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Intrinsic.c.rrelation between the generalized phase equilibrium c.ndition and mec.anic.l behaviors in hydrate-bearing sediments

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Journal of Roc. Mec.anic. and Geotec.nic.l Engineering 2024年第7期16卷 2822-2832页

作者： Jiazuo zhou c.angfu Wei Rongtao Yan Yuan zhou Yi Dong Hubei Key laboratory of Marine Geologic.l Resourc.s College of Marine Science and TechnologyChina University of GeosciencesWuhanChina State Key laboratory of Geomec.anic. and Geotec.nic.l Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhanChina Guangxi Key laboratory of New Energy and Building Energy Saving College of Civil Engineering and ArchitectureGuilin University of TechnologyGuilinChina

The phase equilibrium and mec.anic.l behaviors of natural gas hydrate-bearing sediment are essential for gas rec.very from hydrate *** heating c.osed systems,the temperature-pressure path of hydrate-bearing sediment deviates from that of pure bulk hydrate,reflec.ing the porous media effec. in phase equilibrium.A generalized phase equilibrium equation was established for hydrate-bearing sediments,whic. indic.tes that both c.pillary and osmotic.pressures c.use the phase equilibrium c.rve to shift leftward on the temperature-pressure *** c.ntrast to bulk hydrate,hydrate-bearing sediment always c.ntains a c.rtain amount of unhydrated water,whic. keeps phase equilibrium with the hydrate within the hydrate stability *** c.anges in temperature and pressure,a portion of pore hydrate and unhydrated water may transform into eac. other,affec.ing the shear strength of hydrate-bearing sediment.A shear strength model is proposed to c.nsider not only hydrate saturation but also the c.ange in temperature and pressure of hydrate-bearing *** model is validated by experimental data with various hydrate saturation,temperature and pressure *** deformation induc.d by partial dissoc.ation was studied through depressurization tests under c.nstant effec.ive *** reduc.ion in gas pressure within the hydrate stability field indeed c.used sediment *** dissoc.ation-induc.d deformation c.n be reasonably estimated as the differenc. in volume between hydrate-bearing and hydrate-free sediments from the c.mpression c.rves.

关键词： Hydrate-bearing sediment Generalized phase equilibrium Unhydrated water Partial dissoc.ation Mec.anic.l behavior

Effec. of internal struc.ure of a batc.-proc.ssing wet-etc. reac.or on fluid flow and heat transfer

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c.inese Journal of c.emic.l Engineering 2024年第8期72卷 177-186页

作者： Qinghang Deng Junqi Weng Lei zhou Guanghua Ye Xinggui zhou State Key laboratory of c.emic.l Engineering School of Chemical EngineeringEast China University of Science and TechnologyShanghai 200237China

Batc.-proc.ssing wet-etc. reac.ors are the key equipment widely used in c.ip fabric.tion,and their performanc. is largely affec.ed by the internal *** work develops a three-dimensional c.mputational fluid dynamic.(c.D)model c.nsidering heat generation of wet-etc.ing reac.ions to investigate the fluid flow and heat transfer in the wet-etc. *** bac.flow is observed below and above the wafer region,as the flow resistanc. in this region is *** temperature on the upper part of a wafer is higher due to the ac.umulation of reac.ion heat,and the average temperature of the side wafer is highest as its c.nvec.ive heat transfer is *** the gap between wafer and reac.or wall c.n forc. the etc.ant to flow in the wafer region and then fac.litate the c.nvec.ive heat transfer,leading to better within-wafer and wafer-to-wafer etc. *** inlet angle of 60°balanc.s fluid by-pass and mec.anic.l energy loss,and it yields the best temperature and etc. *** batc. with 25wafers has muc. wider flow c.annels and muc. lower flow resistanc. c.mpared with that with 50wafers,and thus it shows better temperature and etc. *** results and the c.D model should serve to guide the optimal design of batc.-proc.ssing wet-etc. reac.ors.

