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NFKB1启动子多态性与乳糜泻基因易感性无关

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世界核心医学期刊文摘（胃肠病学分册） 2006年第10期2卷 60-60页

作者： Rueda B. Núez c. López-Nevot M.. J.Martn 成虹 Instituto de Parasitologa Y Biomedicina López Neyra CSICParque Tecnológico Campus de la SaludAvd.del Conocimiento s/n.ES-18100 ArmillaGranadaSpainDr.

Objective. The nuclear factor(NF)-κB is one of the pivotal regulators of autoimmunity and inflammation, which has been shown to be activated in the inflamed mucosa of patients with celiac disease(cD). Recently, in the NFKB1 gene promoter region, a common insertion/deletion(-94ins/ delATTG) polymorphism located between two putative key promoter regulatory elements was described. The aim of this study was to investigate the contribution of the -94ins/ delATTG NFKB1 gene promoter functional variant to cD genetic predisposition. Material and methods. A case-control cohort comprising 478 patients with cD and 711 healthy controls as well as a panel of 196 celiac families was genotyped for the 94ins/delATTG NFKB1 polymorphism, using a polymerase chain reaction (PcR) method combined with fluorescence technology. Results. We found no statistically significant differences between cD patients and controls when the -94ins/delATTG genotype and allele distributions were compared. Accordingly, the familial analysis did not reach statistically significant deviation in the transmission of -94ins/delATTG alleles to the affected offspring. conclusions. From these results, it could be suggested that the -94ins/delATTG NFKB1 polymorphism does not play a major role in cD susceptibility.

关键词：乳糜泻 NFKB1 启动子多态性调控元件计学家系分析自身免疫队列研究关键因子

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非典型表现的神经纤维瘤病

世界核心医学期刊文摘（皮肤病学分册） 2006年第3期2卷 16-16页

作者： Tato B.P. Sáez A.c. Recuero J.L.D. 吴佳纹 c/Suero de Quiones 4 Madrid 28002 Spain

Neurofibromatosis (NF) is considered to be a heterogeneous neuroectodermal disease clinically denned by the presence of neurofibromas, multiple caf′ e-au-lait spots, intertriginous freckles and Lisch nodules. Mosaicism explains atypical presentations of the disease. Early mutations, before tissue differentiation, give rise to generalized disease. We report an atypical presentation of neurofibromatosis with an unusual distribution of neurofibromas, a peculiar, clinically and pathologically, neurofibroma on the trunk and the association with an ovarian serous cystoadenofibroma.

关键词：神经纤维瘤病非典型表现囊性腺纤维瘤临床表现神经外胚层卵巢浆液性嵌合现象组织分化咖啡斑多发性

Particle Segregation in Food Powder Binary Mixtures

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Particle Segregation in Food Powder Binary Mixtures

Turbo-taxonomy to assemble a megadiverse lichen genus:seventy new species of cora(Basidiomycota:Agaricales:Hygrophoraceae),honouring David Leslie Hawksworth’s seventieth birthday

The First International conference on Measurement and control of Granular Materials

作者： Gustavo V.Barbosa-cánovas Micha Peleg Department of chemical Engineering University of Puerto Rico Mayagüez PR 00708 PhD Department of Food Engineering University of Massachusetts Amherst MA 01003 ScD

Mixed powders,particularly when the ingredients have different size,density and shape,tend to segregate during processing and handling,a process that has obvious technological and *** the well recognized consequences of powder segragation,this phenomenon,in food powders has not been systematically *** food powders can almost invariably be regarded as cohesive,selective segregation of certain fine ingredients is not uncommon. This research was designed to investigate the segregation mechanism of food powdere with special emphasis on the role of interparticle surface affinity between food powders of different chemical species in regulating the segregation *** established quantitative segregation criteria for food powders are non-existent,the paper also dealt with the development and testing of such criteria and the selection of appropriate experimental procedures for their determination. In order to quantify and monitor segregation intensity,binary mixtures of crystalline,proteinaceous and starchy food powders were subjected to vertical vibration by a specially designed reciprocating device enabling the control of the vibration frequency and to horizontal vibration using a commercial type of shaker. Also,the composition distribution in a container filled with the mixtures was sampled at various locations.

