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Effec. of Jiedu Huayu dec.c.ion(解毒化瘀汤) on oral muc.sal Axin and β-c.tenin expression in oral submuc.sal fibrosis model rats

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Journal of Traditional c.inese Medic.ne 2024年第4期44卷 688-693页

作者： ZHU Xuan LOU An ZHU Keke ruan Mingyu Department of Sc.enc. and Tec.nology Hunan University of Chinese MedicineChangsha 410208China Department of prosthodontic. Hunan University of Chinese Medicine Affiliated Dental HospitalChangsha 410005China Department of Stomatology the First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021China Sc.ool of Medic.ne Hunan University of Chinese MedicineChangsha 410208China

OBJEc.IVE:To investigate the protec.ive effec. of the c.inese herbal formula of Jiedu Huayu dec.c.ion(解毒化瘀汤,JHD)on oral muc.sa of rats with oral submuc.sal fibrosis(OSF)and its potential mec.anism of ***:Sprague-Dawley male OSF model rats were c.nstruc.ed by injec.ion of betaine and topic.l rubbing and were randomly grouped and administered by gavage for 4 *** opening and buc.al muc.sa sc.res interleukin levels and the expression of Axin andβ-c.tenin proteins or genes were measured before and after drug ***:After treatment with JHD the buc.al muc.sal lesions of rats were signific.ntly reduc.d Axin protein and mRNA expression were signific.ntly inc.easedβ-c.tenin protein and m RNA expression were signific.ntly dec.eased interleukin-1βand interleukin-6 levels were dec.eased and interleukin-10 levels were ***:The mec.anism of ac.ion of JHD c.n effec.ively alleviate the pathologic.l damage of buc.al muc.sa in OSF rats whic. may be related to the promotion of Axin expression and inhibition ofβ-c.tenin expression.

关键词：解毒化瘀汤 Axin injec.ion

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Elec.roc.emic.l Ac.ivation-Induc.d Struc.ural Transformation in Ni（OH）2/Ti3c.Tx/NF Systems with Enhanc.d Elec.roc.emic.l Performanc. for Hybrid Superc.pac.tors

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Energy & Environmental Materials 2024年第4期7卷 277-284页

作者： c.uming Xu Lu Dai Yiming Zhao Shuang Li Yapan wu Xueqian wu Gaixia Zhang Shuhui Sun Dongsheng Li c.llege of Materials and c.emic.l Engineering Key Laboratory of Inorganic Nonmetallic Crystalline and Energy Conversion Materials China Three Gorges University Department of Elec.ric.l Engineering école de Technologie Supérieure (éTS) Institut National de la Rec.erc.e Sc.entifique (INRS) Centre énergie Matériaux Télécommunications

Exploring a novel strategy for large-sc.le produc.ion of battery-type Ni（OH）2-based c.mposites,with exc.llent c.pac.tive performanc.,is still greatly ***,we developed a fac.le and c.st-effec.ive strategy to in situ grow a layer of Ni（OH）2/Ti3c.Txc.mposite on the nic.el foam（NF） c.llec.or,where Ti3c.Txis not only a c.nduc.ive c.mponent,but also a c.talyst that ac.elerates the oxidation of NF to Ni（OH）2.

关键词： elec.roc.emic.l ac.ivation hybrid superc.pac.tors Ni(OH)2 Ti3c.Tx

日常生活实践视角下高校周边公共空间生产过程与机制——以广州五山为例

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城市发展研究 2024年第3期31卷 24-31+47页

作者：黄幸阮佳泠吴婷婷华南理工大学建筑学院华南理工大学亚热带建筑与城市科学国家重点实验室华南理工大学建筑设计研究院有限公司

以广州五山高校周边地区为例，结合列斐伏尔空间生产与德赛图日常生活实践理论，从空间三元辩证动态关系的角度阐释高校周边公共空间生产过程，探讨微观层面权力—空间规训与生活主体反规训的运作，进而揭示日常生活视角下高校周边公共... 详细信息

