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Genes & Diseases 2024年第4期11卷 86-89页

作者： Do-Won Jeong hye-Jin Kim Jong-Wan Park Seulbee Lee hyeryeon Jung Eugene c.Yi Nacksung Kime Yang-Sook chun Department of Biomedical Sciences Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Physiology Seoul National University College of MedicineSeoul 03080Republic of Korea Ischemic.h.poxic Disease Institute Seoul National University College of MedicineSeoul 03080Republic of Korea Department of Molecular Medicine and Biopharmaceutical Sciences Graduate School of Convergence Science and Technology and College of Medicine Or College of PharmacySeoul National UniversitySeoul 03080Republic of Korea Department of Pharmacology Chonnam National University Medical SchoolGwangju 61469Republic of Korea

Bone undergoes continuous remodeling by tightly-coordinated actions of bone-resorbing osteoclasts and boneforming osteoblasts.1 Recent studies document that the dysregulation of histone methylation profiles is associated with the progression of ***,the specific epigenetic modifiers are incompletely *** this study,we demonstrate an inhibitory role of a variegation 3-9 homolog 1(SUV39h1)in osteoclast formation.

关键词： osteoclast remodeling incomplete

Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

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Journal of Integrative Plant Biology 2024年第6期66卷 1192-1205页

作者： Santosh Kumar Rana hum Kala Rana Jacob BLandis Tianhui Kuang Juntong chen hengchang Wang Tao Deng charles c.Davis hang Sun cAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas Biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI computational Biology center Boyce Thompson InstituteIthacaNew York 14853USA cAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary Biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest china comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial hengduan Mountains north-south migration Stellera chamaejasme

各种制动工况下整体辗钢车轮的温度场、变形及应力

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国外铁道车辆 1996年第4期33卷 18-20页

作者： c.h.Киселев 曹小琪

介绍了各种制动工况下辗钢车轮的发热量、残余应力、变形以及轮辋磨耗的计算和测试结果。为减小应力和变形，在机车上应装有动力制动。

关键词：制动发热量车轮应力变形铁路机车温度场

Geotechnical Properties of Incinerator Residue in Taipei

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Geotechnical Properties of Incinerator Residue in Taipei

hybrid-Vlasov simulation of soft X-ray emissions at the Earth’s dayside magnetospheric boundaries

第10届亚洲地区土壤力学与基础工程会议

作者： Lee,c. ho,c.h. Jeng,c.J. National central Univ.chungli Taiwan China National central Univ.chungli Taiwan China National central Univ.chungli Taiwan China

＜正＞Since the space available for land fill of refuse in Taiwan is limited,incineration treatment to reduce the amount of refuse has become a major method for the *** residue is composed of fly ash and *** ash may have the problem of heavy metals leachate and not suitable for engineering *** for slag,there is no such *** on gradation analysis,fly ash could be categorized as silty sand and slag could be classified as well-graded gravel with *** of them have the potential of pozzolanic reaction with cement or *** this study,it is also observed that slag exhibits light weight,low compressibility and high strength ***,slag can be utilized as a usable fill material to help alleviate the incinerator residue disposal problems and simultaneously produce usable lands.

关键词：

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Earth and Planetary Physics 2024年第1期8卷 70-88页

作者： M.Grandin h.K.connor S.hoilijoki M.Battarbee Y.Pfau-Kempf U.Ganse K.Papadakis M.Palmroth Department of Physics University of HelsinkiHelsinkiFinland NASA Goddard Space Flight center GreenbeltMD20771USA Space and Earth Observation centre Finnish Meteorological InstituteHelsinkiFinland

Solar wind charge exchange produces emissions in the soft X-ray energy range which can enable the study of near-Earth space regions such as the magnetopause,the magnetosheath and the polar cusps by remote sensing *** Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)and Lunar Environment heliospheric X-ray Imager(LEXI)missions aim to obtain soft Xray images of near-Earth space thanks to their Soft X-ray Imager(SXI)*** earlier modeling works have already simulated soft X-ray images as might be obtained by SMILE SXI during its mission,the numerical models used so far are all based on the magnetohydrodynamics description of the space *** investigate the possible signatures of ion-kinetic-scale processes in soft Xray images,we use for the first time a global hybrid-Vlasov simulation of the geospace from the Vlasiator *** simulation is driven by fast and tenuous solar wind conditions and purely southward interplanetary magnetic *** first produce global X-ray images of the dayside near-Earth space by placing a virtual imaging satellite at two different locations,providing meridional and equatorial *** then analyze regional features present in the images and show that they correspond to signatures in soft X-ray emissions of mirrormode wave structures in the magnetosheath and flux transfer events(FTEs)at the *** results suggest that,although the time scales associated with the motion of those transient phenomena will likely be significantly smaller than the integration time of the SMILE and LEXI imagers,mirror-mode structures and FTEs can cumulatively produce detectable signatures in the soft X-ray *** instance,a local increase by 30%in the proton density at the dayside magnetopause resulting from the transit of multiple FTEs leads to a 12%enhancement in the line-of-sight-and time-integrated soft X-ray emissivity originating from this ***,a proton density increase by 14%in the magnetosheath

