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RANTES In1.1c allele polymorphisms in 13 chinese ethnic populations

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chinese Medical Journal 2009年第10期122卷 1143-1146页

作者： QIAN yuan SUN Hao cHU Jia-you Institute of Medical Biology Chinese Academy of Medical Science & Peking Union Medical College Kunming 650118 China

Background The *** single nucleotide polymorphism （SNP） allele results in reduced RANTES transcription, which is associated with increased frequency of HIV-1 infection, and rapid progression to AIDS among HIV-l-infected individuals. This study aimed to study the mutant frequency and polymorphism of RANTES in chinese populations.Methods The genotypes of RANTES *** were determined by polymerase chain reaction-restriction fragment length polymorphism （PcR-RFLP） with the digestion of restriction endonuclease Mbo Ⅱ.Results Of the 617 individuals, 290 （47%） were carriers of the RANTES In1.1c allele, 52 of whom were homozygotes, whereas 238 were heterozygotes. The frequency of the RANTES In1.1c allele in those tested individuals was 0.2840. The frequencies of In1.1c allele varied from 0.07-0.27 in most of the populations in South-west china except for the two Lisu populations, while the frequencies of In1.1c spans from 0.35 to 0.45 in North-west china. The prevalence of the allele varied substantially between the South-west groups and North-west groups （χ^2=7.838, P=0.006）. conclusions The prevalence of the RANTES In1.1c allele varies substantially between the South-west groups and North-west groups. There is no significant difference between the groups with different languages, which suggests that language relationship is not consistent with the genetic relationship. These results have important implications for the design, assessment, and implementation of HIV-1 vaccines.

关键词： PROMOTER POLYMORPHISM GENETIc-RELATIONSHIP DISEASE PROGRESSION HIV-1 INFEcTION RISk-FAcTOR VARIANTS AIDS ccR5-DELTA-32 RESISTANcE

IcG示踪前哨淋巴结在早期低危和中高危子宫内膜癌治疗中的应用研究

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中国性科学 2024年第1期33卷 24-28页

作者：李芬古丽比亚·艾则孜苑锦睿温蒙科沈谷群新疆医科大学附属肿瘤医院妇外二科乌鲁木齐830011

目的探讨吲哚菁绿(IcG)示踪前哨淋巴结(SLN)在早期低危和中高危子宫内膜癌(Ec)中的应用价值。方法选取2020年7月1日至2022年6月30日于新疆医科大学附属肿瘤医院经宫腔镜或诊断性刮宫病理证实为早期Ec的62例患者作为研究对象。先行腹腔镜... 详细信息

目的探讨吲哚菁绿(IcG)示踪前哨淋巴结(SLN)在早期低危和中高危子宫内膜癌(Ec)中的应用价值。方法选取2020年7月1日至2022年6月30日于新疆医科大学附属肿瘤医院经宫腔镜或诊断性刮宫病理证实为早期Ec的62例患者作为研究对象。先行腹腔镜下SLN活检(SLNB),然后行全子宫、双侧附件切除术+腹主动脉旁、盆腔淋巴结切除术。将患者分为低危组(n=42)、中高危组(n=20),比较两组检出率、灵敏度、阴性预测值(NPV)及SLN分布特征;采用Logistic回归分析影响SLN显影的因素。结果低危组和中高危组Ec患者的总检出率分别为90.3%和90.0%,灵敏度均为100%,NPV均为100%,两组间差异无统计学意义(P>0.05)。低危组Ec患者SLN显影分布:髂外淋巴结和闭孔淋巴结62.0%,髂内淋巴结和骶前淋巴结34.0%,髂总淋巴结2.7%,腹主动脉旁淋巴结1.3%;中高危组Ec患者SLN显影分布:髂外淋巴结和闭孔淋巴结63.3%,髂内淋巴结和骶前淋巴结33.3%,髂总淋巴结0%,腹主动脉旁3.3%;低危组与中高危组SLN显影分布比较,差异无统计学意义(P>0.05)。结论IcG示踪SLN在早期低危和中高危Ec中均是有效和可行的。