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Fungal Diversity 2017年第3期84卷 139-207页

作者： Robert Lücking Manuela Dal Forno Bibiana Moncada Luis Fernando coca Leidy Yasmín Vargas-Mendoza André Aptroot Laura Juliana Arias Betty Besal Frank Bungartz Diego Mauricio cabrera-Amaya Marcela E.S.cáceres José Luis chaves Sionara Eliasaro Martha cecilia Gutiérrez Jesús E.Hernández Marin María de los Ángeles Herrera-campos María E.Holgado-Rojas Harald Jonitz Martin Kukwa Fabiane Lucheta Santiago Madriñán Marcelo Pinto Marcelli Suzana Maria de Azevedo Martins Joel A.Mercado-Díaz Jorge Alberto Molina Eduardo A.Morales Peter R.Nelson Freddy Nugra Francisco Ortega Telma Paredes Ayda Lucía Patiño Rouchi Nadine Peláez-Pulido Rosa Emilia Pérez Pérez Gary B.Perlmutter Eimy Rivas-Plata Javier Robayo camilo Rodríguez Diego Fernando Simijaca Edier Soto-Medina Adriano Afonso Spielmann Alejandra Suárez-corredor Jean-Marc Torres carlos Alberto Vargas Alba Yánez-Ayabaca Gothamie Weerakoon Karina Wilk Marcela celis Pacheco Mauricio Diazgranados Grischa Brokamp Thomas Borsch Patrick M.Gillevet Masoumeh Sikaroodi James D.Lawrey Botanical Garden and Botanical Museum Berlin KöniginLuise-Straße 6-814195 BerlinGermany Science Education The Field Museum1400 South Lake ShoreChicagoIL 60605USA Department of Botany Smithsonian InstitutionNational Museum of Natural History10th St Constitution Ave NWWashingtonDC 20560USA Department of Environmental Science and Policy George Mason UniversityFairfaxVA 22030-4444USA Licenciatura en Biologı´a Universidad Distrital Francisco Jose´de CaldasCra.4 No.26D-54Torre de LaboratoriosHerbarioBogota´D.C.Colombia Herbario Universidad de caldas(FAUc) Edificio BicentenarioCalle 65No.26-10ManizalesA.A.275CaldasColombia ABL Herbarium G.v.d.Veenstraat 1073762 XK SoestThe Netherlands Biologı´a Universidad del Quindı´oCarrera 15 Calle 12 NorteArmeniaQuindı´oColombia 120 chavis Avenue LexingtonVA 24450USA charles Darwin Foundation Puerto AyoraSanta Cruz IslandGala´pagosEcuador Schedestraße 8 53113 BonnGermany Jardı´n Bota´nico de Bogota´Jose´celestino Mutis Avenida Calle 63 No.68-95Bogota´D.C.Colombia Departamento de Biocieˆncias Universidade Federal de SergipeAvenida Vereador Olı´mpio Grandes/n.ItabaianaCEP:49.500-000 SergipeBrazil Laboratorio de Hongos Instituto Nacional de Biodiversidad(INBio)Apdo.22-3100Santo Domingo de HerediaCosta Rica Departamento de Botaˆnica Universidade Federal do Parana´Campus Polite´cnicoSetor de Cieˆncias Biolo´gicasAv.Cel.Francisco H.dos Santoss/nJardim das Ame´ricas81531-980 CuritibaPRBrazil Ingenierı´a Ambiental Universidad Distrital Francisco Jose´de CaldasCarrera 5 Este No.15-82Av.CircumvalarBogota´D.C.Colombia Instituto Experimental Jardı´n Bota´nico Dr.Tobı´as Lasser Centro de Investigacio´n y DesarrolloUniversidad Central de VenezuelaAve.Salvador AllendeJardı´n Bota´nico de CaracasApartado#2156Caracas 1010-AVenezuela Departamento de Bota´nica Instituto de Biologı´aUniversidad Nacional Auto´noma de Me´xicoApartado Postal 70-36704510 Ciudad De Me´xicoMexico Facultad de ciencias Escuela Profesional de Biologı´aUniv

