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Ac.uired sensorineural hearing loss,oxidative stress,and mic.oRNAs

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Neural Regeneration Researc. 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Nec. Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Nec. Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Fac.lty of Medic.ne–The University of British c.lumbia VancouverBCCanada

Hearing loss is the third leading c.use of human ***-related hearing loss,one type of ac.uired sensorineural hearing loss,is largely responsible for this esc.lating global health ***-induc.d,ototoxic.and idiopathic.sudden sensorineural are other less c.mmon types of ac.uired hearing *** etiology of these c.nditions is c.mplex and multi-fa c.orial involving an interplay of genetic.and environmental *** stress has rec.ntly been proposed as a lik.ly link.ng c.use in most types of ac.uired sensorineural hearing *** non-c.ding RNA sequenc.s k.own as mic.oRNAs(miRNAs)have inc.easingly been shown to play a role in c.llular hypoxia and oxidative stress responses inc.uding promoting an apoptotic.*** hair c.ll death is a c.ntral histopathologic.l finding in sensorineural hearing *** these c.lls do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Sc.enc. c.re c.llec.ion,and *** databases over the period August 1,2018 to July 31,2023 were searc.ed with"hearing loss,""hypoxamiRs,""hypoxia,""mic.oRNAs,""isc.emia,"and"oxidative stress"text words for English language primary study public.tions or registered c.inic.l *** red c.inic.l trials k.own to the senior author we re also assessed.A total of 222studies were thus *** exc.uding duplic.tes,editorials,retra c.ions,sec.ndary researc. studies,and non-English language artic.es,39 primary studies and c.inic.l trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subjec. journal artic.es and 8 registered c.inic.l trial database entries whic. form the basis of this narrative *** miR-34a and miR-29b levels inc.ease with age in *** miRNAs were demonstrated in human neuroblastoma and murine c.c.lear c.ll lines to target Sirtuin 1/peroxisome proliferato r-ac.ivated rec.ptor gamma c.ac.ivator-1-alpha(SIRT1/P Gc.1α),SIRT

关键词： hearing loss hypoxia mic.oRNAs oxidative stress sensorineural

Multiple sc.erosis is at a c.ec.point: advanc.ng the program

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Neural Regeneration Researc. 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessic. L.Williams Department of Neurosc.enc.s Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biologic.l Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sc.erosis(MS) is a c.ronic.inflammatory and demyelinating disease of the c.ntral nervous system(c.S). Patients with MS experienc. sensory and motor func.ion loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sc.erosis damage

Allelopathic.effec. of Ac.rus tatarinowii upon algae

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Journal of Environmental Sc.enc.s 2001年第4期13卷 481-484页

作者： He, c.-q. Wang, c.-k. Dept. of Environmental Sc.enc./Eng. Shanghai University Shanghai 200072 China

Besides c.mpeting with algae for light and mineral nutrients (i. e. N, P, etc.), the root system of Ac.rus tatarinowii exc.etes some c.emic.l substanc.s, whic. injure and eliminate alga c.lls, to inhibit the growth of the algae. When the algae c.lls were treated in 'A. tatarinowii water', some of the c.lorophyll a were destroyed and the photosynthetic.rate of algae dec.eased mark.dly and the ability of alga c.lls to deoxidize triphenyltetrazolium c.loride (TTc. reduc.d greatly. Then alga c.lls turned from bright red to bluish green under fluoresc.nc. mic.osc.pe. These showed that the allelopathic.effec.s of A. tatarinowii on algae were obvious and planting A. tatarinowii c.n c.ntrol some green algae. The experiment on the extrac.ions of the sec.etions of the root system showed that the inhibitory effec. had a c.nc.ntration effec.. If the c.nc.ntration of the root sec.etion was below 30 μl/disc. the inhibitory rate was negative; if it was over 45 μl/disc. the inhibitory rate was positive. This proved that the influenc. of the root sec.etion on the same ac.eptor was a k.nd of c.nc.ntration effec.. When the c.nc.ntration of the root sec.etion was low, it promoted the growth of algae; when the c.nc.ntration reac.ed a definite threshold value, it restrained the growth of algae. In present c.se, the threshold value was between 30 μl/disc.and 45 μl/disc.

关键词： Algae c.lls c.lorophyll c.nc.ntration (proc.ss) Deoxidants Photosynthesis

A smooth c.-ordination c.ntrol for a hybrid autonomous power system （HAPS） with battery energy storage （BES）

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Frontiers in Energy 2015年第1期9卷 31-42页

作者： c. k. ARAVINDI c. NAGAMANI G. SARAVANA ILANGO Department of Elec.ric.l and Elec.ronic. Engineering National Instituteof Technology Tiruchirappalli 620015 India Department of Elec.ric.l and Elec.ronic. Engineering National Instituteof Technology Trichy 620015 India

The standalone hybrid power system c.nstitu- tes a sync.ronous generator driven by a diesel engine, renewable energy sourc. （wind） apart from a battery energy storage system. A c.herent c.ntrol strategy to regulate the voltage and frequenc. of the standalone grid is proposed in this paper. The system is simulated using Matlab/Simulink.for preliminary validation and further tested on a laboratory prototype whic. involves a TMS320LF2407A DSP c.ntroller to digitally implement the c.ntrol strategy. The dynamic.behavior of the system is perused through the direc. c.nnec.ion of an induc.ion mac.ine. The c.ntrol strategy is verified for step c.anges in load and variation in wind power.

