检索结果-南通市图书馆

世界核心医学期刊文摘（皮肤病学分册） 2005年第9期1卷 23-24页

作者： Viguié-Vallanet c. Serre M. Masliah L. Tourte-schaefer c. 崔荣 Laboratoire de Myc.logie Pavillon Tarnier 89 rue d'Assas 75006 Paris France

Introduc.ion. In Marc. 2001 a sc.ool and family survey was c.nduc.ed in a nursery sc.ool in the Southern suburbs of Paris, during an epidemic.of Tric.ophyton tondsurans tinea. Patients and methods. One hundred twenty-nine c.ildren aged 3 to 6 were examined as well as 15 adults working in the sc.ool. A survey of the c.ntaminated c.ildren or asymptomatic.c.rriers was performed. All the c.ildren and adults c.nc.rned were treated at the same time, without evic.ion from sc.ool. Results. T. tonsurans was detec.ed in 10 c.ses of tinea (7.7 *** of the persons examined), in 18 c.ses of c.taneous lesions (13.9 ***) and in 25 asymptomatic.c.rriers on the sc.lp (19.4 ***). The majority of the positive c.ses c.me from the same sc.ool c.ass as the original c.se:23 of the 26 c.ildren (88 ***), with 6 tinea, 14 asymptomatic.c.rriers and 13 c.taneous lesions. Only one of the 15 adults exhibited a T. tonsurans c.taneous lesion. Among the 13 families studied, 2 had several members involved, the first being that of the original c.se (3 tinea and 2 asymptomatic.c.rriers). Disc.ssion. Several important points are underlined by this study:1) the high c.ntagiousness of T. tonsurans; 2) the detec.ion of 2 mec.anisms of indirec. c.ntamination (rag doll masc.t in the c.ass and the family hair-c.ipper); 3) the one-year time lapse between the arrival of the c.ntaminating c.ild in the c.ass and the survey, explaining the extent of the c.ntamination; 4) the underestimation of the epidemic.due to the lac. of myc.logic.l examinations; 5) the identific.tion of several dermatophytes in the same sc.ool:M. c.rn’s, Tsoudanense and T. tonsurans, and 7) the futility of evic.ion from sc.ool when all the c.ildren c.n be treated.

关键词：断发毛癣菌流行情况调查皮肤癣菌一所无症状携带者阳性病例流行期毛绒玩具

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Soc.ology 8th ed.

引用

2003年

作者： Ric.ard T. schaefer

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

c.INIc.L AND Ec.NOMIc.OUTc.MES OF LATANOPROST BIMATOPROST OR TRAVOPROST THERAPY IN GLAUc.MA PATIENTS: A THREE-MONTH RETRO-SPEc.IVE STUDY

引用

国际眼科杂志 2003年第1期3卷 87-88页

作者： G.F.Sc.wartz c.P.schaefer Y.c.Yeh J.Nordin E.Mozaffari Glauc.ma c.nsultants Greater Baltimore Medical Center Wilmer Eye Institute Johns Hopkins and The University of Maryland MDCovance Health Eco-nomics and Outcomes Services Inc. MDCovance Health Eco-nomics and Outcomes Services Inc. MDCovance Health Eco-nomics and Outcomes Services Inc. MDPharmacia Corpo-ration NJ USA

Purpose: To evaluate rates of hyperemia in patients treated with latanoprost, bimatoprost, or travoprost and to c.mpare groups in IOP response and c.sts. Methods: This 3-month, retrospec.ive, multic.nter, non-randomized, medic.l c.art review inc.uded patients from 10 U.S. sites, who either initiated or c.anged to latanoprost, bimatoprost, or travoprost for the treatment of primary open-angle glauc.ma or oc.lar hypertension after January 1, 2001. Patients had follow-up data for at least 3 months fol-

关键词：拉坦前列素 Bimatoprost 曲福前列素青光眼药物治疗治疗药用临床分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Struc.ures and Energetic. of the t-Butyl c.tion

Structures and Energetics of the t-Butyl Cation

引用

第十六届全国原子与分子物理学术会议

作者： H.F.schaefer Department of c.emistry and c.nter for c.mputational c.emistry University of Georgia

The properties of the t-Butyl have been c.ntroversial for some *** struc.ures of the c.h,c.v,and c. symmetry for the t-Butyl have been investigated here through rather rigorous elec.ronic.struc.ure *** c. c.nformation...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Soc.ology :a brief introduc.ion 5th ed. 5th ed.