关键词： magnetosphere magnetosheath numerical simulation SMILE LEXI soft X-ray emissions hybrid-Vlasov model polar cusp flux transfer events mirror-mode waves

一种新型口服选择性雄激素受体调节药enobosarm在雄激素受体阳性、雌激素受体阳性和hER2阴性晚期乳腺癌中的活性和安全性(研究G200802):一项随机、开放标签、多中心、多国、平行设计的2期试验

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中国临床药理学杂志 2024年第9期40卷 1371-1371页

作者： PALMIERI c LINDEN h BIRRELL S N 王超群

雄激素受体在雌激素受体阳性乳腺癌中具有抑制肿瘤的作用。本研究评估了enobosarm(一种口服选择性雄激素受体调节剂)在雌激素受体(ER)阳性、人类表皮生长因子受体2(hER2)阴性和雄激素受体(AR)阳性疾病的妇女中的活性和安全性。

关键词：激素受体阳性晚期乳腺癌抑制肿瘤 G200 平行设计

hydroelectrolytic and Energetic Replenisher in horses Undergoing Marcha Training

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Open Journal of Veterinary Medicine 2024年第8期14卷 203-216页

作者： José D. Ribeiro Filho Bruna M. Ribeiro Micheline O. Silva Samuel R. Alves Anaïs c. Benitez Waleska M. F. Dantas Marcel F. B. Avanza Raffaella B. c. Teixeira Pedro Ancelmo N. Ermita Laice A. Silva Rinaldo B. Viana hélio c. Manso Filho Department of Veterinary Federal University of Viosa Viosa Brazil Institute of Studies of the Wet Tropic Federal University of Southern and Southeastern Par Xinguara Brazil Department of Veterinary clinic and Surgery Federal University of Minas Gerais Belo Horizonte Brazil Institute of Animal health and Production Federal Rural University of Amazonia Belm Brazil Zootecnics Department Federal Rural University of Pernambuco Recife Brazil

The study aimed to assess the clinical, laboratory, and blood gas analysis of horses undergoing Marcha training and the effects of voluntary ingestion of hydroelectrolytic and energy replenishers after exercise. Eight horses of both genders aged between 5 and 10 years, were included in the study. The exercise consisted of a 10-min warm-up followed by 45 min uninterrupted Marcha on a flat dirt track in the morning. After exercise, the horses received one of the following treatments: Drinking water (control group);hydroelectrolytic and energy replenisher containing sodium chloride, potassium chloride, calcium acetate, magnesium chloride, sodium citrate, dextrose, maltodextrin, and sucrose in three different concentrations (Replenishers A, B, and c). The horses were distributed across the four treatments in a 4 × 4 Latin Squares design using a Split-plot system with 48-hr intervals. clinical and laboratory evaluations were conducted at four time points: T0 - 5 min before exercise;T1 - up to 5 min after exercise;T2 - 2 hr after starting treatment;and T4 - 4 hr after beginning treatment. concentrations of urea, creatinine, lactate, phosphorus, and ionized calcium significantly changed after exercise. An increase in blood ph and a decrease in chloride concentrations were observed when replenishers B and c were offered after exercise. The replacements were ingested spontaneously by the animals in a volume greater than that of the control group (water). Replacement B was the most ingested by the animals, demonstrating its greatest potential.

关键词： Dehydration Electrolyte Replacement Exercise Rehydration Voluntary Intake

Impact of payment source, referral site, and place of residence on outcomes after allogeneic transplantation in Mexico

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World Journal of Transplantation 2024年第2期14卷 76-87页

作者： Andrés Gómez-De León Yesica A López-Mora Valeria García-Zárate Ana Varela-constantino Sergio U Villegas-De Leon Xitlaly J González-Leal Raúl del Toro-Mijares Anna c Rodríguez-Zúñiga Juan F Barrios-Ruiz Victor Mingura-Ledezma Perla R colunga-Pedraza Olga G cantú-Rodríguez césar h Gutiérrez-Aguirre Luz Tarín-Arzaga Elías E González-López David Gómez-Almaguer hematology Service Universidad Autónoma de Nuevo LeónFacultad de Medicina y Hospital Universitario Dr.JoséEleuterio GonzálezMonterrey 64460Nuevo LeónMexico hemato-logy Service Clínica Gómez AlmaguerMonterrey 64710Nuevo LeónMexico hematology Service Instituto Tecnológico de Estudios Superiores de MonterreyTec SaludEscuela de Medicina Ignacio SantosMonterrey 64710Nuevo LeónMexico