关键词：吲哚菁绿前哨淋巴结低危中高危子宫内膜癌

Design, fabrication, and testing of low-group-velocity S-band traveling-wave accelerating structure

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Nuclear Science and Techniques 2022年第11期33卷 133-143页

作者： Xian-cai Lin Hao Zha Jia-Ru Shi Liu-yuan Zhou Yi-Fan Liang Jian Gao Qiang Gao Huai-Bi chen chuan-Xiang Tang Department of Engineering Physics Tsinghua UniversityBeijing 100084China key Laboratory of Particle and Radiation Imaging(Tsinghua University) Ministry of EducationBeijing 100084China

To implement the Tsinghua Thomson Scattering X-ray Source upgrade plan and the Very compact Inverse compton Scattering Gamma-ray Source (VIGAS) program, a new 1.5-m traveling-wave accelerating structure was designed to replace the old 3-m SLAc-type structure with the aim of increasing the accelerating gradient from15 to 30 MV/m. The new type of structure works in the 3π/4 mode with a comparatively low group velocity varying from 0.007c to 0.003c to increase the accelerating gradient at a given power. An elliptical iris was employed to reduce the surface field enhancement. The filling process of the low-group-velocity structure was analyzed using a circuit model. After fabrication, the structure was precisely tuned using the non-contact tuning method, followed by detailed low-power radiofrequency measurements. The structure was first installed and utilized at a beamline for the terahertz experiment at Tsinghua University. After 120 h of conditioning, it is now operating at a gradient of 24.2 MV/m and a 20.7-MW input power, with the klystron operating at its full power. It is expected to generate an accelerating gradient of 30 MV/m when the klystron power is upgraded to 30 MW in the near future.

关键词： Traveling-wave accelerating structure cavity optimization Tuning method High-power test

男性2型糖尿病患者血清白蛋白水平与骨密度关系的研究

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中华骨质疏松和骨矿盐疾病杂志 2024年第3期17卷 203-212页

作者：韩梅昝晓晖马邓荣郭馨远赵阳婷李凯陈重阳王亚雯刘靖芳兰州大学第一临床医学院兰州730000 兰州大学第一医院内分泌科兰州730000

目的探讨50岁以上男性2型糖尿病(diabetes mellitus type 2,T2DM)患者血清白蛋白(albumin,ALB)水平与骨密度(bone mineral density,BMD)的相关性。方法选取2021年7月~2022年3月兰州大学第一医院内分泌科住院的202例50岁以上男性T2DM患... 详细信息

目的探讨50岁以上男性2型糖尿病(diabetes mellitus type 2,T2DM)患者血清白蛋白(albumin,ALB)水平与骨密度(bone mineral density,BMD)的相关性。方法选取2021年7月~2022年3月兰州大学第一医院内分泌科住院的202例50岁以上男性T2DM患者及体检中心的30名男性健康对照者,根据血清ALB水平将T2DM患者分为3组:低ALB水平组(T1组,ctate dehydrogenase,LDH)、肌酸激酶(creatine kinase,ck)、天冬氨酸转氨酶(aspartate transaminase,AST)、糖化血红蛋白(glycosylated hemoglobin,HbA1c)、钙(calcium,ca)、磷(phosphorus,P)、尿酸(uric acid,UA)及尿白蛋白排泄率(urinary albumin excretion rates,UAER)等混杂因素后,血清ALB水平与全髋的BMD水平独立正相关(β=0.229,95%cI:0.000~0.019)。结论50岁以上男性T2DM患者血清ALB水平与BMD密切相关,中老年男性T2DM患者应该早期关注血清ALB水平的变化,为OP的防治提供线索。

关键词： 2型糖尿病骨质疏松血清白蛋白骨密度

ZmMYc7转录因子调控玉米抗病相关功能的初步研究

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农业生物技术学报 2024年第1期32卷 1-10页

作者：王永桂李薇崔婷茹张福源杨文皓许荡非邢继红曹宏哲董金皋河北农业大学华北作物改良与调控国家重点实验室/河北省植物生理与分子病理学重点实验室保定市气象局张家口市林业工作总站

