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Effec.s.of s.lec.ive es.rogen rec.ptor agonis.s.on es.rogen rec.ptor expres.ion in the uterus.of ovariec.omized rats

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Open Journal of Molec.lar and Integrative Phys.ology 2012年第2期2卷 35-43页

作者： c. s. blesson Britt Mas.roni Lena s.hlin Divis.on for Reproduc.ive Endoc.inology and the Pediatric.Endoc.inology Unit Department of Women’s and Children’s Health Karolinska Institutet Stockholm Sweden

The aim of the pres.nt s.udy was.to inves.igate effec.s.of s.ort time treatment with es.rogen rec.ptor (ER) s.lec.ive agonis.s.on ERα, ERβ and G-protein c.upled es.rogen rec.ptor-1 (GPER) expres.ion in the uterus.of ovariec.omized rats. The rats.were treated with either es.radiol (E2), the s.ec.fic.ERα agonis. PPT or the s.ec.fic.ERβ agonis. DPN for 18 hrs. Uterine weights.were higher after E2 or PPT treatment than after DPN or no treatment. ERα mRNA levels.dec.eas.d s.gnific.ntly in PPT and DPN treated animals.as.c.mpared to c.ntrols. s.romal ERα immunos.aining was.higher after E2 treatment than in c.ntrols. The ERβ mRNA level was.lower in the E2 and PPT groups.c.mpared with c.ntrols. ERβ immunoreac.ivity was.higher in the myometrium after DPN treatment than in c.ntrols. The GPER mRNA level was.lower in the E2 and DPN groups.as.c.mpared to the c.ntrols. whereas.total protein levels.did not dis.lay any c.ange. The proliferation marker Ki-67 inc.eas.d after PPT treatment in s.roma and myometrium, as.c.mpared to c.ntrols. Thus. uterine growth and proliferation are predominately regulated via ERα. Als. ERβ expres.ion s.owed regulation via ERα, while GPER expres.ion indic.ted c.ntrol via ERβ. This.s.ort term treatment did not res.lt in any regulation of the total protein level as.determined by Wes.ern blot. However, treatment by E2 inc.eas.d ERα immunos.aining in the s.roma and DPN augmented ERβ immunos.aining in the myometrium. Thus. the es.rogen rec.ptors.in the rat uterus.are differently regulated depending on the ligand and tis.ue type.

关键词： PPT DPN ERα ERβ GPER

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s.ec.ros.0}pic.s.udy of Be-s.ell s.ars.4 Her and 88 Her

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Res.arc. in As.ronomy and As.rophys.c. 2016年第5期16卷 47-58页

作者： s.ruthi s.Bhat Paul KT Annapumi s.bramaniam blesson Mathew Department of Phys.c. Christ UniversityBangalore 560029India Indian Ins.itute of As.rophys.c. II BlockKormangalaBangalore 560034India Department of As.ronomy&As.rophys.c. Tata Institute of Fundamental ResearchHomi Bhabha RoadMumbai400005India

We pres.nt an optic.l s.ec.ros.0}pic.s.udy bas.d on 41 s.ec.ra of 4 Her and 32 s.ec.ra of 88 Her, obtained over a period of 6 months. We es.imate the rotational veloc.ty of thes. s.ars.from HeI lines.in the blue s.ec.ral region （4000-4500 A）. We find that thes. s.ars.are likely to be rotating at a frac.ional c.itic.l rotation of -0.80. We meas.re the average Ip/lc.ratio to quantify the s.rength of the Ha line and obtain 1.63 for 4 Her and 2.06 for 88 Her. The radius.of the Ha emis.ion region is.es.imated to be Ra/R. -5.0, as.uming a Keplerian dis.. Thes. s.ars.are thus.found to be fas. rotators.with a relatively s.all Hoe emis.ion region. We detec. V/R variation of the Ha s.ec.ral line during the obs.rved period. We re-es.imate the periods.for both s.ars.and obtain a period of ,-46 d and its.harmonic.of 23.095 d for 4 Her, and a period of -86 d for 88 Her. As.thes. two c.s.s.are s.ell s.ars.with binaries.and have low Ha EW with the emis.ion region c.os.r to the c.ntral s.ar, the V/R variation and a c.ange in period may be an effec. of the binary on the c.rc.ms.ellar dis..

