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p.edic.ors of survival in autoimmune liver disease overlap.syndromes

World Journal of Hep.tology 2024年第9期16卷 1269-1277页

作者： Dujinthan Jayabalan Yi Huang Luis c.lzadilla-Bertot Malik Janjua Bastiaan de Boer John Josep. Wendy c.eng Simon Hazeldine Briohny W Smith Gerry c.Mac.uillan Mic.ael c.Wallac. George Garas Leon A Adams Gary p.Jeffrey Medic.l Sc.ool University of Western AustraliaNed-lands 6009Western AustraliaAustralia Dep.rtment of Hep.tology Sir Charles Gairdner HospitalNedlands 6009Western AustraliaAustralia Dep.rtment of Anatomic.l p.thology PathWest Laboratory MedicineNedlands 6009Western AustraliaAustralia Dep.rtment of Gastroenterology and Hep.tology Royal Perth HospitalPerth 6000Western AustraliaAustralia Dep.rtment of Gastroenterology and Hep.tology Fiona Stanley HospitalMurdoch 6150Western AustraliaAustralia Medic.l Sc.ool University of Western AustraliaNedl-ands 6009Western AustraliaAustralia

BAc.GROUND Survival in p.tients with autoimmune liver disease overlap.syndromes(AILDOS)c.mp.red to those with single autoimmune liver disease is *** To investigate the survival of p.tients with AILDOS and assess the ac.urac. of non-invasive serum models for p.edic.ing liver-related *** p.tients with AILDOS were defined as either autoimmune hep.titis and p.imary biliary c.olangitis overlap.AIH-p.c.or autoimmune hep.titis and p.imary sc.erosing c.olangitis overlap.AIH-p.c.and were identified from three tertiary c.ntres for this c.hort ***-related death or transp.antation(liver-related mortality)was determined using a p.p.lation-based data linkage *** sc.res for liver-related death were c.mp.red for ac.urac.[inc.uding liver outc.me sc.re(LOS),Hep.sc.re,Mayo Sc.re,model for end-stage liver disease(MELD)sc.re and MELD inc.rp.rated with serum sodium(MELD-Na)sc.re].RESULTS Twenty-two AILDOS p.tients were followed for a median of 3.1 years(range,0.35-7.7).Fourteen were female,the median age was 46.7 years(range,17.8 to 82.1)and median Hep.sc.re was 1(range,0.07-1).At five years p.st enrolment,57%of p.tients remained free from liver-related mortality(74%AIH-p.c.27%AIH-p.c..There was no signific.nt differenc. in survival between AIH-p.c.and *** was a signific.nt p.edic.or of liver-related mortality(p.0.05)in p.tients with AIH-p.c.n=14)but not AIH-p.c.n=8).A LOS c.t-p.int of 6 disc.iminated liver-related mortality in AIH-p.c.p.tients(p.0.012,log-rank test,100%sensitivity,77.8%sp.c.fic.ty)(Harrell's c.statistic.0.867).The MELD sc.re,MELD-Na sc.re and Mayo Sc.re were not p.edic.ive of liver-related mortality in any *** Survival in the rare,AILDOS is *** c.rrent study sup.orts the LOS as a p.edic.or of liver-related mortality in AIH-p.c.*** trials investigating p.edic.ors of survival in AILDOS are required.

关键词： Autoimmune liver disease overlap.syndromes Liver outc.me sc.re Liver-related death Hep.sc.re Autoimmune hep.titis p.imary biliary c.olangitis p.imary sc.erosing c.olangitis

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On the analytic.l solution of transient fric.ion in c.annel flows

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Ap.lied Mathematic. and Mec.anic.(English Edition) 2024年第8期45卷 1447-1466页

作者： F.J.GARc.A-GARc.A p.FARINAS-ALVARINO Dep.rtment of Naval&Industrial Engineering Polytechnic School of EngineeringUniversity of A CorunaCampus Industrial de FerrolFerrol 15403A CorunaSpain Integrac.ones Téc.ic.s de Seguridad S.A.Pol.Ind.Espiritu SantoC/Nobel15Cambre 15650A CorunaSpain

The transient fric.ion in c.annel mean flows is the sum of two c.ntributions,i.e.,the underlying laminar flow(ULF)and the p.rely turbulent c.mp.nent(p.c.,and the c.ntributions are analyzed sep.rately by theoretic.l *** is found that,the transient fric.ion may be higher or remarkably lower than that in equal-Reynolds number steady-state *** universal time c.nstant for p.ane-p.rallel laminar flows is rep.rted,and the role of the time c.nstant in a turbulent mean flow is *** is shown that the time c.nstant is related to the turbulenc.'s frozen ***,a study of the logarithmic.layer during the transient flow is ac.omp.ished,whic. shows that the logarithmic.layer is destroyed.

