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Zircon chemistry and new laser ablation U–Pb ages for uraniferous granitoids in SW cameroon

Acta Geochimica 2020年第1期39卷 43-66页

作者： V.F.Embui c.E.Suh J.m.cottle J.Etame J.mendes c.m.agyingi A.Vishiti E.m.Shemang B.Lehmann Department of Geology University of BueaP.O.Box 63BueaSouth West RegionCameroon Ore Treatment Laboratory Institute of Geological and Mining Research(IRGM)P.O.Box 4110YaoundeNlongkakCameroon Department of Geology Mining and Environmental ScienceUniversity of BamendaP.O.Box 39BambiliCameroon Department of Earth Sciences and Earth Research Institute Webb Hall 2028University of CaliforniaSanta BarbaraCA 93106-9630USA Laboratory of Geosciences Natural resources and Environment Department of Earth SciencesFaculty of ScienceUniversity of DoualaP.O.Box 24157DoualaCameroon Department of civil Engineering University Institute of TechnologyUniversity of DoualaP.O.Box 8698DoualaCameroon Departamento de Geologia IGEOUniversidade Federal do Rio de JaneiroCidade UniversitariaRio de Janeiro 21910-949Brazil Department of Earth and Environmental Sciences Botswana International University of Science and TechnologyPrivate Bag 16PalapyeBotswana mineral Resources Technical University of ClausthalClausihal-ZellerfeldGermany

The Ekomedion two-mica granite,southwestern cameroon,has potential for uranium and molybdenum ***,we present LA-IcP-mS U-Pb ages,Lu-Hf isotope characteristics,trace element concentrations and Ti-geothermometry of zircon from this granite hosting U-mo mineralization in pegmatitic *** majority of zircon are cL-dark though some cL-bright cores were also identified.U-Pb zircon age data range from 121±3 to743±11 ma with only 5 of 34 ages being near *** concordant mean age of 603±12 ma is similar to ages of granitic intrusions along the central African Shear Zone in *** ages with mean of261±6 ma reveal open system behavior with respect to Pb and/or *** e Hfi values range from-20.3 *** implies that U-mo was remobilized during partial melting of the surrounding *** Th/U>0.1 as well as an increasing Hf with decreasing Th/U indicates that fractional crystallization was the main factor that controlled U-mo mineralization in pegmatitic pods.Y and Y/Ho ratios cluster from 29 to 33 close to the chondritic ratio of 28 and indicate fractionation of Y and Ho with low F contents during the earliest stages of *** stage accumulation of F-rich magmatic-hydrothermal fluids impacted U-mo mineralization as a *** contains a prominent negative Eu anomaly pointing to a fractionating system rich in *** Ti-in-zircon temperatures span 672℃to1232℃with the temperatures at the high end reflecting interference from mineral inclusions in the zircon grains while the lower temperature values are linked to crystallization.

关键词： Zircons Uranium-molybdenum cameroon

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Bulk petroleum geochemistry of shales from the onshore Rio del Rey Basin,cameroon

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Energy Geoscience 2022年第2期3卷 111-119页

作者： christopher m.agyingi Noel c.Tangko Emmanuel Eseme Department of Geology University of BueaCameroon P.O.Box 63BueaCameroon Activation Laboratories Ltd AncasterONCanada

Petroleum production in the Rio del Rey Basin,which is an extension of the Niger Delta of Nigeria into cameroon,has been limited to the Tertiary offshore portion since the late *** to dedlining reserves in this offshore portion,the onshore cretaceous portion of the basin attracted significant attention in the last *** the present *** from outcrops in the onshore portion of the basin were analyzed to evaluate their potential as source rocks,assess hydrocarbon generation,and highlight their signifcance for *** observations,total organic carbon(TOc)measure-ments,and Rock Eval pyrolysis were used to generate data for these ***-eval S2 values(0.42-3 mg Hc/g rock)based on measured present-day TOc values(0.58-2.44 wtx)of the shales studied signify poor to fair source rock potentials,whereas calculated S2 values(1.74-8.19 mg Hc/g rock)based on estimated original TOc values(0.67-2.87 wt%)produced fair to good source rocks containing Type Ⅱ/Ⅲ kerogen,which were transformed by maturity to the present-day Type Ⅲ/Ⅳ *** of the samples based on Tmax values varying between 439 and 471℃are equivalent to maturity values ranging between 0.74% R_(r) and 1.32% R_(r), and these represent the peak oil to condensate/wet gas zones of hy-drocarbon *** results demonstrate that mature source rocks are present in the onshore part of the Rio del Rey Basin,and thus,it is suitable for petroleum exploration.

关键词： Shale Rio del Rey Basin Total organic carbon Rock-eval Petroleum geochemistry cameroon

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

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Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EmBASE,Ovid mEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

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Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

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multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

multiple sclerosis(mS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with mS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo centro de Biología molecular Severo Ochoa(cBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

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Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

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Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(cNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

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SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KcD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (Gc) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in Gc progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KcD kinases. KATOIII and SNU-5 Gc cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KcD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (Ic) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KcD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KcD kinases for treating Gc and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (Gc) JAK2 molecular docking molecular dynamics simulation PI3KcD SBL-JP-0004

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