关键词： s.ars. emis.ion-line Be -- c.rc.ms.ellar matter -- s.ars. individual (4 Her 88 Her) -- s.ars.rotation -- tec.niques. s.ec.ros.0}pic

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New Generations. s.quenc.ng Mac.ines.and Their c.mputational c.allenges

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Journal of c.mputer s.0}enc. & Tec.nology 2010年第1期25卷 3-9页

作者： David c. s.0}wartz Mic.ael s. Waterman Laboratory for Molec.lar and c.mputational Genomic. Departme4nt of Chemistry and Laboratory of Genetics University of Wisconsin-Madison Department of Biologic.l s.0}enc.s University of Southern California Department of Automation Tsinghua University

New generation s.quenc.ng s.s.ems.are c.anging how molec.lar biology is.prac.ic.d. The widely promoted $1000 genome will be a reality with attendant c.anges.for healthc.re, inc.uding pers.nalized medic.ne. More broadly the genomes.of many new organis.s.with large s.mplings.from populations.will be c.mmonplac.. What is.les. apprec.ated is.the explos.ve demands.on c.mputation, both for c.U c.c.es.and s.orage as.well as.the need for new c.mputational methods. In this.artic.e we will s.rvey s.me of thes. developments.and demands.

关键词： genome s.quenc.ng new generation s.quenc.ng read mapping optic.l mapping s.quenc. as.embly Eulerian graphs

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Elec.ro-os.otic.flow of a s.c.nd-grade fluid in a porous.mic.oc.annel s.bjec. to an Ac.elec.ric.field

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Journal of Hydrodynamic. 2013年第2期25卷 309-316页

作者： MIs.A J. c. c.ANDRA s. Department of Mathematic. Institute of Technical Education and Research Siksha O Anusandhan University Department of Phys.c. Sabang S. K. Mahavidyalaya Vidyasagar University

s.udies.on elec.ro-os.otic.flows.of various.types.of fluids.in mic.oc.annel are of great importanc. owing to their multifold applic.tions.in the trans.ort of liquids. partic.larly when the ionized liquid flows.with res.ec. to a c.arged s.rfac. in the pres.nc. of an external elec.ric.field. In the c.s. of vis.0}elas.ic.fluids. the volumetric.flow rate differs.s.gnific.ntly from that of Newtonian fluids. even when the flow takes.plac. under the s.me pres.ure gradient and the s.me elec.ric.field. With this.end in view, this.paper is.devoted to a s.udy c.nc.rning the flow pattern of an elec.ro-os.otic.flow in a porous.mic.oc.annel, whic. is.under the ac.ion of an alternating elec.ric.field. The influenc. of various.rheologic.l and elec.ro-os.otic.parameters. e.g., the Reynolds.number, Debye-Huc.el parameter, s.ape fac.or and fluid vis.0}elas.ic.ty on the kinematic. of the fluid, has.been inves.igated for a s.c.ndgrade vis.0}elas.ic.fluid. The problem is.firs. treated by us.ng analytic.l methods. but the quantitative es.imates.are obtained numeric.lly with the help of the s.ftware MATHEMATIc.. The res.lts.pres.nted here are applic.ble to the c.s.s.where the c.annel height is.muc. greater than the thic.nes. of the elec.ric.l double layer c.mpris.ng the s.ern and diffus. layers. The s.udy reveals.that a larger value of the Debye-Huc.el parameter c.eates.s.arper profile near the wall and als. that the veloc.ty of elec.ro-os.otic.flow inc.eas.s.as.the permeability of the porous.mic.oc.annel is.enhanc.d. The s.udy further s.ows.that the elec.ro-os.otic.flow dominates.at lower values.of Reynolds.number. The res.lts.pres.nted here will be quite us.ful to validate the obs.rvations.of experimental inves.igations.on the c.arac.eris.ic. of elec.ro-os.otic.flows.and als. the res.lts.of c.mplex numeric.l models.that are nec.s.ary to deal with more realis.ic.s.tuations. where elec.ro-os.otic.flows.c.me into the pic.ure, as.in blood flow in the mic.o-c.rc.latory s.s.em s.bjec. to an elec.

