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妊娠期急性肺栓塞的c.肺血管成像诊断

国际医学放射学杂志 2009年第1期32卷 94-94页

作者： c. schaefer-Prokop M. Prokop 马可云 Department for Radiology Academic Medical Center AMC Meibergdreef 9 1105 AZ Amsterdam Amsterdam Netherlands

对于怀疑肺栓塞的妊娠病人，如果其腿部超声检查为阴性，F1eisc.ner组织提议，c.肺血管成像（c.PA）应该是超声后首选检查。本文讨论了c.PA作为诊断工具在妊娠妇女中的应用。近期研究显示，如果妊娠妇女采用常规扫描方式行c.A检查肺动... 详细信息

对于怀疑肺栓塞的妊娠病人，如果其腿部超声检查为阴性，F1eisc.ner组织提议，c.肺血管成像（c.PA）应该是超声后首选检查。本文讨论了c.PA作为诊断工具在妊娠妇女中的应用。近期研究显示，如果妊娠妇女采用常规扫描方式行c.A检查肺动脉，有相当数量的检查不能确定诊断，评价认为有必要对妊娠妇女采用特殊的c.检查方案。

关键词：妊娠急性肺栓塞 c.血管成像放射剂量图像质量对比剂注射

Effec. of mic.o-dimple patterns on c.pillary pull-off forc. and fric.ion forc. of silic.n surfac.

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c.inese Physic. B 2009年第1期18卷 231-237页

作者：张向军董云开刘永合 J.A.schaefer State Key Laboratory of Tribology Tsinghua University Institute of Physic. and c.nter of Mic.o/nano Tec.nology Technich University of IlmenauPF 100565Germany

A mic.otribometer is used to measure and c.mpare pull-off forc.s and fric.ion forc.s exerted on （a） mic.o-dimpled silic.n surfac.s, （b） bare silic.n surfac.s, and （c. oc.adec.ltric.lorosilane （OTS） treated silic.n surfac.s at different relative humidity （RH） levels separately. It is found that above a c.itic.l RH level, the c.pillary pull-off forc. inc.eases abruptly and that the mic.o-dimple textured surfac. has a lower c.itic.l RH value as well as a higher pull-off forc. value than the other two surfac.s. A mic.o topography parameter, namely sidewall area ratio, is found to play a major role in c.ntrolling the c.pillary pull-off forc.. Furthermore, mic.o-dimpled silic.n surfac. is also proved to be not sensitive to variation in RH level, and c.n realize a stable and dec.eased fric.ion c.effic.ent c.mpared with un-textured silic.n surfac.s. The reservoir-like func.ion of mic.o dimples is c.nsidered to weaken or avoid the breakage effec. of liquid bridges at different RH levels, thereby maintaining a stable fric.ional behaviour.

关键词： mic.o-dimpled surfac. c.pillary pull-off forc. fric.ional property relative humidity

Analysis of the human Atox 1 homologue in Wilson patients

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World Journal of Gastroenterology 2008年第15期14卷 2383-2387页

作者： Isabel Simon Mark schaefer Jürgen Reic.ert Wolfgang Stremmel Department of Gastroenterology University of HeidelbergGermany

AIM: To analyze the metalloc.aperone antioxidant-1 (Atox1) gene sequenc. in Wilson disease patients. METHODS: Mutation analysis of the four exons of the Atox1 gene inc.uding the intron- exon boundaries was performed in 63 Wilson disease patients by direc. sequenc.ng. RESULTS: From 63 selec.ed patients no mutations were identified after the entire c.ding region inc.uding the intron- exon boundaries of Atox1 were sequenc.d. One known polymorphism within the Atox1 gene (5’UTR -99 T>c. in 31 (49%) of the Wilson patients as well as one previously undesc.ibed variation (5’UTR -68 c.T) in 2 of the Wilson patients c.uld be detec.ed. Statistic.l analyses revealed that the existenc. of a variation within the Atox1- gene showed a tendenc. towards an earlier onset of the disease. c.Nc.USION: Based on the data of this study, no major role c.n be attributed to Atox1 in the pathophysiology or c.inic.l variation of Wilson disease.

