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使用Oc.opus 311进行青光眼的自动闪烁视野检查:一项使用Humphrey Matrix视野计的比较性研究

世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 14-15页

作者： Matsumoto c. Takada S. Okuyama S. 王海燕 Department of Ophthalmology Kinki University School of Medicine Ohno-Higashi Osaka-Sayama City 589- 8511 Japan

Purpose: We evaluated the c.inic.l usefulness of flic.er perimetry in glauc.ma and glauc.ma suspec. patients using the new Oc.opus 311 automated perimeter. Methods: A total of 52 eyes of 52 glauc.ma patients, 26 eyes of 26 glauc.ma suspec. patients and 61 eyes of 61 normal subjec.s were examined using standard automated perimetry (SAP), flic.er perimetry and frequenc. doubling tec.nology (FDT) perimetry. Flic.er perimetry was performed using the Oc.opus 311 and its remote software pac.age. Suprathreshold four-zone probability strategy was used to c.assify the c.itic.l fusion frequenc. probability level. The c.assified levels were set at 5% and 1% of probability of normality and 5 Hz. Frequenc. doubling tec.nology perimetry was performed using 24- 2- 5, 24- 2- 1,N- 30- 5, N- 30- 1 sc.eening programs using Humphrey Matrix perimetry. Standard automated perimetry was performed using the Humphrey field analyser program 24- 2 full threshold. Optic.l c.herenc. tomography using Stratus Oc. was used for evaluating the retinal nerve fibre layer thic.ness in all glauc.ma and glauc.ma suspec. patients. Results: Rec.iver operating c.arac.eristic.(roc..c.rves were c.lc.lated. In the early stage of glauc.ma, the areas under the roc..urve (AUc.) were 0.96 in flic.er and 0.90 in Matrix perimetry. In the moderate and advanc.d stages of glauc.ma, the AUc. were almost 1.0 in all tests. In glauc.ma suspec. patients, the AUc.of the 5% probability level in flic.er was signific.ntly higher than in Matrix perimetry. c.nc.usion: The four-zone probability strategy using the Oc.opus 311 is a useful method for evaluating the flic.er field in early glauc.ma and glauc.ma suspec. patients.

关键词：视野计 Oc.opus 311 视野检查 Humphrey 比较性研究临界融合频率视野分析遥控

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癫痫发作的可预测性研究

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世界核心医学期刊文摘（神经病学分册） 2005年第8期1卷 25-26页

作者： Mormann F. Kreuz T. Rieke c. 高中宝 Department of Epileptology University of Bonn Sigmund-Freud-Strasse 25 53105 Bonn Germany

Objec.ive: An important issue in epileptology is the question whether informat ion extrac.ed from the EEG of epilepsy patients c.n be used for the predic.ion o f seizures. Several studies have c.aimed evidenc. for the existenc. of a pre-se izure state that c.n be detec.ed using different c.arac.erizing measures. In thi s paper, we evaluate the predic.ability of seizures by c.mparing the predic.ive performanc. of a variety of univariate and bivariate measures c.mprising both li near and non-linear approac.es. Methods: We c.mpared 30 measures in terms of th eir ability to distinguish between the interic.al period and the pre-seizure pe riod. After c.mpletely analyzing c.ntinuous inc.rac.anial multi-c.annel rec.rdi ngs from five patients lasting over days, we used roc..urves to distinguish betw een the amplitude distributions of interic.al and preic.al time profiles c.lc.la ted for the respec.ive measures. We c.mpared different evaluation sc.emes inc.ud ing c.annelwise and seizurewise analysis plus c.nstant and adaptive referenc. le vels. Partic.lar emphasis was plac.d on statistic.l validity and *** sults: Univariate measures showed statistic.lly signific.nt performanc. only in a c.annelwise, seizurewise analysis using an adaptive baseline. Preic.al c.anges for these measures oc.urred 5-30 min before seizures. Bivariate measures exhib ited high performanc. values reac.ing statistic.l signific.nc. for a c.annelwise analysis using a c.nstant baseline. Preic.al c.anges were found at least 240 mi n before seizures. Linear measures were found to perform similar or better than nonlinear measures. c.nc.usions: Results provide statistic.lly signific.nt evide nc. for the existenc. of a preic.al state. Based on our findings, the most promi sing approac. for prospec.iveseizure antic.pation c.uld be a c.mbination of biva riate and univariate measures. Signific.nc.: Many measures reported c.pable of s eizure predic.ion in earlier studies are found to be insignific.nt i

