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Journal of Bionic Engineering 2009年第4期6卷 203-213页

作者： V.Presser S.SchultheiB c.berthold K.GNickel Institute

The spines of pencil and lance urchins Heterocentrotus mammillatus and Phyllacanthus imperialis were studied as a model of light-weight material with high impact *** complex and variable skeleton construction ('stereom') of body and spines of sea urchins consists of highly porous Mg-bearing calcium *** basically brittle material with pronounced single-crystal cleavage does not fracture by spontaneous catastrophic device failure but by graceful failure over the range of tens of millimeter of bulk compression *** was observed in bulk compression tests and blunt indentation experiments on regular,infiltrated and latex coated sea urchin spine *** characterization was carried out using X-ray computer tomography,optical and scanning electron *** behavior is interpreted to result from the hierarchic structure of sea urchin spines from the rnacroscale down to the *** derived from this study see ceramics with layered porosity as a possible biomimetic construction for appropriate applications.

关键词： sea urchin urchin spines biominmitic mechanical behavior compression calcite

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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Assessment of myocardial viability using a minimally invasive laser Doppler flowmetry on pig model

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Journal of Innovative Optical Health Sciences 2021年第2期4卷 51-57页

作者： Karina Litvinova berthold Stegemann Francisco Leyva Aston Medical School Aston University Aston TriangleB47ETBirminghamUK cardiology Department Queen Elizabeth Hospital Mindelsohn WayB152THBirminghamUK

Background:The intra-operative real-time assessment of tissue viability can potentially improve therapy delivery and clinical outcome in cardiovascular *** ablation therapy for the treatment of supraventricular or ventricular arrhythmia continues to be done without being able to assess if the intended lesion and lesion size have been ***,we report a method for continuous measurements of cardiac muscle microcirculation to provide an instrument for real-time ablation ***:We performed two acute open chest animal studies to assess the ability to perform real-time monitoring of creation and size of ablation lesion using a standard RF irrigated *** ablation and laser Doppler were applied to different endocardial areas of alive open-chest ***:We performed two experiments at three different RF ablation energy setting and different ablation ***-fusion signals before and after ablation were found extensively and distinctively *** in-creasing the ablation energy and time,the perfusion signal was ***:In vivo assessing the local microcirculation during RF ablation by laser Doppler can potentially be useful to differentiate between viable and nonviable ablated beating heart in real time.

关键词： Beating heart RF ablation perfusion real-time monitoring myocardial microcirculation

Analysing the quality of Swiss National Forest Inventory measurements of woody species richness

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Forest Ecosystems 2020年第3期7卷 478-488页

作者： berthold Traub Rafael O.Wüest Scientific Service NFI Swiss Federal Research Institute WSLZürcherstrasse 1118903BirmensdorfSwitzerland Spatial Evolutionary Ecology Swiss Federal Research Institute WSLZürcherstrasse 1118903BirmensdorfSwitzerland

Background: Under ongoing climate and land-use change, biodiversity is continuously decreasing and monitoring biodiversity is becoming increasingly important. National Forest Inventory(NFI) programmes provide valuable timeseries data on biodiversity and thus contribute to assessments of the state and trends in biodiversity, as well as ecosystem functioning. Data quality in this context is of paramount relevance, particularly for ensuring a meaningful interpretation of changes. The Swiss NFI revisits about 8%–10% of its sample plots regularly in repeat surveys to supervise the quality of ***: We analysed the relevance of observer bias with equivalence tests, examined data quality objectives defined by the Swiss NFI instructors, and calculated the pseudo-turnover(PT) of species composition, that is, the percentage of species not observed by both teams. Three attributes of woody species richness from the latest Swiss NFI cycles(3 and 4) were analysed: occurrence of small tree and shrub species(1) on the sample plot and(2) at the forest edge, and(3) main shrub and trees species in the upper ***: We found equivalent results between regular and repeat surveys for all attributes. Data quality, however,was significantly below expectations in all cases, that is, as much as 20%–30% below the expected data quality limit of 70%–80%(proportion of observations that should not deviate from a predefined threshold). PT values were about 10%–20%, and the PT of two out of three attributes decreased significantly in NFI4. This type of uncertainty –typically caused by a mixture of overlooking and misidentifying species – should be considered carefully when interpreting change figures on species richness estimates from NFI ***: Our results provide important information on the data quality achieved in Swiss NFIs in terms of the reproducibility of the collected data. The three applied approaches proved to be effective for evaluating the quality of plot