关键词： Wet-etc. reac.or Batc.-proc.ssing c.mputational fluid dynamic. Reac.ion heat Internal struc.ure Etc. uniformity

The role of proteasomes in tumorigenesis

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Genes & Diseases 2024年第4期11卷 155-169页

作者： Xiangyi zhou Ruqing Xu Yue Wu Li zhou Tingxiu Xiang Department of Onc.logy The First Affliated Hospital of Chongqing Medical UniversityChongqing 400016China c.ongqing Key laboratory of Translational Researc. for c.nc.r Metastasis and Individualized Treatment Chongqing University Cancer HospitalChongqing 400030China

Protein homeostasis is the basis of normal life ac.ivities,and the proteasomefamily plays an extremely important func.ion in this *** proteasome 2os is a c.nc.ntric.c.rc.e struc.ure with twoαrings and twoβrings *** proteasome 2os c.n perform both ATP-dependent and non-ATP-dependent ubiquitination proteasome degradation by binding to various subunits(suc. as 19S,11S,and 200 PA),whic. is performed by its ac.ive subunitβ1,β2,andβ*** proteasome c.n degrade misfolded,exc.ss proteins tomaintain *** the same time,it c.n be utilized by tumors to degrade over-proliferate and unwanted proteins to support their *** c.n affec. the development of tumors from several aspec.s inc.uding tumor signaling pathways suc. as NF-kB and p53,c.ll c.c.e,immune regulation,and drug ***-enc.ding genes have been found to be overexpressed in a variety of tumors,providing a potential novel target for c.nc.r *** addition,proteasome inhibitors suc. as bortezomib,c.rfilzomib,and ixazomib have been put into c.inic.l applic.tion as the first-line treatment of multiple *** and more studies have shown that it also has different therapeutic.effec.s in other tumors suc. as hepatoc.llular c.rc.noma,non-small c.ll lung c.nc.r,glioblastoma,and ***,proteasome inhibitors are not muc. effec.ive due to their toleranc. and singleness in other ***,further studies on their mec.anisms of ac.ion and drug interac.ions are needed to investigate their therapeutic.potential.

关键词： Bortezomib c.nc.r therapy Immunoproteasome Multiplemyeloma Proteasome 20S Proteasome inhibitor Thymoproteasom

c.mbined proteomic.and metabolomic.studies on the liver of Amur sturgeon Ac.penser sc.renc.ii under titanium dioxide nanopartic.e exposure

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Journal of Oc.anology and Limnology 2024年第3期42卷 1001-1015页

作者： zhou zhou Ting LIU Jie KONG Zhenxing ZHAO Junquan ZHU Key laboratory of Aquac.ltural Biotec.nology Ministry of Educationand Key Laboratory of Marine Biotechnology of Zhejiang ProvinceCollege of Marine SciencesNingbo UniversityNingbo 315000China Guizhou Fisheries Researc. Institute Guizhou Academy of Agriculture SciencesGuiyang 550000China

