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Herbal medicine Yin Zhi huang induces cYP3A4-mediated sulfoxidation and cYP2c19-dependent hydroxylation of omeprazole

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Acta Pharmacologica Sinica 2007年第10期28卷 1685-1692页

作者： Lan FAN,Guo WANG,Lian-sheng WANG,Yao cHEN,Wei ZHANG,Yuan-fei huang,Rui-xue huang,Dong-li HU,DanWANG,Hong-hao ZHOU~2Pharmacogenetics Research Institute,Institute of clinical Pharmacology,central South University,Hu-nan 410078,china Pharmacogenetics Research Institute Institute of Clinical Pharmacology Central South University Hu-nan China

Aim:To explore the potential interactions between Yin Zhi huang (YZH) andomeprazole,a substrate of cYP3A4 and ***:Eighteen healthyvolunteers,including 6 cYP2c19~*1/~*1,6 cYP2c19~*1/~*2 or ~*3 and 6 cYP2c19~*2/~*2 were enrolled in a 2-phase,randomized,crossover clinical *** each phase,the volunteers received either placebo or 10 mL YZH oral liquid,3 times daily for *** all the patients took a 20 mg omeprazole capsule *** sampleswere collected up to 12 h after omeprazole *** concentrationsof omeprazole and its metabolites were quantified by HPLc with UV ***:After 14 d of treatment of YZH,plasma omeprazole significantlydecreased and those of omeprazole sulfone and 5-hydroxyomeprazole signifi-cantly *** ratios of the area under the plasma concentration-timecurves from time 0 to infinity (AUc0-∞of omeprazole to 5-hydroxyomprazole andthose of omeprazole to omeprazole sulfone decreased by 64.80%±12.51% (P=0.001) and 63.31%±18.45% (P=0.004) in cYP2c 19~*1/~*1,57.98%±14.80% (P=0.002)and 54.87%±18.42% (P=0.003) in cYP2c19~*1/~*2 or ~*3,and 37.74%±16.07% (P=0.004) and 45.16%±15.54% (P=0.003) in cYP2c19~*2/~*2,*** of the AUc0-∞ratio of omeprazole to 5-hydroxyomprazole in cYP2c19~*1/~*1and cYP2c19~*1/~*2 or ~*3 was greater than those in cYP2c19~*2/~*2 (P=0.047and P=0.009).conclusion:YZH induces both cYP3A4-catalyzed sulfoxidationand cYP2c 19-dependent hydroxylation of omeprazole leading to decreases inplasma omeprazole concentrations.

关键词： Yin Zhi huang induction cYP3A4 cYP2c19 omeprazole

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一种面向交通安全的违禁品轻量级检测方法

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湖南工业大学学报 2025年第1期39卷 72-78页

作者：翁成康黄贤明黄海洋湖南工业大学计算机学院湖南株洲412007

针对X光安检图像中摆放杂乱、故意遮挡、小型不规则物品检测等问题,以及安检工作对实时性、快速性的要求,基于YOLO v5s网络模型提出了一种结合改进的轻量级实时违禁品监测方法LRcD,以辅助安检人员快速进行检测。通过在模型的主干中使用D... 详细信息

针对X光安检图像中摆放杂乱、故意遮挡、小型不规则物品检测等问题,以及安检工作对实时性、快速性的要求,基于YOLO v5s网络模型提出了一种结合改进的轻量级实时违禁品监测方法LRcD,以辅助安检人员快速进行检测。通过在模型的主干中使用DenseOne模块替代YOLO v5s主干中的c3模块,进而丰富特征,提高网络的特征表达能力;为了提高推理速度,使用SimSPPF替换YOLO v5s主干中的SPPF;同时引入WIoU(Wise-IoU)损失函数,抑制了冗余特征对检测网络的影响,增强了网络获取违禁品中包含的多尺度特征的能力。在针对X光下行李物品图片的EDS数据集中进行测试,mAP达68.96%,FPS达136.9,对比近年来被广泛使用的其他经典目标检测模型,分别平均提升了6.35%与66.7%。