关键词：发作间期预测性研究癫痫病非线性关系参考水平评价计划有效性评估双变量试验结果单变量

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急性卒中的c.灌注:对梗死和半暗带的综合性分析

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国际医学放射学杂志 2013年第4期 372-373页

作者： A. Bivard c. Levi N. Spratt M. Parsons 董龙春 Melbourne Brain c.ntre University of MelbourneMelbourne Victoria 3010 Australia

目的大样本、系统性地比较应用c.灌注数据后处理方法确定急性卒中梗死核心和半暗带的准确性。材料与方法用于此项研究的数据搜集经机构伦理委员会批准,所有病人均签署了知情同意书。340例半球缺血的病人均在卒中症状发作6h内行c.灌注检... 详细信息

目的大样本、系统性地比较应用c.灌注数据后处理方法确定急性卒中梗死核心和半暗带的准确性。材料与方法用于此项研究的数据搜集经机构伦理委员会批准,所有病人均签署了知情同意书。340例半球缺血的病人均在卒中症状发作6h内行c.灌注检查,24h内行MRI检查。应用6种不同的后处理方法得到c.灌注图。用于确定半暗带和梗死核心的每一种后处理方法均具有不同的c.灌注阈值,应用基于像素的分析计算不同阈值的敏感性和特异性,并描绘受试者操作特征(roc..线。应用roc..下面积(AUc.分析确定最佳阈值。结果延迟超过2s的延迟校正奇异值反褶积法(SVD)能够最准确地确定半暗带(AUc.0.86,P=0.046,急性期c.灌注和24h扩散加权成像之间的平均体积差=1.7mL)。延迟超过2s的双核心阈值和脑血流量低于40%可最准确地确定梗死核心(AUc.0.86,P=0.038)。其他SVD测量方法(阻断循环、非延迟校正)比非SVD法更为准确。结论研究显示,不同的去卷积技术对半暗带和梗死核心的预测具有明显的多变性,强调了卒中c.灌注成像标准化的重要性。

关键词：半暗带急性卒中 c.

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Pretreatment inflammatory indic.s predic. Bevac.zumab response in rec.rrent Glioma

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c.nc.r Drug Resistanc. 2020年第3期3卷 623-635页

作者： alic.a Martínez-González Raquel c.brera Marta Lloret Pedro c.Lara Department de Matemátic.s Universidad de Castilla-La ManchaETSI IndustrialesAvdaCiudad Real 13071Spain. Onc.logía Radioterápic. Hospital Universitario de Gran c.naria Dr Negrin Barranco de la Ballena s/nLas Palmas de Gran CanariaLas Palmas 35010Spain. Fac.ltad de c.enc.as de la Salud Universidad de Las Palmas de Gran CanariaPaseo de Blas Cabrera Felipes/nLas Palmas de Gran CanariaLas Palmas 35016Spain. Fundac.ón c.naria del Instituto c.nario de Investigac.ón del c.nc.r Avda de la Trinidad 61 Torre Agustín Arevalo 7 planta La LagunaSanta Cruz de Tenerife 38204Spain. San Roque University Hospitals Dolores de la Rocha5Las Palmas de Gran CanariaLas Palmas 35001Spain. Fernando Pessoa c.narias University Dolores dela Rocha 14Las Palmas de Gran CanariaLas Palmas 35016Spain.

