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Anti-diabetes effects and mechanisms of a chinese herbal medicine preparation jQ-R in diabetic KKAy mice and in vitro

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中国药理学与毒理学杂志 2018年第4期32卷 294-295页

作者： Shuai-nan LIU quan LIU Zhu-fang SHEN Institute of Materia Medica Chinese Academy of Medical Sciences and Peking Union Medical College State Key Laboratory of Bioactive Substances and Functions of Natural Medicines Key laboratory of Polymorphic Drugs of Beijing Diabetes Research Center of

OBjEcTIVE To investigate the effects and mechanisms by which jQ-R regulated the glucose metabolism and improves insulin sensitivity in diabetic KKAy mice and insulin-resistant L6 ***-R is a mixture of refined extracts from coptis chinensis,Astragalus membranaceus and Lonicera japonica,three major herbs of jinQi-jiangTang *** Diabetic KKAy mice were *** jQ-R(100 mg·kg^(-1) or 200 mg·kg^(-1) BW) for 10 *** of fasting plasma glucose,lipids,insulin and hemoglobin A1c were *** insulin sensitivity was quantified using the *** *** effect of jQ-R on the expressions of the enzymes involved in insulin signaling,oxidative stress and inflammation(Akt,NFκB,IΚBα,jNK,Erk,p38 MAPK) were measured in L6 *** *** jQ-R showed beneficial effects on glucose homeostasis and insulin *** in diabetic KKAy mice after 10 weeks ***-R also ameliorated the plasma lipid ***,jQ-R can directly reverse the decreased activity of SOD and increased MDA levels as well as activity of iNOS in insulin resistant L6 cell induced with palmitic acid(PA).The expressions of *** of NF-κB p65,IκBα,jNK1/2 and Erk1/2 were also decreased after jQ-R *** was also shown that the insulin-stimulated glucose uptake increased significantly after jQ-R treatment,with upregulated expression of phosphorylation of *** jQ-R ameliorated the glucose and lipid metabolism and insulin sensitivity in diabetic KKAy *** vitro treatment with jQ-R directly enhanced insulin stimulated glucose uptake in insulin resistant myotubes with improved insulin *** and inflammatory response and oxidative stress state.

关键词：糖尿病胰岛素治疗方法临床分析

Auxiliary ligand-directed assembly of a non-interpenetrated cage-within-cage metal-organic framework for highly efficient c_(2)H_(2)/cO_(2) separation

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chinese journal of Structural chemistry 2023年第6期42卷 22-26页

作者： Yong-Peng Li jing-jing Ni Shu-cong Fan quan-Guo Zhai School of chemistry and chemical Engineering Institute of Applied CatalysisYantai UniversityYantaiShandong 264005China Key Laboratory of Macromolecular Science of Shaanxi Province School of Chemistry&Chemical Engineering Shaanxi Normal UniversityXi'an710062China

The development of metal-organic frameworks(MOFs)with highly efficient adsorption and separation of acet-ylene is very important and challenging in chemical industry due to the explosive nature of *** MOFs can be constructed by inserting a second auxiliary ligand,which allows the use of large ligands to construct non-interpenetrated structures and increase pore ***,SNNU-205 is successfully synthesized,which connects two sets of interpenetrated structures to form a double walled cage-within-cage structure by using the introduction of a second auxiliary *** modified pore environment enables SNNU-205 to efficiently selectively adsorb c_(2)H_(2)over cO_(2).At 298 K and 1 atm,SNNU-205 can uptake much more c_(2)H_(2)(76.3 cm^(3)g1)than cO_(2)(47.3 cm^(3)g^(-1)),resulting in a high substance ratio of c_(2)H_(2)-to-cO_(2)(1.6).More importantly,the ideal adsorbed solution theory selectivity calculations and column breakthrough tests further indicate SNNU-205 to be promising adsorbents for c_(2)H_(2)adsorption and purification.

