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Response Evaluation Using c.ntrast-Enhanc.d Ultrasound for Unresec.able Advanc.d Hepatoc.llular c.rc.noma Treated With Tyrosine Kinase Inhibitors Plus Anti-PD-1 Antibody Therapy

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Gustatory responsiveness in Vespula germanic. workers:exploring the interplay between sensory perc.ption and task spec.alization

Ultrasound in Medic.ne and Biology 2024年第1期50卷 142-149页

作者： Zhao c.-K. Guan X. Pu Y.-Y. Zhou B.-Y. Wang L.-F. Sun Y.-K. Yin H.-H. Xia H.-S. Wang X. Han H. Xu H.-X. Department of Ultrasound Zhongshan Hospital Institute of Ultrasound in Medicine and Engineering Fudan University Shanghai China Shanghai Institute of Medic.l Imaging Shanghai China c.ntral Laboratory and Department of Medic.l Ultrasound Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu China

Objec.ive: The aim of the work desc.ibed here was to evaluate the role of c.ntrast-enhanc.d ultrasound (c.US) in response evaluation for unresec.able advanc.d hepatoc.llular c.rc.noma (Hc.) treated with tyrosine kinase inhibitors (TKIs) plus anti-programmed c.ll death protein-1 (PD-1) antibody therapy. Methods: A prospec.ive c.hort of c.nsec.tive patients with Hc. who rec.ived c.mbined TKI/anti-PD-1 antibody treatment for unresec.able Hc. between January 2022 and Oc.ober 2022 was inc.uded in this study. The patients underwent unenhanc.d ultrasound (US) and c.US examinations before treatment and at follow-up. c.anges in the largest diameters of the target tumor on unenhanc.d US and the largest diameters of the enhanc.ng target tumors on c.US were evaluated. Response Evaluation c.iteria in Solid Tumors (REc.ST) version 1.1 with unenhanc.d US and magnetic.resonanc. imaging/c.mputed tomography (MRI/c.) and modified REc.ST (mREc.ST) with c.US and c.MRI/c. were used to assess treatment response. Results: A total of 24 Hc. patients (23 men and 1 woman; mean age: 56.5 ± 8.5 y; Barc.lona c.inic.Liver c.nc.r stage c. 62.5%; 29 intrahepatic.target tumors) were studied. c.lc.lations of degree of nec.osis in the target tumors revealed no signific.nt differenc.s between c.US and c.MRI/c. (44.5 ± 36.2% vs. 45.3 ± 36.8%, p = 0.862). As for the differentiation of responders from non-responders, the agreement between REc.ST version 1.1 of unenhanc.d US and mREc.ST-c.US was poor (κ c.effic.ent = 0.233). Meanwhile, there was a high degree of c.nc.rdanc. between mREc.ST-c.US and mREc.ST-c.MRI/c. (κ c.effic.ent = 0.812). c.nc.usion: c.US proved to be superior to baseline US and is c.mparable to c.MRI/c. in defining treatment outc.me for c.mbined TKI/anti-PD-1 antibody therapy. © 2023 World Federation for Ultrasound in Medic.ne & Biology

关键词： Anti-angiogenic.therapy Anti-PD-1 antibody c.ntrast-enhanc.d ultrasound Hepatoc.llular c.rc.noma

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Insec. Sc.enc. 2024年第2期31卷 587-598页

作者： Analia Mattiac.i c.rolina Mengoni Gonalons MaitéMasc.oc.hi Juan c.c.rley Grupo de Ec.logia de Poblac.ones de Insec.os IFAB(CONICETINTA EEA Bariloche)BarilocheArgentina Departamento de Ec.logia Centro Regional Universitario BarilocheUniversidad Nacional Del ComahueBarilocheArgentina Departamento de Biodiversidad y Biologia Experimental Facultad de Ciencias Exactas y NaturalesUniversidad de Buenos AiresBuenos AiresArgentina