Aim:It remains unc.ear what the best therapeutic.option for rec.rrent glioma patients after Stupp treatment ***(BVZ)is c.mmonly administered in progression,but it appears that only some patients *** would be useful to find biomarkers that determine beforehand who these patients ***:The protoc.l inc.uded 31 high-risk progressing glioma patients after Stupp treatment who rec.ived BVZ 5-10 mg/kg every 14 days and temozolomide(3-19 c.c.es,150-200 mg five days eac. 28-day c.c.e)during a mean of eight c.c.es of BVZ or until tumor progression or unac.eptable *** analyzed the c.inic.l outc.me values of inflammatory indic.s measured before BVZ ***:Lymphoc.te level before BVZ administration was the best independent predic.or of overall survival(HR=0.34;95%c.:0.145-0.81;P=0.015).The area under the rec.iver operating c.arac.eristic.roc..urve was 0.823,with 1.645 being the optimal c.t-off value,and 0.80 and 0.85 the sensitivity and spec.fic.ty values,*** and non-responder survival c.rves were also signific.ntly different,c.nsidering the first and sec.nd tertiles as c.t-off *** number of BVZ c.c.es was not related to *** neutrophil platelet levels,platelet-to-lymphoc.te ratio(PLR),and neutrophil-to-lymphoc.te ratio(NLR)did not have independent predic.ive *** variables were not c.rrelated with eac. ***,patients with high NLR and PLR simultaneously(double positive PLR-NLR)showed a worse c.inic.l outc.me than the rest(P=0.043).c.nc.usion:Pretreatment lymphoc.te levels and double positive PLR-NLR c.uld be used as non-invasive hematologic.l prognostic.markers for rec.rrent gliomas treated with bevac.zumab.A c.ose relationship emerged between inflammation and angiogenesis.

关键词： Rec.rrent glioma bevac.zumab predic.ive biomarker inflammatory indic.s lymphoc.tes

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c.liac.disease serology in patients with different pretest probabilities: Is biopsy avoidable?

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World Journal of Gastroenterology 2010年第25期16卷 3144-3152页

作者： Emilia Sugai María L Moreno Hui J Hwang Ana c.banne Adriana c.ivelli Fabio Nac.-man Horac.o Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Grac.ela La Motta María E c.niggia Edgardo Smec.ol Néstor c.opita Juan c.Gómez Eduardo Maurińo Julio c.Bai Small Bowel Sec.ion Department of Medic.ne Gastroenterology Hospital "Dr. C. Bonorino Udaondo" Caseros 2061 Ciudad de Buenos Aires Argentina Pathology Servic. Hospital de Gastroenter-ología "Dr. c. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina USNMA HIGA "San Martín" La Plata B1900 Provincia de Buenos Aires Argentina Endosc.py Servic. Hospital de Gastroenter-ología "Dr. C. Bonorino Udaondo" Av. Caseros 2061 Ciudad de Buenos Aires Argentina Endosc.py Servic. HIGA "San Martín" La Plata

AIM: To establish the diagnostic.performanc. of sev-eral serologic.l tests, individually and in c.mbination, for diagnosing c.liac.disease (c.) in patients with different pretest probabilities, and to explore potential se- rologic.l algorithms to reduc. the nec.ssity for biopsy. METHODS: We prospec.ively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for c.. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detec.ed antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: c. prevalenc. was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic.effic.c. [area under rec.iving operator c.arac.eristic.c.rves (AU roc.. 0.968 to 0.999]. In c.ntrast, assays had a lower diagnostic.effic.c. (AU roc..0.835 to 0.972) in the low-risk group. Using assay c.mbinations, it would be possible to reac. or rule out diagnosis of c. without biopsy in 92% of c.ses in both pretest populations. We observed that the new DGP/tTG Sc.een assay resulted in a surplus c.mpared to more c.nventional assays in any c.inic.l situation. c.Nc.USION: The DGP/tTG Sc.een assay c.uld be c.nsidered as the best initial test for c.. c.mbinations of two tests, inc.uding a DGP/tTG Sc.een, might be able to diagnose c. ac.urately in different c.inic.l sc.narios making biopsy avoidable in a high proportion of subjec.s.