关键词： standalone hybrid power system batteryenergy storage system (BESS) power c.nversion

Inflammasome link. traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease

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Neural Regeneration Researc. 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovic. Yazan Bouc.i Juan Pablo de Rivero Vac.ari Jennifer c.Munoz Pareja Andrew Reisner Laura Blac.well Yehia Mec.ref k.vin k.Wang J.Adrian Tyndall Binu Tharak.n Firas k.beissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurologic.l Surgery and the Miami Projec. to c.re Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric.c.itic.l c.re Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatric. Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of c.emistry and Bioc.emistry Texas Tech UniversityLubbockTXUSA Morehouse Sc.ool of Medic.ne AtlantaGAUSA

Traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease are three distinc. neurologic.l disorders that share c.mmon pathophysiologic.l mec.anisms involving neuroinflammation. One sequela of neuroinflammation inc.udes the pathologic.hyperphosphorylation of tau protein, an endogenous mic.otubule-assoc.ated protein that protec.s the integrity of neuronal c.tosk.letons. Tau hyperphosphorylation results in protein misfolding and subsequent ac.umulation of tau tangles forming neurotoxic.aggregates. These misfolded proteins are c.arac.eristic.of traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease and c.n lead to downstream neuroinflammatory proc.sses, inc.uding assembly and ac.ivation of the inflammasome c.mplex. Inflammasomes refer to a family of multimeric.protein units that, upon ac.ivation, release a c.sc.de of signaling molec.les resulting in c.spase-induc.d c.ll death and inflammation mediated by the release of interleuk.n-1β c.tok.ne. One spec.fic.inflammasome, the NOD-lik. rec.ptor protein 3, has been proposed to be a k.y regulator of tau phosphorylation where it has been shown that prolonged NOD-lik. rec.ptor protein 3 ac.ivation ac.s as a c.usal fac.or in pathologic.l tau ac.umulation and spreading. This review begins by desc.ibing the epidemiology and pathophysiology of traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and disc.ss the role of the NOD-lik. rec.ptor protein 3 inflammasome in the formation of tau deposits and how suc. tauopathic.entities spread throughout the brain. We then propose a novel framework.link.ng traumatic.brain injury, c.ronic.traumatic.enc.phalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal c.ntinuum. Finally, we disc.ss potential therapeutic.targets that may interc.pt this pathway and ultimately minimize long-term neurologic.l dec.ine.

关键词： Alzheimer's disease c.spase-1 c.ronic.traumatic.enc.phalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic.brain injury

Mac.onutrients and Health—Steps to Ameliorating the Nutrition Transition Trap

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Biomedic.l and Environmental Sc.enc.s 2001年第1期14卷 124-129页

作者： D. c. k. ROBERTS Sc.ool of Health Sc.enc.s Faculty of Medicine and Health Sciences

c.untries that have made the health transition from a c.mmunic.ble disease base to a non c.mmunic.ble disease base find themselves gripped in an epidemic.of wealth c.eated diseases mediated by altered mac.onutrient intak.s, energy intak.s and reduc.ion in physic.l ac.ivity. Avoiding the negative impac. of the nutrition transition while ac.epting the positive aspec.s of the wealth transition c.n best be ac.ieved by foc.ssing on public.sing the benefits of a low fat diet in the c.ntext of an ac.ive lifestyle. How this is ac.ieved should reflec. ec.logic.lly sound food produc.ion appropriate to national needs. c.untries that ac.ieve this will be in the best position to c.pitalize on the reduc.ion in c.mmunic.ble disease rates without c.using a rise in non c.mmunic.ble disease rates.

关键词： physic.l ac.ivity food produc.ion

Ultra‑Transparent and Multifunc.ional IZVO Mesh Elec.rodes for Next‑Generation Flexible Optoelec.ronic.

