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Molecular Plant 2021年第6期14卷 888-904页

作者： Yaoguang Yu Wei Fu Jianqu Xu Yawen Lei Xin Song Zhenwei Liang Tao Zhu Yuhui Liang yuanhao Hao Liangbing yuan chenlong Li State key Laboratory of Biocontrol Guangdong Provincial Key Laboratory of Plant ResourcesSchool of Life SciencesSun Yat-Sen UniversityGuangzhouChina

Switch defective/sucrose non-fermentable(SWI/SNF)chromatin remodeling complexes are multi-subunit machines that play vital roles in the regulation of chromatin structure and gene ***,the mechanisms by which SWI/SNF complexes recognize their target loci in plants are not fully ***,we show that the Arabidopsis thaliana bromodomain-containing proteins BRD1,BRD2,and BRD13 are core subunits of SWI/SNF complexes and critical for SWI/SNF genomic *** three BRDs interact directly with multiple SWI/SNF subunits,including the BRAHMA(BRM)catalytic *** and transcriptomic analyses of the brd1 brd2 brd13 triple mutant revealed that these BRDs act largely redundantly to control gene expression and developmental processes that are also regulated by ***-wide occupancy profiling demonstrated that these three BRDs extensively colocalize with BRM on *** loss of function of three BRD genes results in reduced BRM protein levels and decreased occupancy of BRM on chromatin across the ***,we demonstrated that the bromodomains of BRDs are essential for genomic targeting of the BRD subunits of SWI/SNF complexes to their target ***,these results demonstrate that BRD1,BRD2,and BRD13 are core subunits of SWI/SNF complexes and reveal their biological roles in facilitating genomic targeting of BRM-containing SWI/SNF complexes in plants.

关键词： SWI/SNF complexes chromatin remodeling bromodomain BRAHMA Arabidopsis

Expression of Toll-like Receptor 2/4 on Alveolar Macrophage in the Model of Total Hepatic Ischemia/Reperfusion Injury in Mice

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The chinese-German Journal of clinical Oncology 2006年第4期5卷 298-300页

作者： GU yuanting WU Heshui XU Jianbo WANG Lin TIAN yuan WANG chunyou Department of General Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China Department of Surgery the First Affiliated Hospital Zhengzhou University Zhengzhou 450052 China Department of Pediatrics Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430022 China

Objective： To explore the expression and meaning of Toll-like receptor 2/4 in alveolar macrophage during the process of total hepatic ischemia in mice. Methods： BALB/c mice were used in a model of total hepatic ischemia/reperfusion. Alveolar Macrophage were collected at the time point of lh, 6h and 12h by the means of bronchoalveolar lavage （BAL）, and its TLR2/4 mRNA and protein were detected with Flow cytometry and Real-time PcR. The level of TNF in BAL fluid were measured. The concentration of MPO, the ratio of wet/dry and lung histological scores were used to assess the degrees of lung injuries. Results： At the three time points of hepatic ischemia reperfusion, the expression of TLR2/4 protein of and mRNA were up-regulated and the level of TLR2 was on the rise continually. TLR4 at the time of 6 h reached the peak value （P〈0.01）. The level of TNF-2 in BAL fluid reached the highest point at the time of 6 h （P〈0.01）. The ratio of wet/dry rose continually during hepatic ischemia reperfusion. After 1 h, the level of MPO increased rapidly. Then it reached the peak value during the period of 6 h to 12 h. conclusion： TLR2/4 on the mice of alveolar macrophage were activated in the process of hepatic ischemia/reperfusion and involved in the injury of lung.

关键词： Toll-like receptors liver hepatic ischemia reperfusion injury of lungs, alveolar macrophage

microRNA与母体孕期营养不良者的子代脂质代谢紊乱的关系

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中国研究型医院 2024年第4期11卷 65-71页

作者：曾缘任瑶林余洁任婧吴伊凡张茜肖新华中国医学科学院北京协和医学院、北京协和医院内分泌科、国家卫生健康委员会内分泌重点实验室北京100730

“健康和疾病的发育起源”假说提出:除了遗传和环境因素,生命早期(包括胎儿和婴幼儿时期)的不利因素会增加成年后罹患慢性疾病的风险。表观遗传修饰可能是生命早期经历营养不良导致成年后发生代谢紊乱的潜在机制。因此,母体孕期若有营... 详细信息