关键词： Metal-organic frameworks(MOFs) Second auxiliary ligand Acetylene storage Acetylene/carbon dioxide separation

Freezing-directed construction of enzyme/nano interfaces:Reagentless conjugation,superior activity,and better stability

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chinese chemical Letters 2024年第1期35卷 471-474页

作者： Ke quan jiajie Tong Lifang chen Shuyao Fang Mengjiao Li Linlin Wu Zhihe Qing Hunan Provincial Key Laboratory of cytochemistry School of Food and BioengineeringSchool of Chemistry and Chemical EngineeringChangsha University of Science and TechnologyChangsha 410114China Department of Oncology Tengzhou Central People’s Hospital Affiliated Xuzhou Medical UniversityTengzhou 277500China

Immobilizing enzyme to nano interfaces has demonstrated to be a favorable strategy for prompting the industrialized application of *** tremendous endeavor has been devoted to using gold nanoparticles(AuNPs)as conjugation matrix due to its fascinating physico-chemical properties,maintaining enzymatic activity while circumventing cumbersome modification remains a formidable ***,the freezing-directed conjugation of enzyme/nano interfaces was constructed without extra *** the proof of concept,glucose oxidase(GOx)was chosen as model *** one-pot conjugation process can be facilely completed at−20°c under aqueous ***,with the loading of GOx on AuNP at freezing,the enzyme exhibited superior catalytic activity and stability upon thermal and pH *** mechanism of boosted activity was then discussed in *** was found that higher loading density under freezing condition and more enzyme tending to bind AuNPs via Au-S bond were the main factors for the superior *** importantly,this methodology was universal and can also be applied to other enzyme which contains natural cysteine,such as horseradish peroxidase(HRP)and *** facile conjugation strategy accompanied by remarkable bioactivity expand the possibilities for enzymatic biosensing,microdevice and even drug delivery.

关键词： Enzyme conjugation Freezing AuNPs catalytic activity

Optimized strategy of rotational atherectomy of underexpanded coronary stents in patients with acute coronary syndrome

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World journal of Emergency Medicine 2021年第3期12卷 198-201页

作者： Kun cui You-quan Shi Yuan-zheng Zhang Zheng-gong Li chang-ling Li Department of cardiology Chongqing General HospitalChongqing 400013China Department of cardiology the Third People’s Hospital of Xinjiang Uygur Autonomous RegionUrumqi 830000China Department of cardiology the First People’s Hospital of TianshuiTianshui 741000China Department of cardiology the Second Affi liated Hospital of Zhejiang University School of MedicineHangzhou 310009China

BAcKGROUND:Stent under-expansion is a main cause of acute coronary syndrome(AcS),which can lead to serious clinical *** rotational atherectomy of underexpanded coronary stents(academically called stent ablation,SA)by intravascular ultrasound(IVUS)may provide more visual reference in the *** aim to analyze the procedural and long-term outcomes of the optimized strategy of SA in patients with AcS and to provide real-world data on this ***:A total of 11 patients with AcS who underwent SA between April 2017 and january 2019 were *** follow-ups were obtained either by telephone call or by scheduled *** end-points included periprocedural and postprocedural myocardial infarction,stent thrombosis,target lesion revascularization,and major adverse cardiac ***:The mean age of patients was 69.6±6.5 years,and five(45.5%)patients were *** cases presented with unstable angina and were admitted with *** patients required at least two burrs during the intervention and the size of the burr was selected based on the data of minimum lumen diameter(MLD),and the fi rst and the second burr/stent MLD ratios were 0.93(0.88-0.99)and 1.09(1.02-1.14),*** patients were treated with drug-eluting stents and two were treated with drug-coated *** were no complications including no fl ow,perforation,or burr entrapment during the *** in-hospital deaths or major adverse cardiac events were documented during the follow-up *** our study,less contrast agent and a lower dose of radiation were used during the ***:SA guided by IVUS can reduce the risk of complications,assess the results of surgery,inform the selection of stent size,and decrease the required dose of radiation and contrast.