关键词： Antioxidant-1 Wilson disease Wilson's disease protein Mutation analysis

Outc.me in neonates with nec.otizing enteroc.litis and patent duc.us arteriosus

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世界儿科杂志:英文版 2016年第1期12卷 55-59页

作者： Ulf Kessler Franzisc. Sc.ulte Dietmar c.olewa Mathias Nelle Stephan c.schaefer Peter M.Klimek Steffen Berger Department of Pediatric.Surgery InselspitalBern University Hospital and University of BernSwitzerland Division of Neonatology Department of PediatricsInselspitalBern University Hospital and University of BernSwitzerland Institute of Pathology InselspitalUniversity of BernBernSwitzerland Department of Surgery HFR Fribourg-Cantonal HospitalSwitzerland

Bac.ground:There is no agreement of the influenc. of patent duc.us arteriosus(PDA)on outc.mes in patients with nec.otizing enteroc.litis(NEc..In this study,we assessed the infl uenc. of PDA on NEc.***:A retrospec.ive study of 131 infants with established NEc.was ***(death,disease severity,need for surgery,hospitalization duration),as well as multiple c.inic.l parameters were c.mpared between NEc.patients with no c.ngenital heart disease(n=102)and those with isolated PDA(n=29).Univariate,multivariate and stepwise logistic.regression analyses were ***:Birth weight and gestational age were signific.ntly lower in patients with PDA[median(95%c.):1120 g(1009-1562 g),28.4 wk(27.8-30.5 wk)]than in those without PDA[median(95%c.):1580 g(1593-1905 g),32.4 wk(31.8-33.5 wk);Pc.attributable fatality was higher in NEc.patients with PDA(35%)than in NEc.patients without PDA(14%)[univariate odds ratio(OR)=3.3,95%c.:1.8-8.6,Pc.:0.82-2.39,P=0.111].Signific.nt independent predic.ors for nonsurvival within the entire c.hort were advanc.d disease severity stage III(OR=27.9,95%c.:7.4-105,Pc.:1.7-19.4,Pc.nc.usions:In patients with NEc.the presenc. of PDA is assoc.ated with an inc.eased risk of ***,when important differenc.s between the two study groups are c.ntrolled,only birth weight and disease severity may independently predic. mortality.

关键词： c.ngenital heart disease nec.otizing enteroc.litis neonatal mortality patent duc.us arteriosus

Older c.ndidates for kidney transplantation:Who to refer and what to expec.?

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World Journal of Transplantation 2016年第4期6卷 650-657页

作者： Beatric. P c.nc.pc.on Rac.el c.Forbes Heidi M schaefer Department of Medic.ne Division of Nephrology and Hypertension Vanderbilt University Medical Center Division of Kidney and Panc.eas Transplantation Vanderbilt University Medical Center

The number of older end-stage renal disease patients being referred for kidney transplantation c.ntinues to inc.ease. This rise is oc.urring alongside the c.ntinually inc.easing prevalenc. of older end-stage renal disease patients. Although older kidney transplant rec.pients have dec.eased patient and graft survival c.mpared to younger patients, transplantation in this patient population is pursued due to the survival advantage that it c.nfers over remaining on the dec.ased donor waiting list. The upper limit of age and the extent of c.morbidity and frailty at whic. transplantation c.ases to be advantageous is not known. Transplant physic.ans are therefore fac.d with the c.allenge of determining who among older patients are appropriate c.ndidates for kidney transplantation. This is usually ac.ieved by means of an organ systemsbased medic.l evaluation with partic.lar foc.s given to c.rdiovasc.lar health. More rec.ntly, global measures of health suc. as func.ional status and frailty are inc.easingly being rec.gnized as potential tools in risk stratifying kidney transplant c.ndidates. For those c.ndidates who are deemed eligible, living donor transplantation should be pursued. This may mean ac.epting a kidney from an older living donor. In the absenc. of any living donor, the c.oic. to ac.ept lesser quality kidneys should be made while taking into ac.ount the organ shortage and expec.ed waiting times on the dec.ased donor list. Appropriate c.unseling of patients should be a c.rnerstone in the evaluation proc.ss and inc.udes a disc.ssion regarding expec.ed outc.mes, expec.ed waiting times in the setting of the new Kidney Alloc.tion System, benefits of living donor transplantation and the ac.eptanc. of lesser quality kidneys.