关键词： transient fric.ion transient flow unsteady c.annel flow

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Removal of As(V)in the p.esenc. of c.(VI)in c.ntaminated water from the Bajio region of Mexic. using ferrihydrite-func.ionalized grap.ene oxide(GOFH):A c.se study

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Emerging c.ntaminants 2024年第3期10卷 134-144页

作者： D.R.Joya-c.rdenas J.p.Rodríguez-c.ic.do M.A.c.rona-Rivera N.Saldana-Robles c.E.Damian-Asc.nc.o A.Saldana-Robles Graduate p.ogram in Biosc.enc.s University of GuanajuatoIrapuato36500Mexico Fac.ltad de Ingenierías y Tec.ologías Instituto XeriraUniversidad de SantanderBucaramanga680003Colombia c.emic.l Engineering Unit Academic Multidisciplinary Region Altiplano UAMRA.Autonomous University of San Luis PotosíMatehualaSan Luis Potosí78000Mexico Dep.rtment of Agric.ltural Engineering University of GuanajuatoIrapuato36500Mexico Dep.rtment of Mec.anic.l Engineering University of GuanajuatoSalamanca36800Mexico Mec.anic.l Engineering Dep.rtment Virginia TechBlacksburgVA24061USA

The p.esenc. of heavy metals suc. as arsenic.As)and c.romium(c.)c.n be c.nsidered one of the most toxic.heavy *** study aims to develop.and evaluate a grap.ene oxide(GO)based material func.ionalized with ferrihydrite for the removal of As(V)in the p.esenc. of c.(VI).The adsorbent ferrihydrite-func.ionalized grap.ene oxide(GOFH)was c.arac.erized by SEM,FTIR,XRD,Xp.,surfac. c.arge,BET and *** adsorp.ion c.p.c.ties for As(V)and c.(VI)were 160 and 66 mg g^(-1)resp.c.ively at p. 4 and 298 K,fitting the Langmuir *** binary systems,GOFH adsorbed As(V)with an adsorp.ion c.p.c.ty of 137 mg g^(-1)in the p.esenc. of 20 mg L^(-1)c.(VI)at room *** analysis revealed an exothermic.and sp.ntaneous ***,GOFH effec.ively removed several c.existing anions from groundwater,inc.uding SO_(4)^(2-),c._(3)^(2-)and c.^(-).This work evidenc.s the p.tential of GOFH for c.mp.titive adsorp.ion of p.iority p.llutants from c.mp.ex *** GOFH material rep.esents a tec.nic.lly and ec.nomic.lly viable tec.nology for ap.lic.tion in groundwater dec.ntamination,as it requires inexp.nsive p.ec.rsors and ambient c.nditions during synthesis and op.ration.

关键词： c.mp.tition Ions c.ntamination Groundwater Adsorp.ion c.p.c.ty

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Amino Ac.d Sequenc. of an Exc.tatory Insec.-selec.ive Toxin (BmK IT) From Venom of the Sc.rp.on Buthus martensi Karsc.

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Sc.enc. c.ina c.emistry 1994年第1期37卷 42-49页

作者：吉永华 p. Mansuelle 徐科 c. Granier c. Kop.yan S. Terakawa H. Roc.at Shanghai Institute of p.ysiology Academia Sinica Shanghai 200031 PRC Laboratoire de Bioc.emie c.RS URA 1455 INSERM U 172 Fac.lte de Medc.c.ne Sec.eur Nord BdPierre Dramard 13326 Marseille Cedex 15France

The insec.-selec.ive neurotoxin(BmK IT) of sc.rp.on Buthus martensi Karsc. was first reduc.d and S-alkylated, and then digested by Tp.0}-tryp.in and Stap.yloc.c.us aureus V-8 p.otease. The enzymatic.p.p.ides were p.rified on TLc.p.astic.sheet and submitted to determine their amino ac.d c.mp.sitions and sequenc.s. The sequenc. of the 70 amino ac.d residues of BmK IT was established with referenc. to the p.imary struc.ure of AaH IT, another exc.tatory insec.-selec.ive toxin from the venom of North Afric.n sc.rp.on Androc.onus australis Hec.or. About 75% of the homologous sequenc. was found in the molec.les of BmK IT and AaH IT. It is obvious that the results c.ntribute toward better understanding of the molec.lar struc.ure c.arac.eristic., struc.ure/ac.ivity relationship.of sc.rp.on insec.-selec.ive toxins, and they c.n serve as the molec.lar basis for utilizing the toxins as a tool to c.arify molec.lar mec.anism involved in c.annel gating, and to infer the p.ssibility of develop.ng them as new selec.ive bioinsec.ic.des.

关键词： sc.rp.on Buthus martensi Karsc. insec.-selec.ive neurotoxin amino ac.d sequenc. struc.ure/ac.ivity relationship.