“健康和疾病的发育起源”假说提出:除了遗传和环境因素,生命早期(包括胎儿和婴幼儿时期)的不利因素会增加成年后罹患慢性疾病的风险。表观遗传修饰可能是生命早期经历营养不良导致成年后发生代谢紊乱的潜在机制。因此,母体孕期若有营养不良(如热量摄入过少或铁、叶酸等微量营养素缺乏)、肥胖、高血糖等,可能通过表观遗传机制增加子代成年后慢性代谢性疾病的易感性。最新研究表明,生命早期不论是经历营养不良,还是营养过剩,都会影响成年后肝脏、骨骼肌、血液等组织中调控糖脂代谢相关microRNA的表达。基于此,以下重点介绍作为表观遗传机制之一的microRNA,在母体孕期营养不良状态下可能导致子代脂质代谢异常的潜在机制,以期为以非酒精性脂肪性肝病为代表的脂代谢紊乱疾病的发生机制以及生命早期干预治疗提供科学依据。

关键词：营养不良微RNA 妊娠子代生命早期

Effective extraction of photoneutron cross-section distribution using gamma activation and reaction yield ratio method

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Nuclear Science and Techniques 2023年第11期34卷 103-111页

作者： Zhi‑cai Li Yue Yang Zong‑Wei cao Xin‑Xiang Li Yun yuan Zong‑Qing Zhao Gong‑Tao Fan Hong‑Wei Wang Wen Luo School of Nuclear Science and Technology University of South ChinaHengyang 421001China Science and Technology on Plasma Physics Laboratory Laser Fusion Research CenterChina Academy of Engineering PhysicsMianyang 621900China Shanghai Advanced Research Institute Chinese Academy of SciencesShanghai 201210China

Photoneutron cross-section(PNcS)data are important in various current and emerging *** a few sophis-ticated methods have been developed,there is still an urgent need to study the PNcS *** this study,we propose the extraction of PNcS distributions using a combination of gamma activation and reaction yield ratio *** verify the validity of the proposed extraction method,experiments for generating^(62,64)cu and^(85m,87m)Sr isotopes via laser-induced pho-toneutron reactions were performed,and the reaction yields of these isotopes were *** the proposed extraction method,the PNcS distributions of^(63)cu and^(86)Sr isotopes(leading to^(85m)Sr isotope production)were successfully *** extracted PNcS distributions were benchmarked against available PNcS data or TALYS calculations,demonstrating the validity of the proposed extraction *** applications for predicting the PNcS distributions of the 30 iso-topes are further *** conclude that the proposed extraction method is an effective complement to the available sophisticated methods for measuring and evaluating PNcS data.

关键词： Photonuclear data Photoneutron cross section Gamma activation Reaction yield TALYS calculation

固体添加剂2-(噻吩-2-亚甲基)丙二腈的合成及其有机光伏性能

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河北科技师范学院学报 2024年第2期38卷 59-65页

作者：沈星星罗丹何源杨述谢家平侯文龙韩璐河北科技师范学院化学工程学院河北秦皇岛066600 南昌大学化学学院河北科技师范学院分析测试中心

为了提高有机光伏器件性能,合成了一种结构简单、成本低的固体添加剂2-(噻吩-2-亚甲基)丙二腈(SAT),并测试了其对非富勒烯有机太阳能电池性能的影响。测试结果显示,优化后的共混薄膜的紫外可见吸收光谱红移了14 nm,荧光强度显著降低。而... 详细信息

为了提高有机光伏器件性能,合成了一种结构简单、成本低的固体添加剂2-(噻吩-2-亚甲基)丙二腈(SAT),并测试了其对非富勒烯有机太阳能电池性能的影响。测试结果显示,优化后的共混薄膜的紫外可见吸收光谱红移了14 nm,荧光强度显著降低。而且,薄膜的结晶度更高,形成的相分离形貌更加均匀,分子堆叠更加有序,有利于激子分离和电荷传输。与未使用SAT优化的器件相比,当SAT的质量浓度为5 mg/mL时,开路电压由0.85 V降低至0.83 V,短路电流由21.15 mA/cm^(2)提升至23.58 mA/cm^(2),填充因子由65.70%提升至71.17%,能量转换效率由11.89%提升至13.90%。

关键词：有机太阳能电池固体添加剂 2-(噻吩-2-亚甲基)丙二腈光伏性能

c–c motif chemokine ligand 16 inhibits the progression of liver cirrhosis via inactivating hepatic stellate cells

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 440-448页

作者： Jian-Yong Zhuo Di Lu Zu-yuan Lin Bei-Ni cen Xu-Yong Wei Hai-Yang Xie Shu-Sen Zheng Xiao Xu Department of Hepatobiliary and Pancreatic Surgery the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China NHc key Laboratory of combined Multi-organ Transplantation Key Laboratory of the Diagnosis and Treatment of Organ TransplantationCAMSHangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery Shulan(Hangzhou)HospitalHangzhou 310003China

