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Underutilization of Living Donor Liver Transplantation in the United States: Bias against MELD 20 and Higher

Journal of clinical and Translational Hepatology 2016年第3期4卷 169-174页

作者： Ryan B.Perumpail Eric R.Yoo George cholankeril Lupe Hogan Melodie Deis Waldo c.concepcion c.andrew bonham Zobair M.Younossi Robert J.Wong Aijaz Ahmed Division of Gastroenterology and Hepatology Stanford University School of Medicine Stanford CA USA Department of Medicine University of Illinois College of Medicine Chicago IL USA Division of Gastroenterology and Hepatology University of Tennessee Health Sciences Center Memphis TN USA Division of Surgery Division of Abdominal Transplantation Stanford University School of Medicine Stanford CA USA Department of Medicine Center for Liver Diseases Inova Fairfax HospitalFalls Church VA USA Division of Gastroenterology and Hepatology Alameda Health System Highland Hospital CampusOakland CA USA

Background and Aims:Utilization of living donor liver transplantation (LDLT) and its relationship with recipient Model for End-Stage Liver Disease (MELD) needs further evaluation in the United States (U.S.).We evaluated the association between recipient MELD score at the time of surgery and survival following ***:All *** LDLT recipients with MELDcategories (MELDcox proportional hazards ***:Overall,2,258 patients underwent *** to patients with MELDcompared to patients with MELDcant difference in long-term post-LDLT survival among those with MELD 15-19 (HR:1.11,95% cI:0.85-1.45,p =0.45) and a non-significant trend towards lower survival in patients with MELD 20-24 (HR:1.28,95%cI:0.91-1.81,p =0.16).Only 14% of LDLTs were performed in patients with MELD 20-24 and the remaining 86% in patients with MELD< ***:LDLT is underutilized in patients with MELD 20 and higher.

关键词： Living donors Liver transplantation Waitlist Model for End-Stage Liver Disease(MELD)

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Mechanisms underlying detection of seed dormancy by a scatter-hoarding rodent

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Integrative Zoology 2020年第2期15卷 89-102页

作者： Mekala SUNDARAM Ashley E.HIGDON Karl V.WOOD connie c.bonham Robert K.SWIHART Department of Forestry and Natural Resources Purdue UniversityWest LafayetteUSA Department of chemistry Purdue UniversityWest LafayetteUSA Department of Biochemistry Purdue UniversityWest LafayetteUSA Department of Geological Sciences Stanford UniversityStanfordCaliforniaUSA

The mechanism underlying detection of seed dormancy by scatter-hoarding rodents is unclear,although previous work suggests that the pericarp plays an important role in signaling dormancy *** gray squirrels(Sciurus carolinensis)consume early germinating seeds as they are more likely to perish immediately,whereas dormant seeds tend to be *** examine the mechanisms underlying dormancy detection,we characterized physical and chemical differences between germinating and dormant pericarps of northern red oak(Quercus rubra),American chestnut(castanea dentata)and the Bc3 hybrid of chinese chestnut and American chestnut(castanea mollissima×***)using scanning electron microscopy and gas chromatography-mass spec*** found that,as seeds break dormancy,the wax layer on the pericarp degrades and is accompanied by the escape of lower molecular weight kernel compounds or lipid metabolism *** field experiments showed that squirrels were 4-8 times more likely to consume seeds that were altered to remove pericarp wax coating or that were sprayed with seed *** argue that dormancy detection by scatter-hoarding rodents is a complex process involving physical cues such as loss of pericarp wax and chemical cues such as emission of olfactory cues.

关键词： cache pericarp wax scatter-hoarding seed consumption

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马尼托巴省西北部Kasmere湖地区以铀为重点的矿产资源数据的综合分析

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世界核地质科学 1985年第1期 44-51页

作者： G.F.bonham-carter c.F.chung 薛治安冯江

地质背景卡斯梅尔(Kasmere)湖地区是加拿大地盾丘吉尔构造区的一部分。表1是该区1:50,000地质图的岩石单元层。本区最老的岩石(图1)是太古代叶片状花岗岩类岩石,年龄为2,600—2,700百万年,其上面不整合地覆盖着下元古代阿菲比亚期变质... 详细信息

地质背景卡斯梅尔(Kasmere)湖地区是加拿大地盾丘吉尔构造区的一部分。表1是该区1:50,000地质图的岩石单元层。本区最老的岩石(图1)是太古代叶片状花岗岩类岩石,年龄为2,600—2,700百万年,其上面不整合地覆盖着下元古代阿菲比亚期变质沉积岩(1,900百万年,5a—16单元层)。这些岩石分布在一个NE-SW向的沃拉斯顿褶皱带内,该带控制了本区地质构造和地球物理场的走向。本区北部发育有阿菲比亚期赫维茨群变质沉积岩(14、15、16单元层)。本区大部分为冰川沉积物覆盖,基岩露头占2％。本区虽然还没有发现铀矿床,但在加拿大矿物产地(cANMINDEX)数据文件里就包含有13个铀“产地”。

关键词：湖泊沉积物阿菲 Kasmere 变质沉积岩变质岩单元层综合分析地球物理场放射性异常地球化学异常岩石单元不整合地质构造自相关值黑云母片麻岩岩石类型岩石分类矿产资源矿藏资源马尼托

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Adjuvant therapy for hormone receptor-positive breast cancer: Perspective from a survey on breast cancer physicians' acceptance of practice-changing data

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chinese Journal of cancer Research 2023年第2期35卷 191-196页

作者： Asian Institute of clinical Oncology(AIcO)Expert Panel Louis W.c.chow 不详 Organisation for Oncology and Translational Research Unit 160416/FStrand 5050 Bonham StrandSheung WanHong Kong SARChina

A cross-sectional online survey was conducted.A high proportion of the chinese breast cancer(Bc)physician respondents(n=77)would prescribe extended adjuvant endocrine therapy(AET)with aromatase inhibitors(AI)beyond 5 years for postmenopausal females with Bc,especially those with higher *** with≥15 years of clinical experience were more likely to prescribe a longer duration of AET for low-risk *** of the respondents considered intermittent letrozole as an acceptable *** respondents would prescribe adjuvant chemotherapy to genomic high-intermediate risk[Oncotype DX recurrence score(RS)21-25]females aged≤50 years regardless of the clinical risk classification.

关键词： Breast neoplasms surveys and questionnaires chemotherapy adjuvant practice patterns physicians

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