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Nano-Mic.o Letters 2025年第1期17卷 293-309页

作者： k.ran A.Nirmal Tuk.ram D.Dongale Atul c.k.ot c.enjie Yao Nahyun k.m Tae Geun k.m Sc.ool of Elec.ric.l Engineering Korea UniversityAnam‑ro 145Seongbuk‑guSeoulRepublic of Korea c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and BiotechnologyShivaji UniversityKolhapur 416004India

Mec.anic.lly durable transparent elec.rodes are essential for ac.ieving long-term stability in flexible optoelec.ronic.***,they are c.uc.al for applic.tions in the fields of energy,display,healthc.re,and soft *** meshes represent a promising alternative to traditional,brittle,metal oxide c.nduc.ors due to their high elec.ric.l c.nduc.ivity,optic.l transparenc.,and enhanc.d mec.anic.l *** this paper,we present a simple method for fabric.ting an ultra-transparent c.nduc.ing metal oxide mesh elec.rode using selfc.ac.ing-assisted *** this method,we produc.d an elec.rode with ultra-transparenc.(97.39%),high c.nduc.anc.(Rs=21.24Ωsq^(−1)),elevated work.func.ion(5.16 eV),and good mec.anic.l *** also evaluated the effec.iveness of the fabric.ted elec.rodes by integrating them into organic.photovoltaic.,organic.light-emitting diodes,and flexible transparent memristor devic.s for neuromorphic.c.mputing,resulting in exc.ptional devic. *** addition,the unique porous struc.ure of the vanadium-doped indium zinc.oxide mesh elec.rodes provided exc.llent flexibility,rendering them a promising option for applic.tion in flexible optoelec.ronic..

关键词： Self-c.ac.ing template Vanadium-doped indium zinc.oxide mesh Organic.solar c.lls Organic.light-emitting diodes Flexible transparent memory

Mac.ine learning empowers effic.ent design of ternary organic.solar c.lls with PM6 donor

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Journal of Energy c.emistry 2025年第1期100卷 337-347页

作者： k.ran A.Nirmal Tuk.ram D.Dongale Santosh S.Sutar Atul c.k.ot Tae Geun k.m Sc.ool of Elec.ric.l Engineering Korea University c.mputational Elec.ronic. and Nanosc.enc. Researc. Laboratory School of Nanoscience and Biotechnology Shivaji University Yashwantrao c.avan Sc.ool of Rural Development Shivaji University

Organic.solar c.lls(OSc.) hold great potential as a photovoltaic.tec.nology for prac.ic.l ***, the traditional experimental trial-and-error method for designing and engineering OSc. c.n be c.mplex, expensive, and time-c.nsuming. Mac.ine learning(ML) tec.niques enable the profic.ent extrac.ion of information from datasets, allowing the development of realistic.models that are c.pable of predic.ing the effic.c. of materials with c.mmendable ac.urac.. The PM6 donor has great potential for high-performanc. OSc.. However, it is c.uc.al for the rational design of a ternary blend to ac.urately forec.st the power c.nversion effic.enc.(Pc.) of ternary OSc.(TOSc.) based on a PM6 ***, we c.llec.ed the devic. parameters of PM6-based TOSc. and evaluated the feature importanc. of their molec.le desc.iptors to develop predic.ive models. In this study, we used five different ML algorithms for analysis and predic.ion. For the analysis, the c.assific.tion and regression tree provided different rules, heuristic., and patterns from the heterogeneous dataset. The random forest algorithm outperforms other predic.ion ML algorithms in predic.ing the output performanc. of PM6-based TOSc.. Finally, we validated the ML outc.mes by fabric.ting PM6-based TOSc.. Our study presents a rapid strategy for assessing a high Pc. while eluc.dating the substantial influenc. of diverse desc.iptors.

关键词： Random forests

Effec.s of Boron Nitride Nanopowder on Thermal, c.emic.l and Gas Barrier Properties of Starc.

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c.inese Journal of Polymer Sc.enc. 2014年第10期32卷 1311-1318页

作者： Gopal c. Pradhan Lingaraj Behera Sarat k. Swain Department of c.emistry North Orissa University Takatpur Baripada 757003 India Department of c.emistry Veer Surendra Sai University of Technology Burla Sambalpur 768018 India

Starc./boron nitride （starc./BN） bionanoc.mposites were prepared with the reinforc.ment of boron nitride nano powder by solution tec.nique. The dispersion of BN in the starc. was ac.ieved by a c.ntinuous sonic.tion proc.ss. The interac.ion between starc. and boron nitride nanopowder was investigated by Fourier transform infrared （FTIR） spec.rosc.py. The struc.ural properties of starc./BN bionanoc.mposites was studied by X-ray diffrac.ion （XRD）. The high resolution transmission elec.ron mic.osc.py （HRTEM） was used for the study of dispersion of boron nitride in starc. matrix and diffrac.ion patterns were studied by selec.ed area elec.ron diffrac.ion （SAED）. Thermal stability of the starc. was inc.eased with rising c.nc.ntrations of boron nitride due to inc.rporation of rigid nano BN with starc. matrix. The substantial reduc.ion in oxygen permeability was obtained by inc.easing the c.nc.ntration of BN. The biodegradability of synthesized bionanoc.mposites was measured by using ac.ivated sludge water. Further, it was notic.d that, starc./BN bionanoc.mposites are resistant towards inorganic.ac.ds and bases. The tensile strength of starc./BN bionanoc.mposites was inc.eased whereas; the water resistanc. property of the materials was dec.eased with inc.easing BN loading.

关键词： Starc. Boron nitride Bionanoc.mposites Oxygen permeability.