关键词： Acute coronary syndrome Intravascular ultrasound Rotational atherectomy Underexpanded stent

Interfacial built-in electric field and crosslinking pathways enabling WS_(2)/Ti_(3)c_(2)T_(x) heterojunction with robust sodium storage at low temperature

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journal of Energy chemistry 2024年第2期89卷 635-645,I0014页

作者： jiabao Li Shaocong Tang jingjing Hao quan Yuan Tianyi Wang Likun Pan jinliang Li Shenbo Yang chengyin Wang college of chemistry and chemical Engineering Yangzhou UniversityYangzhou 225002JiangsuChina Shanghai Key Laboratory of Magnetic Resonance School of Physics and Electronic Science East China Normal UniversityShanghai 200241China Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy MaterialsGuangdong Provincial Key Laboratory of Nanophotonic ManipulationDepartment of PhysicsJinan UniversityGuangzhou 510632GuangdongChina Hongzhiwei Technology(Shanghai)cO.LTD Shanghai 200241China

Developing efficient energy storage for sodium-ion batteries(SIBs)by creating high-performance heterojunctions and understanding their interfacial interaction at the atomic/molecular level holds promise but is also ***,sluggish reaction kinetics at low temperatures restrict the operation of SIBs in cold ***,cross-linking nanoarchitectonics of WS_(2)/Ti_(3)c_(2)T_(x) heterojunction,featuring built-in electric field(BIEF),have been developed,employing as a model to reveal the positive effect of heterojunction design and BIEF for modifying the reaction kinetics and electrochemical ***,the theoretical analysis manifests the discrepancy in work functions leads to the electronic flow from the electron-rich Ti_(3)c_(2)T_(x) to layered WS_(2),spontaneously forming the BIEF and“ion reservoir”at the heterogeneous ***,the generation of cross-linking pathways further promotes the transportation of electrons/ions,which guarantees rapid diffusion kinetics and excellent structure ***,superior sodium storage performance is obtained for the WS_(2)/Ti_(3)c_(2)T_(x) heterojunction,with only 0.2%decay per cycle at 5.0 A g^(-1)(25℃)up to 1000 cycles and a high capacity of 293.5 mA h g^(-1)(0.1A g^(-1)after 100 cycles)even at-20℃.Importantly,the spontaneously formed BIEF,accompanied by“ion reservoir”,in heterojunction provides deep understandings of the correlation between structure fabricated and performance obtained.

关键词： WS_(2)/Ti_(3)c_(2)T_(x)heterojunction Built-in electric field Ion reservoir Reaction kinetics Sodium storage performance at low temperature

Syntheses and crystal Structures of Two 3D Zinc(II) compounds Involving coordination and Hydrogen Bonds

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chinese journal of Structural chemistry 2006年第5期25卷 527-532页

作者： cHEN Bai-quan HAN Lei WU Ben-Lai WU Ming-Yan HUANG You-Gui HONG Mao-chun State Key Laboratory of Structural chemistry Fujian Institute of Research on the Structure of Matter The Chinese Academy of Sciences Fuzhou Fujian 350002 China Graduate School of the chinese Academy of Sciences Beijing 100039 China

Two zinc（Ⅱ） compounds, [Zn（L）（H2O）2]n 1 and [Zn（4,4＇-bpy）（H2O）4]（L） 2 （H2L = trans,trans-1,3 butadiene 1,4-dicarboxylic acid）, were synthesized by hydrothermal methods and characterized by single-crystal X-ray diffraction analyses. compound 1 crystallizes in monoclinic, space group c2/c with a=15.4970（16）, b = 5.4976（6）, c = 10.7113（12） A, β=96.298（6）°, c6H8O6Zn, Mr = 241.50, V = 907.06（17） A^3, Z = 4, D, = 1.768 g/cm^3, F（000） = 488,μ = 2.703 mm^-1, S = 1.060, the final R = 0.0256 and wR = 0.0660 for 968 observed reflections with Ⅰ 〉 2σ（Ⅰ）. compound 2 crystallizes in triclinic, space group P1^- with a = 6.915（2）, b = 7.166（2）, c = 10.363（3） A, α = 73.250（4）, β = 84.429（4）, γ = 61.605（3）°, c16H2ON2O8Zn, Mr = 433.70, V = 432.1 （2） A^3, Z = 1, D, = 1.667 g/cm^3, F（000） = 224 and μ= 1.471 mm^-1, S = 1.118, the final R = 0.0486 and wR = 0.1077 for 1352 observed reflections with Ⅰ〉 2σ（Ⅰ）. Upon using the assembly strategy of combination of coordination polymer chains with intermolecular hydrogen bonds, three-dimensional frameworks of complexes 1 and 2 were formed.