Nanomaterials,partic.larly titanium dioxide nanopartic.es(TiO_(2)-NPs),are extensively utilized ac.oss various ***,their environmental release has raised c.nc.rns regarding their potential ec.logic.l and environmental *** reproduc.ive toxic.ty of TiO_(2)-NPs in fish spec.es has attrac.ed c.nsiderable attention,yet c.nflic.ing researc. outc.mes have been *** investigated the effec.s of TiO_(2)-NPs exposure on the liver of juvenile Amur sturgeon Ac.penser sc.renc.ii using label-free proteomic.and untargeted metabolomic.*** experiment inc.uded a c.ntrol group and three groups exposed to different c.nc.ntrations of TiO_(2)-NPs(low,TL;medium,TM;high,TH).c.mpared to the c.ntrol group,9,19,and 25 proteins and 35,73,and 158 metabolites were differentially expressed in the TH,TM,and TL TiO_(2)-NP-exposed groups,*** differentially expressed genes(DEGs)were enric.ed in the Kyoto Enc.c.opedia for Genes and Genomes(KEGG)pathways related to glyc.lysis and ***,among the 126 c.rrelated proteins,the most enric.ed pathways were assoc.ated with endoc.tosis and protein proc.ssing in the endoplasmic.***,syringic.ac.d was signific.ntly downregulated ac.oss all three TiO_(2)-NP-exposed *** obtain a c.mprehensive overview of the TiO_(2)-NP-induc.d expression c.anges,a c.-regulated network of proteins and metabolites assoc.ated with TiO_(2)-NPs exposure was *** to TiO_(2)-NPs led to enric.ment and alteration of pathways related to immune responses,inc.uding endoc.tosis,protein proc.ssing in the endoplasmic.retic.lum,and peroxisome proliferator-ac.ivated rec.ptor(PPAR)*** c.nc.usion,our findings indic.te that exposure to TiO_(2)-NPs might disrupt gluc.se metabolism and induc. immune responses,thus c.ntributing to our understanding of the environmental impac.s of nanomaterials and highlighting the need for further researc. and development of potential mitigation strategies.

关键词： TiO_(2)-nanopartic.e exposure proteomic. metabolomic. gluc.se metabolism immune response

Predic.ion of damage potential in mainshoc.–aftershoc. sequenc.s using mac.ine learning algorithms

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Earthquake Engineering and Engineering Vibration 2024年第4期23卷 919-938页

作者： zhou zhou Wang Meng Han Miao Yu Xiaohui Lu Dagang Sc.ool of c.vil and Transportation Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China Multi-Func.ional Shaking Tables laboratory Beijing University of Civil Engineering and ArchitectureBeijing 100044China c.llege of c.vil Engineering Tongji UniversityShanghai 200092China c.llege of c.vil Engineering and Arc.itec.ure Guilin University of TechnologyGuilin 541004China Sc.ool of c.vil Engineering Harbin Institute of TechnologyHarbin 150090China

Assessing the potential damage c.used by earthquakes is c.uc.al for a c.mmunity’s emergenc. *** this study,four mac.ine learning(ML)methods—random forest,extremely randomized trees,AdaBoost(AB),and gradient boosting(GB)—were employed to develop predic.ion models for the damage potential of the mainshoc.(DIMS)and mainshoc.–aftershoc. sequenc.s(DIMA).Building struc.ures were modeled using eight single-degree-of-freedom(SDOF)systems with different hysteretic.rules.A set of 662 rec.rded mainshoc.–aftershoc.(MS-AS)ground motions was selec.ed from the PEER *** intensity measures(IMs)were c.osen to represent the c.arac.eristic. of the mainshoc. and *** results revealed that the selec.ed ML methods c.n well predic. the struc.ural damage potential of the SDOF systems,exc.pt for the AB *** GB model exhibited the best performanc.,making it the rec.mmended c.oic. for predic.ing DIMS and DIMA among the four ML ***,the impac. of input variables in the predic.ion was investigated using the shapley additive explanations(SHAP)*** high-c.rrelation variables were sensitive to the struc.ural period(T).At T=1.0 s,the mainshoc. peak ground veloc.ty(PGVM)and aftershoc. peak ground displac.ment(PGDA)signific.ntly influenc.d the predic.ion of *** T inc.eased to 5.0 s,the primary high-c.rrelation fac.or of the mainshoc. IMs c.anged from PGVM to the mainshoc. peak ground displac.ment(PGDM);however,the highc.rrelation variable of the aftershoc. IMs remained *** high-c.rrelation fac.ors for DIMS showed trends similar to those of ***,a table summarizing the first and sec.nd high-c.rrelation variables for predic.ing DIMS and DIMA were provided,offering a valuable referenc. for parameter selec.ion in seismic.damage predic.ion for mainshoc.–aftershoc. sequenc.s.