关键词：轻量化卷积神经网络 X光图像注意力机制违禁品检测

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Review on fate of chlorine during thermal processing of solid wastes

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Journal of Environmental Sciences 2019年第4期31卷 13-28页

作者： Peng Lu Qunxing huang A.c.(Thanos) Bourtsalas Nickolas J.Themelis Yong chi Jianhua Yan State Key Laboratory of clean Energy Utilization Zhejiang University Earth Engineering center Columbia University

chlorine(cl) is extensively present in solid wastes, causing significant problems during the thermal conversion of waste to energy or fuels, by combustion, gasification or *** paper introduces the analytical methods for determining the cl content in solid materials and presents the concentrations of cl in various types of wastes, as reported in literature. Then, it provides a comprehensive analysis on the cl emission behavior and cl species formed during the thermal processing of the inorganic and organic cl sources. The challenges resulted from the reactions between the formed cl species and the ferrous metals, the heavy metals and the organic matters are summarized and discussed, e.g., high temperature corrosion, heavy metal evaporation and dioxin formation. The quality degradation of products(oil, char and syngas) by cl is analyzed. Finally, the available controlling methods of cl emission, including pre-treatment(water washing, sorting,microwave irradiation and stepwise pyrolysis) and in-furnace(absorbents, co-treatment and catalysts) methods are assessed.

关键词： chlorine Solid wastes Thermal processing Emission controlling methods

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Microphysical characteristics of Extreme-Rainfall convection over the Pearl River Delta Region, South china from Polarimetric Radar Data during the Pre-summer Rainy Season

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Advances in Atmospheric Sciences 2023年第5期40卷 874-886页

作者： Hao huang Kun ZHAO Johnny cLcHAN Dongming HU Key Laboratory for Mesoscale Severe Weather/MOE and School of Atmospheric Sciences Nanjing UniversityNanjing 210023China State Key Laboratory of Severe Weather and Joint center for Atmospheric Radar Research CMA/NJUBeijing 100081China School of Energy and Environment City University of Hong KongHong Kong 999077China Guangdong Meteorological Observatory Guangzhou 510062China

During the pre-summer rainy season,heavy rainfall occurs frequently in South *** on polarimetric radar observations,the microphysical characteristics and processes of convective features associated with extreme rainfall rates(ERcFs)are *** the regions with high ERcF occurrence frequency,sub-regional differences are found in the lightning flash rate(LFR)*** the region with higher LFRs,the ERcFs have larger volumes of high reflectivity factor above the freezing level,corresponding to more active riming *** addition,these ERcFs are more organized and display larger spatial coverage,which may be related to the stronger low-level wind shear and higher terrain in the *** the region with lower LFRs,the ERcFs have lower echo tops and lower-echo ***,no clear differences of the most unstable convective available potential energy(MUcAPE)exist in the ERcFs in the regions with different LFR *** of the LFRs,raindrop collisional coalescence is the main process for the growth of raindrops in the *** the ERcFs within the region with lower LFRs,the main mechanism for the rapid increase of liquid water content with decreasing altitude below 4 km is through the warm-rain processes converting cloud drops to ***,in those with higher LFRs,the liquid water content generally decreases with decreasing altitude.

关键词： microphysics extreme rainfall rate polarimetric radar lightning flash rate

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Multisensor Data Fusion for High Quality Data Analysis and Processing in Measurement and Instrumentation

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Journal of Bionic Engineering 2007年第1期4卷 53-62页

作者： Yan-bo huang Yu-bin Lan W. c. Hoffmann R. E. Lacey USDA ARS Agricultural Engineer Areawide Pest Management Research Unit Texas 77845 USA Biological and A g ricultural Engineering Department Texas A ＆M University Texas 77843-2117 USA