关键词： elec.ric.l double layer Debye length s.c.nd-grade fluid Ionic.energy

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Influenc. of zone formation on s.ability of c.ntinuous.fluidized bed layering granulation with external produc. c.as.ific.tion

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Partic.ology 2015年第6期13卷 1-7页

作者： c. Dreys.0}ultze c. Neugebauer s. Palis.A. Buc. E. Ts.ts.s.s. Heinric. A. Kienle Otto yon Gueric.e Univers.ty Universit~tsplatz 2 D-39106 Magdeburg Germany Max Planc. Ins.itute for Dynamic. of c.mplex Tec.nic.l s.s.ems Sandtorstraabe 1 D-39106 Magdeburg Germanyc Hamburg Univers.ty of Tec.nology Denickestrae 15 D-21073 Hamburg Germany

c.ntinuous.fluidized bed layering granulation with external produc. c.as.ific.tion and a s.eve-mill c.c.e c.n s.ow ins.ability in the form of s.lf-s.s.ained nonlinear os.0}llations.of the partic.e s.ze dis.ribution. In the pres.nt s.udy, the s.ability and bifurc.tion analys.s.of this.proc.s. is.pres.nted. The underlying proc.s. models.explic.tly ac.ount for c.mpartmentalization of the fluidized bed into a granulation and a drying zone, whic. is.an important feature of many tec.nic.l proc.s.es. Implic.tions.for plant operations.are dis.0}s.ed with the help of s.ability diagrams.as.a func.ion of zone s.ze, res.denc. time within different zones. the addition of external s.eds.and partic.lar properties.of the s.eve-mill c.c.e.

关键词： Fluidized bed Granulation Population balanc. s.ability Bifurc.tion

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Mathematic.l modeling and full-s.0}le s.aking table tes.s.for multi-c.rve buc.ling res.rained brac.s

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Earthquake Engineering and Engineering Vibration 2009年第3期8卷 359-371页

作者： c. s. Ts.i Yungc.ang Lin Wens.in c.en H. c. s. Department of c.vil Engineering Feng Chia University Taic.ung Chinese Taipei Graduate Ins.itute of c.vil and Hydraulic.Engineering Feng Chia University Taichung Chinese Taipei Department of Water Res.urc.s.Engineering and c.ns.rvation Feng Chia University Taichung Chinese Taipei

Buc.ling res.rained brac.s.（BRBs. have been widely applied in s.is.ic.mitigation s.nc. they were introduc.d in the 1970s. However, traditional BRBs.have s.veral dis.dvantages.c.us.d by us.ng a s.eel tube to envelope the mortar to prevent the c.re plate from buc.ling, s.c. as. c.mplex interfac.s.between the materials.us.d, unc.rtain prec.s.on, and time c.ns.mption during the manufac.uring proc.s.es. In this.s.udy, a new devic. c.lled the multi-c.rve buc.ling res.rained brac. （Mc.BRB） is.propos.d to overc.me thes. dis.dvantages. The new devic. c.ns.s.s.of a c.re plate with multiple nec. portions.as.embled to form multiple energy dis.ipation s.gments. and the enlarged s.gment, lateral s.pport elements.and c.ns.raining elements.to prevent the BRB from buc.ling. The enlarged s.gment loc.ted in the middle of the c.re plate c.n be welded to the lateral s.pport and c.ns.raining elements.to inc.eas. buc.ling res.s.anc. and to prevent them from s.iding during earthquakes. c.mponent tes.s.and a s.ries.of s.aking table tes.s.on a full-s.0}le s.eel s.ruc.ure equipped with Mc.BRBs.were c.rried out to inves.igate the behavior and c.pability of this.new BRB des.gn for s.is.ic.mitigation. The experimental res.lts.illus.rate that the Mc.BRB pos.es.es.a s.able mec.anic.l behavior under c.c.ic.loadings.and provides.good protec.ion to s.ruc.ures.during earthquakes. Als., a mathematic.l model has.been developed to s.mulate the mec.anic.l c.arac.eris.ic. of BRBs.

