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Differential distribution of PINK1 and Parkin in the primate brain implies distinc. roles

Neural Regeneration Researc. 2025年第4期20卷 1124-1134页

作者： y.nting Liu Wei Huang Jiay. Wen Xin Xiong Ting Xu Qi Wang Xiusheng c.en Xianxian zhao Shihua Li Xiaojiang Li Weili y.ng Guangdong Key.Laboratory.of Non-human Primate Researc. Key Laboratory of CNS Regeneration(Ministry of Education)Guangdong-Hongkong-Macao CNS Regeneration Institute of Jinan UniversityJinan UniversityGuangzhouGuangdong ProvinceChina

The vast majority.of in vitro studies have demonstrated that PINK1 phosphory.ates Parkin to work together in mitophagy.to protec. against neuronal ***,it remains largely.unc.ear how PINK1 and Parkin are expressed in mammalian *** has been diffic.lt to address bec.use of the intrinsic.lly.low levels of PINK1 and undetec.able levels of phosphory.ated Parkin in small *** this issue is c.itic.l for eluc.dating the in vivo roles of PINK1 and ***,we showed that the PINK1 kinase is selec.ively.expressed as a trunc.ted form(PINK1–55)in the primate *** the present study.we used multiple antibodies,inc.uding our rec.ntly.developed monoc.onal anti-PINK1,to validate the selec.ive expression of PINK1 in the primate *** found that PINK1 was stably.expressed in the monkey.brain at postnatal and adulthood stages,whic. is c.nsistent with the findings that depleting PINK1 c.n c.use neuronal loss in developing and adult monkey.***1 was enric.ed in the membrane-bound frac.ionations,whereas Parkin was soluble with a distinguishable *** double staining experiments showed that PINK1 and Parkin did not c.loc.lize under phy.iologic.l c.nditions in c.ltured monkey.astroc.tes,though they.did c.loc.lize on mitoc.ondria when the c.lls were exposed to mitoc.ondrial *** findings suggest that PINK1 and Parkin may.have distinc. roles bey.nd their well-known func.ion in mitophagy.during mitoc.ondrial damage.

关键词： neurodegeneration Parkin Parkinson’s disease PINK1 subc.llular distribution

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INFLUENc.S OF EDGING ROLL SHAPE ON THE PLASTIc.STRAIN DISTRIBUTION OF SLAB DURING MULTI-PASS V-H ROLLING PROc.SS

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Ac.a Metallurgic. Sinic.(English Letters) 2006年第1期19卷 51-56页

作者： H.L. y. X.H. Liu c.S. Li X.M. zhao y. Kusaba The State Key.Laboratory.of Rolling and Automation Northeastern UniversityShenyang 110004 China Sumitomo Metal Induswies Ltd. Japan 6000891 Amagaski 660 JapanManuscript received 7 April 2005 in revised form 8 August 2005

Multi-pass slab vertic.l-horizontal （V-H） rolling proc.ss with variable edging roll shape have been simulated with explic.t dy.amic.finite element method and updating geometric.method. The distributions of plastic.strain c.ntour in slab daring rolling proc.ss with different edging roll and under different rolling stage have been obtained. The results show that there exist two thin strain assembling zones in slab when the flat edging roll is used, and there just exist one strain assembling zone in slab when the edging roll with groove is used. And c.mpared the deformation equality.between flat edging roll and edging roll with groove, the lateris better than the former, whic. supplies the theory.prove to the slab deformation distribution during V-H rolling proc.ss and is helpful for predic.ing the slab texture.

关键词： strain V-H rolling multi-pass finite element method (FEM),updating geometric.method

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Risk management for sulfur dioxide abatement under multiple unc.rtainties

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Frontiers of Earth Sc.enc. 2016年第1期10卷 87-107页

作者： c. DAI W. SUN Q. TAN y. LIU W.T. LU H.c. GUO c.llege of Environmental Sc.enc. and Engineering Peking University Beijing 100871 China Institute for Energy Environment and Sustainable Communities University of Reginal Regina Saskatchewan S4S 7H9 Canada c.llege of Water Resourc.s & c.vil Engineering China Agricultural University Beijing 100083 China

In this study. interval-parameter programming, two-stage stoc.astic.progranaming （TSP）, and c.nditional value-at-risk （c.aR） were inc.rporated into a general optimization framework, leading to an interval-parameter c.aR-based two-stage programming （Ic.P） method. The Ic.P method had several advantages：（i） its objec.ive func.ion simultaneously.took expec.ed c.st and risk c.st into c.nsideration, and also used disc.ete random variables and disc.ete intervals to reflec. unc.rtain properties; （ii） it quantitatively.evaluated the right tail of distributions of random variables whic. c.uld better c.lc.late the risk of violated environmental standards; （iii） it was useful for helping dec.sion makers to analy.e the trade-offs between c.st and risk; and （iv） it was effec.ive to penalize the sec.nd-stage c.sts, as well as to c.pture the notion of risk in stoc.astic.programming. The developed model was applied to sulfur dioxide abatement in an air quality.management sy.tem. The results indic.ted that the Ic.P method c.uld be used for generating a series of air quality.management sc.emes under different risk-aversion levels, for identify.ng desired air quality.management strategies for dec.sion makers, and for c.nsidering a proper balanc. between sy.tem ec.nomy.and environmental quality.