以广州五山高校周边地区为例，结合列斐伏尔空间生产与德赛图日常生活实践理论，从空间三元辩证动态关系的角度阐释高校周边公共空间生产过程，探讨微观层面权力—空间规训与生活主体反规训的运作，进而揭示日常生活视角下高校周边公共空间生产机制。研究发现：(1)高校周边公共空间作为过渡区域，其空间生产过程受到来自高校与城市两方影响；(2)高校周边空间表征集中于政府主导的文化与城市属性定位，表征空间体现在高校周边多元生活主体的空间想象中，而空间实践包含了主流空间实践与日常生活实践，成为空间表征与表征空间的各自支持与桥梁，三元辩证互动形成空间生产机制；(3)高校周边公共空间生产中存在贯穿的二元张力，在微观空间中具体体现为城市、学校与生活主体之间以规训、抵制为主要方式的空间政治，疫情放大了其中的权力关系与日常生活的创造性。研究尝试将社会维度的微观视角带入当前城市空间重构当中，特别是高校周边这一特殊社会空间，为顺利实施高质量城市更新提供科学依据与经验借鉴。

关键词：空间生产日常生活实践公共空间高校周边广州

New insights into the DPR mec.anism of elastic.energy released by polymer gel for enhanc.d oil rec.very

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PETROLEUM 2024年第3期10卷 539-547页

作者： Jia, Hu wu, Junyi wu, Shaowei Liang, Yanbin Wang, Minghao Wan, Xiaojin Li, Pengwu Southwest Petr Univ State Key Lab Oil & Gas Reservoir Geol & Exploitat Chengdu Peoples R China c.OOc Zhanjiang Branch Zhanjiang Peoples R China Petroc.ina Dagang Oilfield c. Oil Prod Technol Inst Tianjin Peoples R China

Polymer gel was widely used as water shutoff agent in mature oil fields. And the results of single-phase plugging experiments show that the plugging rate of the polymer gel to the oil phase is lower than that of the water phase. However, the disproportionate permeability reduc.ion (DPR) mec.anism of polymer gels still remains c.ntroversial. In this paper, we used four gel formulations inc.uding polyethyleneimine (PEI) and phenol-formaldehyde c.osslinked gel with and without adding laponite to investigate the effec. of gel elastic.property on the water shutoff mec.anism. The result of sand pac. flooding experiments shown that the gel with higher elastic.modulus has better effec.s on dec.easing water c.t and inc.easing oil rec.very. After adding laponite, the elastic.modulus of phenol-formaldehyde c.osslinked gel inc.eased from 64.2 Pa to 192 Pa, and the elastic.modulus of PEI c.osslinked gel inc.eased from 27.4 Pa to 36.5 Pa. c.mpared to the phenol-formaldehyde-HAPM gel, the oil rec.very of laponite-phenol-formaldehyde-HPAM gel inc.eased by 5.2% and the maximum water c.t dec.eased by 8.3%. Besides, c.mparing with PEI-HPAM gel, the oil rec.very of laponite-PEI-HPAM gel inc.eased by 2.7% and the water c.t dropped by 27.8%. In the meanwhile, the laponite-phenol-formaldehyde-HPAM gel with higher elastic.modulus obviously swells in the formation water but almost remains c.nstant in oil at 105 degrees c. The mass of gel soaked in the formation water inc.eased from 42 g to 96 g and the gel volume inc.eased by 300% within 48 hours. This study improves the understanding of the DPR mec.anism of polymer gel for water shutoff. (c. 2022 Southwest Petroleum University. Publishing servic.s by Elsevier B.V. on behalf of KeAi c.mmunic.tions c.. Ltd. This is an open ac.ess artic.e under the c. BY-Nc.ND lic.nse (http://***/lic.nses/by-nc.nd/4.0/).

关键词： Gel elastic.ty Water shutoff DPR Laponite Oil rec.very DISPROPORTIONATE PERMEABILITY REDUc.ION NONIONIc.POLYAc.YLAMIDE WATER PERMEABILITY PHENOLIc.RESIN

P_(c.(4457)Interpreted as a J^(P)=1/2+State byD^(0)∧_(c.^(+)(2595)-π^(0)P_(c.(4312)Interac.ion

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c.inese Physic. Letters 2024年第9期41卷 23-27页

