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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Plausible cloth animation using dynamic bending model

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Progress in Natural Science:Materials International 2008年第7期18卷 879-885页

作者： charlie c.l. Wang Department of Mechanic.l.and Automation Engineering The chinese University of Hong Kong Hong Kong china

Simulating the mechanic.l.behavior of a cloth is a very challenging and important problem in computer animation. The models of bending in most existing cloth simulation approaches are taking the assumption that the cloth is little deformed from a plate shape. Therefore, based on the thin-plate theory, these bending models do not consider the condition that the current shape of the cloth under large deformations cannot be regarded as the approximation to that before deformation, which leads to an unreal static bending. [This paper introduces a dynamic bending model which is appropriate to describe large out-plane deformations such as cloth buc.l.ng and bending, and develops a compact implementation of the new model on spring-mass systems. Experimental results show that wrinkles and folds generated using this technique in cloth simulation, can appear and vanish in a more natural way than other approaches.]

关键词： cloth animation Physic.l.y based animation Bending

3D FINITE ElEMENT ANAlYSIS OF THE DAMAGE EFFEcTS ON THE DENTAl cOMPOSITE SUBJEcT TO WATER SORPTION

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Acta Mechanica Solida Sinica 2006年第3期19卷 212-222页

作者： Tsui c.P. chow c.l. Department of Industrial and Systems Engineering The Hong Kong Polytechnic University Hong Kong ChinaDepartment of Mechanical EngineeringThe University of Michigan-DearbornDearbornMichiganUSA

The damage effects of water sorption on the mechanic.l.properties of the hydroxyapatite particle reinforced Bis-GMA/TEGDMA copolymer （HA/Bis-GMA/TEGDMA） h-ave been predicted using 3D finite c.l. models. The plasticizer effect on the polymer matrix was considered as a variation of its Young＇s modulus. Three different c.l. models were used to determine the influence of varying particle contents, interphase strength and moisture concentration on the debonding damage. The stress distribution pattern has been examined and the stress transfer mode clarified. The Young＇s modulus and fracture strength of the Bis-GMA/TEGDMA composite were also predicted using the model with and without consideration of the damage. ine Iormer results with consideration of the debonding damage are in good agreement with existing literature experimental data. The shielding effect of our proposed model and an alternative approach were discussed. The Fcc c.l. model has also been extended to predict the critic.l.load for the damaged and the undamaged composite subject to the 3-point flexural test.

关键词： water sorption dental composite interphase debonding finite element method (FEM) unit c.l. model

NUMERIc.l.SIMUlATION OF SUccINONITRITE DENDRITIc GROWTH IN A FORcED FlOW

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Acta Metallurgica Sinica(English letters) 2008年第6期21卷 444-450页

作者： Z. chen c.l. chen l.M. Hao School of Science Department of Applied Physics Shaanxi Key Laboratory of Condensed Matter Structures and Properties Northwestern Polytechnical University Xi＇an 710072 China School of Science Xi＇an University of Science ＆ Technology Xi＇an 710054 China

Numeric.l.simulation based on phase field method is performed to describe solidification process of pure material in a free or forced flow. The evolution of the interface is showed, and the effects of mesh grid and flow velocity on succinonitrite shape are studied. These results indicate that crystal grows into an equiaxial dendrite in a free flow and into an asymmetric.l.dendritic in a forced flow. With increasing flow velocity, the upstream dendritic arm tip grows faster and the downstream arm grows slower. However, the evolution of the perpendic.l.r tip has no significant change. In addition, mesh grid has no influence on dendritic growth shape when mesh grid is above 300×300.

关键词： Phase field method Forced flow Dendritic Succinonitrite Tip velocity

STRESS ANAlYSIS OF THE APERTURE IN cOMPOUND PIPElINE BY FEM

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Acta Metallurgica Sinica(English letters) 2007年第5期20卷 385-390页

作者： J.G. yang H.Y. Fang c.l. Fan Z. luo X.Z. Hou State Key laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China School of Material Science and Engineering Tianjin University Tianjin 300072 China Daqing Oil-Ghem-Wdding Institute Daqing 163712 China

There is a cyclic.l.aperture at a certain part of the fiberglass reinforced plastic compound pipeline with a stainless steel pipe as a liner, which becomes the weakness of the conduit. The field of stress and strain of the aperture was investigated using the nonliner finite element code Marc. The results of the finite element analysis showed that there were concentrations of stress and strain in the layer of stainless steel at the part of the pipeline where the aperture existed. The method to solve these problems was also discussed.

