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Design and current progress of the Apollon 10 PW project

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High Power Laser Science and Engineering 2015年第1期3卷 32-35页

作者： J.P.Zou c.le blanc D.N.Papadopoulos G.chériaux P.Georges G.Mennerat F.Druon L.lecherbourg A.Pellegrina P.Ramirez F.Giambruno A.Fréneaux F.leconte D.Badarau J.M.Boudenne *** T.Valloton J.L.Paillard J.L.Veray M.Pina P.Monot J.P.chambaret P.Martin F.Mathieu P.Audebert F.Amiranoff Laboratoire pour l’Utilisation des Lasers Intenses CNRSEcole Polytechnique Laboratoire d’Optique Appliquée ENSTA Paris TechCNRS Laboratoire charles Fabry UMR 8501Institut d’OptiqueCNRSUniversité Paris Sud cEA IramisSPAM

The objective of the Apollon project is the generation of 10 PW peak power pulses of 15 fs at 1 shot/minute. In this paper the Apollon facility design, the technological challenges and the current progress of the proj... 详细信息

关键词： titanium lasers PW class facilities

Effect of probiotic administration on the intestinal microbiota, current knowledge and potential applications

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World Journal of Gastroenterology 2014年第44期20卷 16518-16528页

作者： Alejandra de Moreno de le blanc Jean Guy le blanc centro de Referencia para Lactobacilos San Miguel de Tucuman

Although it is now known that the human body is colonized by a wide variety of microbial populations in different parts(such as the mouth, pharynx and respiratory system, the skin, the gastro- and urogenital tracts), many effects of the complex interactions between the human host and microbial symbionts are still not completely understood. The dysbiosis of the gastrointestinal tract microbiota is considered to be one of the most important contributing factors in the development of many gastrointestinal diseases such as inflammatory bowel disease, irritable bowel syndrome and colorectal cancer, as well as systemic diseases like obesity, diabetes, atherosclerosis and non-alcoholic fatty liver disease. Fecal microbial transplantations appear to be promising therapies for dysbiosis-associated diseases; however, probiotic microorganisms have been growing in popularity due to increasing numbers of studies proving that certain strains present health promoting properties, among them the beneficial balance of the intestinal microbiota. Inflammatory bowel diseases andobesity are the pathologies in which there are more studies showing this beneficial association using animal models and even in human clinical *** this review,the association of the human gut microbiota and human health will be discussed along with the benefits that probiotics can confer on this symbiotic activity and on the prevention or treatment of associated diseases.

关键词： Probiotics Dysbiosis Gut microbiota Symbiosis Treatment

Analysis of a Prototypical Multisc.le Method coupling Atomistic and continuum Mechanics:the convex case

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Acta Mathematicae Applicatae Sinica 2007年第2期23卷 209-216页

作者： Xavier blanc claude le Bris Frédériclegoll Laboratoire J.L.-Lions Université Pierre et Marie CurieBoite courrier 187F-75252 ParisFrance cERMIcS Ec.le Nationale des Ponts et chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance cERMIcS Ec.le Nationale des Ponts et chaussées 6 et 8 avenue Blaise PascalCité DescartesF-77455 Marne-la-Vallée and MICMACInria RocquencourtF-78153 Le ChesnayFrance EDF R & D1 avenue du Général de GaulleF-92140 ClamartFrance

In order to describe a solid which deforms smoothly in some region, but non smoothly in some other region, many multisc.le methods have been recently proposed that aim at coupling an atomistic model （discrete mechanics） with a macroscopic model （continuum mechanics）. We provide here a theoretical basis for such a coupling in a one-dimensional setting, in the case of convex energy.

关键词： Multisc.le methods variational problems continuum mechanics discrete mechanics

current perspectives on mesenchymal stromal cell therapy for graft versus host disease

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cellular & Molecular Immunology 2023年第6期20卷 613-625页

作者： Nadir Kadri Syivie Amu llen lacobaeus Erik Boberg Katarina le blanc Department of Laboratory Medicine Karolinska InstitutetStockholmSweden Department of clinical Neuroscience Division of NeurologyKarolinska Institute and Karolinska University HospitalStockholmSweden Department of Haematology Karolinska University HospitalStockholmSweden Department of cell Therapies and Allogeneic Stem cell Transplantation Karolinska University Hospital StockholmSweden