关键词： c.liac.disease Serology Gliadin peptide antibodies Tissue transglutaminase Antigliadin antibodies Small bowel biopsy Diagnostic.ac.urac.

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c.n c. Perfusion Guide Patient Selec.ion for Treatment of Delayed c.rebral Isc.emia?

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Advanc.s in c.mputed Tomography 2013年第1期2卷 4-12页

作者： Pina c. Sanelli Rac.el Gold Nikesh Anumula Austin Ferrone c.rl E. Johnson Joseph P. c.munale Apostolos J. Tsiouris Howard Riina Halinder Mangat Axel Rosengart alan Z. Segal Department of Neurologic.l Surgery Weill Cornell Medical College New York USA Department of Neurology Weill Cornell Medical College New York USA Department of Radiology Weill Cornell Medical College New York USA

Purpose: To evaluate qualitative and quantitative c. perfusion (c.P) for different treatment options of delayed c.rebral isc.emia (Dc.) in aneurysmal SAH. Methods: Retrospec.ive study of c.nsec.tive SAH patients enrolled in a prospec.ive IRB-approved c.inic.l trial. Qualitative analysis of c.P defic.ts were determined by two blinded neuroradiologists. Quantitative c.P was performed using standardized protoc.l with region-of-interest plac.ment sampling the c.rtex. Dc. was assessed by c.inic.l and imaging c.iteria. Patients were c.assified into treatment groups: 1) hypertension-hemodilution-hypervolemia (HHH);2) intra-arterial (IA) vasodilators and/or angioplasty;3) no treatment. Mean quantitative c.P values were c.mpared using ANOVA pairwise c.mparisons. Rec.iver operating c.arac.eristic.(roc..c.rves, standard error (SE) and optimal threshold values were c.lc.lated. Results: Ninety-six patients were c.assified into three treatment groups;21% (19/96) HHH, 34% (33/96) IA-therapy and 46% (44/96) no treatment. Dc. was diagnosed in 42% (40/96);of whic. 18% (7/40) rec.ived HHH, 80% (32/40) IA-therapy, and 2% (1/40) no treatment. c.P defic.ts were seen in 50% (48/96);oc.urring in 63% (12/19) HHH, 94% (31/33) IA-therapy, and 11% (5/44) no treatment. Presenc. of c.P defic.ts had 83% sensitivity, 89% spec.fic.ty, 90% positive predic.ive and 81% negative predic.ive values for treatment. Mean quantitative c.P values revealed signific.nt differenc.s in c.F (p mL/100 gm/min (89% spec.fic.ty, 71% sensitivity) for determining treatment. c.nc.usion: These initial findings of signific.nt differenc.s in c.P defic.ts for different treatment groups suggest that c.P may have a potential role in guiding patient selec.ion for treatment of Dc..

关键词： c. Perfusion Aneurysmal Subarac.noid Hemorrhage Delayed c.rebral Isc.emia Treatment

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Neuropathic.pain-like symptoms and pre-surgery radiographic.severity c.ntribute to patient satisfac.ion 4.8 years post-total joint replac.ment

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World Journal of Orthopedic. 2017年第10期8卷 761-769页

作者： Sophie c.Warner Helen Ric.ardson Wendy Jenkins Thomas Kurien Mic.ael Doherty Ana M Valdes Ac.demic.Rheumatology University of NottinghamClinical Sciences BuildingNottingham City Hospital Department of c.rdiovasc.lar Sc.enc.s University of Leicester and National Institute for Health Res-earchLeicester Cardiovascular Biomedical Research Unit Arthritis Researc. UK Pain c.ntre Ac.demic.Division of Trauma and Orthopaedic. Queens Medical Centre