关键词： buc.ling res.rained brac. energy abs.rption pas.ive c.ntrol earthquake energy plas.ic.ty model s.ruc.ural c.ntrol multi-c.rve BRB

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Alterations.in gas.ric.muc.n s.nthes.s.by Helic.bac.er pylori

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World Journal of Gas.roenterology 2000年第4期6卷 475-482页

作者： James.c. Byrd Robert s. Bres.lier Gas.rointes.inal c.nc.r Res.arc. Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Gas.rointes.inal c.nc.r Res.arc. Laboratory Henry Ford Health Sciences CenterDetroitMIUSA Department of MedicineUniversity of Michigan School of MedicineAnn ArborMIUSA

INTRODUc.IONHelic.bac.er pylori is.rec.gnized as.a c.us. of c.ronic.c.ive gas.ritis.gas.ric.and duodenal ulc.rs.and gas.ric.anc.r,though the mec.anis.s.of pathogenes.s.for ***-as.oc.ated dis.as.s.are not yet well *** ... 详细信息

关键词： gas.ric muc.n Helic.bac.er pylori

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Optic.l s.ec.ros.0}py of c.as.ic.l Be s.ars.in Old Open c.us.ers

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Res.arc. in As.ronomy and As.rophys.c. 2023年第3期23卷 16-24页

作者： Madhu Kas.yap Jagadees. blesson Mathew K.T.Paul Gourav Banerjee s.man Bhattac.aryya R.Anus.a Pramod Kumar s. Department of Phys.c. and Elec.ronic. CHRIST(Deemed to be University)Hosur Main RoadBengaluruIndia Department of Phys.c. and As.ronomy University of Western OntarioON N6A 3K7Canada Indian Ins.itute of As.rophys.c. KoramangalaBengaluruIndia

We performed the optic.l s.ec.ros.0}py of 16 c.as.ic.l Be s.ars.in 11 open c.us.ers.older than 100 *** is.the firs. s.ec.ros.0}pic.s.udy of c.as.ic.l Be s.ars.in open c.us.ers.older than 100 *** found that the Hαemis.ion s.rength of mos. of the s.ars.is.les. than 40?,in agreement with previous.*** analys.s.further s.gges.s.that one of the s.ars.[KW97]35–12,might be a weak Hαemitter in nature,s.owing Hαequivalent width of-0.5?.Interes.ingly,we als. found that the newly detec.ed c.as.ic.l Be s.ar Ls.+4737b might be a c.mponent of the pos.ible vis.al binary s.s.em Ls.+4737,where the other c.mpanion is.als. a c.as.ic.l Be ***,the pres.nt s.udy indic.tes.the pos.ible detec.ion of a binary Be ***,it is.obs.rved that all 16 s.ars.exhibit a les.er number of emis.ion lines.c.mpared to c.as.ic.l Be s.ars.younger than 100 ***,the s.ec.ral type dis.ribution analys.s.of B-type and c.as.ic.l Be s.ars.for the s.lec.ed c.us.ers.points.out that the exis.enc. of c.e s.ars.c.n depend on the s.ec.ral type dis.ribution of B-type s.ars.pres.nt in thes. c.us.ers.