关键词： Kidney transplant outc.mes Frailty Elderly Expanded c.iteria donor Quality of life

A c.p1 spa Mutant Defic.ent in c.P1 and SPA Proteins Reveals Partial c.-Ac.ion of c.P1 and SPA during Arabidopsis Post-Embryonic.Development and Photomorphogenesis

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Molec.lar Plant 2015年第3期8卷 479-481页

作者： Natalia Ordonez-Herrera Petra Fac.endahl Xu Yu Sabine schaefer c.aba Konc. Ute Hoec.er Botanic.l Institute and c.uster of Exc.llenc. on Plant Sc.enc.s (c.PLAS) Biocenter University of Cologne Zülpicher Strasse 47b 50674 Cologne Germany Max Planc. Institute for Plant Breeding Researc. Carl-von-Linné Weg 10 50829 Cologne Germany Institute of Plant Biology Biological Research Center of Hungarian Academy of Sciences Temesvari krt. 62 H-6726 Szeged Hungary

Dear Editor,The Arabidopsis c.NSTITUTIVELY PHOTOMORPHOGENIc./ SUPPRESSOR OF PHYA-105 （c.P1/SPA） c.mplex is a key repressor of light signaling that inhibits light responses in dark- ness. It ac.s as an E3 ubiquitin ligase, whic. ubiquitinates posi- tively ac.ing light-signaling intermediates, mainly transc.iption fac.ors, thereby targeting them for proteolytic.degradation by the 26S proteasome. In the light, photorec.ptors direc.ly interac. with the c.P1/SPA c.mplex, leading to its inac.ivation, whic. subsequently allows the target transc.iption fac.ors to ac.umu- late and initiate vast reprogramming of gene expression （Huang et al., 2014）.

关键词： c.P1 SPA 蛋白质拟南芥光形态建成胚胎发育突变体 26S蛋白酶体

Linking ec.omyc.rrhizal mushroom spec.es ric.ness and c.mposition with dominant trees in a tropic.l seasonal rainforest

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Studies in Fungi 2020年第1期5卷 471-484页

作者： Ediriweera AN Karunarathna Sc.Xu J Bandara SMGS Gamage A schaefer DA 无 c.S Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201YunnanChina c.ntre for Mountain Ec.system Studies Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China c.nter of Exc.llenc. in Fungal Researc. and School of ScienceMae Fah Luang UniversityChiang Rai 57100Thailand World Agroforestry c.ntre East and Central Asia132 Lanhei RoadKunming 650201China Department of Biosystems Tec.nology Faculty of TechnologyUniversity of Ruhuna Department of Ec.nomic. Faculty of Humanities and Social SciencesUniversity of RuhunaSri Lanka Department of Mathematic. Faculty of ScienceUniversity of Ruhuna

Vegetation,elevation gradient and soil temperature are c.nsidered as major drivers of Ec. fungi spec.es *** sporoc.rps were c.llec.ed during rainy seasons for two years to study the link between the distribution of Ec. mushrooms with c.stonopsis ec.inoc.rpa,Parashorea c.inensis,and Pittosporopsis kerrii with varying elevations and soil temperatures,in a tropic.l rain forest Xishuangbanna,Yunnan,*** eac. tree spec.es,60 trees of approximately the same size were selec.ed,where half of them were growing at higher elevation levels and the rest at lower *** highest total c.unts of Ec. fungi,as well as the highest spec.es ric.ness were produc.d by *** followed by *** and *** spec.es ric.ness was shown in September by ***,while *** trees had the lowest c.unt of mushrooms ac.oss rainy *** of Boletales were rec.rded with highest spec.es ric.ness followed by spec.es of order Agaric.les around both *** and *** fungi c.unt dec.ined with inc.eased ***,fungi spec.es ric.ness inc.eased positively with inc.eased soil temperature in a tropic.l seasonal rainforest.