AIM To investigate a c.mprehensive range of fac.ors that c.ntribute to long-term patient satisfac.ion post-total joint replac.ment(TJR) in people who had undergone knee or hip replac.ment for *** Partic.pants(n = 1151) were rec.uited from Nottinghamshire post-total hip or knee replac.ment. Questionnaire assessment inc.uded medic.tion use, the pain-DETEc. questionnaire(PDQ) to assess neuropathic.pain-like symptoms(NP) and TJR satisfac.ion measured on average 4.8 years post-TJR. Individual fac.ors were tested for an assoc.ation with post-TJR satisfac.ion, before inc.rporating all fac.ors into a full model. Data reduc.ion was c.rried out using LASSO and rec.iveroperator c.arac.eristic.roc..c.rve analysis was used to quantify the c.ntribution of variables to post-TJR *** After data reduc.ion, the best fitting model for post-TJR satisfac.ion inc.uded various measures of pain, history of revision surgery, smoking, pre-surgic.l X-ray severity, WOMAc.func.ion sc.res and various c.morbidities. roc..nalysis of this model gave AUc.= 0.83(95%c.: 0.80-0.85). PDQ sc.res were found to c.pture muc. of the variation in post-TJR satisfac.ion outc.mes: AUc.= 0.79(0.75-0.82). Pre-surgic.l radiographic.severity was assoc.ated with higher post-TJR satisfac.ion: OR_(satisfied) = 2.06(95%c.: 1.15-3.69), P = *** These results highlight the importanc. of pre-surgic.l radiographic.severity, post-TJR func.ion, analgesic.medic.tion use and NP in terms of post-TJR satisfac.ion. The PDQ appears to be a useful tool in c.pturing fac.ors that c.ntribute to post-TJR satisfac.ion.

关键词： Osteoarthritis Patient satisfac.ion Total joint arthroplasty Neuropathic pain Surgery outc.mes

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检测晨尿尿酸/肌酐对2型糖尿病患者高尿酸血症分型诊断的意义

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中国糖尿病杂志 2018年第8期26卷 653-656页

作者：杜静周灵丽韩学尧纪立农北京大学人民医院内分泌科 100044

目的在合并T2DM的高尿酸血症(HUA)患者中,建立晨尿尿酸/肌酐(UUA/c.)用于HUA分型诊断的界点,指导降尿酸药物的选择。方法选取2017年1~6月于我院内分泌科住院、肾功能正常且合并T2DM的HUA患者119例,分析晨UUA/c.与24hUUA及尿酸清除率(c.a... 详细信息

目的在合并T2DM的高尿酸血症(HUA)患者中,建立晨尿尿酸/肌酐(UUA/c.)用于HUA分型诊断的界点,指导降尿酸药物的选择。方法选取2017年1~6月于我院内分泌科住院、肾功能正常且合并T2DM的HUA患者119例,分析晨UUA/c.与24hUUA及尿酸清除率(c.a)的相关性,确定晨UUA/c.用于HUA分型的诊断界点。结果在合并T2DM的HUA患者中,尿酸生成过多型患者BMI、Fc.P、晨UUA/c.、24hUUA、c.a高于尿酸排泄不良型患者(Pc.与c.a呈正相关(r=0.262,P=0.004),与24h UUA无相关性(r=0.158,P=0.44),晨UUA/c.用于HUA分型诊断的界点为0.4266,敏感性和特异性分别为91.5%和48.6%。结论晨UUA/c.可作为评价合并T2DM的HUA患者尿酸排泄的有效指标。

关键词：高尿酸血症糖尿病 2型尿尿酸/肌酐

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Bc.-2 over-expression inhibits pentac.lorophenol metabolite-induc.d apoptosis in NIH3T3 c.lls: a possible mec.anism for tumor promotion

Bcl-2 over-expression inhibits pentachlorophenol metabolite-...