Graft versus host disease(GvHD)is the clinical condition in which bone marrow-derived mesenchymal stromal cells(Mscs)have been most frequently *** this review,we summarize the experience from clinical trials that have paved the way to *** Msc-based therapy has shown an exceptional safety profile,identifying potency assays and disease biomarkers that reliably predict the capacity of a specific MSc batch to alleviate GvHD has been *** GvHD diagnosis and staging are based solely on clinical criteria,individual patients recruited in the same clinical trial may have vastly different underlying biology,obscuring trial outcomes and making it difficult to determine the benefit of Mscs in subgroups of *** accumulating body of evidence indicates the importance of considering not only the cell product but also patient-specific biomarkers and/or immune characteristics in determining MSc responsiveness.A mode of action where intravascular MSc destruction is followed by monocyte-efferocytosis-mediated skewing of the immune repertoire in a permissive inflammatory environment would both explain why cell engraftment is irrelevant for Msc efficacy and stress the importance of biologic differences between responding and nonresponding *** recommend a combined analysis of clinical outcomes and both biomarkers of disease activity and MSc potency assays to identify patients with GvHD who are likely to benefit from MSc therapy.

关键词： MSc GVHD Hematological malignancies acute GVHD chronic GVHD

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澳大利亚生物安全三级实验室的建设要求

中国家禽 2007年第20期29卷 27-30页

作者： Peter le blanc Smith 澳大利亚动物卫生研究所

　　1 传染性微生物风险级别　　风险级别共有4个:风险级别1,风险级别2,风险级别3,风险级别4.各个国家对同样的生物因子依据其是否为本地或外来病原体在分类上有细小差别. ……

关键词：实验室管理人员防护服 Pc 服装生物安全试验操作大气微粒分散体系气溶胶生物危险放射性物质高压灭菌实验人员风险级别煤气灯本生灯危险性物质化学药品大洋洲澳大利亚

Monotonic Diamond and DDFV Type Finite-Volume Schemes for 2D Elliptic Problems

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communications in computational Physics 2023年第7期34卷 456-502页

作者： Xavier blanc Francois Hermeline Emmanuel Labourasse Julie Patela UniversitéParis cité Sorbonne UniversitéCNRSLaboratoire Jacques-Louis LionsF-75013 ParisFrance cEA DAMDIFF-91297 ArpajonFrance UniversitéParis-Saclay CEA DAM DIFLaboratoire en Informatique Haute Performance pour le Calcul et la Simulation91297 ArpajonFrance

The DDFV(Discrete Duality Finite Volume)method is a finite volume scheme mainly dedicated to diffusion problems,with some outstanding *** scheme has been found to be one of the most accurate finite volume methods for diffusion *** the present paper,we propose a new monotonic extension of DDFV,which can handle discontinuous tensorial diffusion ***,we compare its performance to a diamond type method with an original interpolation method relying on polynomial *** is achieved by adapting the method of Gao et al[A finite volume element scheme with a monotonicity correction for anisotropic diffusion problems on general quadrilateral meshes]to our *** a technique does not require the positiveness of the secondary *** show that the two new methods are second-order accurate and are indeed monotonic on some challenging benchmarks as a Fokker-Planck problem.

关键词： Finite volume method anisotropic diffusion monotonic method DDFV scheme

Scientific challenges and instrumentation for the International Meridian circle Program

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Science china Earth Sciences 2021年第12期64卷 2090-2097页

作者： William LIU Michel blanc chi WANG Eric DONAVAN John FOSTER Mark leRTER Hermann OPGENOOTYH Liwen REN National Space Science centre Chinese Academy of SciencesBeijing100190China University of Toulouse Toulouse31400France University of calgary CalgaryT2N 1N4Canada MIT Haystack Observatory CambridgeMA01886USA University of leicester LeicesterLE17RHUK University of Umeå UmeåSE-90187Sweden

Earth’s ecosystems and human activities are threatened by a broad spectrum of hazards of major importance for the safety of ground infrastructures,space systems and space flight:solar activity,earthquakes,atmospheric and climatic disturbances,changes in the geomagnetic field,fluctuations of the global electric *** and understanding these major hazards to better predict and mitigate their effects is one of the greatest scientific and operational challenges of the 21st *** diverse,these hazards share one feature in common:they all leave their characteristic imprints on a critical layer of the Earth’s environment:its ionosphere,middle and upper atmosphere(IMUA).The objective of the International Meridian circle Program(IMcP),a major international program led by the chines Academy of Sciences(cAS),is to deploy,integrate and operate a global network of research and monitoring instruments to use the IMUA as a screen on which to detect these *** this article,we first show that the geometry required for the IMcP global observation system leads to a deployment of instruments in priority along the 120°E-60°W great meridian circle,which will cover in an optimal way both the dominant geographic and geomagnetic latitude variations,possibly complemented by a second Great circle along the 30°E-150°W meridians to capture longitude ***,starting from the chinese Meridian Project(cMP)network and using it as a template,we give a preliminary and promising description of the instruments to be integrated and deployed along the 120°E-60°W great circle running across china,Australia and the Americas.