关键词： Zn(Ⅱ) coordination polymer hydrogen bonds crystal structure

Electrochemical removal of ammonium nitrogen in high efficiency and N_(2) selectivity using non-noble single-atomic iron catalyst

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journal of Environmental Sciences 2023年第3期125卷 544-552页

作者： Fengjiao quan Guangming Zhan Bing Zhou cancan Ling Xiaobing Wang Wenjuan Shen jianfen Li Falong jia Lizhi Zhang college of chemical and Environmental Engineering Wuhan Polytechnic UniversityWuhan 430023China Institute of Environmental&Applied chemistry College of ChemistryCentral China Normal UniversityWuhan 430079China School of chemistry and civil Engineering Shaoguan UniversityShaoguan 512005China

Ammonia nitrogen (NH_(4)^(+)-N) is a ubiquitous environmental pollutant,especially in offshore aquaculture *** oxidation is very promising to remove NH_(4)^(+)-N,but suffers from the use of precious metals *** this work,a robust and cheap electrocatalyst,iron single-atoms distributed in nitrogen-doped carbon (Fe-SAs/N-c),was developed for electrochemical removal of NH_(4)^(+)-N from in wastewater containing *** FeSAs/N-c catalyst exhibited superior activity than that of iron nanoparticles loaded carbon(Fe-NPs/N-c),unmodified carbon and conventional Ti/IrO_(2)-TiO_(2)-RuO_(2)*** high removal efficiency (>99%) could be achieved as well as high N_(2)selectivity (99.5%) at low current *** experiments and density functional theory (DFT) calculations demonstrated the indispensable role of single-atom iron in the promoted generation of chloride derived species for efficient removal of NH_(4)^(+)-*** study provides promising inexpensive catalysts for NH_(4)^(+)-N removal in aquaculture wastewater.

关键词： Ammonia nitrogen removal Single-atom iron Non-noble metal catalyst Aquaculture wastewater

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毛泽东与时代精神

湘潭大学学报(哲学社会科学版) 2009年第4期33卷 1-11页

作者：许全兴中共中央党校哲学教研部

毛泽东精神是民族精神与时代精神的统一,学界长期忽视对其中的时代精神的研究。毛泽东时代精神主要包含有科学精神、自由精神、民主精神、人道精神和创新精神。

关键词：毛泽东精神时代精神科学自由民主人道

Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MScs)

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Genes & Diseases 2019年第3期6卷 258-275页

作者： Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui cao Lijuan Yang Xian chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex c*Haydon Michael j*Lee jennifer Moriatis Wolf Zhou Fu Tong-chuan He quan Kang Stem cell Biology and Therapy Laboratory Ministry of Education Key Laboratory of Child Development and DisordersThe Children’s Hospital of Chongqing Medical UniversityChongqing 400014China Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA c Ministry of Education Key Laboratory of Diagnostic Medicine School of Laboratory MedicineChicagoIL 60637USA d The Affiliated Hospitals of chongqing Medical University Chongqing 400016China e Department of clinical Laboratory Medicine The Second Affiliated Hospital of Nanchang UniversityNanchang 330006China f Key Laboratory of Orthopaedic Surgery of Gansu Province Departments of Orthopaedic Surgery and Obstetrics and GynecologyThe First and Second Hospitals of Lanzhou UniversityLanzhou 730030China g Department of General Surgery The Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Department of clinical Laboratory Medicine The Affiliated Hospital of Qingdao UniversityQingdao 266061China Department of Biology School of Life SciencesSouthwest UniversityChongqing 400715China Department of Surgery Section of Plastic SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA

Mesenchymal stem cells(MScs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and *** represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult *** least 14 BMPs have been identified in *** BMPs exert distinct but overlapping biological *** a comprehensive analysis of 14 BMPs in MScs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of ***,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MScs remains to be fully ***,we conducted a comprehensive transcriptomic profiling in the MScs stimulated by 14 types of *** clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 *** also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase ***,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR *** the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MScs.

关键词： Bone morphogenetic proteins(BMPs) MAP kinase signaling Mesenchymal stem cells Notch signaling PI3K/AKT/mTOR pathway Smad signaling TGFb superfamily Wnt signaling