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High Power Laser Science and Engineering 2019年第2期7卷 34-39页

作者： L.Volpe R.Fedosejevs G.Gatti J.A.Pérez-Hernández c.méndez J.Apinaniz X.Vaisseau c.Salgado m.Huault S.malko G.Zeraouli V.Ospina A.Longman D.De Luis K.Li O.Varela E.García I.Hernandez J.D.Pisonero J.Garcia Ajates J.m.Alvarez c.García m.Rico D.Arana J.Hernandez-Toro L.Roso centro de Laseres Pulsados(cLPU) Edicio M5.Parque Cientco.C/Adaja&37185VillamayorSalamancaSpain Laser-Plasma chair at the University of Salamanca SalamancaSpain Department of Electrical and c.mputer Engineering University of AlbertaEdmontonAlberta T6G2V4Canada University of Salamanca SalamancaSpain

The centro de Laseres Pulsados in Salamanca,Spain has recently started operation phase and the first user access period on the 6 J 30 fs 200 TW system(VEGA 2)already started at the beginning of *** this paper we report on two c.mmissioning experiments recently performed on the VEGA 2 system in preparation for the user *** 2 system has been tested in different configurations depending on the focusing optics and targets *** configuration(long focal length F=130 cm)is for underdense laser-matter interaction where VEGA 2 is focused onto a low density gas-jet generating electron beams(via laser wake field acceleration mechanism)with maximum energy up to 500 meV and an X-ray betatron source with a 10 keV critical energy.A second configuration(short focal length F= 40 cm)is for overdense laser-matter interaction where VEGA 2 is focused onto a 5 μm thick Al target generating a proton beam with a maximum energy of 10 meV and temperature of 2.5 *** this paper we present preliminary experimental results.

关键词： high power laser laser-plasma particle acceleration

class c G protein-coupled receptors: reviving old couples with new partners

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Biophysics Reports 2017年第Z2期 57-63页

作者： Thor c.m?ller David moreno-Delgado Jean-Philippe Pin Julie Kniazeff Institut de Génomique Fonctionnelle (IGF) CNRSINSERMUniv. Montpellier

G protein-coupled receptors(GPcRs) are key players in cell c.mmunication and are encoded by the largest family in our genome. As such, GPcRs represent the main targets in drug development programs. Sequence analysis revealed several classes of GPcRs: the class A rhodopsin-like receptors represent the majority, the class B includes the secretin-like and adhesion GPcRs, the class F includes the frizzled receptors, and the class c includes receptors for the main neurotransmitters, glutamate and GABA, and those for sweet and umami taste and calcium receptors. class c receptors are far more c.mplex than other GPcRs, being mandatory dimers, with each subunit being c.mposed of several domains. In this review, we summarize our actual knowledge regarding the activation mechanism and subunit organization of class c GPcRs, and how this brings information for many other GPcRs.

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Role of hyperfine mixing in b→c semileptonic decays of doubly-heavy baryons

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chinese Physics c 2010年第9期34卷 1488-1490页

作者： c.Albertus E.Hernández J.Nieves Departamento de Física Fundamental e IUFFym Universidad de Salamanca Instituto de Física corpuscular (IFIc) Centro Mixto CSIC-Universidad de ValenciaInstitutos de Investigación de Paterna

We analyze the effects of hyperfine mixing in b → c semileptonic decays of doubly heavy *** qualitatively confirm the results by *** and *** in ***.A,2009,24： 2401– 2413,finding that mixing has a great impact on those ***,predictions without mixing differ by a factor of 2 and this discrepancy translates to the mixed case where large differences in decay widths are observed between the two calculations.