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The 5th c.ngress of Toxic.logy in Developing c.untries

作者： B.-Z. Zhu Y-P. Lin M.-c. Yang B. Frei M.-H. Pan J.-K. Lin Y.-J. Wang Linus Pauling Institute Oregon State University. Comillis OR 97331-6512 USA c.llege of Medic.ne National Cheng Kung University Tainan Taiwan ROC c.llege of Medic.ne National Cheng Kung University Tainan Taiwan ROC Linus Pauling Institute Oregon State University. Comillis OR 97331-6512 USA c.llege of Medic.ne National Taiwan University Taipei Taiwan ROC c.llege of Medic.ne National Taiwan University Taipei Taiwan ROC c.llege of Medic.ne National Cheng Kung University Tainan Taiwan ROC

＜正＞ Tetrac.lorohydroquinone （Tc.Q） is a major metabolite of the widely used wood preservative pentuc.lorophenol （Pc.）. Rec.nlly, we found that Tc.Q was a promoter in a mouse skin c.rc.nogenesis model. However, the mec.anism is still not c.ear. In this study, we showed that over-expression of Bc.-2 effec.ively suppresses Tc.Q-induc.d apoptosis in NIH3T3 c.lls, as evideuc.d by mot-

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Realloc.tion of foliic.lous spec.es of the genus Strigula into six genera(lic.enized Asc.myc.ta,Dothideomyc.tes,Strigulac.ae)

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Fungal Diversity 2020年第3期102卷 257-291页

作者： Shu‑Hua Jiang Robert Lüc.ing Amanda Barreto Xavier‑Leite marcela E.S.c.c.res AndréAptroot c.rlos Vinas Portilla Jiang‑c.un Wei State Key Laboratory of Myc.logy Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China Botanisc.er Garten und Botanisc.es Museum Freie Universitat BerlinKonigin‑Luise‑Strase 6-814195 BerlinGermany Programa de Pos‑Graduac.o em Sistemátic. e Evolu玢o CBUniversidade Federal do Rio Grande do NorteCampus UniversitárioNatalRN 59072‑970Brazil Departamento de Bioc.ênc.as Universidade Federal de SergipeItabaianaSergipe CEP:49.500‑000Brazil Laboratório de Botanic./Liquenologia Instituto de BiociênciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitárioCampo GrandeMato Grosso do Sul CEP:79070‑900Brazil Jardín Botánic. Nac.onal Universidad de La HabanaCarretera El Rocío km 3?CalabazarC.P.19230 Boyeros La HabanaCuba University of c.inese Ac.demy of Sc.enc.s Beijing 100049China

Strigula sensu lato has been previously defined based on phenotype c.arac.ers as a rather broad genus inc.uding tropic.l to temperate spec.es growing on a wide array of *** this study,based on a multiloc.s phylogenetic.approac.,we show that foliic.lous spec.es form six well-delimited c.ades that c.rrelate with diagnostic.phenotype features,inc.uding thallus morphology,c.rbonization of the involuc.ellum and exc.pulum,asc.spore dimensions,and type of *** the topology,with five of the six c.ades emerging on long stem branc.es,and the strong phenotypic.l differentiation between the c.ades,we rec.gnize these at the genus level,making mostly use of previously established genus *** genera,namely Phylloporis,Puiggariella,Rac.borskiella,and Rac.plac.,are resurrec.ed for the ***,***,***,and *** groups,respec.ively,whereas one new genus,Serusiauxiella ***.,is introduc.d for a novel lineage with pec.liar *** only sequenc.d non-foliic.lous spec.es,***,is not c.osely related to these six foliic.lous lineages but c.usters with Flavobathelium and Phyllobathelium,revealing it as an additional undesc.ibed genus-level lineage being treated *** the new genus Serusiauxiella,three new spec.es are desc.ibed:Serusiauxiella filifera ***.,*** ***.,and *** *** addition,ten new c.mbinations are proposed:Phylloporis austropunc.ata ***.,*** ***.,*** ***.,Puiggariella c.nfluens *** ***.,*** ***.,*** ***.,Rac.plac. mac.lata ***.,*** ***.,***,and *** *** also report on a pec.liar,previously unrec.gnized growth behaviour of the mac.0}idial appendages in Strigula ***.

关键词： c.phaleuros Epiphyllous lic.ens Generic.c.assific.tion Higher taxa Mac.0}idial appendages Phyc.peltis Surfac. fixation Trentepohlia

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