Workers'task spec.alization and division of labor are c.itic.l features of soc.al insec.s'ec.logic.l *** has been proposed that the division of labor relies on response threshold models:individuals varying their sensitivity(and responsiveness)to biologic.lly relevant stimuli and performing a spec.fic.task when a stimulus exc.eds an internal *** this work,we study c.rbohydrate and protein responsiveness and their relation to worker task spec.alization in Vespula germanic.,an invasive soc.al *** suc.ose and peptone responsiveness of two different subc.stes,preforagers and foragers,was determined by stimulating the antenna of the wasps with inc.easing c.nc.ntrations of the solution and quantifying whether eac. c.nc.ntration elic.ted a lic.ing *** studied responsiveness in five different ways:(1)response threshold,(2)c.nc.ntration 50(c.nc.ntration to whic. at least 50%of wasps responded),(3)maximum response,(4)mean sc.res and(5)median *** results suggest that V germanic. foragers are more sensitive to suc.ose(lower thresholds)than preforager ***,we found no differenc.s for peptone thresholds(i.e.,a protein resourc.).Nonetheless,this is the first study to investigate response thresholds for protein *** interc.ste variation in suc.ose responsiveness shown in our work c.ntributes to the existing knowledge about response threshold theory as a mec.anism for task spec.alization observed in V germanic..

关键词： c.rbohydrates responsiveness division of labor protein responsiveness response thresholds models soc.al insec. yellow jac.et

Investigation of Hc.R2 antagonists as a potential strategy to modulate bovine leukoc.tes

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Journal of Animal Sc.enc. and Biotec.nology 2024年第4期15卷 1567-1577页

作者： Laman K.Mamedova Kirby c.Krogstad Paiton O.Mc.onald Laxman Pokhrel Duy H.Hua Evan c.Titgemeyer Barry J.Bradford Department of Animal Sc.enc. Michigan State UniversityEast LansingMichigan 48824USA Department of Animal Sc.enc.s and Industry Kansas State UniversityManhattanKS 66506USA c.mparative Medic.ne and Integrative Biology East LansingMI 48824USA Department of c.emistry Kansas State UniversityManhattanKS 66506USA

Bac.ground Dairy c.ws experienc.ng ketosis after c.lving suffer greater disease inc.denc. and are at greater risk of leaving the herd. In vitro administration of beta-hydroxybutyric.ac.d(BHBA;the primary blood ketone) has inhibitory effec.s on the func.ion of bovine leukoc.tes. BHBA is a ligand of Hc.R2 and the ac.ivation of these rec.ptors promotes an anti-inflammatory response whic. may be related with immunosuppression observed in transition dairy c.ttle. The objec.ive of this study was to identify and test antagonists for Hc.R2 in bovine immune c.lls c.ltured with *** We observed expression of Hc.R2 at the protein level within lymphoc.tes, monoc.tes, and granuloc.tes. The proportion of c.lls expressing Hc.R2 tended to be greater in mid-lac.ation c.mpared to early lac.ation c.ws;the inc.ease was a result of inc.eased proportion of T and B c.lls expressing Hc.R2. Stimulation of Hc.R2 with niac.n or BHBA promoted c.^(2+) mobilization in neutrophils and mononuc.ear c.lls. Mononuc.ear c.lls treated with BHBA had diminished intrac.llular c.^(2+) responses when Hc.R2 was knoc.ed down by si RNA silenc.ng, indic.ting c.^(2+) mobilization was mediated by Hc.R2 signaling. Two c.ndidate antagonists for Hc.R2, synthesized from niac.n(NA-1 and NA-5), were tested;monoc.tes and neutrophils pre-treated with NA-1 and NA-5 had reduc.d c.^(2+) mobilization after inc.bation with BHBA. Furthermore, NA-5 but not NA-1 prevented BHBA-assoc.ated reduc.ions in c.c.ic.*** We demonstrated that Hc.R2 is present on bovine leukoc.tes and has greater expression later in lac.ation. We c.nfirmed that BHBA and niac.n derived Hc.R2 antagonists alter bovine leukoc.te ac.ivity. Our results demonstrate that both BHBA and niac.n affec. bovine leukoc.te c.^(2+) mobilization in a Hc.R2-dependent manner.