关键词： International Meridian circle Program Ionosphere Middle-upper atmosphere Space weather chinese Meridian Project

Role of endoscopic ultrasound fine-needle aspiration evaluating adrenal gland enlargement or mass

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World Journal of Nephrology 2014年第3期3卷 92-100页

作者： Melissa Martinez Julia le blanc Mohammad Al-Haddad Stuart Sherman John DeWitt Department of Gastroenterology and Hepatology Indiana University School of Medicine Indianapolis In 46202 United States

AIM： To report the clinical impact of adrenal endoscop-ic ultrasound fine-needle aspiration （EUS-FNA） in the evaluation of patients with adrenal gland enlargement or ***： In a retrospective single-center case-series, patients undergoing EUS-FNA of either adrenal gland from 1997-2011 in our tertiary care center were included. Medical records were reviewed and results of EUS, cytology, adrenal size change on follow-up imag-ing ≥ 6 mo after EUS and any repeat EUS or surgery were abstracted. A lesion was considered benign if：（1） EUS-FNA cytology was benign and the lesion remained 〈 1 cm from its original size on follow-up computed tomography （cT）, magnetic resonance imaging or repeat EUS ≥ 6 mo after EUS-FNA; or （2） subsequent adrenalectomy and surgical pathology was benign. RESULTS： Ninety-four patients had left （n = 90） and/or right （n = 5） adrenal EUS-FNA without adverse events. EUS indications included： cancer staging or suspected recurrence （n = 31）, pancreatic （n = 20）, medi-astinal （n = 10）, adrenal （n = 7）, lung （n = 7） mass or other indication （n = 19）. Diagnoses after adrenal EUS-FNA included metastatic lung （n = 10）, esophageal （n= 5）, colon （n = 2）, or other cancer （n = 8）; benign primary adrenal mass or benign tissue （n = 60）; or was non-diagnostic （n = 9）. Available follow-up confrmed a benign lesion in 5/9 non-diagnostic aspirates and 32/60 benign aspirates. Four of the 60 benign aspirates were later confrmed as malignant by repeat biopsy, follow-up cT, or adrenalectomy. Adrenal EUS-FNA diagnosed metastatic cancer in 24, and ruled out metastasis in 10 patients. For the diagnosis of malignancy, EUS-FNA of either adrenal had sensitivity, specifcity, positive predic-tive value and negative predictive value of 86%, 97%, 96% and 89%, ***： Adrenal gland EUS-FNA is safe, mini-mally invasive and a sensitive technique with signifcant impact in the management of adrenal gland mass or enlargement.

关键词： Adrenal gland neoplasms/diagnosis Adrenal glands/pathology Adrenal gland/ultrasonography Adrenal gland neoplasms/secondary Endosonography Biopsy Fine-needle

Stricturing crohn's disease-like colitis in a patient treated with belatacept

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World Journal of Gastroenterology 2017年第48期23卷 8660-8665页

作者： Anne Bozon Guillaume Jeantet Benjamin Rivière Natalie Funakoshi Gaspard Dufour Roman combes Jean-christophe Valats Sylvie Delmas Jean Emmanuel Serre Michael Bismuth Jeanne Ramos Moglie le Quintrec Pierre blanc Guillaume Pineton de chambrun Gastroenterology Department Saint-Eloi HospitalMontpellier University Hospital Nephrology Department Lapeyronie HospitalMontpellier University Hospital Pathology Department Guy de Chauliac HospitalMontpellier University Hospital

cytotoxic T-lymphocyte-associated antigen 4(cTLA-4) modifying agents have been involved in the development of intestinal inflammation,especially therapeutic monoclonal antibodies directed against cTLA-4. Here we report the appearance of a severe stricturing crohn's disease-like colitis in a patient with a kidney allograft who was treated with belatacept,a recombinant cTLA-4-Ig fusion protein.

关键词： crohn’s disease colitis Belatacept HHV-6 Inflammatory bowel disease