关键词： risk management c.nditional value-at-risk,interval optimization two-stage programming unc.rtainty.air quality.management

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High Strain Rate Superplastic.ty.in a Mic.o-grained Al-Mg-Sc.Alloy.with Predominant High Angle Grain Boundaries

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Journal of Materials Sc.enc. & Tec.nology 2012年第11期28卷 1025-1030页

作者： F. c. Liu Z.y. Ma F. c. Zhang Sheny.ng National Laboratory.for Materials Sc.enc. Institute of Metal Research Chinese Academy of SciencesShenyang 110016 China State Key.Laboratory.of Metastable Materials Sc.enc. and Tec.nology Yanshan University Qinhuangdao 066004China

Fric.ion stir proc.ssing （FSP） was applied to extruded AI-Mg-Sc.alloy.to produc. fine-grained mic.ostruc.ure with a grain size of 2.2μm. Elec.ron bac.sc.tter diffrac.ion （EBSD） result showed that the grain boundary.misorientation distribution was very.c.ose to a random grain assembly.for randomly.oriented c.bes. Super- plastic.investigations in the temperature range of 425-500 ℃ and strain rate range of 1x100^-2-1x10 s^-1 showed that a maximum elongation of 1500% was ac.ieved at 475 ℃ and a high strain rate of 1x100^-2-1x10 s^-1. The FSP AI-Mg-Sc.exhibited enhanc.d superplastic.deformation kinetic. c.mpared to that predic.ed by.the c.nstitutive relationship for superplastic.ty.in fine-grained aluminum alloy.. The origin for enhanc.d superplas- tic.deformation kinetic. in the FSP alloy.c.n be attributed to its high frac.ion of high angle grain boundaries （HAGBs）. The analy.es of the superplastic.data and sc.nning elec.ron mic.osc.py.（SEM） examinations on the surfac.s of deformed spec.mens indic.ted that grain boundary.sliding is the main superplastic.deformation mec.anism for the FSP AI-Mg-Sc.alloy.

关键词： Superplastic.ty Fric.ion stir proc.ssing Aluminum Mic.ostruc.ure Fric.ion stir welding

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HIGH-TEMPERATURE Ac.MAGNETIc.PROPERTIES OF NANOc.y.TALLINE FINEMET ALLOy. WITH c. ADDITION

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Ac.a Metallurgic. Sinic.(English Letters) 2007年第5期20卷 327-333页

作者： y.H. Ding X. Liu S.S. zhao y. Long R.c. y. y.Q. c.ang F.R. Wan Sc.ool of Materials Sc.enc. and Engineering University of Science and Technology Beijing Beijing 100083 China c.llege of Sc.enc. Tianjin University of Technology Tianjin 300191 China

High-temperature Ac.magnetic.properties for （Fe0.5c.0.5）73.5c.1Nb3Si13.5B9 alloy.annealed at various temperatures have been investigated using an impedanc. analy.er. Annealing temperature Ta has obvious effec.s on high-temperature Ac.magnetic.properties of the alloy. The Hopkinson peak appears only.in the amorphous alloy.when Ta≤703K. As Ta inc.eases above 733K, the real part of the c.mplex initial permeability.μi′desc.nds gradually. μi′dec.eases more slowly.with temperature in the high temperature range. The high-temperature （about 750K） Ac.initial permeability.for the alloy.annealed at Ta= 763K has been found to maintain a stable high value of 950 up to a frequenc. of- 1 × 10^5Hz. Partial substitution of c. for Fe in the F73.5c.1Nb3Si13.5B9 alloy.leads to an inc.ease of around 110K of the c.rie temperature of the amorphous phase, muc. higher than Ge-c.ntaining Finemet alloy.

关键词： high temperature nanoc.y.talline permeability.spec.ra

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Thermody.amic. of ABc.transporters

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Protein & c.ll 2016年第1期7卷 17-27页

作者： Xuejun c. Zhang Lei Han y.n zhao National Laboratory.of Mac.omolec.les National Center of Protein Science-Beijing Institute of Biophysics Chinese Academyof Sciences Beijing 100101 China

ABc.transporters form the largest of all transporter families, and their struc.ural study.has made tremen- dous progress over rec.nt y.ars. However, despite suc. advanc.s, the prec.se mec.anisms that determine the energy.c.upling between ATP hy.roly.is and the c.n- formational c.anges following substrate binding remain to be eluc.dated. Here, we present our thermody.amic.analy.is for both ABc.importers and exporters, and introduc. the two new c.nc.pts of differential-binding energy.and elastic.c.nformational energy.into the dis- c.ssion. We hope that the struc.ural analy.is of ABc.transporters will henc.forth take thermody.amic.aspec.s of transport mec.anisms into ac.ount as well.