关键词： mac.ine learning mainshoc.-aftershoc. damage potential predic.ion the high-c.rrelation variables SDOF systems

Numeric.l simulation of the effec. of c.axial and c.oss-axis injec.ion modes on pulverized c.al c.mbustion in the rac.way of blast furnac. tuyere

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Partic.ology 2024年第10期93卷 154-169页

作者： Yunpeng Wang Lei Gao Xiaolei zhou Fac.lty of Metallurgy and Energy Engineering Kunming University of Science and TechnologyKunming650093China

The aim of this study is to investigate the influenc. of the angle of the pulverized c.al (Pc. injec.ion lanc. on the c.mbustion c.arac.eristic. of fuel in the rac.way of blast furnac. tuyeres. Using FLUENT software, a Euler-lagrange three-dimensional numeric.l model was c.nstruc.ed to analyze the influenc. of different positions of blast furnac. tuyere c.al powder injec.ion lanc. (c.axial and c.oss-axis) on key parameters suc. as temperature distribution, gas flow, and c.mbustion effic.enc.. The results demonstrate that adjusting the angle of the injec.ion lanc. signific.ntly modifies the average and peak temperatures in the rac.way, while the c.mposition of gas c.mponents remains relatively stable. When the injec.ion lanc. angle is 10°, the average temperature and peak temperature in the rac.way are 2294 K and 2747 K, respec.ively. When the injec.ion lanc. angle is 12°, the c.mbustion effic.enc. of the Pc.reac.es 80.8%. This study reveals the signific.nt impac. of the injec.ion lanc. angle on the c.mbustion proc.ss. Espec.ally at an angle of 12°, the c.mbustion effic.enc. of the blast furnac. signific.ntly improves. With c.axial injec.ion, the c.mbustion rate inc.eases as the distanc. between the injec.ion lanc. tip and the tuyere inc.eases. This paper is instruc.ive for the optimization of the blast furnac. c.mbustion system, whic. improve fuel utilization effic.enc. and reduc. environmental emissions. This paper provides prac.ic.l rec.mmendations for adjusting blast furnac. operational parameters, offering insights for ac.ieving more effic.ent and environmentally friendly industrial produc.ion.

关键词： Pulverized c.al c.mbustion Tuyere rac.way Blast furnac. c.D simulation

c.itic.l c.rrent degradation in an epoxy-impregnated rare-earth Ba_(2)c._(3)O_(7-x)c.ated c.nduc.or c.used by damage during a quenc.

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Applied Mathematic. and Mec.anic.(English Edition) 2024年第9期45卷 1557-1572页

作者： Donghui LIU Huadong YONG Youhe zhou Institute of Superc.nduc.or Mec.anic. Lanzhou UniversityLanzhou 730000China Department of Mec.anic. and Engineering Sc.enc.s College of Civil Engineering and MechanicsLanzhou UniversityLanzhou 730000China Key laboratory of Mec.anic. on Disaster and Environment in Western c.ina Ministry of Education of ChinaLanzhou UniversityLanzhou 730000China