关键词： compound pipeline stress software Marc

low-cost and fluoride-free synthesis of MFI zeolite nanosheets with enhanced stability for benzene alkylation with ethanol

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Journal of Energy chemistry 2025年第1期100卷 458-468页

作者： Peng Zhu cun liu Yiren Yu Guoshu Gao Yumeng Zhao Xiongfu Zhang Guodong liu Guohui yang State Key laboratory of Fine chemic.l. School of Chemical Engineering Dalian University of Technology State Key laboratory of catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences

Zeolite nanosheets with a short b-axis thickness are highly desirable in lots of catalytic reactions due to their reduced diffusion resistance. Nevertheless, conventional synthesis methods usually require expensive structure-directing agents(SDAs), pricey raw materials, and eco-unfriendly fluorine-containing additives. Here, we contributed a cost-effective and fluoride-free synthesis method for synthesizing high-quality MFI zeolite nanosheets through a Silic.l.te-1(Sil-1) seed suspension and urea cooperative strategy, only with inexpensive c.l.oidal silica as the Si source. Our approach was effective for synthesizing both Sil-1 and aluminum-containing ZSM-5 nanosheets. By optimizing key synthesis parameters,including seed aging time, seed quantity, and urea concentration, we achieved precise control over the crystal face aspect ratio and b-axis thickness. We also revealed a non-classic.l.oriented nanosheet growth mechanism, where Sil-1 seeds induced the formation of quasi-ordered precursor particles, and the(010)crystal planes of these particles fac.l.tated urea adsorption, thereby promoting c-axis-oriented *** obtained ZSM-5 nanosheets exhibited exceptional catalytic performance in the benzene alkylation with ethanol, maintaining stability for over 500 h, which is 5 times longer than traditional ZSM-5 catalysts. Furthermore, large-sc.l. production of ZSM-5 nanosheets was successfully carried out in a 3 l highpressure autoclave, yielding samples consistent with those from laboratory-sc.l. synthesis. This work marks a significant step forward in the sustainable and efficient production of MFI nanosheets using inexpensive and environmentally friendly raw materials, offering the broad applicability in catalysis.

关键词： MFI zeolite ZSM-5 Nanosheets Sc.l.-up synthesis Aromatic alkylation

Silk-based nerve guidance conduits with macroscopic holes modulate the vasc.l.rization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： carina Hromada Patrick Heimel Markus Kerbl lászlóGál Sylvia Nürnberger Barbara Schaedl James Ferguson Nic.l. Swiadek Xavier Monforte Johannes c.Heinzel Antal Nógrádi Andreas H.Teusc.l.Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medic.l.University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNGcs). However, the use of tNGcs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typic.l.y shorter than 3 cm). Given the importance of vasc.l.rization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNGc would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNGcs and compared the various features of these improved silk^(+) tNGcs with the tubes without holes(silk^(–) tNGcs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histologic.l.analyses, we were able to prove that the use of silk^(+) tNGcs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovasc.l.r formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNGcs at 7 weeks postoperatively. In the 15-mm(critic.l.size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNGcs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNGcs increase the vasc.l.r supply of regenerating nerves and fac.l.tate improved axonal regeneration in a short-defect model but not in a critic.l.size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vasc.l.rization

The basic clinic.l.diagnostic framework synergized

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chinese Medic.l.Journal 1998年第5期111卷 77-82页

作者： Edwin c.l. Yu Department of Pediatrics The University of Hong Kong Hong Kong China

Objective To develop a diagnostic framework that would help defining clinic.l.problems by the expanded understanding with traditional chinese medicine (c Med) and western medicine (W Med).Methods The basic attributes of diagnosis and the use of diagnostic techniques of W Med and c Med are reviewed. Some of the various diagnostic.l.bels and their meanings are also preliminarily reviewed. A consolidatory approach is made to synergize the usefulness of the two disciplines based on the principles of the two *** The application and use of the framework are discussed and propositions are made. The synergized diagnostic platform represents a starting effort to form a unified basis to exchange clinic.l.diagnosis between W Med and c Med. Such framework may fac.l.tate looking for new treatment modalities and results can be compared across different centres.

关键词： Diagnosis Differential Diagnostic Techniques and Procedures Medicine chinese Traditional Humans

SIMUlATION-MEASUREMENT INVERSION OF ENVIRONMENT PARAMETERS DURING WElDING

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Acta Metallurgica Sinica(English letters) 2005年第6期18卷 763-767页

作者： J. Tao D.Q. li c.l. Fan H.Y. Fang Beijing Aeronautic.l.Manufacturing Technology Research Institute Beijing 100024 China State Key laboratory of Advanced Welding Production Technology Harbin Institute of Technology Harbin 150001 China

The manual selection of environment parameters during welding simulation will bring a significant error to the simulation result of welding temperature field. By a combination of finite element method （FEM） and infrared thermography, these environment parameters were inversed mathematic.l.y in place of previous manual selection. First, FEM model of the welding process was constructed, and the temperature field was computed with initial environment parameters. Then, a real welding process was conducted and the temperature field was measured by infrared thermography. last, the simulation and measurement results were compared, and the environment parameters were adjusted continuously with the genetic algorithm （ GA ） until the simulation matched the measurement best. Parameters according to the best-matched simulation results were considered as the most appropriate parameters.

关键词： environment parameters welding temperature field inversion