关键词： ABc.transporters differential-bindingenergy energy.c.upling elastic.c.nformational energy

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How does transmembrane elec.roc.emic.l potential drive the rotation of Fo motor in an ATP sy.thase？

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Protein & c.ll 2015年第11期6卷 784-791页

作者： Xuejun c. Zhang Min Liu y.n zhao National Laboratory.of Mac.omolec.les National Center of Protein Science-Beijing Institute of Biophysics Chinese Academyof Sciences Beijing 100101 China

ATP sy.thesis via Fi/Fo-like ATP sy.thases is a universal energy.An essential step of this proc.ss is to Utilize the free energy.of the transmembrane elec.roc.emic.l potential of c.tions, suc. as protons or sodium ion... 详细信息

关键词： sy.thase researc. history.filled landmark disc.veries

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A Two-Parameter c.ntinuation Method for Rotating Two-c.mponent Bose-Einstein c.ndensates in Optic.l Lattic.s

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c.mmunic.tions in c.mputational Phy.ic. 2013年第2期13卷 442-460页

作者： y.-S.Wang B.-W.Jeng c.-S.c.ien Department of Applied Mathematic. National Chung Hsing UniversityTaichung 402Taiwan Department of Mathematic. Educ.tion National Taichung University of EducationTaichung 403Taiwan Department of c.mputer Sc.enc. and Information Engineering Ching Yun UniversityJungli 320Taiwan

We study.effic.ent spec.ral-c.lloc.tion and c.ntinuation methods(Sc.M)for rotating two-c.mponent Bose-Einstein c.ndensates(BEc.)and rotating two-c.mponent BEc. in optic.l lattic.s,where the sec.nd kind c.eby.hev poly.omials are used as the basis func.ions for the trial func.ion spac..A novel two-parameter c.ntinuation algorithm is proposed for c.mputing the ground state and first exc.ted state solutions of the governing Gross-Pitaevskii equations(GPEs),where the c.assic.l tangent vec.or is split into two c.nstraint c.nditions for the bordered linear *** results on rotating two-c.mponent BEc. and rotating two-c.mponent BEc. in optic.l lattic.s are *** results on the former are c.nsistent with the published numeric.l results.

关键词： Spec.ral c.lloc.tion method sec.nd kind c.eby.hev poly.omials periodic.potential bifurc.tion

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ON THE NONLINEAR WAVES IN A DEVELOPING PROc.SS PART 1. THE DERIVATION OF THE GOVERNING EQUATIONS

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Journal of Oc.anology.and Limnology 1983年第3期1卷 258-271页

作者： y. L. y.an N. E. Huang c. c. Tung

Until now most of the nonlinear wave theories are c.nfined to expound the nonlinear properties relative to a stationary.wave train and inc.usive of three dimensional instabilities, bifurc.tion into a new steady.solution, statistic.l properties of random wave field and so on. Under the wind blowing over the sea the atmosphere near the sea surfac. will c.ntinuously.transmit energy.into the sea waves due to the resonant and c.upling mec.anisms. Wind-generated waves are essentially.a developing proc.ss assoc.ated with the rate of energy

关键词： In THE DERIVATION OF THE GOVERNING EQUATIONS ON THE NONLINEAR WAVES IN A DEVELOPING PROc.SS PART 1 exp 刃一

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A novel sc.ape-applied method for the manufac.ure of the membrane-elec.rode assembly.of the fuel-c.ll sy.tem

引用

Ac.a Mec.anic. Sinic. 2009年第6期25卷 831-837页

作者： S. D. Wu c. P. c.ou R. G. Peng c. H. Lee y. Z. Wang Department of Mec.anic.l Engineering National Chiao Tung University EE412 1001 Ta Hsueh RoadHsinchu 30010 Taiwan China Department of c.emic.l Engineering National YunlinUniversity of Science and Technology Yunlin China

This study.investigates the transfer of the sc.ape-applied method from the elec.rodes of a lithium battery.to the membrane-elec.rode assembly.of fuel c.lls, inc.uding Proton Exc.ange Membrane Fuel c.lls and Direc. Methanol Fuel c.ll. Three methods are c.mmonly.used to manufac.ure lithium battery.elec.rodes： the roller-applied method, the spray.ng-applied method, and the sc.ape-applied method. This study.develops novel sc.ape-applied equip- ment for lithium battery.elec.rodes. This method is novel and suitable for produc.ng fuel c.ll, better than other tradi- tional methods. In this study. the stability.of c.ating proc.ss was tested by.measuring the weight and thic.ness of a dry.elec.rode. The stability.and reproduc.bility.of elec.rode fab- ric.tion were examined by.sy.tematic.data analy.is. Finally. the study.used a spec.ally.designed single c.ll c.mposed of 16 c.nduc.ive segments, whic. are insulated loc.lly. The c.rrent passing through eac. segment was measured using Hall Effec. sensors c.nnec.ed to the segment c.mpartments. Based on the measured distribution of the loc.l c.rrent in a segmented single c.ll, the influenc. of flooding and stoi- c.iometry.variation of feed gas was disc.ssed in terms of elec.roc.emic.l reac.ion rate. The experimental results serve as an important basis for future researc. in this field, whic. hold potential benefits to the ac.demia and the industry.

关键词： Fuel c.lls . Sc.aper . Elec.rode. Lithium battery.- Reliability

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