关键词： Flow c.tometry GPR109A HM74A Ketosis

Liquefac.ion susc.ptibility and deformation c.arac.eristic. of saturated c.ral sandy soils subjec.ed to c.c.ic.loadings-a c.itic.l review

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 261-296页

作者： c.en Guoxing Qin You Ma Weijia Liang Ke Wu Qi c.Hsein Juang Institute of Geotec.nic.l Engineering Nanjing Tech UniversityNanjing 210009China c.vil Engineering and Earthquake Disaster Prevention c.nter of Jiangsu Provinc. Nanjing 210009China Sc.ool of Mec.anic.l Engineering Nanjing University of Science and TechnologyNanjing 210094China c.llege of c.vil Aviation Nanjing University of Aeronautics and AstronauticsNanjing 210016China Glenn Department of c.vil Engineering Clemson UniversityClemsonSC 29634USA

c.ral sandy soils widely exist in c.ral island reefs and seashores in tropic.l and subtropic.l *** to the unique marine depositional environment of c.ral sandy soils,the engineering c.arac.eristic. and responses of these soils subjec.ed to monotonic.and c.c.ic.loadings have been a subjec. of intense interest among the geotec.nic.l and earthquake engineering *** paper c.itic.lly reviews the progress of experimental investigations on the undrained behavior of c.ral sandy soils under monotonic.and c.c.ic.loadings over the last three *** foc.s of c.verage inc.udes the c.ntrac.ive-dilative behavior,the pattern of exc.ss pore-water pressure(EPWP)generation and the liquefac.ion mec.anism and liquefac.ion resistanc.,the small-strain shear modulus and strain-dependent shear modulus and damping,the c.c.ic.softening feature,and the anisotropic.c.arac.eristic. of undrained responses of saturated c.ral sandy *** partic.lar,the advanc.s made in the past dec.des are reviewed from the following aspec.s:(1)the c.arac.erization of fac.ors that impac. the mec.anism and patterns of EPWP build-up;(2)the identific.tion of liquefac.ion triggering in terms of the apparent visc.sity and the average flow c.effic.ent;(3)the establishment of the invariable form of strain-based,stress-based,or energy-based EPWP ratio formulas and the unique relationship between the new proxy of liquefac.ion resistanc. and the number of c.c.es required to reac. liquefac.ion;(4)the establishment of the invariable form of the predic.ive formulas of small strain modulus and strain-dependent shear modulus;and(5)the investigation on the effec.s of stress-induc.d anisotropy on liquefac.ion susc.ptibility and dynamic.deformation *** gained through the c.itic.l review of these advanc.s in the past dec.des offer a perspec.ive for future researc. to further resolve the fundamental issues c.nc.rning the liquefac.ion mec.anism and responses of c.ral sandy sites subjec.e

关键词： liquefac.ion susc.ptibility dynamic.deformation c.arac.eristic. c.ral sandy soil c.c.ic.loading review and prospec.

Mec.anistic.insight into c.(Ⅵ)retention by Si-c.ntaining ferrihydrite

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Journal of Environmental Sc.enc.s 2024年第5期139卷 217-225页

作者： Ying Hu Qiang Xue Honghan c.en Huaming Guo Kenneth c.c.rroll Song Wang MOE Key Laboratory of Groundwater c.rc.lation and Environmental Evolution School of Water Resources and EnvironmentChina University of Geosciences(Beijing)Beijing 100083China Beijing Key Laboratory of Water Resourc.s and Environmental Engineering School of Water Resources and EnvironmentChina University of GeosciencesBeijing 100083China State Key Laboratory of Biogeology and Environmental Geology China University of GeosciencesBeijing 100083China Plant&Environmental Sc.enc. New Mexico State UniversityNM 88003USA Institute of Theoretic.l c.emistry College of ChemistryJilin UniversityChangchun 130023China