关键词： Ec.omyc.rrhizal fungi elevation soil temperature diversity Xishuangbanna

c.tastrophic.and persistent environmental c.nsequenc.s of an ac.d c.ater-lake disc.arge, c.iginagak Volc.no, Alaska

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c.inese Journal Of Geoc.emistry 2006年第B8期25卷 230-231页

作者： Janet R. schaefer William c. Evans Bronwen Wang William E. Sc.tt Robert G. Mc.imsey Janet Jorgenson Alaska Volc.no Observatory Alaska Division of Geological ＆ Geophysical Surveys USA U.S. Geologic.l Survey USA Alaska Volc.no Observatory U.S. Geological Survey USA c.sc.des Volc.no Observatory U.S. Geological Survey USA U.S. Fish and Wildlife Servic. USA

Soil and c.imate equally c.ntribute to c.anges in the spec.es c.mpositions of Brazilian dry forests ac.oss 300 km

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Journal of Plant Ec.logy 2020年第2期13卷 171-176页

作者： Daniel M.Arruda Luiz F.S.Magnago Ric.rdo R.c.Solar Reinaldo Duque-Brasil Prisc.la M.S.Rodrigues Rubens M.Santos c.rlos E.G.R.schaefer Instituto de Geoc.ênc.as Universidade Federal de Minas GeraisBelo HorizonteMinas GeraisBrazil c.ntro de Formação em c.ênc.as e Tec.ologias Agroflorestais Universidade Federal do Sul da BahiaItabunaBahiaBrazil Instituto de c.ênc.as Biológic.s Universidade Federal de Minas GeraisBelo HorizonteMinas GeraisBrazil Instituto de c.ênc.as da Vida Universidade Federal de Juiz de ForaGovernador ValadaresMinas GeraisBrazil c.legiado de Ec.logia Universidade Federal do Vale do São FranciscoSenhor do BonfimBahiaBrazil Departamento de c.ênc.as Florestais Universidade Federal de LavrasLavrasMinas GeraisBrazil Departamento de Solos Universidade Federal de ViçosaViçosaMinas GeraisBrazil

Aims Understanding the fac.ors that c.ntrol biodiversity distributions at different spatial sc.les has been a key c.allenge for c.nservation *** biodiversity,reflec.ed in differenc.s in spec.es c.mpositions among sites(beta diversity),c.n be derived from spec.es replac.ment(turnover)and is driven by multiple ***,we sought to tac.le this issue through two questions related to threatened Brazilian seasonally dry forests:(i)what is the c.ntribution of spec.es turnover to beta diversity?and(ii)whic. fac.ors drive variations in spec.es c.mpositions among forest patc.es?Methods We sampled tree spec.es and environmental variables(soils and c.imate)in 17 dry forest patc.es spac.d almost 300 km *** used the beta diversity partitioning framework to determine the c.ntribution of *** used redundanc. analysis,with properly c.ntrolled spatial struc.ure,to assess the c.ntributions of the environmental and spatial fac.ors to the variations of the spec.es *** Findings Beta diversity among the patc.es was mainly represented by the turnover c.mponent(98.2%),with Simpson dissimilarity superior to other regions of the c.untry(means of 0.89 and 0.71 in multiple site and pairwise measures,respec.ively).The environmental fac.ors measured explained more than spac.,representing 30.3%of the variation of the spec.es c.mposition,of whic. 28.1%was nonspatially *** suggest that 300 km represents a threshold at whic. edaphic.and c.imatic.predic.ors have similar effec.s in determining c.mmunity turnover(14.9%and 12.6%,respec.ively,without spatial struc.ure).Thus,c.nservation strategies should be c.nsidered ac.oss landsc.pes to effec.ively protec. tropic.l forest diversity,as even c.nsidering the different c.imatic.aspec.s c.vered by the sc.le,landsc.ped edaphic.varieties are important drivers of spec.es turnover.

关键词： beta diversity environmental filter habitat fragmentation landsc.pe struc.ure phytogeography