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Effect of the sintering technique on the ferroelectric and d33 piezoelectric coefficients of Bi0.5(Na0.84K0.16)0.5TiO3 ceramic

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Journal of Advanced ceramics 2019年第2期8卷 278-288页

作者： G.HERNANDEZ-cUEVAS J.R.LEYVA MENDOZA P.E.GARcíA-cASILLAS c.a.rodríguez gonzález J.F.HERNANDEZ-PAZ G.HERRERA-PéREZ L.FUENTES-cOBAS S.DíAZ DE LA TORRE O.RAYMOND-HERRERA H.cAMAcHO-MONTES Instituto de Ingeniería y Tecnología Universidad Autónoma de Ciudad JuárezAv.Del Charro 450 Norte Cd.JuárezChihuahua32310México centro de Investigación en Materiales Avanzados Miguel de Cervantes 120Chihuahua 31109ChihuahuaMéxico centro de Investigación e Innovación Tecnológica Instituto Politécnico NacionalCerrada de Cecati s/nAzcapotzalcoSanta Catarina02250Ciudad de MéxicoMéxico centro de Nanociencias y Nanotecnología Universidad Nacional Autónoma de MéxicoKm.107 Carretera Tijuana-EnsenadaAP.14Ensenada 22860Baja CaliforniaMéxico

In the search of lead-free piezoelectric materials,ceramic processing techniques offer potential tools to increase the piezoelectric and ferroelectric properties in addition to new chemical *** of pure BNKT16(Bi0.5(Na0.84K0.16)0.5TiO3)phase were synthesized by sol–gel method with a low crystallization temperature(750℃).ceramic samples were sintered by pressureless sintering(PLS),sinter-forging(SF),and spark plasma sintering(SPS)***,morphological,and chemical characterizations were performed by XRD,Raman,EDS,and *** samples by PLS and SF exhibit rod-like grains associated to bismuth *** highest remanent polarization(11.05μc/cm2),coercive field(26.2 kV/mm),and piezoelectric coefficient(165 pc/N)were obtained for SF *** piezoresponse force microscopy(PFM)analysis shows that the crystallites at the nanoscale exhibit piezoelectric phenomenon and the highest piezoelectric response is reported for PLS *** presence of the rhombohedral phase,the increase in grain and crystallite size,and the oriented rod-like inclusions favoring the crystallographic texture are facts that enhance the piezoelectric coefficient for BNKT16 piezoceramics.

关键词： lead-free piezoelectrics sol–gel pressureless sintering (PLS) sinter-forging (SF) spark plasma sintering(SPS) piezoresponse

Beyond wrecking a wall:revisiting the concept of blood–brain barrier breakdown in ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 1944-1956页

作者： Julia castillo-gonzález Elena gonzález-Rey Institute of Parasitology and Biomedicine Lopez-Neyra(IPBLN) CSICPT SaludGranadaSpain

The blood–brain barrier constitutes a dynamic and interactive boundary separating the central nervous system and the peripheral *** tightly modulates the ion transport and nutrient influx,while restricting the entry of harmful factors,and selectively limiting the migration of immune cells,thereby maintaining brain *** the well-established association between blood–brain barrier disruption and most neurodegenerative/neuroinflammatory diseases,much remains unknown about the factors influencing its physiology and the mechanisms underlying its ***,the role of blood–brain barrier breakdown in the translational failure underlying therapies for brain disorders is just starting to be *** review aims to revisit this concept of“blood–brain barrier breakdown,”delving into the most controversial aspects,prevalent challenges,and knowledge gaps concerning the lack of blood–brain barrier *** moving beyond the oversimplistic dichotomy of an“open”/“bad”or a“closed”/“good”barrier,our objective is to provide a more comprehensive insight into blood–brain barrier dynamics,to identify novel targets and/or therapeutic approaches aimed at mitigating blood–brain barrier ***,in this review,we advocate for considering the diverse time-and location-dependent alterations in the blood–brain barrier,which go beyond tight-junction disruption or brain endothelial cell breakdown,illustrated through the dynamics of ischemic stroke as a case *** this exploration,we seek to underscore the complexity of blood–brain barrier dysfunction and its implications for the pathogenesis and therapy of brain diseases.