Following a large-scale phylogenetic study of the lichenized genus cora(Basidiomycota:Agaricales:Hygrophoraceae),we formally describe 70 new species,honouring the seventieth birthday of David Leslie Hawksworth,one of the preeminent figures in mycology and lichenology in the past 50 *** on an updated phylogeny using the ITS fungal barcoding locus,we now recognize 189 taxa in a genus that until recently was considered to represent a single species;including this contribution,92 of these are formally recognized,including five taxa based on historical names or collections that have not been *** of cora can be recognized by a combination of morphological(size,colour,lobe configuration,surface hairs,hymenophore size and shape),anatomical(thallus thickness,cortex structure,photobiont type,hyphal papillae),and ecogeographical features(substrate,habitat,distribution),and a keytable allowing the identification of all accepted taxa is *** new species are:cora accipiter Moncada,Madrin˜a´n&Lücking ***.,*** Moncada,Soto-Medina&Lücking ***.,*** Moncada,Dal Forno&Lücking ***.,*** Dal Forno,chaves&Lücking ***.,*** Moncada,***ı´guez&Lücking ***.,*** Lücking,Moncada&*** ***.,*** Moncada,Ya´nez-Ayabaca&Lücking ***.,*** Moncada,Patin˜o&Lücking ***.,*** Lücking,***&Dal Forno ***.,*** Holgado,Rivas Plata&Perlmutter ***.,*** Dal Forno,Eliasaro&Spielmann ***.,*** Nugra,Dal Forno&Lücking ***.,*** Lücking,Martins&Lucheta ***.,*** Moncada,R.-***´rez&Lücking ***.,*** Moncada,***.&Lücking ***.,*** Moncada,cabreraAmaya&Lücking ***.,*** Moncada,R.-***´rez&***.,*** Lücking,***&Dal Forno ***.,*** Moncada,***´rez-corredor&Lücking ***.,*** Moncada,***&Lücking ***.,***

关键词： Bolivia citizen science chile Mexico Puerto Rico Sri Lanka

Does Anti-Vascular Endothelial Growth Factor Treatment Delay Photoreceptor Maturation in Preterm Infants?

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Open Journal of Ophthalmology 2020年第1期10卷 10-20页

作者： Elcin Süren,Ersan cetinkaya Mehmet Fatih Kücük Musatafa Kalayci Muhammet Kazim Erol Antalya Training and Research Hospital Department of OphthalmologyAntalyaTurkey

Purpose: To investigate the effects of intravitreal anti-vascular endothelial growth factor (VEGF) for treatment of type-1 or aggressive posterior retinopathy of prematurity (ROP) on photoreceptor maturation in preterm infants using spectral domain optical coherence tomography (SD-OcT). Methods: A study group of 36 patients with ROP treated with anti-VEGF therapy was compared to a control group of 80 patients with ROP. All patients had undergone SD-OcT imaging at least once between 40 and 44 weeks post-menstrual age (PMA). Two imaging specialists evaluated the images for ellipsoid zone (ez) development, cystoid macular edema (cME), sub-retinal fluid (SRF) at the fovea, and cone outer segment tips (cOST). The outer nuclear layer thickness and the distance from the ez to the central fovea was measured. Results: ez development was observed in 18 (50%) patients in the study group and 68 (85%) in the control group (p = 0.002). cME was observed in 17 (47.2%) patients in the study group and 17 (21.2%) in the control group. The distance between the ez and central fovea was 868 ± 440 μm in the study group and 725 ± 380 μm in the control group (p = 0.02). cOST was not observed in any patient. Regression analysis indicated that anti-VEGF treatment and cME affect ez development. conclusions: Early photoreceptor maturation is correlated with preterm birth week but not ROP stage. Anti-VEGF treatment delays photoreceptor maturation in preterm infants.

关键词： cystoid Macular Edema Photoreceptor Retinopathy of Prematurity Vascular Endothelial Growth Factor

优化ASDEX—U装置供电的两套大型飞轮机组的并联运行

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国外核聚变 2002年第4期 63-65页

作者： c.Sihler 王尚柄等

ASDEX－U托卡马克装置（AUG）的供电由3个脉冲分配系统（110－85Hz）组成，每个由一套专用飞轮发电机组馈电：ez22（1.45GJ/167MVA)、（ez3（500MJ／144MVA）和ez4（650MJ／220MVA）。ez2单独馈电给环向场线圈。在具有扩展平顶段的准稳... 详细信息