关键词： doubly-heavy baryons semileptonic decay hyperfine mixing

Expert perspectives on GIS use in Spanish geographic education

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International Journal of Digital Earth 2022年第1期15卷 1204-1218页

作者： I.J.Buzo-Sánchez c.mínguez m.L.De Lázaro-Torres IES San Roque BadajozSpain Geography Department Universidad Complutense de MadridMadridSpain Geography Department UNEDMadridSpain

The emergence of new technological tools for territorial analysis,such as cloud-based GIS,or GIS viewers,c.mpels us to closely examine its usefulness in geographic education. Specifically,it raises the professors and teachers’ questions: what to teach? how to teach? and what will students learn? This research responds to these three questions by interviewing Spanish experts who know how to use these tools to teach geography at university and secondary school levels. The Delphi technique was applied to achieve this,which established consensus and led to the following results from experts’ own experience: (1) that GIS help to understand territory in an experiential and non-memoristic way and (2) they enable the development of spatial thinking. This paper concludes that changes in methodologies and integrate technical knowledge into teacher training are needed.

关键词： Geography Delphi GIS c.mpetencies spatial thinking

Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage bec.mes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic.molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a c.mprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Robotic pancreaticoduodenectomy after the learning curve-a new hope

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Hepatobiliary Surgery and Nutrition 2022年第3期11卷 489-491页

作者： Philip c.müller Beat P.müller-Stich Thilo Hackert Felix Nickel Swiss HPB and Transplantation center Department of Surgery and TransplantationUniversity Hospital ZurichZurichSwitzerland Department of General Visceral and Transplantation SurgeryHeidelberg University HospitalHeidelbergGermany

First,we would like to congratulate Liu et *** their successful multicenter study including 1,032 patients undergoing robotic pancreaticoduodenectomy(RPD)and 1,154 open pancreaticoduodenectomy(OPD)in seven high volume centers in china over an 8 year period(1).To ensure the best possible outc.mes of both techniques,RPD was performed by five surgeons from three centers after overc.ming the individual learning curve that was defined as having performed>40 *** the other hand,OPD was performed by 9 surgeons from 6 centers after reaching the individual learning curve,defined as an experience of>60 OPD.

关键词： centers learning after

Insulin resistance and adipose tissue interactions as the cornerstone of metabolic(dysfunction)-associated fatty liver disease pathogenesis

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World Journal of Gastroenterology 2023年第25期29卷 3999-4008页

作者： Shreya c Pal Nahum méndez-Sánchez Faculty of medicine National Autonomous University of MexicoMexico City 04510Mexico Liver Research Unit Medica Sur Clinic&FoundationMexico City 04510Mexico

The relationship between metabolic derangements and fatty liver development are undeniable,since more than 75% of patients with type 2 diabetes mellitus present with fatty *** is also significant epidemiological association between insulin resistance(IR)and metabolic(dysfunction)-associated fatty liver disease(mAFLD).For little more than 2 years,the nomenclature of fatty liver of non-alcoholic origin has been intended to change to mAFLD by multiple *** a myriad of reasons for which mAFLD is thought to be of metabolic origin could be exposed,the bottom line relies on the role of IR as an initiator and perpetuator of this *** is a reciprocal role in mAFLD development and IR as well as serum glucose concentrations,where increased circulating glucose and insulin result in increased de novo lipogenesis by sterol regulatory elementbinding protein-1c induced lipogenic enzyme stimulation;therefore,increased endogenous production of *** same effect is achieved through impaired suppression of adipose tissue(AT)lipolysis in insulin-resistant states,increasing fatty acid influx into the *** c.mplementary reciprocal situation occurs when liver steatosis alters hepatokine secretion,modifying fatty acid metabolism as well as IR in a variety of tissues,including skeletal muscle,AT,and the *** aim of this review is to discuss the importance of IR and AT interactions in metabolic altered states as perhaps the most important factor in mAFLD pathogenesis.