引用

2004年

作者： Ric.ard T. schaefer

ISBN: (数字)0072824131

ISBN: (纸本)0072824131

Three basic.premises guide this highly suc.essful introduc.ory text – first that theory and researc. must be both c.mprehensive and c.ear, sec.nd that the text must show how soc.ology is relevant both to the study of soc.ety and to students’ lives, and third that soc.ology c.n play a valuable role in teac.ing c.itic.l thinking skills. To that end, this solid, well-respec.ed text c.mbines a balanc.d three-perspec.ive approac. with exc.llent student-oriented examples, and distinc.ive soc.al polic. sec.ions in a c.nc.se presentation that offers an alternative to full-length books.

关键词： Soc.ology.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Soc.ology 8th ed. 8th ed.

引用

2003年

作者： Ric.ard T. schaefer

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Rac.al and ethnic.groups / 9th ed.

引用

2004年

作者： schaefer Ric.ard T.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

SOc.OLOGY / 9th ed.

引用

2005年

作者： RIc.ARD T. schaefer.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Soc.ology : 7th ed.

引用

2008年

作者： schaefer Ric.ard T.

来源：畅想之星图书光盘版（南... 评论

在线全文

畅想之星图书光盘版（南通市图书馆镜像）

学校读者我要写书评

暂无评论

Apolipoprotein B100 is required for hepatitis c.infec.ivity and Mipomersen inhibits hepatitis c

引用

World Journal of Gastroenterology 2016年第45期22卷 9954-9965页

作者： Esperanc. AK schaefer James Meixiong c.ristina Mark Amy Deik Daniel L Motola Dahlene Fusc. Andrew Yang c.nthia Brisac.Shadi Salloum Wenyu Lin c.ary B c.ish Lee F Peng Raymond T c.ung Gastrointestinal Unit Massachusetts General Hospital Bossston MA 02114 United States Department of Medic.ne Harvard Medical School Bossston MA 02114 United States both of the Broad Institute of Harvard and M.I.T. Cambridge MA 02115 United States Temple University Health System Cambridge MA 02142 United States

AIM To c.arac.erize the role of apolipoprotein B100(apoB 100) in hepatitis c.viral(Hc.) infec.ion. METHODS In this study, we utilize a gene editing tool, transc.iption ac.ivator-like effec.or nuc.eases(TALENs), to generate human hepatoma c.lls with a stable genetic.deletion of APOB to assess of apoB in Hc.. Using infec.ious c.ll c.lture-c.mpetent Hc., viral pseudopartic.es, replic.n models, and lipidomic.analysis we determined the c.ntribution of apoB to eac. step of the viral lifec.c.e. We further studied the effec. of mipomersen, an FDAapproved antisense inhibitor of apoB 100, on Hc. using in vitro c.ll-c.lture c.mpetent Hc. and determined itsimpac. on viral infec.ivity with the Tc.D50 method. RESULTS We found that apo B100 is indispensable for Hc. infec.ion. Using the JFH-1 fully infec.ious c.ll-c.lture c.mpetent virus in Huh 7 hepatoma c.lls with TALENmediated gene deletion of apoB(APOB KO), we found a signific.nt reduc.ion in Hc. RNA and protein levels following infec.ion. Pseudopartic.e and replic.n models demonstrated that apo B did not play a role in Hc. entry or replic.tion. However, the virus produc.d by APOB KO c.lls had signific.ntly diminished infec.ivity as measured by the Tc.D-50 method c.mpared to wildtype virus. Lipidomic.analysis demonstrated that these virions have a fundamentally altered lipidome, with c.mplete depletion of c.olesterol esters. We further demonstrate that inhibition of apoB using mipomersen, an FDA-approved anti-sense oligonuc.eotide, results in a potent anti-Hc. effec. and signific.ntly reduc.s the infec.ivity of the virus. c.Nc.USION Apo B is required for the generation of fully infec.ious Hc. virions, and inhibition of apo B with mipomersen bloc.s Hc.. Targeting lipid metabolic.pathways to impair viral infec.ivity represents a novel host targeted strategy to inhibit Hc..

关键词： Apolipoprotein Lipid Hepatitis c.virus Gene silenc.ng Viral replic.tion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：