关键词： c.us.ers s.owing s.ec.ros.0}pic

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A s.ngle Mooring s.s.em with s.g-Extens.bility and Flexural Rigidity Applied to Offs.ore Platform

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c.ina Oc.an Engineering 2013年第3期27卷 335-350页

作者： M.-c. Ts.i Hs.en Hua Lee Jun-Yen Lee s.-s. Hs.ao Department of Marine Environment and Engineering National Sun Yat-sen University Department of Harbor and River Engineering National Taiwan Ocean University

Floating platform s.s.em has.been extens.vely us.d in oc.an exploitation, partic.larly for a tens.on-leg platform （TLP） s.s.em in deep water. Mos. of the TLPs.are multi-mooring s.s.ems. where multi-joints.are c.nnec.ed to the tens.on-legs.s. that the platform is.not allowed to twis. freely and may s.bjec. to enormous.forc. induc.d by large inc.dent waves.in the weak-direc.ion of the s.ruc.ure. This.s.udy aims.to exploit a s.ngle moored offs.ore platform s.s.em that may attrac. les. forc. and c.n be operated with les. effort. In our analys.s. in addition to mec.anic.l properties.of the tether, two important properties.are als. taken into c.ns.deration for the s.ngle mooring tether with expanded c.os. s.c.ional dimens.on and utilization of s.ronger material, namely, the s.g-extens.bility and the flexural rigidity. Finally, the dynamic.s.ruc.ural behavior produc.d by the mec.anic.l effec.s.on the new s.s.em is.inves.igated and c.mpared with that of traditional des.gn while the wave-s.ruc.ure interac.ions.of large body are als. ac.ounted for. Our s.udy finds.that the neglec. of s.g-extens.bility or the flexural rigidity of large, s.rong mooring c.ble may res.lt in a c.ns.rvative but not nec.s.arily s.fe des.gn.

关键词： tention leg platform (TLP) s.ngle mooring platform s.s.em flexural rigidity s.g extens.bility wave-s.ruc.ure interac.ions

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A dynamic.two-zone model of c.ntinuous.fluidized bed layering granulation with internal produc. c.as.ific.tion

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Partic.ology 2017年第2期15卷 8-14页

作者： c. Neugebauer s. Palis.A. Buc. E. Ts.ts.s.s. Heinric. A. Kienle Otto yon Gueric.e Univers.ty Universitatsplatz 2 D-39106 Magdeburg Germany Max Planc. Ins.itute for Dynamic. of c.mplex Tec.nic.l s.s.ems Sandtorstraβe 1 D-39106 Magdeburg Germany Hamburg Univers.ty of Tec.nology Denickestraβe 15 D-21073 Hamburg Germany

A dynamic.two-zone model is.propos.d to addres. the formation of granulation and drying zones.in fluidized bed layering granulation proc.s.es.with internal produc. c.as.ific.tion. The model as.umes.a c.ns.ant volume for the granulation zone, but a variable overall volume for the fluidized bed to ac.ount for c.as.ified produc. removal. The model is.us.d to s.udy the effec. of various.proc.s. parameters.on dynamic. and proc.s. s.ability. s.ability is.s.own to depend on the s.paration diameter of produc. removal and the flow rate of the injec.ed liquid. A lower and upper range of s.paration diameters.with s.able proc.s. behavior are found. In an intermediate range ins.ability in the form of s.lf-s.s.ained os.0}llations.is.obs.rved. The lower s.ability boundary is.in qualitative agreement with rec.nt experimental obs.rvations.（s.0}midt, Büc., ＆ Ts.ts.s. 2015）; the upper boundary was.reported in a theoretic.l paper by Vreman, Van Lare, and Houns.ow （2009） bas.d on a s.ngle zone model.

关键词： Layering granulation Zone formation Internal produc. c.as.ific.tion Population balanc. modeling s.ability analys.s

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