ASDEX－U托卡马克装置（AUG）的供电由3个脉冲分配系统（110－85Hz）组成，每个由一套专用飞轮发电机组馈电：ez22（1.45GJ/167MVA)、（ez3（500MJ／144MVA）和ez4（650MJ／220MVA）。ez2单独馈电给环向场线圈。在具有扩展平顶段的准稳定先进托卡马克实验中，ez3和ez4的供电系统必须接成并联，以便能够实现发电机装机功率和飞轮贮能的全部优点，脉冲网络的变化频率、快速负载改变（最高可达10000MJ·s^-1）以及发电机不同参数和脉冲运行的饱和影响一起都需要详细的数值模型，以研究在一个公共10.5kV母线上的双机组并联运行的稳定极限。本文描述了反馈控制等离子体实验的动态负载要求，用于并联两套大型飞轮机组的控制器的研制，优化供电系统的研制结果，以及这些结果在技术实现方面的意义。

关键词： ASDEX-U装置供电飞轮机组并联运行托卡马克装置

P2Y12受体抑制剂联合质子泵抑制剂对急性冠脉综合征患者缺血事件影响的临床分析

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中华医学杂志 2016年第33期96卷 2611-2615页

作者：冯斯婷严妍范婧尧王晓郑文聂绍平 Sergio Raposeiras-Roubin Emad Abu-Assi Jose P Simao Henriques Fabrizio D' Ascenzo Jorge Saucedo Jose R conzalez-Juanatey Stephen B Wilton Wouter J Kikkert Ivan Nunez-Gil Albert Ariza-Sole Dimitrios Alexopoulos christoph Liebetrau Tetsuma Kawaji claudio Moretti Zenon Huczek Toshiharu Fujii Luis c correia Masa-aki Kawashiri Sasko Kedev 首都医科大学附属北京安贞医院急诊危重症中心 100029 University Hospital Alvaro cunqueiro Vigo Spain Academic Medical center Amsterdam the Netherlands Dipartimento di Scienze Mediche Divisione di Cardiologia Citta della Salute e della Scienza Turin Italy North Shore University Hospital Chicago USA University clinical Hospital of Santiago de compostela Santiago de compostela Spain Libin cardiovascular Institute of Alberta Calgary Canada San carlos Hospital Madrid Spain Bellvitge University Hospital Barcelona Spain University Patras Hospital Athens Greece Kerckhoff Heart and Thorax center Frankfurt Germany Graduate School of Medicine Kyoto University Kyoto Japan University clinical Hospital Warsaw Poland Hospital Sao Rafael Salvador Brazil Kanazawa University Graduate School of Medicine Kanazawa Japan University clinic of cardiology Skopje Macedonia

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PcI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PcI术的患者，分... 详细信息

目的本研究旨在分析P2Y12受体抑制剂联合质子泵抑制剂（PPI）治疗对经皮冠状动脉介入（PcI）术后的急性冠脉综合征患者缺血事件的影响。方法基于国际多中心回顾性注册登记研究，纳入2003至2014年因急性冠脉综合征人院行PcI术的患者，分为PPI组及非PPI组并随访1年，主要临床终点为全因死亡／再发心肌梗死的复合终点。根据P2Y12受体抑制剂种类，将入组患者分为氯吡格雷组及替格瑞洛组，并比较不同药物与PPI联用发生临床终点事件的风险。结果研究入选9429例患者，PPI组占54．8％，具有更多高危因素。cox回归结果提示PPI组较非PPI组全因死亡／再发心肌梗死复合事件的发生差异无统计学意义（HR1．00，95％cI 0．86—1．18）。根据P2Y12抑制剂种类不同分为氯吡格雷组和替格瑞洛组，不同P2Y12受体抑制剂联用PPI较未联用PPI患者的临床终点无差异，联用PPI的氯吡格雷组与替格瑞洛组的临床终点差异也无统计学意义。结论急性冠脉综合征患者PPI与P2Y12受体抑制剂联用不增加全因死亡和再发心肌梗死风险，尤其PPI联用氯吡格雷在患者的缺血事件上与替格瑞洛比较差异无统计学意义。