Background:Liver cirrhosis results from many forms of chronic damage,characterized by accumulation of extracellular *** present study aimed to explore a potential non-invasive biomarker and its mechanism in the progression of liver ***:Gene Expression Omnibus(GEO)dataset(GSE15654,n=216)was analyzed to screen genes associated with progression of liver cirrhosis.A total of 181 plasma samples,including healthy control(Hc,n=20),chronic hepatitis B(cHB,n=77)and HBV-related liver cirrhosis(Lc,n=84),were enrolled for *** vitro and in vivo experiments were employed for the mechanistic ***:GEO dataset analysis showed that relatively low mRNA-expression of c–c motif chemokine ligand 16(ccL16)was associated with elevated child-Pugh score(P=0.034)and worse prognosis(P=0.025).Plasma ccL16 level decreased in a stepwise pattern,with a median concentration of 10.29,6.57 and 4.47 ng/mL in the Hc,cHB and Lc groups,respectively(PccL16 was significantly related to hepatic dysfunction both in the cHB and Lc groups(Pcombination of ccL16 and ALT showed improved distinguishing capability for Lc compared to either *** vitro,ccL16 expression was downregulated by lipopolysaccharide and *** of ccL16 from human normal liver cell line(LO2)reduced the extracellular matrix associated proteins(col1 and col4)in human hepatic stellate cell line(LX-2).In vivo,the pathological feature of cirrhosis was alleviated by the hepatocytespecific expression of ***:ccL16 could be a feasible plasma marker to predict the occurrence and progression of liver ***16 might impact liver cirrhosis through inactivating hepatic stellate cells.

关键词： c-c motif chemokine ligand 16 Liver cirrhosis Hepatitis B virus infection

The reactions of perfluoro-and α,α-dichloropolyfluoroalkanesulfinates

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chinese Journal of chemistry 1986年第4期4卷 381-386页

作者： HUANG Wei-yuan cHEN Jian-Long Shanghai Institute of Organic chemistry, Academia Sinica, Shanghai Shanghai Institute of Organic chemistry Academia Sinica Shanghai

Sodium perfluoroalkanesulfinate, RFSO2Na [RF=cl（cF2）4, 1a; cF3（cF2）5, 1b; cl（cF2）6,1c] reacted with bromine in aqueous solution to give the corresponding sulfonyl bromide RFSO2Br（2a--2c） and in acetonitrile or acetic acid, to form perfluoroalkyl bromide RFBr （3a--3c）. Heatingin acetonitrile at 80℃, 2a--2c were converted smoothly into 3a-3c. However, reaction of sodiumα,α--dichloropolyfluoroalkanesulfinate Rccl2SO2Na (R= cF3, cl（cF2）_n, n = 2, 4, 6, 5a-5d) withbromine in aqueous solution gave directly the corresponding bromoalkanes 1--bromo--1,1-di-chloropolyfluoroalkane Rccl2Br （6a-6d）. In aqueous potassium iodide solution, 1a--1c, 5a and5b also reacted with iodine to form the corresponding iodo-polyfluoroalkane 4a-4c, 7a and 7b di-rectly. 6a and 7a underwent free radical addition to alkene readily in the presence of free radicalinitiator and reacted with Na2S2O4in the usual way to form α,α--dichloropolyfluoroethane sulfinate（5a）. 5a was stable in strong acid, but reacted with strong base to yield 10. 5a was oxidised byhydrogen peroxide to the sulfonate 11 and reduced by zinc in dilute acid to from the α--chlorosulfinate 12.

关键词： The reactions of perfluoro-and dichloropolyfluoroalkanesulfinates

Noninvasive ultrasound deep brain stimulation of nucleus accumbens induces behavioral avoidance

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Science china(Life Sciences) 2020年第9期63卷 1328-1336页

作者： Lili Niu Yanchen Guo Zhengrong Lin Zhe Shi Tianyuan Bian Lin Qi Long Meng Anthony AGrace Hairong Zheng Ti-Fei yuan Paul c.Lauterbur Research center for Biomedical Imaging Institute of Biomedical and Health EngineeringShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Shanghai key Laboratory of Psychotic Disorders Shanghai Mental Health CenterShanghai Jiao Tong University School of MedicineShanghai 200030China key Laboratory for Quality Evaluation of Bulk Herbs of Hunan Province Hunan University of Chinese MedicineChangsha 410208China college of Medicine and Biological Information Engineering Northeastern UniversityShenyang 110016China Departments of Neuroscience Psychiatry and PsychologyUniversity of PittsburghPittsburghPA 15260USA co-innovation center of Neuroregeneration Nantong UniversityNantong 226001China

Ultrasound stimulation is an emerging noninvasive option in treating neuropsychiatric disorders. The present study investigates the behavioral alterations resulting from ultrasound stimulation on the nucleus accumbens(NAc) in freely moving mice. Our results show that an acute ultrasound stimulation on the NAc, rather than the visual cortex or auditory cortex, led to a pronounced avoidance behavior, while repeated NAc ultrasound stimulation resulted in an obvious conditioned place aversion with changes in synaptic protein(Glu A1/2 subunit) expression. Notably, NAc ultrasound stimulation suppressed the morphine-induced conditioned place preference. The results provide evidence that NAc ultrasound stimulation can be applied as a potential noninvasive therapeutic option in treating psychiatric disorders.