关键词： Biodiversity Data quality Equivalence test Forest inventory Monitoring Observer agreement Richness Pseudo-turnover

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Supporting consistency in Linked Specialized Engineering Models Through Bindings and Updating

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Tsinghua Science and Technology 2008年第S1期13卷 165-170页

作者： Albertus H. Olivier Gert c. van Rooyen berthold Firmenich Karl E. Beucke cAD in der Bauinformatik Department of Civil Engineering Bauhaus-University Weimar civil Engineering Informatics Department of Civil Engineering University of Stellenbosch Informatik im Bauwesen Department of Civil Engineering Bauhaus-University Weimar

currently, some commercial software applications support users to work in an integrated environment. However, this is limited to the suite of models provided by the software vendor and consequently it forces all the parties to use the same software. In contrast, the research described in this paper investigates ways of using standard software applications, which may be specialized for different professional domains. These are linked for effective transfer of information and a binding mechanism is provided to support consistency. The proposed solution was implemented using a cAD application and an independent finite element application in order to verify the theoretical aspects of this work.

关键词： cAD/FEM integration structural engineering model consistency support binding mechanism

A review of monitoring systems of pavement condition in paved and unpaved roads

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Journal of Traffic and Transportation Engineering(English Edition) 2020年第5期7卷 629-638页

作者： Amir Shtayat Sara Moridpour berthold Best Auinash Shroff Diuyajeetsinh Raol School of Engineering RMIT UniversityMelbourneVIC 3000Australia Faculty of civil Engineering Nuremberg Institute of TechnologyNuremberg 90121Germany School of Engineering and Technology Central Queensland UniversityMelbourneVIC 3000Australia

The rising number of vehicles on roadways expedites the urge to increase efforts in implementing monitoring systems that look after road pavement conditions. This rising in number of vehicles on roadways also cause more damages and distresses on road pavement. Road pavement conditions should be accurately evaluated to identify the severity of pavement damages and types of pavement distress. Therefore, monitoring systems are considered a significant step of maintenance processes. Paved roads and unpaved roads require regular maintenance to provide for and preserve users' usability, accessibility, and safety. Transport agents and researches would spend a lot of time and money in inspecting some sections of the roadway surface;that inspection would then be followed by results recording and data analysis to diagnose the type of treatment required. These monitoring systems have been developed using various methods that include smart technologies and prepared equipment. Many related studies evaluate road pavement degradation and distress, while others focus on identifying the best maintenance monitoring approach in terms of time and cost. This paper set out to explore different monitoring techniques used to evaluate road pavement surface condition. Also, this study introduces dynamic and static monitoring systems used in both paved and unpaved roads to identify the severity of pavement degradations and types of pavement distress on road surfaces and also this study explains the used equipment in the previous monitoring studies.

