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A novel non-invasive model to predict high-risk varices in cirrhotic patients

Hepatobiliary Surgery and Nutrition 2024年第3期13卷 530-532页

作者： Kelvin K.c.Ng Department of Surgery The Chinese University of Hong Kong Medical CentreHong KongChina

Acute variceal bleeding is one of the most common and potentially life-threatening complications in patients with liver *** is conventionally diagnosed by oesophagogastroduodenoscopy,which is invasive to patients and carries hospital *** would be more cost-effective if non-invasive tests could screen out high-risk patients who developed acute variceal bleeding requiring endoscopic *** can potentially reduce the need for invasive procedures for cirrhotic *** recent years,there have been advancements in non-invasive methods for assessing the risk of variceal *** include transient elastography(FibroScan)of the liver and spleen,platelet count,imaging modalities[ultrasound or magnetic resonance imaging(MRI)],and non-invasive liver function tests[child-Pugh score or the Model for End-Stage Liver Disease(MELD)score].The 2015 Baveno VI consensus is developed by an international panel of experts to improve the diagnosis and management of portal hypertension and its complications,specifically focusing on variceal bleeding in patients with cirrhosis(1).The consensus emphasizes using noninvasive methods to screen out high-risk varices(HRV)requiring therapeutic *** key features of the Baveno VI criteria include a liver stiffness measurement(LSM)count>150,000/*** can confidently rule out *** has been proven to avoid unnecessary endoscopy up to 40%with a specificity of up to 46%(2).In recent years,spleen stiffness measurement(SSM)has been a useful tool to assess portal hypertension and to predict ***,the revised Baveno VII consensus in 2022 recommends SSM≤40 kPa would avoid more unnecessary endoscopy in patients who fall outside Baveno VI criteria,with a missed HRV rate of<5%(3).

关键词： Non-invasive model high-risk varices cirrhosis

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Effects of dietary management combined with exercise interventions on type 2 diabetes:A pilot before-after study in the same patient

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clinical Traditional Medicine and Pharmacology 2024年第2期5卷 1-5页

作者： Fengyun Sun Leilei Fu Wenting Zhao Ying Zhao Haoying Wang Qing’er Meng Guangzhong Du Huanyuan Wang Department of Acupuncture-Moxibustion and Tuina Qilu Hospital of Shandong UniversityShandong UniversityJinan 250012ShandongChina Shandong University Qilu Hospital High-tech Zone Hospital Jinan 250014ShandongChina

This work was supported by the National Key Research and Development Program of china(2022YFc3500401),the National Natural Science Foundation of china(No.82205250)and the Natural Science Foundation of Shandong Provinc... 详细信息

关键词： Type 2 diabetes Dietary management Exercise interventions Hemoglobin A1c Dyslipidemia

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Liver transplantation as an alternative for the treatment of neuroendocrine liver metastasis: Appraisal of the current evidence

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Hepatobiliary & Pancreatic Diseases International 2024年第2期23卷 146-153页

作者： Philip c.Muller Matthias Pfister Dilmurodjon Eshmuminov Kuno Lehmann Department of Surgery and Transplantation University Hospital ZurichRämistrasse 100Zurich CH-8091Switzerland

Background:Liver transplantation(LT)for neuroendocrine liver metastases(NELM)is still in *** comparing LT with liver resection(LR)for NELM are scarce,as patient selection is heterogeneous and experience is *** goal of this review was to provide a critical analysis of the evidence on LT versus LR in the treatment of *** sources:A scoping literature search on LT and LR for NELM was performed with PubMed,including English articles up to March ***:International guidelines recommend LR for NELM in resectable,well-differentiated tumors in the absence of extrahepatic metastatic disease with superior results of LR compared to systemic or liver-directed *** liver surgery has extended resectability criteria whilst entailing increased perioperative risk and short disease-free *** highly selected patients(based on the Milan criteria)with unresectable NELM,oncologic results of LT are *** factors include tumor biology(G1/G2)and burden,waiting time for LT,patient age and extrahepatic *** on low-level evi-dence,LT for low-grade NELM within the Milan criteria resulted in improved disease-free survival and overall survival compared to *** benefits of LT were lost in patients beyond the Milan ***:With adherence to strict selection criteria especially tumor biology,LT for NELM is becoming a valuable option providing oncologic benefits compared to *** evidence suggests even stricter selection criteria with regard to tumor biology.