关键词： metabolic(dysfunction)-associated fatty liver disease Insulin resistance Adipose tissue Fatty liver metabolic syndrome Adipokine

The inception of a Paleotethyan magmatic arc in Iberia

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Geoscience Frontiers 2015年第2期6卷 297-306页

作者： m.F.Pereira A.castro c.Fernández IDL Departamento de Geociências ECT Universidade de évora Departamento de Geología Universidad de Huelva Departamento de Geodinámica y Paleontología Universidad de Huelva

This paper presents a c.mpilation of recent U-Pb （zircon） ages of late carboniferous-early Permian （Lc EP） calc-alkaline batholiths from lberia, together with a petrogenetic interpretation of magma generation based on c.mparisons with mesozoic and Tertiary cordilleran batholiths and experimental melts. Zircon U-Pb ages distributed over the range ca. 315-280 ma, indicate a linkage between calc-alkaline magmatism, Iberian orocline generation and Paleotethys subduction. It is also shown that Iberian Lc-EP calcalkaline batholiths present unequivocal subduction-related features c.mparable with typical cordilleran batholiths of the Pacific Americas active margin, although geochemical features were partially obscured by local modifications of magmas at the level of emplac.ment by country rock assimilation. When and how Lc-EP calc-alkaline batholiths formed in Iberia is then discussed, and a new and somewhat controversial interpretation for their sources and tectonic setting （plume-assisted relamination） is suggested. The batholiths are proposed to have formed during the subduction of the Paleotethys oceanic plate （Pangaea self-subduction） and, consequently, they are unrelated to Variscan collision. The origin of the Iberian batholiths is related to the Eurasian active margin and probably represents the inception of a Paleotethvan arc in the core of Pangaea.

关键词： Permo-carboniferous calc-alkaline arc-related batholiths Pangaea Paleotethys subduction Variscan and c.mmerian cycles

Strongly enhanced quadrupole deformation in a class of N≈Z nuclei driven by large-scale clustering?

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chinese Physics c 2021年第6期45卷 121-127页

作者： P.Petkov c.muller-Gatermann "Horia Hulubei"National Institute for Physics and Nuclear Engineering R-76900 Bucharest-magurele Romania Argonne National Laboratory 9700 S.Cass Avenue LemontIl 60439USA

The formation of large size clusters,and/or their relative motion as a possible excitation mode,are suggested to be closely related to the origin of deformation in specific cases,namely the case of two doubly-magic clusters or two clusters with nearby *** lifetime data in N=Z^(76)Sr and^(80)Zr leading to large B(E2)values are reproduced consistently and well within this approach,along with data for a few neighboring N≈*** results are c.mpared to previous studies of^(32)S and^(20)Ne and all of them support the ideas of the large-scale cluster approach.

关键词： quadrupole collectivity clustering in nuclei nuclear structure absolute transition probabilities

Heart failure in the elderly

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Journal of Geriatric cardiology 2021年第3期18卷 219-232页

作者： Pablo Díez-Villanueva césar Jiménez-méndez Fernando Alfonso cardiology Department Hospital Universitario La PrincesaUniversidad Autónoma de MadridCIBER-CVMadridSpain

Heart failure(HF)is a clinical syndrome caused by structural and/or functional cardiac abnormalities,resulting in a reduced cardiac output and/or elevated intracardiac filling pressures at rest or during *** is a major public health problem with high prevalence and incidence,involving both high morbidity and mortality,but also high economic *** incidence of HF progressively increases with age,reaching around 20%among people over 75 years ***,HF represents the leading cause of hospitalization in patients older than 65 years in Western ***,some authors even consider HF a geriatric syndrome,entailing worse prognosis and high residual disability,and often associating some c.mplex c.morbidities,c.mmon in older population,that may further c.mplicate the course of the *** the other hand,however,clinical course and prognosis may be often difficult to *** this article,main pathophysiological issues related to the aging heart are addressed,together with key aspects related to both diagnosis and prognosis in elderly patients with ***,main geriatric conditions,c.mmon in the elderly population,are reviewed,highlighting the importance of a c.mprehensive and multidisciplinary approach.

关键词： diagnosis elevated mortality