fluid-structure interaction Experimental analysis Numerical simulation Vulnerability Preliminary design

QcD sum rule study of J^(P)=1^(±)exotic states with two heavy quarks in the molecular picture

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chinese Physics c 2024年第6期48卷 31-37页

作者： T.m.Aliev S.Bilmis m.Savcı Department of Physics Middle East Technical UniversityAnkara06800Turkey TUBiTAK ULAKBim Ankara06510Turkey

in this study,the spectroscopic parameters of exotic molecular states composed of mesons containing two heavy quarks(scalar-axial and pseudoscalar-axial meson combinations)are investigated within the QcD sum *** findings reveal that molecular states containing charm quarks do not form bound states,whereas states with b-quarks can form exotic molecular *** observation has significant implications for understanding the structure of these exotic states.

关键词： QcD sum rules exotic mesons molecular states

Analysis of strong decays of SU(3)partners ofΩ(2012)baryon

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chinese Physics c 2024年第8期48卷 34-41页

作者： T.m.Aliev S.Bilmis m.Savci Department of Physics Middle East Technical UniversityAnkara 06800Turkey TUBiTAK ULAKBim Ankara 06510Turkey

We estimate the coupling constants and decay widths of the SU(3)partners of theΩ(2012)hyperon,as discovered by the BELLE collaboration,using the distribution amplitudes of the octet baryons within the light cone sum rules *** study includes a comparison of the obtained results for the relevant decay widths with those derived within the framework of the flavor SU(3)*** observe a good agreement between the predictions of both ***,our result on the decay width ofΩ→ΞK is compatible with the existing experimental result within the uncertainties of the model *** results can provide helpful insights for determining the nature of the SU(3)partners of theΩ(2012)baryon.

关键词： coupling constants light cone sum rule hyperon

Superior antibody and membrane protein‑specific T‑cell responses to coronaVac by intradermal versus intramuscular routes in adolescents

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World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel m.S.cheng carolyn A.cohen Daniel Leung Xiwei Wang Xiaofeng mu Yuet chung Tsun ming Lau manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo c.H.Tsang Sara chaothai Tsz chun Kwan John K.c.Li Karl c.K.chan Leo L.H.Luk Jenson c.H.Ho Wing Yan Li Amos m.T.Lee Jennifer H.Y.Lam Sau man chan Wilfred H.S.Wong issan Y.S.Tam masashi mori Sophie A.Valkenburg malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of microbiology and immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia center for immunology and infection c2i Hong KongChina

Background Optimising the immunogenicity of cOViD-19 vaccines to improve their protection against disease is *** dosing by intradermal(iD)administration has been shown to be equally immunogenic as intramuscular(im)administration for several vaccines,but the immunogenicity of iD inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-coV-2)at the full dose is *** study(NcT04800133)investigated the superiority of antibody and T-cell responses of full-dose coronaVac by iD over im administration in *** Participants aged 11–17 years received two doses of im or iD vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(im-cc versus iD-cc)and post-dose 3(imccc versus iD-ccc).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(igG),S-receptor-binding domain(RBD)igG,S igG Fcγreceptor iiia(FcγRiiia)-binding,SNm[sum of individual(S),nucleocapsid protein(N),and membrane protein(m)peptide pool]-specific interleukin-2(iL-2)+cD4^(+),SNm-specific iL-2^(+)cD8^(+),S-specific iL-2^(+)cD8^(+),N-specific iL-2^(+)cD4^(+),N-specific iL-2^(+)cD8^(+)and m-specific iL-2^(+)cD4^(+)responses fulfilled the superior and non-inferior criteria for iD-cc compared to im-cc,whereas igG avidity was *** iD-ccc,S-RBD igG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S igG avidity,S igG FcγRiiia-binding,m-specific iL-2^(+)cD4^(+),interferon-γ+cD8^(+)and iL-2^(+)cD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for im-cc,iD-cc,im-ccc and iD-ccc,*** iD groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and m-specific T-cell responses by iD inactivated SARScoV-2 vaccination and serves as the basis for future research to improve the

关键词： coronaVac coronavirus disease 2019 immunity intradermal Vaccine

One-neutron stripping process in the^(209)Bi(^(6)Li,^(5)Li)^(210)Bi*reaction reaction

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Nuclear Science and Techniques 2024年第6期35卷 120-129页

作者： Gao-Long Zhang Zhen-Wei Jiao Guang-Xin Zhang E.N.cardozo B.Paes Shi-Peng Hu Jian-Qiang Qian Daniele mengoni Wei-Wei Qu cong-Bo Li Yun Zheng Huan-Qiao Zhang Hui-Bin Sun Nan Wang chun-Lei Zhang J.J.Valiente-Dobón D.Testov m.mazzocco A.Gozzelino c.Parascandolo D.Pierroutsakou m.La commara A.Goasduff D.Bazzacco D.R.Napoli F.Galtarossa F.Recchia A.illana S.Bakes i.Zanon S.Aydin Gde Angelis m.Siciliano R.menegazzo S.m.Lenzi S.Akkoyun L.F.canto J.Lubian School of Physics Beihang UniversityBeijing 100191China Sino-French institute of Nuclear Engineering and Technology Sun Yat-Sen UniversityZhuhai 519082China instituto de Física Universidade Federal Fluminense24210-340 NiteróiRio de JaneiroBrazil Laboratorio TANDAR Comisión Nacional de Energía AtómicaBKNA1650 San MartíınArgentina institute for Advanced Study in Nuclear Energy and Safety Shenzhen UniversityShenzhen 518060China Shenzhen Key Laboratory of Research and manufacture of High Purity Germanium materials and Fetectors Shenzhen UniversityShenzhen 518060China iNFN Sezione di PadovaPaduaItaly Dipartimento di fisica Astronomia dell’Universita di padova PaduaItaly State Key Laboratory of Radiation medicine and Protection School of Radiation Medicine and ProtectionSoochow UniversitySuzhou 215123China china institute of Atomic Energy Beijing 102413China The Key Laboratory of Beam Technology and material modification of ministry of Education College of Nuclear Science and TechnologyBeijing Normal UniversityBeijing 100875China Laboratori Nazionali di Legnaro INFN35020 LegnaroItaly iNFN Sezione di Napoli80126 NaplesItaly Dipartimento di Farmacia Universitàdi Napoli“Federico II”80131 NaplesItaly Department of Natural and mathematical Sciences Faculty of EngineeringTarsus University33480 MersinTurkey Physics Division Argonne National LaboratoryLemontILUSA Department of Physics Sivas Cumhuriyet UniversitySivasTurkey instituto de Física Universidade Federal do Rio de JaneiroRio de Janeiro CP 6852821941-972Brazil

One-neutron stripping process between^(6)Li and^(209)Bi was studied at 28,30,and 34 meV using the in-beamγ-ray spectroscopy ***γ-γcoincident analysis clearly identified twoγ-rays feeding the ground and long-lived isomeric states,which were employed to determine the cross *** one-neutron stripping cross sections were similar to the cross sections of complete fusion in the^(6)Li+^(209)Bi system,but the one-neutron stripping cross sections decreased more gradually at the sub-barrier region.A coupled-reaction-channel calculation was performed to study the detailed reaction mechanism of the one-neutron stripping process in^(6)*** calculations indicated that the first excited state of 5 Li is critical in the actual one-neutron transfer mechanism,and the valence proton of 209Bi can be excited to the low-lying excited state in(^(6)Li,^(5)Li)reaction,unlike in the(d,p)reaction.

关键词： Transfer reaction Weakly bound nuclei cross section