关键词： Liver transplantation Neuroendocrine liver metastases Liver resection Selection criteria Tumor biology

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政策性农业保险的理论演进——兼论中国农业保险研究进展

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保险研究 2024年第3期 3-18页

作者：易福金燕菲儿杨柳浙江大学中国农村发展研究院浙江大学公共管理学院南京农业大学经济管理学院

本文依据我国农业保险市场发展脉络,系统梳理了实践中的关键问题和理论依据,尝试探讨现阶段经典保险理论未能有效指导实践的原因,探寻实现农业保险市场供给侧和需求侧良性互动的可能路径。本研究旨在强调,将国际农业保险理论不加改进地... 详细信息

本文依据我国农业保险市场发展脉络,系统梳理了实践中的关键问题和理论依据,尝试探讨现阶段经典保险理论未能有效指导实践的原因,探寻实现农业保险市场供给侧和需求侧良性互动的可能路径。本研究旨在强调,将国际农业保险理论不加改进地应用于中国农业保险研究,造成了当前理论分析与现实脱节的严峻挑战。未来需要找准根植于国情的农业保险理论研究关键问题,把握住中国农业转型期以及农业保险高质量发展战略的历史性机遇,构建适合我国国情的农业保险理论。

关键词：农业保险理论高质量发展

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“政治技术”理论范式的特征与建构

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前沿 2024年第2期 78-86页

作者：褚尔康天津师范大学政治与行政学院天津300387

伴随着近代工业革命发展,技术作为一种独立的革命性力量登上历史舞台,而工业文明的发展也推动了技术作为独立的力量影响社会发展和推动了人类进步。随着“科学革命—技术革命—工业革命—社会革命”研究逻辑体系的建构完成,学术界进一... 详细信息

伴随着近代工业革命发展,技术作为一种独立的革命性力量登上历史舞台,而工业文明的发展也推动了技术作为独立的力量影响社会发展和推动了人类进步。随着“科学革命—技术革命—工业革命—社会革命”研究逻辑体系的建构完成,学术界进一步催生“技术政治”理论的形成和发展。作为一种新的理论范式,技术政治学本身是从技术哲学角度对技术本身的政治学问题进行分析。而作为传统政治学研究体系中新的研究领域,政治的技术理论体系建构则是在如何打破现有的技术限制,突破人类已有的认识空间,扩大人类认识和改造世界的方法空间方面发挥了重要作用。在技术政治学基础上,如何深化“政治技术”理论研究,作为进一步深化以技术系统为特征的技术政治学实践空间,具有重要的范式转型意义。

关键词：技术政治政治技术技术政治学技术哲学治理现代化

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变曲率旋转壳体承载能力分析与几何构型设计

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华中科技大学学报（自然科学版） 2024年第3期52卷 97-104页

作者：付晓梅志远张二白雪飞海军工程大学舰船与海洋学院湖北武汉430033

针对圆柱形壳体承载效率的局限性问题,提出了变曲率壳体的设计思路.基于薄膜理论和无矩理论,推导了非闭合母线的旋转壳应力与屈曲载荷计算公式.以广义等强度壳理论作为评价耐压壳体承载能力的重要指标,对不同构型旋转壳的应力与屈曲载... 详细信息