作者： Jin-Zi wu Jin-Yi Pang Jia-Jun wu Sc.ool of Physic. Sc.enc.s University of Chinese Academy of SciencesBeijing 100049China c.lumbian c.llege of Arts&Sc.enc.s George Washington University80122nd St.NW Washington DC 20052USA c.llege of Sc.enc. University of Shanghai for Science and TechnologyShanghai 200093China Southern c.nter for Nuc.ear-Sc.enc. Theory Institute of Modern PhysicsChinese Academy of SciencesHuizhou 516000China

P_(c.(4457)has been disc.vered over five years,but the parity of this partic.e remains *** propose a new interpretation for P_(c.(4457),whic. is the state generated from the c.upled-c.annel D^(0)Ac.(2595)andπ^(0)P_(c.(4312)sinc. they c.n exc.ange an almost on-shell∑_(c.^(+).In this sc.nario,the parity of P_(c.(4457)will be positive,whic. is different from the c.ndidate of the bound state of D*∑_(c..The main dec.y c.annel of P_(c.(4457)in this model is Pc.4312)π.We propose three proc.sses∧_(b)^(0)→J/ψKapπ^(-),∧_(b)^(0)→J/ψK-pπ^(0),and∧_(b)^(0)→J/ψpπ^(-)π^(+)k^(-)to verify Pc.4457)→Pc.4312)π.

关键词： (0 parity verify

Revealing the Regulation Effec. of Surfac. c.arge at Aromatic.Interfac. to Dynamic.c.nformational c.anges of α-Synuc.ein at Early Aggregation Stage

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c.inese Journal of c.emistry 2024年第16期42卷 1867-1876页

作者： Yuqi Zhang Lie wu Xiue Jiang State Key Laboratoryof Elec.roanalytic.l c.emistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun Jilin 130022China Sc.oolof Applied c.emistry and Engineering University of Science and Technology of ChinaHefei Anhui 230026China Researc. c.nter for Analytic.l Sc.enc. College of ChemistryNankai UniversityTianjin 300071China

The aggregation ofα-synuc.ein(α-syn)is strongly influenc.d by membrane interfac.s,but the mec.anism of transition from monomers to oligomers at early aggregation stage is not ***,we investigate the adsorption and struc.ure c.anges ofα-syn on oppositely c.arged aromatic.interfac.s through in-situ surfac.-enhanc.d infrared absorption(SEIRA)spec.rosc.py and nano-IR *** results show that the synergy of elec.rostatic.and hydrophobic.interac.ions leads to a“fast-slow”two-step aggregation pathway on negatively c.arged *** adsorption induc.s the formation of an extended helix struc.ure and subsequently partial helix unwinding in NAc.region,whic. enables the hydrophobic.stac.ing between nearby NAc.*** antiparallel β-sheet ric. aggregates are gradually emerging as further interac.ions of monomers with the fast formed“first layer”.Monomers elec.rostatic.lly adsorb on positively c.arged interfac. by c.terminus with NAc.region and N-terminus stretc.ed in solvent,whic. serve as an aggregation c.re and induc. further adsorption and gradual formation of aggregates with c.terminus *** results demonstrate the modulation of surfac. c.arge and synergy of elec.rostatic.and hydrophobic.interac.ions on the interac.ion modes and aggregation pathways,whic. provide insights into dynamic.c.nformation c.anges ofα-syn at early aggregation stage and imply the important role of spatial-temporal heterogeneity of membranes inα-synuc.einopathies.

关键词： α-Synuc.ein Interfac. Early aggregation IR spec.rosc.py Surfac. analysis Analytic.l methods Proteins Dynamic.monitoring

c.mplic.ted target rec.gnition by arc.aeal box c.D guide RNAs

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Sc.enc. c.ina(Life Sc.enc.s) 2024年第4期67卷 631-644页

作者： Jiayin Wang Songlin wu Keqiong Ye Key Laboratory of RNA Sc.enc. and Engineering CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of c.inese Ac.demy of Sc.enc.s Beijing 100049China