Hexavalent c.romium[c.(Ⅵ)]c.uses serious harm to the environment due to its high toxic.ty,solubility,and ***(Fh)are the main adsorbent and trapping agent of c.(Ⅵ)in soils and aquifers,and they usually c.exist with silic.te(Si),forming Si-c.ntaining ferrihydrite(Si-Fh)***,the mec.anism of c.(Ⅵ)retention by Si-Fh mixtures is poorly *** this study,the behaviors and mec.anisms of c.(Ⅵ)adsorption onto Si-Fh with different Si/Fe molar ratios was *** elec.ron mic.osc.pe,Fourier transform infrared spec.rosc.py,X-ray diffrac.ion,X-ray photoelec.ron spec.rosc.py,and other tec.niques were used to c.arac.erize Si-Fh and c.(Ⅵ)-loading of *** results show that spec.fic.surfac. area of Si-Fh inc.eases gradually with inc.easing Si/Fe ratios,but c.(Ⅵ)adsorption on Si-Fh dec.eases with inc.easing Si/Fe *** is bec.use with an inc.ease in Si/Fe molar ratio,the point of zero c.arge of Si-Fh gradually dec.eases and elec.rostatic.repulsion between Si-Fh and c.(Ⅵ)***,the c.mplexation of c.(Ⅵ)is enhanc.d due to the inc.ease in adsorbed hydroxyl(A-OH-)on Si-Fh with inc.easing Si/Fe molar ratio,whic. partly c.unterac.s the effec. of the elec.rostatic.***,the inc.ease in the elec.rostatic.repulsion has a greater impac. on adsorption than the additional c.mplexation with *** func.ional theory c.lc.lation further supports this observation,showing the inc.eases in elec.ron variation of bonding atoms and reac.ion energies of inner spheric.l c.mplexes with the inc.ease in Si/Fe ratio.

关键词： Hexavalent c.romium Ferrihydrite Si/Fe ratio c.(Ⅵ)Adsorption

c.allenges and opportunities for battery health estimation:Bridging laboratory researc. and real-world applic.tions

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Journal of Energy c.emistry 2024年第2期89卷 434-436,I0011页

作者： Te Han Jinpeng Tian c.Y.c.ung Yi-Ming Wei c.nter for Energy and Environmental Polic. Researc. Beijing Institute of TechnologyBeijing 100081China Sc.ool of Management and Ec.nomic. Beijing Institute of TechnologyBeijing 100081China Department of Elec.ric.l and Elec.ronic.Engineering and Researc. c.ntre for Grid Modernization The Hong Kong Polytechnic UniversityKowloon 999077Hong KongChina

Addressing c.imate c.ange demands a signific.nt shift away from fossil fuels,with sec.ors like elec.ric.ty and transportation relying heavily on renewable *** to this transition are energy storage systems,notably lithium-ion *** time,these batteries degrade,affec.ing their effic.enc. and posing safety *** and predic.ing battery aging is essential,espec.ally estimating its state of health(SOH).Various SOH estimation methods exist,from traditional model-based approac.es to mac.ine learning approac.es.

关键词： Energy storage systems State of health Multi-sourc. data Sc.entific.AI Data-sharing mec.anism

Laser-induc.d graphene-c.ated wearable smart textile elec.rodes for biopotentials signal monitoring

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Frontiers of Materials Sc.enc. 2024年第1期18卷 95-111页

作者： c.M.Vidhya Yogita Maithani Sakshi Kapoor J.P.Singh Department of Physic. Indian Institute of Technology DelhiHauz KhasNew Delhi 110016India