关键词： Road engineering Maintenance Road monitoring Degradation Dynamic monitoring Static monitoring

Effect of human autologous serum and fetal bovine serum on human corneal epithelial cell viability,migration and proliferation in vitro

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International Journal of Ophthalmology(English edition) 2017年第6期10卷 908-913页

作者： Ming-Feng Wu Tanja Stachon1 berthold Seitz Achim Langenbucher Nora Szentmary Department of Ophthalmology Saarland University Medical Center Experimental Ophthalmology Saarland University Department of Ophthalmology Semmelweis University

AIM： To analyze the concentration-dependent effects of autologous serum （AS） and fetal bovine serum （FBS） on human corneal epithelial cell （HcEc） viability, migration and proliferation. METHODS： AS was prepared from 13 patients with non- healing epithelial defects Dulbecco＇s modified eagle medium/ Ham＇s F12 （DMEM/F12） with 5% FBS, 0.5% dimethyl sulphoxide （DMSO）, 10 ng/mL human epidermal growth factor, 1% insulin-transferrin-selenium, then were incubated in serum media： DMEM/F12 supplemented by 5%, 10%, 15% or 30% AS or FBS. HcEc viability was analyzed using cell proliferation kit XTI＇, migration using a wound healing assay, proliferation by the cell proliferation enzyme-linked immunosorbent assay （ELISA） BrdU kit. Statistical analysis was performed using the generalized linear model, the values at 30% AS or 30% FBS were used as the baselines. RESULTS： HcEc viability was the highest at 30% AS or 15% FBS and the lowest at 10% AS or 30% FBS application. HcEc migration was the quickest through 30% AS or 30% FBS and the slowest through 5% AS or 5% FBS concentrations. Proliferation was the most increased through 15% AS or 5% FBS and the least increased through 30% AS or 30% FBS concentrations. HcEc viability at 10% and 15% AS was significantly worse （P=0.001, P=0.023） compared to baseline and significantly better at 15% FBS （P=0.003） concentrations. HcEc migration was significantly worse （P〈0.007） and HcEc proliferation significantly better （P〈0.001） in all concentration groups compared to baseline. cONcLUSION： For the best viability of HcEc 30% AS or 15% FBS, for HcEc migration 30% AS or 30% FBS, for proliferation 15% AS or 5% FBS should be used. Therefore, we suggest the use of 30% AS in clinical practice.

关键词： autologous serum eye drops serum concen-tration migration proliferation viability human comeal epithelialcells

Macular vascularisation changes analysed using OcT angiography after successful rhegmatogenous retinal detachment repair

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International Journal of Ophthalmology(English edition) 2023年第1期16卷 81-87页

作者： Marie Hartmann Alaa Din Abdin Doris Fraenkel christian Munteanu berthold Seitz Shady Suffo Department of Ophthalmology Saarland University Medical CenterHomburg/Saar 66421Germany

AIM:To analyse the macular vascularisation changes analysed using optical coherence tomography angiography(OcTA)after successful rhegmatogenous retinal detachment(RRD)repair by comparing gas vs silicone oil and macula-on vs ***:This retrospective data collection included 77 eyes with RRD that underwent pars plana vitrectomy(PPV)and gas or silicone oil *** performed an OcTA during the postoperative control between 6 and 24mo after the last surgery and evaluated the main parameters measured by OcTA:foveal avascular zone(FAZ)and parafoveolar vascular density(PVD)in the superficial capillary *** patients were divided into four groups:RRD with macular involvement treated with gas tamponade,RRD without macular involvement treated with gas tamponade,RRD with macular involvement treated with silicone oil tamponade and RRD without macular involvement treated with silicone oil tamponade.A one-way ANOVA test combined with post hoc Bonferroni corrections compared FAZ sizes and PVD in all four ***:The FAZ size was statistically significantly larger in eyes with RRD involving the macula than in those not involving it(P=0.005).There was no statistically significant difference in the FAZ sizes of the eyes treated with silicone oil tamponade compared to those treated with gas tamponade(P=0.54).There was no statistically significant difference in the PVD comparing all four ***:Despite the known risks associated with silicone oil,our findings suggest that the type of tamponade used during PPV to treat an RRD has no significant effect on the future integrity of the PVD or the size of the FAZ in the superficial capillary plexus as measured by OcTA.

关键词： retina vitrectomy optical coherence tomography angiography