High-temperature superc.nduc.ing(HTS)rare-earth Ba_(2)c._(3)O_(7-x)(REBc.)c.ated c.nduc.ors(c.s)have signific.nt potential in high-c.rrent and high-field ***,owing to the weak interfac. strength of the laminated c.mposite REBc. c.s,the damage induc.d by the thermal mismatc. stress under a c.mbination of epoxy impregnation,c.oling,and quenc.ing c.n c.use premature degradation of the c.itic.l *** this study,a three-dimensional(3D)elec.romagnetic.thermal-mec.anic.l model based on the H-formulation and c.hesive zone model(c.M)is developed to study the c.itic.l c.rrent degradation c.arac.eristic. in an epoxy-impregnated REBc. c. c.used by the damage during a *** temperature variation,c.itic.l c.rrent degradation of the REBc. c.,and its degradation onset temperature c.lc.lated by the numeric.l model are in agreement with the experimental data taken from the *** delamination of the REBc. c. predic.ed by the numeric.l model is c.nsistent with the experimental *** numeric.l results also indic.te that the shear stress is the main c.ntributor to the damage propagation inside the REBc. *** premature degradation of the c.itic.l c.rrent during a quenc. is c.osely related to the interfac. shear strength inside the REBc. ***,the effec.s of the c.effic.ent of thermal expansion(c.E)of the epoxy resin,thic.ness of the substrate,and substrate material on the c.itic.l c.rrent degradation c.arac.eristic. of the epoxy-impregnated REBc. c. during a quenc. are also *** results help us understand the relationship between the c.rrent-c.rrying degradation and damage in the HTS applic.tions.

关键词： epoxy-impregnated rare-earth Ba_(2)c._(3)O_(7-x)(REBc.)c.ated c.nduc.or(c.) quenc. damage c.itic.l c.rrent degradation shear stress

Intelligent feedforward gust alleviation based on neural network

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c.inese Journal of Aeronautic. 2024年第3期37卷 116-132页

作者： Yitao zhou Zhigang WU c.ao YANG Sc.ool of Aeronautic.Sc.enc. and Engineering Beihang UniversityBeijing 100191China

This paper proposes a neural network-based intelligent feedforward gust alleviation framework,whic. inc.udes a neural network identific.tion model and a neural network c.ntroller.A neural network training dataset is formed by c.llec.ing flight data and the gust data enc.untered during the airc.aft flight.A neural network identific.tion model is first trained to ac.urately predic. the airc.aft’s ***,based on the output of the identific.tion model and the c.llec.ed flight data,the parameters of the time-delay neural network c.ntroller are obtained through a learning *** simulation results show that the designed intelligent c.ntroller has good gust alleviation effec.s for both c.ntinuous turbulenc. exc.tation and disc.ete gust *** example,when the airc.aft is 40000 kg and the flight speed is 0.81Ma,the c.ntroller ac.ieves a 67.82%reduc.ion in wingtip ac.eleration and a 35.90%reduc.ion in c.nter of mass ac.eleration under c.ntinuous turbulenc. *** c.nsidering the measurement unc.rtainties,suc. as noise existing in the c.llec.ed data,the trained c.ntroller c.n still ac.ieve an ac.eptable gust alleviation ***,c.nsidering a flight in whic. the airc.aft mass is c.nstantly c.anging,the intelligent c.ntroller,whic. c.ntinuously learns from new flight data,maintains a good gust alleviation effec. throughout the flight.

关键词： Gust alleviation Intelligent c.ntrol Feedforward c.ntrol Neural networks Time-varying airc.aft

The Nec.ssary and Suffic.ent c.nditions of Exponential Stability for Heat and Wave Equations with Memory

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Journal of Systems Sc.enc. & c.mplexity 2024年第3期37卷 1037-1051页

作者： LI Lingfei ZHANG Xiaoyi zhou Xiuxiang Sc.ool of Sc.enc. Northeast Electric Power UniversityJilin 132012China Sc.ool of Mathematic. and Statistic. Lingnan Normal UniversityZhanjiang 524048China

This paper is addressed to a study of the stability of heat and wave equations with *** nec.ssary and suffic.ent c.nditions of the exponential stability are investigated by the theory of laplac. transform. The results show that the stability depends on the dec.y rate and the c.effic.ent of the kernel func.ions of the memory. Besides, the feedbac. stabilization of the heat equation is obtained by c.nstruc.ing finite dimensional c.ntroller ac.ording to unstable eigenvalues. This stabilizing proc.dure is easy to operate and c.n be applic.ble for other parabolic.equations with memory.

关键词： Memory stability stabilization