BAcKGROUND The impact of social determinants of health in allogeneic transplant recipients in low-and middle-income countries is poorly *** observational study analyzes the impact of place of residence,referring institution,and transplant cost coverage(out-of-pocket vs government-funded vs private insurance)on outcomes after allogeneic.h.matopoietic stem cell transplantation(allohScT)in two of Mexico's largest public and private *** To evaluate the impact of social determinants of health and their relationship with outcomes among allogeneic transplant recipients in *** In this retrospective c.h.rt study,we included adolescents and adults≥16 years who received a matched sibling or haploidentical transplant from *** were selected without regard to their diagnosis and were sourced from both a private clinic and a public University hospital in *** payment groups were compared:Out-of-pocket(OOP),private insurance,and a federal Universal healthcare program“Seguro Popular”.Outcomes were compared between referred and institution-diagnosed patients,and between residents of Nuevo Leon and *** outcomes included overall survival(OS),categorized by residence,referral,and payment *** outcomes encompassed early mortality,event-free-survival,graft-versus-host-relapse-free survival,and non-relapse-mortality(NRM).Statistical analyses employed appropriate tests,Kaplan-Meier method,and cox proportional hazard regression *** software included SPSS and R with tidycmprsk *** Our primary outcome was overall *** included 287 patients,n=164 who lived out of state(57.1%),and n=129 referred from another institution(44.9%).The most frequent payment source was OOP(n=139,48.4%),followed by private insurance(n=75,26.1%)and universal coverage(n=73,25.4%).No differences in OS,event-free-survival,NRM,or graft-versus-host-relapse-free survival were observed for patients dia

关键词： hematopoietic cell transplant Social determinants of health Geography haploidentical Out-of-pocket Financial toxicity Survival health services and outcomes hematopoietic malignancy Aplastic anemia

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放射性废物 1

放射性废物

Triple the steady-state reaction rate by decorating the In_(2)O_(3)surface with SiO_(x)for cO_(2)hydrogenation

丛书名：原子能知识丛书

1981年

作者：（美）c.h.福克斯柯普译

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Journal of Energy chemistry 2024年第8期95卷 96-105,I0003页

作者： hao Wang chun Yang Xiaoyan Yu Mingrui Wang Runze Yang Xiaowa Nie Ben hang Yin Alex c.K.Yip chunshan Song Guanghui Zhang Xinwen Guo State Key Laboratory of Fine chemicals Frontier Science Center for Smart MaterialsPSU-DUT Joint Center for Energy ResearchSchool of Chemical EngineeringDalian University of TechnologyDalian 116024LiaoningChina Department of chemistry the Chinese University of Hong KongHong Kong 999077China Paihau-Robinson Research Institute the MacDiarmid Institute for Advanced Materials and NanotechnologyVictoria University of WellingtonWellington 6012New Zealand Department of chemical and Process Engineering The University of CanterburyChristchurch 8041New Zealand

Indium oxide(In_(2)O_(3)),as a promising candidate for cO_(2)hydrogenation to c_(1) products,often suffers from sintering and activity decline,closely related to the undesirable structural evolution under reaction *** on the comprehension of the dynamic evolution,this study presents an efficient strategy to alleviate the agglomeration of In_(2)O_(3)nanoparticles by the surface decoration with highly dispersed silica species(SiO_(x)).Various structural characterizations combined with density functional theory calculations demonstrated that the sintering resulted from the over-reduction,while the enhanced stability originated from the anchoring effect of highly stable In-OSi bonds,which hinders the substantial formation of metallic In(In^(0))and the subsequent agglomeration.0.6Si/In_(2)O_(3)exhibited cO_(2)conversion rate of10.0 mmol g^(-1)h^(-1)at steady state vs.3.5 mmol g^(-1)h^(-1)on In_(2)O_(3)in cO_(2)*** steady-state activity was also achieved on Pd-modified *** to the traditional Pd/In_(2)O_(3)catalyst,the methanol production rate of Pd catalyst supported on 0.6Si/In_(2)O_(3)was enhanced by 23%,showing the potential of In_(2)O_(3)modified by SiO_(x)in serving as a platform *** work provides a promising method to design new In_(2)O_(3)-based catalysts with improved activity and stability in cO_(2)hydrogenation.

关键词： cO_(2)hydrogenation In_(2)O_(3)sintering Dynamic structural evolution Surface SiO_(x)modification DFT simulations