针对圆柱形壳体承载效率的局限性问题,提出了变曲率壳体的设计思路.基于薄膜理论和无矩理论,推导了非闭合母线的旋转壳应力与屈曲载荷计算公式.以广义等强度壳理论作为评价耐压壳体承载能力的重要指标,对不同构型旋转壳的应力与屈曲载荷进行了理论预报,探讨了壳体承载的最优构型.最后基于增材制造技术制备了圆柱壳与变曲率壳模型,设计静压试验验证壳体构型与力学性能的影响规律.结果表明:变曲率壳体具有明显的承载优势,两个主方向应力的比值低于圆柱壳,屈曲载荷高于圆柱壳;改变壳体几何构型对其承载能力有一定影响,当r0/rn确定时影响不明显,综合考虑加工精度及初始缺陷等因素,壳体使用圆弧构型效果较好;提出的理论公式在应力预报方面具有较高准确性,在预报屈曲载荷过程中,由于壳体承载进入了非线性阶段,不可避免地导致了误差,应使用非线性方法进行修正.

关键词：旋转壳体变曲率等强度应力稳定性增材制造

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Impact of vaccination on the dynamics of cOVID-19:A mathematical study using fractional derivatives

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International Journal of Biomathematics 2024年第2期17卷 201-232页

作者： Shraddha Ramdas Bandekar Mini Ghosh c.Rajivganthi Division of Mathematics School of Advanced Sciences Vellore Institute of TechnologyChennaiIndia

Arrival of a new disease marks a yearlong destruction of human lives and economy in general,and if the disease turns out to be a pandemic the loss is ***-19 is one such pandemic that has claimed millions of lives till *** is a suffering throughout the world due to various factors associated with the pandemic,be it loss of livelihoods because of sudden shutdown of companies and lockdown,or loss of lives due to lack of medical aid and inadequate vaccination *** this study,we develop a six-compartmental epidemiological model incorporating *** motivation behind the study is to analyze the significance of higher vaccination efficacy and higher rate of population getting vaccinated in controlling the rise in infectives and thereby the untimely demise of various *** work begins with an ordinary differential equation model followed by stability analysis of the same,after which a fractional-order derivative model of the same is formulated and the existence of uniformly stable solution for the system is *** addition to this,we present the stability of the equilibria in general for the fractional model *** sensitivity analysis of the basic reproduction number along with its correlation with various parameters is *** addition to this,sensitivity of certain state variables in the fractional model with respect to *** orders as well with respect to different infection rate is exhibited in this *** related to lockdown and usage of face shields are incorporated in the entire study,and importance of these is highlighted in the study as *** major takeaway from the study is that mere vaccination will not sufice in eradication of the *** vaccine efficacy plays a major role along with other intervention included in the *** numerical simulations are carried out in MATLAB software using ode45 and fdel2.

关键词： caputo fractional derivative basic reproduction number stability analysis sensitivityanalysis vaccination

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Urotensin-I suppresses the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,Oreochromis mossambicus

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Aquaculture and Fisheries 2024年第3期9卷 339-346页

作者： Jyoti A.Kumbar c.B.Ganesh Neuroendocrinology Research Laboratory Department of Studies in ZoologyKarnatak UniversityDharwad580003India

Urotensin-I(UI)is a peptide belonging to the corticotropin-releasing hormone family,produced in the urophysis of *** investigation was undertaken to examine the effect of UI on the hypothalamo-hypophyseal-ovarian axis in the Mozambique tilapia,a cichlid *** the first experiment,administration of UI(2μg/100μL saline)for 22 days caused a significant reduction in the number of follicles at stages I,II,III(previtellogenic),IV(vitellogenic),and V(preovulatory),concomitant with a significant increase in the percent atresia of follicles at stages II,III,and IV than in *** the pituitary,gonadotropin-releasing hormone(GnRH)-positive fibres were detected in the proximal pars distalis(PPD)in both controls and UI-treated fish;however,there was a significant reduction in the intensity and percent area of GnRH-immunoreactive fibres in fish treated with UI compared with *** serum luteinizing hormone(LH)level was significantly lower,whereas a significant rise in the serum level of cortisol was noticed in UI-treated fish compared with *** the second experiment,treatment with a low dose of UI(10 mM)did not affect the number of AcTH-secreting cells in vitro,but the number of these cells was significantly higher in high-dose UI(50 mM)-treated pituitaries compared to ***,the present investigation reveals for the first time that the treatment of UI affects the follicular development process through the downregulation of the GnRH-LH axis and activation of the pituitary-interrenal pathway in teleosts.