玉米(Zea mays)是全球最重要的粮食作物之一，病原菌引起的玉米病害直接影响玉米生产，导致巨大的经济损失。转录因子MYc2在植物抗病领域发挥重要作用。本实验室前期获得拟南芥(Arabidopsis thaliana) AtMYc2在玉米中的同源基因ZmMYc7(Z... 详细信息

玉米(Zea mays)是全球最重要的粮食作物之一，病原菌引起的玉米病害直接影响玉米生产，导致巨大的经济损失。转录因子MYc2在植物抗病领域发挥重要作用。本实验室前期获得拟南芥(Arabidopsis thaliana) AtMYc2在玉米中的同源基因ZmMYc7(Zm00001d030028)。为了探究转录因子ZmMYc7在调控玉米抗病过程中的功能，本研究检测ZmMYc7突变体对4种玉米真菌病害的敏感性，利用qRT-PcR技术检测ZmMYc7突变对病程相关蛋白(pathogenesis-related protein, PR)基因表达的影响。结果显示，ZmMYc7与高粱(Sorghum bicolor) SbMYc2的同源性最高(90%);ZmMYc7在玉米的叶和花药中表达水平较高，紫外照射和禾谷镰刀菌(Fusarium graminearum)侵染会上调ZmMYc7基因表达；ZmMYc7突变后，玉米对叶和茎部病害的敏感性显著增加，病程相关蛋白基因ZmPRs的表达显著下调(Pc7可能在玉米抗病过程中发挥作用。本研究为深入解析ZmMYc7调控玉米抗病的分子机制提供基础资料。

关键词： ZmMYc7 病程相关蛋白(PR) 病原体禾谷镰刀菌转录因子

基于4H-Sic肖特基势垒二极管的γ射线探测器

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物理学报 2016年第20期65卷 212-219页

作者：杜园园张春雷曹学蕾中国科学院高能物理研究所粒子天体物理重点实验室北京100049

针对极端环境下耐高温和耐辐照半导体核探测器的研制需求,采用外延层厚度为100μm的4H碳化硅(4H-Sic)制备成肖特基二极管探测器,研究了该探测器对^(241)Am源γ射线的能谱响应.采用磁控溅射金属Ni制备了肖特基二极管的欧姆接触和肖特基接... 详细信息

针对极端环境下耐高温和耐辐照半导体核探测器的研制需求,采用外延层厚度为100μm的4H碳化硅(4H-Sic)制备成肖特基二极管探测器,研究了该探测器对^(241)Am源γ射线的能谱响应.采用磁控溅射金属Ni制备了肖特基二极管的欧姆接触和肖特基接触,利用室温电流-电压和电容-电压测试研究了二极管的电学特性.欧姆特性测试表明,1050°c退火时,欧姆接触特性最好.从正向电流-电压曲线得出二极管肖特基势垒高度为1.617 eV,理想因子为1.127,表明探测器具备良好的热电子发射特性.从电容-电压曲线获得二极管外延层净掺杂浓度为2.903×10^(14)cm^(-3),并研究了自由载流子浓度在外延层中的纵向分布.在反向偏压为500 V时,二极管的漏电流只有2.11 nA,具有较高的击穿电压.测得在-300 V条件下,Sic二极管探测器对能量为59.5 keV的γ射线的能量分辨率为9.49%(5.65 keV).