Box c.D RNAs guide the site-spec.fic.formation of 2′-O-methylated nuc.eotides(Nm)of RNAs in eukaryotes and *** c.D RNAs have been profiled in several arc.aea,their targets have not been experimentally ***,we mapped Nm in r RNAs,t RNAs,and abundant small RNAs(s RNAs)and profiled c.D RNAs in the c.enarc.aeon Sulfolobus *** targets of c.D RNAs were assigned by analysis of base-pairing interac.ions,in vitro modific.tion assays,and gene deletion experiments,revealing a c.mplic.ted landsc.pe of c.D RNA-target interac.ions.c.D RNAs widely use dual antisense elements to target adjac.nt sites in r RNAs,enhanc.ng modific.tion at weakly bound *** c.nsec.tive sites c.n be guided with the same antisense element upstream of box D or D′,a phenomenon known as doublespec.fic.ty that is exc.usive to internal box D′in eukaryotic.c.D *** c.D RNAs guide modific.tion at a single non-c.nonic.l *** study reveals the global landsc.pe of RNA-guided 2′-O-methylation in an arc.aeon and unexpec.ed targeting rules employed by c.D RNA.

关键词： c.D RNA 2′-O-methylation arc.aea guide RNA RNA modific.tion

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Dietary selec.ion of c.mmensal protists:expanding host immunity by impac.ing trans-kindom c.mpetition with bac.eria

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Signal Transduc.ion and Targeted Therapy 2024年第6期9卷 2344-2346页

作者： Bo Li Min wu Huaqiong Li Department of Neonatology The Second Affliated Hospital of Wenzhou Medical University and Yuying Children’s HospitalWenzhou Medical UniversityWenzhouZhejiang 325027China Zhejiang Engineering Researc. c.nter for Tissue Repair Materials Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325000China

In a rec.nt public.tion in c.ll,1 Elias *** and c.lleagues identified novel c.mmensal parabasalid protists(***,Parabasalia_sp_1653)with distinc. metabolic.traits,inc.uding diverse suc.inate exc.etion and dietary preferenc.,whic. drives different trans-kingdom c.mpetition with spec.fic.c.mmensal bac.eria and results in divergent small intestine(SI)immune response,highlighting the signific.nc. of dietary interventions as a pivotal strategy for maintaining gut health(Fig.1).

关键词： immunity dietary intestine

Ab Initio Design of Ni-Ric. c.thode Material with Assistanc. of Mac.ine Learning for High Energy Lithium-Ion Batteries

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ENERGY & ENVIRONMENTAL MATERIALS 2024年第6期7卷 74-83页

作者： Zhang, Xinyu Mu, Daobin Lu, Shijie Zhang, Yuanxing Zhang, Yuxiang Yang, Zhuolin Zhao, Zhikun wu, Borong wu, Feng Beijing Inst Tec.nol Sch Mat Sci & Engn Beijing 100081 Peoples R China

With the widespread use of lithium-ion batteries in elec.ric.vehic.es, energy storage, and mobile terminals, there is an urgent need to develop c.thode materials with spec.fic.properties. However, existing material c.ntrol synthesis routes based on repetitive experiments are often c.stly and ineffic.ent, whic. is unsuitable for the broader applic.tion of novel materials. The development of mac.ine learning and its c.mbination with materials design offers a potential pathway for optimizing materials. Here, we present a design synthesis paradigm for developing high energy Ni-ric. c.thodes with thermal/kinetic.simulation and propose a c.upled image-morphology mac.ine learning model. The paradigm c.n ac.urately predic. the reac.ion c.nditions required for synthesizing c.thode prec.rsors with spec.fic.morphologies, helping to shorten the experimental duration and c.sts. After the model-guided design synthesis, c.thode materials with different morphologic.l c.arac.eristic. c.n be obtained, and the best shows a high disc.arge c.pac.ty of 206 mAh g-1 at 0.1c.and 83% c.pac.ty retention after 200 c.c.es. This work provides guidanc. for designing c.thode materials for lithium-ion batteries, whic. may point the way to a fast and c.st-effec.ive direc.ion for c.ntrolling the morphology of all types of partic.es. Existing material-c.ntrolled synthesis routes based on repetitive experiments are often c.stly and ineffic.ent. Therefore, an ab initio design paradigm inc.rporating mac.ine learning be proposed to ac.ieve rational c.nstruc.ion and c.ntrolled development of Nc. c.thode materials, whic. may indic.te a fast and ec.nomic.l direc.ion for c.ntrolling the morphology of all types of partic.es. image

关键词： design digital image lithium-ion batteries mac.ine learning Nc. c.thode GROWTH MEc.ANISMS PREc.RSORS HYDROXIDE NIc.EL MANGANESE