关键词： Urotensin-I cRH family Gonadotropin-releasing hormone Luteinizing hormone Ovary Oreochromis mossambicus

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共情考试

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科学新闻 2024年第4期 59-60页

作者： Jan Philipp R?er 倪伟波德国维藤/黑尔德克大学

“哦，现在我明白了。”同事说，“这就是你在考试上这么努力的原因。”在与一位同事共进午餐时，我分享了自己多年前作为一名患有考试焦虑症的学生所经历的挣扎。她的话让我有点吃惊，但让我开始思考，为什么从7年前开始当教授以来，...

“哦，现在我明白了。”同事说，“这就是你在考试上这么努力的原因。”在与一位同事共进午餐时，我分享了自己多年前作为一名患有考试焦虑症的学生所经历的挣扎。她的话让我有点吃惊，但让我开始思考，为什么从7年前开始当教授以来，我一直把缓解学生考试前的紧张放在首位。我意识到她可能是有道理的：作为学生的经历有助于我理解作为一名教授能做些什么让口试尽可能透明、公平和包容。这需要一些额外的工作，但是值得。

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A global analysis of the introduction pathways and characteristics associated with non-native fish species introduction, establishment, and impacts

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Ecological Processes 2024年第2期13卷 16-31页

作者： camille Bernery céline Bellard Franck courchamp Sébastien Brosse Boris Leroy cNRS Agro Paris Tech Ecologie Systématique Evolution Université Paris-Saclay Unité Biologie des Organismes et Ecosystèmes Aquatiques (BOREA UMR 8067) Muséum National d’Histoire Naturelle Sorbonne Universités Université de Caen Normandie Université des Antilles CNRS IRD Laboratoire évolution & Diversité Biologique (EDB UMR5174) Université Paul Sabatier-Toulouse 3 CNRS IRD UPS

Background The invasion success of introduced freshwater fishes is influenced by many factors, including ecological, species, and socioeconomic characteristics. Most studies that document the importance of these characteristics are conducted at local scales and/or focus on a single step of the invasion process. In this study, we aim to determine the species characteristics, ecological characteristics, and socioeconomic characteristics of non-native freshwater fish invasions. Our assessment was done at the global scale and considers all three steps of the invasion(i.e., introduction, establishment, and impact). For this purpose, we applied generalized linear models to 20 variables collected for 307 non-native species and modeled them as a function of ecological characteristics(i.e., environmental features), species traits(i.e., functional and morphological), and socioeconomic characteristics(i.e., human use and introduction pathways). We considered the number of countries in which each species was introduced, established, or had ecological impacts as a proxy of invasion step success. We also explored the specifics of species introduced through the aquaculture and the ornamental fish trade *** We found that non-native freshwater fishes with broad diets, high parental care, and multiple introduction pathways are the most widely introduced and established worldwide. The number of countries with impacts reported was best explained by the type of introduction pathway(i.e., aquaculture or fisheries). Moreover, among non-native species introduced through aquaculture, those belonging to cypriniformes and having broad diets were the most widely introduced and established species. In contrast, the species introduced through the ornamental fish trade pathway belonged to various taxonomic orders but were mainly native to tropical *** considering several types of factors is important when analyzing the invasion success of freshwater fish and disentang

关键词： Aquaculture Ecology Exotic Freshwater fish Introduction pathway Invasion step Morphology Ornamental fish trade Socioeconomic Trait

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