Multisensor data fusion （MDF） is an emerging technology to fuse data from multiple sensors in order to make a more accurate estimation of the environment through measurement and detection. Applications of MDF cross a wide spectrum in military and civilian areas. With the rapid evolution of computers and the proliferation of micro-mechanical/electrical systems sensors, the utilization of MDF is being popularized in research and applications. This paper focuses on application of MDF for high quality data analysis and processing in measurement and instrumentation. A practical, general data fusion scheme was established on the basis of feature extraction and merge of data from multiple sensors. This scheme integrates artificial neural networks for high performance pattern recognition. A number of successful applications in areas of NDI （Non-Destructive Inspection） corrosion detection, food quality and safety characterization, and precision agriculture are described and discussed in order to motivate new applications in these or other areas. This paper gives an overall picture of using the MDF method to increase the accuracy of data analysis and processing in measurement and instrumentation in different areas of applications.

关键词： multisensor data fusion artificial neural networks NDI food quality and safety characterization precision agriculture

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ASYMPTOTIc BEHAVIOR OF SOLUTIONS FOR THE cHAFEE-INFANTE EQUATION

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Acta Mathematica Scientia 2020年第2期40卷 425-441页

作者： Haochuan huang Rui huang School of Mathematics and Big Data Foshan UniversityFoshan 528000China School of Mathematical Sciences South China Normal UniversityGuangzhou 510631China

In higher dimension,there are many interesting and challenging problems about the dynamics of non-autonomous chafee-Infante *** article is concerned with the asymptotic behavior of solutions for the non-autonomous chafee-Infante equation∂u∂t−Δu=λ(t)(u−u3)in higher dimension,whereλ(t)∈c1[0,T]andλ(t)is a positive,periodic *** denoteλ1 as the first eigenvalue of−Δφ=λφ,x∈Ω;φ=0,x∈∂Ω.For any spatial dimension N≥1,we prove that ifλ(t)≤λ1,then the nontrivial solutions converge to zero,namely,limt→+∞u(x,t)=0,x∈Ω;ifλ(t)>λ1 as t→+∞,then the positive solutions are"attracted"by positive periodic ***,ifλ(t)is independent of t,then the positive solutions converge to positive solutions of−ΔU=λ(U−U^3).Furthermore,numerical simulations are presented to verify our results.

关键词： chafee-Infante equation asymptotic behavior periodic solutions

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High-temperature oxidation behavior of 9cr‒5Si‒3Al ferritic heat-resistant steel

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International Journal of Minerals,Metallurgy and Materials 2020年第9期27卷 1244-1250页

作者： Jun-jun Yan Xue-fei huang Wei-gang huang college of Materials Science and Engineering Sichuan UniversityChengdu 610065China

To improve the oxidation properties of ferritic heat-resistant steels,an Al-bearing 9cr‒5Si‒3Al ferritic heat-resistant steel was *** then conducted cyclic oxidation tests to investigate the high-temperature oxidation behavior of 9cr‒5Si and 9cr‒5Si‒3Al ferritic heat-resistant steels at 900 and 1000℃.The characteristics of the oxide layer were analyzed by X-ray diffraction,scanning electron microscopy,and energy dispersive *** results show that the oxidation kinetics curves of the two tested steels follow the parabolic law,with the parabolic rate constant kp of 9cr‒5Si‒3Al steel being much lower than that of 9cr‒5Si steel at both 900 and 1000℃.The oxide film on the surface of the 9cr‒5Si alloy exhibits cr2MnO4 and cr2O3 phases in the outer layer after oxidation at 900 and 1000℃.However,at oxidation temperatures of 900 and 1000℃,the oxide film of the 9cr‒5Si‒3Al alloy consists only of Al2O3 and its oxide layer is thinner than that of the 9cr‒5Si *** results indicate that the addition of Al to the 9cr‒5Si steel can improve its high-temperature oxidation resistance,which can be attributed to the formation of a continuous and compact Al2O3 film on the surface of the steel.