关键词： ultrasound nucleus accumbens addiction synaptic plasticity brain stimulation

NRG1、VASH-1水平对ASO患者介入治疗后再狭窄的预测价值

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保健医学研究与实践 2024年第6期21卷 61-66页

作者：樊刚李波袁涛齐磊张华文樊嘉莹梁召辉陕西省宝鸡市中医医院介入放射科陕西宝鸡721000 陕西省核工业二一五医院影像科陕西咸阳712000 陕西中医药大学中西医结合临床系陕西咸阳712046 西安交通大学第一附属医院影像科西安710061

目的探讨血清神经调节蛋白1(NRG1)、血管生成抑制蛋白-1(VASH-1)对下肢动脉硬化闭塞症(ASO)患者介入治疗后再狭窄的预测价值,以期为临床治疗提供参考。方法选取选取2021年9月—2023年8月宝鸡市中医医院收治的112例ASO患者作为本次研究... 详细信息

目的探讨血清神经调节蛋白1(NRG1)、血管生成抑制蛋白-1(VASH-1)对下肢动脉硬化闭塞症(ASO)患者介入治疗后再狭窄的预测价值,以期为临床治疗提供参考。方法选取选取2021年9月—2023年8月宝鸡市中医医院收治的112例ASO患者作为本次研究对象。根据介入治疗6个月后患者是否发生再狭窄分为再狭窄组(n=29)和非再狭窄组(n=83)。比较2组患者血清NRG1、VASH-1水平;采用受试者工作特性(ROc)曲线评估血清NRG1、VASH-1对ASO患者介入治疗后再狭窄的预测价值;采用二分类Logistic逐步回归分析探讨ASO患者介入治疗后再狭窄的影响因素。结果再狭窄组患者NRG1水平低于非再狭窄组,VASH-1水平高于非再狭窄组,差异均有统计学意义(Pc曲线显示,血清NRG1联合VASH-1预测ASO患者介入治疗后再狭窄的曲线下面积(AUc)(95%cI)为0.903(0.852~0.954),特异度为87.11%,灵敏度为86.05%,其预测效能较高。2组患者性别构成、年龄、体质量指数、合并症、病变部位、总胆固醇水平、甘油三酯水平、高密度脂蛋白胆固醇(HDL-c)水平比较,差异均无统计学意义(P>0.05);再狭窄组患者吸烟占比、血管完全闭塞占比、血管病变长度、c反应蛋白(cRP)水平、糖化血红蛋白水平、低密度脂蛋白胆固醇(LDL-c)水平均大于非再狭窄组,差异均有统计学意义(Pc逐步回归分析结果显示,cRP≥18.74 mg/L、LDL-c≥3.69 mmol/L、NRG1≤16.98 pg/mL、VASH-1≥553.49 ng/L是ASO患者介入治疗后再狭窄的独立危险因素(P<0.05)。结论血清NRG1水平降低、VASH-1水平升高与ASO患者介入治疗后再狭窄之间关系密切,且这2项指标可作为ASO患者介入治疗后再狭窄的重要预测因子。

关键词：下肢动脉硬化闭塞症再狭窄介入治疗神经调节蛋白1 血管生成抑制蛋白-1

Influence of heat treatment on microstructure and nanohardness of TiAl alloy solidified under high pressure

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china Foundry 2020年第6期17卷 435-440页

作者： Dong-dong Zhu Duo Dong Jie-ren Yang Li Liu Xiao-hong Wang yuan-xiang Zhang Zun-jie Wei key Laboratory of Air-driven Equipment Technology of Zhejiang Province Quzhou UniversityQuzhou 324000China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China State key Laboratory of Solidification Processing Northwestern Polytechnical UniversityXi'an 710072China

The Ti-48at.%Al alloy solidified under different pressures was prepared using a tungsten-carbide six-anvil apparatus and then heat treated at different *** effect of heat treatment on microstructure and mechanical properties of high pressure solidified Ti-48Al alloy was *** results showed that the phase constitution of the Ti-48Al alloy solidified under high pressure did not change after heat *** 1,100℃/12 h Ac(air cooling),the value of c/a showed a slight *** Widmanst?tten structure was formed in the samples solidified under 2 GPa and 4 *** defects were found in the high-pressure *** volume fraction ofα2 particles increased with an increase in *** 1,150℃/4 h Ac,the discontinuous coarsening phenomenon could only be found in the 4 GPa solidified *** formation ofα2 phase can lead to the increase of *** with the samples before heat treatment,the nanohardness increased about 1.0-1.2 GPa.

关键词： heat treatment TiAl microstructure nanohardness