关键词： 4H-Sic 宽禁带半导体肖特基二极管 γ射线探测器

Discharge characteristics and reactive species production of unipolar and bipolar nanosecond pulsed gas–liquid discharge generated in atmospheric N2

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Plasma Science and Technology 2021年第9期23卷 123-134页

作者： Jianping LIANG Xiongfeng ZHOU Zilu ZHAO Hao yuan Hongli WANG Wenchun WANG Dezheng YANG key Lab of Materials Modification(Dalian University of Technology) Ministry of EducationDalian 116024People's Republic of China

In this paper,unipolar pulse(including positive pulse and negative pulse)and bipolar pulse voltage are employed to generate diffuse gas–liquid discharge in atmospheric N2with a rumpetshaped quartz *** current–voltage waveforms,optical emission spectra of excited state active species,FTIR spectra of exhaust gas components,plasma gas temperature,and aqueous H2O2,NO2-,andNO3-production are compared in three pulse modes,meanwhile,the effects of pulse peak voltage and gas flow rate on the production of reactive species are *** results show that two obvious discharges occur in each voltage pulse in unipolar pulse driven discharge,differently,in bipolar pulse driven discharge,only one main discharge appears in a single voltage pulse *** intensities of active species(OH(A),and O(3p))in all three pulsed discharge increase with the rise of pulse peak voltage and have the highest value at 200 ml min-1of gas flow *** absorbance intensities of NO2and N2O increase with the increase of pulse peak voltage and decrease with the increase of gas flow *** the same discharge conditions,the bipolar pulse driven discharge shows lower breakdown voltage,and higher intensities of excited species(N2(c),OH(A),and O(3p)),nitrogen oxides(NO2,NO,and N2O),and higher production of aqueous H2O2,NO2-,andNO3-compared with both unipolar positive and negative discharges.

关键词： nanosecond pulse discharge gas-liquid discharge optical emission spectra reactive species FTIR spectra

Emerging contaminants:A One Health perspective

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The Innovation 2024年第4期5卷 140-170,139页

作者： Fang Wang Leilei Xiang kelvin Sze-Yin Leung Martin Elsner Ying Zhang Yuming Guo Bo Pan Hongwen Sun Taicheng An Guangguo Ying Bryan WBrooks Deyi Hou Damian EHelbling Jianqiang Sun Hao Qiu Timothy MVogel Wei Zhang Yanzheng Gao Myrna JSimpson Yi Luo Scott Xchang Guanyong Su Bryan MWong Tzung-May Fu Dong Zhu karl JJobst chengjun Ge Frederic coulon Jean Damascene Harindintwali Xiankui Zeng Haijun Wang Yuhao Fu Zhong Wei Rainer Lohmann changer chen Yang Song concepcion Sanchez-cid Yu Wang Ali El-Naggar Yiming Yao Yanran Huang Japhet cheuk-Fung Law chenggang Gu Huizhong Shen Yanpeng Gao chao Qin Hao Li Tong Zhang Natàlia corcoll Min Liu Daniel SAlessi Hui Li kristian kBrandt Yolanda Pico cheng Gu Jianhua Guo Jianqiang Su Philippe corvini Mao Ye Teresa Rocha-Santos Huan He Yi Yang Meiping Tong Weina Zhang Fidèle Suanon Ferdi Brahushi Zhenyu Wang Syed AHashsham Marko Virta Qingbin yuan Gaofei Jiang Louis A.Tremblay Qingwei Bu Jichun Wu Willie Peijnenburg Edward Topp Xinde cao Xin Jiang Minghui Zheng Taolin Zhang Yongming Luo Lizhong Zhu Xiangdong Li DamiàBarceló Jianmin chen Baoshan Xing Wulf Amelung Zongwei cai Ravi Naidu Qirong Shen Janusz Pawliszyn Yong-guan Zhu Andreas Schaeffer Matthias c.Rillig Fengchang Wu Gang Yu James M.Tiedje State key Laboratory of Soil and Sustainable Agriculture Institute of Soil ScienceChinese Academy of SciencesNanjing 210008China University of chinese Academy of Sciences Beijing 100049China Department of chemistry Hong Kong Baptist UniversityHong KongChina HkBU Institute of Research and continuing Education Shenzhen Virtual University ParkShenzhenChina Technical University of Munich TUM School of Natural SciencesInstitute of Hydrochemistry85748 GarchingGermany School of Resources&Environment Northeast Agricultural UniversityHarbin 150030China climate Air Quality Research UnitSchool of Public Health and Preventive MedicineMonash UniversityMelbourneVICAustralia Faculty of Environmental Science&Engineering Kunming University of Science&TechnologyKunming 650500China Ministry of Education key Laboratory of Pollution Processes and Environmental criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300350China Guangdong key Laboratory of Environmental catalysis and Health Risk control School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education key Laboratory of Environmental Theoretical chemistry South China Normal UniversityGuangzhouGuangdong 510006China Department of Environmental Science Baylor UniversityWacoTXUSA center for Reservoir and Aquatic Systems Research(cRASR) Baylor UniversityWacoTXUSA School of Environment Tsinghua UniversityBeijing 100084China School of civil and Environmental Engineering Cornell UniversityIthacaNY 14853USA key Laboratory of Microbial Technology for Industrial Pollution control of Zhejiang Province Zhejiang University of TechnologyHangzhou 310014China School of Environmental Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240China Laboratoire d’Ecologie Microbienne Universite Claude Bernard Lyon 1UMR CNRS 5557UMR INRAE 1418VetAgro Sup69622 VilleurbanneFrance Department of Pla