关键词： ferritic heat-resistant steel high-temperature oxidation oxidation kinetics aluminum

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Mechanism of Primary Frequency Regulation for Battery Hybridization in Hydropower Plant

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cSEE Journal of Power and Energy Systems 2024年第5期10卷 2127-2137页

作者： Yiwen Liao Weijia Yang Zhecheng Wang Yifan huang c.Y.chung State Key Laboratory of Water Resources and Hydropower Engineering Science Wuhan UniversityWuhan 430072China Department of Electrical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Battery hybridization in hydropower plants is a hydropower flexibility enhancement technology innovation that can potentially expand hydropower’s contributions to the grid,but its fundamental characteristics and influencing mechanisms are still *** this paper,primary frequency regulation(PFR)performance and the mechanism of this new technology are studied.A battery hybridized hydropower plant(BH-HPP)model,based on a field-measured-data-based hydropower plant(HPP)model and a verified battery simplified model,is *** of system stability and dynamics is undertaken for three different battery control strategies by root locus and participation factor *** to conventional HPPs,analysis results theoretically reveal BH-HPP can not only accelerate system regulation rapidity but also effectively enlarge HPP stability region during PFR *** domain simulation verifies the results and further shows synthetic control has better performance among introduced ***,initial design ranges of control parameters considering battery capacity and a renewable energy source scenario case are also *** work could provide theoretical support for flexibility enhancement solutions for hydropower systems.

关键词： Battery hybridization dynamic response hydropower plant primary frequency regulation stability

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Numerical Study of Heat and Moisture Transfer in Textile Materials by a Finite Volume Method

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communications in computational Physics 2008年第9期4卷 929-948页

作者： c.Ye H.huang J.Fan W.Sun Department of Mathematics City University of Hong KongKowloonHong Kong. Department of Mathematics&Statistics York UniversityTorontoOntario M3J 1P3Canada. Institute of Textiles and clothing Hong Kong Polytechnic UniversityHong Kong

This paper focuses on the numerical study of heat and moisture transfer in clothing assemblies,based on a multi-component and multiphase flow model which includes heat/moisture convection and conduction/diffusion as well as phase change.A splitting semi-implicit finite volume method is proposed for solving a set of nonlinear convection-diffusion-reaction equations,in which the calculation of liquid water content absorbed by fiber is decoupled from the rest of the *** method maintains the conservation of air,vapor and heat flux(energy).Four types of clothing assemblies are investigated and comparison with experimental measurements are also presented.

关键词： Fibrous porous medium multi-component flow clothing assemblies finite volume method condensation/evaporation.

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Exploring transposable element-based markers to identify allelic variations underlying agronomic traits in rice

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Plant communications 2022年第3期3卷 59-71页

作者： Haidong Yan David c.Haak Song Li Linkai huang Aureliano Bombarely School of Plant and Environmental Sciences Virginia TechBlacksburgVA 24061USA Graduate Program in Genetics Bioinformatics and Computational Biology(GBCB)Virginia TechBlacksburgVA 24061USA Department of Grassland Science Animal Science and Technology CollegeSichuan Agricultural UniversityChengdu 611130China Department of Bioscience Universita degli Studi di Milano(UNIMI)20133 MilanoItaly Instituto de Biologıa Molecular y celular de Plantas(IBMcP) UPV-CSIC46022 ValenciaSpain

Transposable elements(TEs)are a major force in the production of new alleles during domestication;nevertheless,their use in association studies has been limited because of their *** have developed a TE genotyping pipeline(TEmarker)and applied it to whole-genome genome-wide association study(GWAS)data from 176 Oryza sativa *** accessions to identify genetic elements associated with specific agronomic *** markers recovered a large proportion(69%)of single-nucleotide polymorphism(SNP)-based GWAS peaks,and these TE peaks retained ca.25%of the *** use of TEs in GWASs may reduce false positives associated with linkage disequilibrium(LD)among SNP markers.A genome scan revealed positive selection on TEs associated with agronomic *** found several cases of insertion and deletion variants that potentially resulted from the direct action of TEs,including an allele of LOc_Os11g08410 associated with plant height and panicle length ***,these findings reveal the utility of TE markers for connecting genotype to phenotype and suggest a potential role for TEs in influencing phenotypic variations in rice that impact agronomic traits.

关键词： transposable element marker agronomic trait rice GWAS

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