关键词： blood–brain barrier disruption drug delivery ischemic stroke neuroinflammation tight-junctions

Impacts of PI3K/protein kinase B pathway activation in reactive astrocytes: from detrimental effects to protective functions

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Neural Regeneration Research 2025年第4期20卷 1031-1041页

作者： Ramón Pérez-Núñez María Fernanda gonzález Ana María Avalos Lisette Leyton cellular communication Laboratory Programa de Biología Celular y MolecularCenter for Studies on ExerciseMetabolism and Cancer(CEMC)Instituto de Ciencias Biomédicas(ICBM)Facultad de MedicinaUniversidad de ChileSantiagoChile Advanced center for chronic Diseases(AccDiS) Faculty of Chemical and Pharmaceutical Sciences&Faculty of MedicineUniversidad de ChileSantiagoChile Instituto de ciencias Biomédicas Facultad de Ciencias de la SaludUniversidad Autónoma de ChileSantiagoChile

Astrocytes are the most abundant type of glial cell in the central nervous *** injury and inflammation,astrocytes become reactive and undergo morphological and functional *** on their phenotypic classification as A1 or A2,reactive astrocytes contribute to both neurotoxic and neuroprotective responses,***,this binary classification does not fully capture the diversity of astrocyte responses observed across different diseases and *** analysis has revealed that reactive astrocytes have a complex landscape of gene expression profiles,which emphasizes the heterogeneous nature of their *** actively participate in regulating central nervous system inflammation by interacting with microglia and other cell types,releasing cytokines,and influencing the immune *** phosphoinositide 3-kinase(PI3K)/protein kinase B(AKT)signaling pathway is a central player in astrocyte reactivity and impacts various aspects of astrocyte behavior,as evidenced by in silico,in vitro,and in vivo *** astrocytes,inflammatory cues trigger a cascade of molecular events,where nuclear factor-κB serves as a central mediator of the pro-inflammatory ***,we review the heterogeneity of reactive astrocytes and the molecular mechanisms underlying their *** highlight the involvement of various signaling pathways that regulate astrocyte reactivity,including the PI3K/AKT/mammalian target of rapamycin(mTOR),αvβ3 integrin/PI3K/AKT/connexin 43,and Notch/PI3K/AKT *** targeting the inactivation of the PI3K/AKT cellular signaling pathway to control reactive astrocytes and prevent central nervous system damage,evidence suggests that activating this pathway could also yield beneficial *** dual function of the PI3K/AKT pathway underscores its complexity in astrocyte reactivity and brain function *** review emphasizes the importance of employing astrocyte-exclusive models to underst

关键词： inflammation integrins neuroprotective neurotoxic phosphatidylinositol 3-kinase reactive astrocytes signal transduction Thy-1(cD90)

New insights into Wnt signaling alterations in amyotrophic lateral sclerosis: a potential therapeutic target?

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Neural Regeneration Research 2020年第9期15卷 1580-1589页

作者： carlos gonzález-Fernández Pau gonzález Francisco Javier rodríguez Laboratory of Molecular Neurology Hospital Nacional de Parapléjicos (HNP)

Amyotrophic lateral sclerosis is a fatal neurodegenerative disorder characterized by upper and lower motor neuron degeneration, which leads to progressive paralysis of skeletal muscles and, ultimately, respiratory failure between 2–5 years after symptom onset. Unfortunately, currently accepted treatments for amyotrophic lateral sclerosis are extremely scarce and only provide modest benefit. As a consequence, a great effort is being done by the scientific community in order to achieve a better understanding of the different molecular and cellular processes that influence the progression and/or outcome of this neuropathological condition and, therefore, unravel new potential targets for therapeutic intervention. Interestingly, a growing number of experimental evidences have recently shown that, besides its well-known physiological roles in the developing and adult central nervous system, the Wnt family of proteins is involved in different neuropathologica conditions, including amyotrophic lateral sclerosis. These proteins are able to modulate, at least, three different signaling pathways, usually known as canonical(β-catenin dependent) and non-canonical(β-catenin independent) signaling pathways. In the present review, we aim to provide a general overview of the current knowledge that supports the relationship between the Wnt family of proteins and its associated signaling pathways and amyotrophic lateral sclerosis pathology, as well as their possible mechanisms of action. Altogether, the currently available knowledge suggests that Wnt signaling modulation might be a promising therapeutic approach to ameliorate the histopathological and functional deficits associated to amyotrophic lateral sclerosis, and thus improve the progression and outcome of this neuropathology.

关键词： ALS astrocytes Frizzled human microglia motor neuron neurodegeneration neuroinflammation spinal cord Wnt

PANoptosis:new insights in regulated cell death in ischemia/reperfusion models

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Neural Regeneration Research 2023年第2期18卷 342-343页

作者： Paloma gonzález-rodríguez Arsenio Fernández-López Área de Biología celular Instituto de BiomedicinaUniversidad de LeónSpain

See related article,pp 357-363The first study describing the cell death and destruction of tissues,organs,and organ systems as programmed events during the development of multicellular organisms was performed by JW Saunders Jr in *** term apoptosis was introduced by Kerr,Wyllie,and currie in 1972 to describe a programmed phenomenon opposite to mitosis in the regulation of animal cell ***,a description of ectodermal cell lineages as programmed cell death in the worm caenorhabditis elegans was publishedby JE Sulston and HR Horvitz in 1976.