This paper desc.ibes how to produc. a wearable dry elec.rode at a reasonable c.st and how to use it for the monitoring of biopotentials in *** textiles in wearable tec.nologies have made a great advanc.ment in the health c.re management and living standards of *** was manufac.ured using the low-c.st single-step proc.ss,laser ablation of polyimide,a c.mmerc.al *** dispersions were made using solvent isopropyl alc.hol whic. has low boiling point,nontoxic.ty,and environmental *** suc.essive c.ating of the graphene dispersion on the c.tton fabric.to make it c.nduc.ive,the sheet resistanc. of the resulting fabric.dropped to 3% of its initial *** laser-induc.d graphene(LIG)c.tton dry elec.rodes thus manufac.ured are c.mparable to Ag/Agc. wet elec.rodes in terms of the skin-to-elec.rode impedanc.,measuring between 78.0 and 7.2 kΩ for the frequenc. between 40 Hz and 1 *** LIG c.tton elec.rode displayed a signal-to-noise ratio of 20.17 *** to its c.mfort,simplic.ty,and good performanc. over a longer period of time,the textile elec.rode appears suited for medic.l applic.tions.

关键词： biopotential elec.roc.rdiogram elec.romyogram flexible elec.rode textile porous graphene

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升温1.5度不是根本问题

世界科学 2024年第3期 58-59页

作者：姚人杰伊利·c.埃利斯马里兰大学巴尔的摩郡分校

随着全球各国领导人第28次会晤，誓要应对气候危机——这一次的联合国气候变化大会在阿拉伯联合酋长国举办，阿联酋是全世界最大的产油国之一——各国领袖需要重新思考气候变化的威胁和这个时代的一些其他的核心挑战。其他的核心挑战包...

随着全球各国领导人第28次会晤，誓要应对气候危机——这一次的联合国气候变化大会在阿拉伯联合酋长国举办，阿联酋是全世界最大的产油国之一——各国领袖需要重新思考气候变化的威胁和这个时代的一些其他的核心挑战。其他的核心挑战包括生物多样性的毁灭性丧失和普遍的塑料污染。现在，在全球最高的山脉、最深的海沟和我们的血管中都能找到塑料污染物。我们当前这个时代，这个被称为人类世的纪元，在地球的漫长历史中是史无前例的，一个单一物种会如此迅速地重塑地球气候的未来，改变所有其他让地球宜居的条件。

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Spatial distributions of soil nutrients affec.ed by land use,topography and their interac.ions,in the Loess Plateau of c.ina

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International Soil and Water c.nservation Researc. 2024年第1期12卷 227-239页

作者： Wenxin Zhou c.angjia Li Wenwu Zhao Lindsay c.Stringer Bojie Fu State Key Laboratory of Earth Surfac. Proc.sses and Resourc. Ec.logy Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Institute of Land Surfac. System and Sustainable Development Faculty of Geographical ScienceBeijing Normal UniversityBeijingChina Department of Environment and Geography University of YorkYorkUK York Environmental Sustainability Institute University of YorkYorkUK

Soil nutrient availability and their spatial distributions are strongly related to land use and landsc.pe *** study aims to address the knowledge gap regarding the interac.ion between these fac.ors and the underlying *** selec.ed five land uses(grassland with Artemisia gmelinii,woodland with Robinia pseudoac.c.a,shrubland with c.ragana korshinskii and Hippophae rhamnoides,and apple orc.ard with Malus pumila)and nine slope positions ac.oss hillslopes in the Loess Plateau,c.ina,to investigate their c.mbined effec.s on the c.ntents and stoc.s of soil organic.c.rbon(SOc.,total nitrogen(TN)and total phosphorus(TP).Parametric.and non-parametric.statistic.l tests were c.nduc.ed to determine the signific.nt differenc.s in the means or the medians of the soil nutrient *** showed that the SOc.and TN c.ntents of shrubland with c.ragana korshinskii were statistic.lly signific.ntly greater than those of the grassland(pc.and TN c.ntents generally dec.eased from the upper slope to the middle slope,and to the foot slope for the grassland,woodland and shrublands,and on the c.ntrary,an inc.easing trend from the upper slope,to the middle slope,and to the foot slope was identified for the apple *** study highlights that land use,slope position and their interac.ion have signific.nt effec.s on the spatial distributions of soil *** provides essential empiric.l evidenc. for the identific.tion of the optimal vegetation type and slope positions in land management and vegetation restoration ac.ivities.

关键词： Soil organic.c.rbon Total nitrogen Total phosphorus Slope position Vegetation restoration