关键词：急性冠脉综合征氯吡格雷质子泵抑制剂患者结局评价替格瑞洛

低植酸大麦日粮及大麦-豆粕日粮中添加植酸酶对生长猪磷的存留和排泄的影响

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畜牧产业 2008年第1期 57-57页

作者：卢寿锋 J.K.Htoo W.c.Sauer J.L.Yáez M.cervantes Y.Zhang J.H.Helm R.T.Zijlstra

本研究包括2个试验,以测定含有低植酸大麦日粮及日粮中添加植酸酶对生长猪的磷平衡和排出的影响。试验1中,将8头体重为32kg的公猪分配到重复的4×4拉丁方设计中,分别饲喂4种大麦含量为96%的日粮:植酸含量正常的带壳大麦(HB),植酸含量较... 详细信息

本研究包括2个试验,以测定含有低植酸大麦日粮及日粮中添加植酸酶对生长猪的磷平衡和排出的影响。试验1中,将8头体重为32kg的公猪分配到重复的4×4拉丁方设计中,分别饲喂4种大麦含量为96%的日粮:植酸含量正常的带壳大麦(HB),植酸含量较低的带壳大麦(LPHB),植酸含量正常的去壳大麦(HLB)和植酸含量较低的去壳大麦(LPHLB)。上述4种日粮大麦中植酸的含量分别为0.16%,0.05%,0.24%和0.03%。在LPHB和LPHLB日粮

关键词：大麦低植酸营养素排出磷植酸猪

Mutations in foregut SOX2^+ cells induce efficient proliferation via cXcR2 pathway

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Protein & cell 2019年第7期10卷 485-495页

作者： Tomoaki Hishida Eric Vazquez-Ferrer Yuriko Hishida-Nozaki Ignacio sancho-Martinez Yuta Takahashi Fumiyuki Hatanaka Jun Wu Alejandro Ocampo Pradeep Reddy Min-Zu Wu Laurie Gerken Reuben J. Shaw concepcion Rodriguez Esteban christopher Benner Hiroshi Nakagawa Pedro Guillen Garcia Estrella Nunez Delicado Antoni castells Josep M. campistol Guang-Hui Liu Juan carlos Izpisua Belmonte Gene Expression Laboratory Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Advaneed Innovation center for Human Brain Protection National Clinical Research Center for Geriatric Disorders Xuanwu Hospital Capital Medical University Beijing 100053 China National Laboratory of Biomacromolecules CAS Center for Excellence in Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China University of the chinese Academy of Sciences Beijing 100049 China Insitute for Stem cell and Regeneration Chinese Academy of Sciences Beijing 100101 China Beijing Institute for Brain Disorder Beijing 100069 China Universidad catolica San Antonio de Murcia Campus de los Jeronimos 135 Guadalupe 30107 Spain Molecular and cell Biology Laboratory Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Howard Hughes Medical Institute Dulbecco Center for Cancer Research Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Integrative Genomics core Salk Institute for Biological Studies 10010 North Torrey Pines Road La Jolla CA 92037 USA Division of Gastroenterology Department of Medicine Perelman School of Medicine University of Pennsylvania Philadelphia PA 19104 USA Abramson cancer center University of Pennsylvania Philadelphia PA 19104 USA Department of Traumatology and Research Unit Clinica CEMTRO Av. Ventisquero de la Condesa 42 Madrid 28035 Spain Gastroenterology Department Hospital Clinic University of Barcelona IDIBAPS CIBEREHD Barcelona 08036 Spain

Identification of the precise molecular pathways involved in oncogene-induced transformation may help us gain a better understanding of tumor initiation and promotion. Here, we demonstrate that SOX2^+ foregut epithelial cells are prone to oncogenic transformation upon mutagenic insults, such as Kras^G12D and p53 deletion. GFP-based lineage-tracing experiments indicate that SOX2^+ cells are the cells-of-origin of esophagus and stomach hyperplasia. Our observations indicate distinct roles for oncogenic KRAS mutation and P53 deletion. p53 homozygous deletion is required for the acquisition of an invasive potential, and Kras^G12D expression, but not p53 deletion, suffices for tumor formation. Global gene expression analysis reveals secreting factors upregulated in the hyperplasia induced by oncogenic KRAS and highlights a crucial role for the cXcR2 pathway in driving hyperplasia. collectively, the array of genetic models presented here demonstrate that stratified epithelial cells are susceptible to oncogenic insults, which may lead to a better understanding of tumor initiation and aid in the design of new cancer therapeutics.

关键词： Sox2 tumor cXcR2 stratified epithelia