关键词： organs insight opposite

changes in microhabitat, but not allelopathy, affect plant establishment after Acacia dealbata invasion

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Journal of Plant Ecology 2017年第4期10卷 610-617页

作者： Paula Lorenzo Jonatan rodríguez Luís gonzález Susana rodríguez-Echeverría centre for Functional Ecology(cFE) Department of Life SciencesUniversity of CoimbraCalçada Martim de Freitas3000-456 CoimbraPortugal Facultade de Bioloxía Departamento de Bioloxía Vexetal e Ciencia do SoloUniversidade de VigoAs Lagoas-Marcosende s/n36310PontevedraSpain

Aims The tree legume Acacia dealbata Link is an aggressive Australian invader that severely affects abiotic and biotic compartments of eco-systems *** invasive species outcompetes native plant communities through direct competition,changes in microhabitat and soil properties under the canopy and the release of allelopathic ***,these effects are usually studied separately and under controlled *** objective of this study was to evaluate the combined effect of these modifications exerted by *** on the establishment of native and invasive species in the *** A full factorial experiment was performed in order to test the com-bined effect of microhabitat,soil type and allelopathy on the establish-ment of the invasive *** and three native species in the field(North-West Spain).We sowed seeds of native or invasive species in pots with different soil type(soil collected under *** or Pinus pinaster),allelopathy status(soil treated or untreated with activated car-bon)and microhabitat(under the canopy of *** or ***).The number and total biomass of established plants were evaluated after 8 *** abiotic properties were determined in all *** Findings The establishment of native and invasive species was signifi-cantly affected by the microhabitat,with a higher number of seedlings under the native forest(***).The establishment of *** seedlings was also significantly promoted by its own soil.A negligible effect of allelopathy was detected on the establishment and growth of both invasive and native *** conclude that(i)the main factor affecting seedling establish-ment was microhabitat rather than changes in soil properties or allelopathy,(ii)soil modifications by *** promote the establishment of its own seedlings,contributing to the progress of invasion and(iii)allelochemicals released by *** do not seem to play a key role for the establishment of native

关键词： plant invasion microhabitat soil changes allelopathy plant establishment

Differences between delusional disorder and schizophrenia:A mini narrative review

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World Journal of Psychiatry 2022年第5期12卷 683-692页

作者： Alexandre gonzález-rodríguez Mary V Seeman Department of Mental Health Mutua Terrassa University HospitalUniversity of BarcelonaBarcelona 08280Spain Department of Psychiatry University of TorontoToronto M5P 3L6OntarioCanada

Psychotic syndromes are divided into affective and non-affective *** among the non-affective forms,substantial differences *** aim of this relatively brief review is to synthesize what is known about the differences between two non-affective psychoses,schizophrenia and delusional disorder(DD),with respect to clinical,epidemiological,sociodemographic,and treatment response characteristics.A PubMed literature search revealed the following:in schizophrenia,hallucinations,negative symptoms and cognitive symptoms are *** are rare in *** to schizophrenia patients,individuals with DD maintain relatively good function,and their delusions are believable;many are beliefs that are widely held in the general *** are generally similar in these two forms of psychosis,with the exception that antidepressants are used more frequently in DD and,for acute treatment,effective antipsychotic doses are lower in DD than in *** is with the hope that the contrasts between these two conditions will aid in the provision of safe and effective treatment for both that this review has been conducted.

关键词： Non-affective psychosis Delusional disorder Schizophrenia Epidemiology Symptoms Treatment response

Weak crossed biproducts and weak projections

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Science china Mathematics 2012年第7期55卷 1321-1352页

作者： FERNNDEZ VILABOA Jose Manuel gonzlez rodríguez Ramon rodríguez RAPOSO Ana Belen Departamento de lxebra Universidad de Santiago de Compostela Departamento de Matemtica Aplicada II Universidade de Vigo Departamento de Matemticas Universidade da Coruna

In this paper, we present the general theory and universal properties of weak crossed biproducts. We prove that every weak projection of weak bialgebras induces one of these weak crossed structures. Finally, we comput... 详细信息

关键词： braided monoidal category preunit crossed product weak Hopf algebra weak projection weakcrossed biproduct

Deposition of carbon nanotubes onto glass fibers using ultrasound standing waves

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Frontiers of Materials Science 2021年第3期15卷 471-475页

作者： Julio Alejandro rodrÍguez-gonzÁlez carlos RUBIO-gonzÁlez Alfonso PÉREZ-SÁNcHEZ centro de Ingeniería y Desarrollo Industrial Departamento de EnergíaAv.Pie de la Cuesta#702Col.Desarrollo San PabloC.P.76125QuerétaroQroMexico

carbon nanotubes(cNTs)are special types of carbon nanostructures with exceptional physical and mechanical properties such as high elastic modulus,high electrical and thermal conductivities,as well as high surface area and large aspect ratios[1].Given their tubular structure and size,cNTs are conceptualized as one-dimensional nanostructures with a crystalline structure of carbon sp2 hybridization formed by carbon–carbon covalent bonds[1].

关键词： carbon fibers exceptional