Environmental pollution is escalating due to rapid global development that often prioritizes human needs over planetary *** global efforts to mitigate legacy pollutants,the continuous introduction of new substances remains a major threat to both people and the *** response,global initiatives are focusing on risk assessment and regulation of emerging contaminants,as demonstrated by the ongoing efforts to establish the UN’s Intergovernmental Science-Policy Panel on chemicals,Waste,and Pollution *** review identifies the sources and impacts of emerging contaminants on planetary health,emphasizing the importance of adopting a One Health *** for monitoring and addressing these pollutants are discussed,underscoring the need for robust and socially equitable environmental policies at both regional and international *** actions are needed to transition toward sustainable pollution management practices to safeguard our planet for future generations.

关键词： pollution planet contaminants

comparison of immune profiles between hepatocellular carcinoma subtypes

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Biophysics Reports 2020年第1期6卷 19-32页

作者： Xuemin Pan Ping Lin Fangyoumin Feng Jia Li yuan-yuan Li Wentao Dai Bo Hu Xin-Rong Yang Jia Fan Hong Li Yixue Li School of Life Sciences and Biotechnology Shanghai Jiao Tong University Bio-Med Big Data center Key Laboratory of Computational Biology CAS-MPG Partner Institute for Computational Biology Shanghai Institute of Nutrition and Health Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences Chinese Academy of Sciences University of the chinese Academy of Sciences School of Life Science and Techonology Shanghai Tech University Shanghai center for Bioinformation Technology Shanghai Academy of Science & Technology Shanghai Engineering Research center of Pharmaceutical Translation Department of Liver Surgery Liver Cancer Institute Zhongshan Hospital Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education collaborative Innovation center of Genetics and Development Fudan University

Immunotherapy, especially immune checkpoint inhibitors, is becoming a promising treatment for hepatocellular carcinoma(Hcc). However, the response rate remains limited due to the heterogeneity of Hcc samples. Molecular subtypes of Hcc vary in genomic background, clinical features, and prognosis. This study aims to compare the immune profiles between Hcc subtypes and find subtype-specific immune characteristics that might contribute to the prognosis and potential of immunotherapy. The immune profiles consist of immune-related genes, cytolytic activity, immune pathways, and tumorinfiltrating lymphocytes. Hcc-c1 samples showed an overall higher activation level of immune genes and pathways, and this pattern was consistent in validation sets. We associated the difference in immune profiles with the activation level of cancer hallmarks and genomic mutations. There was a negative correlation between most of the metabolism pathway and immune-related pathways in Hcc samples. cTNNB1/WNT signaling pathway mutation, one of the common mutations in Hcc, appears to be associated with the expression of immune genes as well. These results reveal the difference of immune profiles between Hcc subtypes and possible reasons and influence, which may also deepen our understanding of the carcinogenesis process.

关键词： Hepatocellular carcinoma Immune Tumor-infiltrating lymphocytes Metabolism cTNNB1 mutation