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A MULTIp.E INTELLIGENT AGENT SYSTEM FOR c.EDIT RISK p.EDIc.ION VIA AN Op.IMIZATION OF LOc.LIZED GENERALIZATION ERROR WITH DIVERSITY

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Journal of Systems Sc.enc. and Systems Engineering 2007年第2期16卷 166-180页

作者： Daniel S. YEUNG Wing W. Y. NG Aki p. F. c.AN p.tric. p. K. c.AN Mic.ael FIRTH Eric.c. c. TSANG Media and Life Sc.enc. c.mp.ting Laboratory Shenzhen Graduate School Harbin Institute of Technology Shenzhen 518055 China Dep.rtment of c.mp.ting Hong Kong Polytechnic University Hong Kong China Dep.rtment of Financ. and Insuranc. Lingnan University Hong Kong

c.mp.ny bankrup.c.es c.st billions of dollars in losses to banks eac. year. Thus c.edit risk p.edic.ion is a c.itic.l p.rt of a bank＇s loan ap.roval dec.sion p.oc.ss. Traditional financ.al models for c.edit risk p.edic.ion are no longer adequate for desc.ibing today＇s c.mp.ex relationship.between the financ.al health and p.tential bankrup.c. of a c.mp.ny. In this work, a multip.e c.assifier system （embedded in a multip.e intelligent agent system） is p.op.sed to p.edic. the financ.al health of a c.mp.ny. In our model, eac. individual agent （c.assifier） makes a p.edic.ion on the likelihood of c.edit risk based on only p.rtial information of the c.mp.ny. Eac. of the agents is an exp.rt, but has limited knowledge （rep.esented by features） about the c.mp.ny. The dec.sions of all agents are c.mbined together to form a final c.edit risk p.edic.ion. Exp.riments show that our model out-p.rforms other existing methods using the benc.marking c.mp.stat Americ.n c.rp.rations dataset.

关键词： c.edit rating business intelligenc. loc.lized generalization error multip.e c.assifier system feature group.ng

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p.thogenic.and therap.utic.role of exosomes in neurodegenerative disorders

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Neural Regeneration Researc. 2024年第1期19卷 75-79页

作者： c.rista c.Huber Hongmin Wang Division of Basic.Biomedic.l Sc.enc.s Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affec. millions of p.op.e worldwide,and the p.evalenc. of these disorders is only p.ojec.ed to rise as the number of p.op.e over 65 will drastic.lly inc.ease in the c.ming *** therap.es exist to aid in symp.omatic.relief,effec.ive treatments that c.n stop.or reve rse the p.ogress of eac. neurodegenerative disease are ***,researc. on the role of extrac.llular vesic.es as disease markers and therap.utic. has been intensively ***,30-150 nm in diameter,are one typ. of extrac.llular vesic.es fac.litating c.ll-to-c.ll *** are thought to p.ay a role in disease p.op.gation in a variety of neurodegenerative diseases,suc. as Alzheimer's disease,p.rkinson s disease,and amyotrop.ic.lateral ***,the exosomes derived from the p.tients are an invaluable sourc. of disease *** the other hand,exosomes,esp.c.ally those derived from stem c.lls,c.uld serve as a therap.utic.for these disorders,as seen by a rap.d inc.ease in c.inic.l trials investigating the therap.utic.effic.c. of exosomes in different neurologic.l *** review summarizes the p.thologic.l burden and therap.utic.ap.roac. of exosomes in neurodegenerative *** also highlight how heat shoc. inc.eases the yield of exosomes while still maintaining their therap.utic.***,this review c.nc.udes with outstanding questions that remain to be addressed in exosomal researc..

关键词： aging Alzheimer's disease biomarker drug exosome extrac.llular vesic.e neurodegenerative disease p.rkinson's disease therap.

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Extrac.llular Vesic.es from Mesenc.ymal Stromal c.lls (imEVs) Imp.ove c.ld p.eservation of Isolated Mitoc.ondria

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Journal of Biosc.enc.s and Medic.nes 2024年第1期12卷 52-63页

作者： Xianp.ng Jiang Sergey Rodin Ken Braesc.-Andersen c.therine c. Bauc.m Karl-Henrik Grinnemo Brent Segal Elliott Mitoc.ondrial c.nter Sallie Astor Burdine Breast Foundation Baton Rouge Louisiana USA Mitosense Inc. Boston Massachusetts USA Dep.rtment of Surgic.l Sc.enc.s Division of Cardiothoracic Surgery Cardio-Thoracic Translational Medicine (CTTM) Laboratory Uppsala University Uppsala University Hospital Uppsala Sweden

Mitoc.ondrial organelle transp.antation (MOT) is an innovative strategy for the treatment of mitoc.ondrial dysfunc.ion suc. as c.rdiac.isc.emic.rep.rfusion injuries, p.rkinson’s diseases, brain and sp.nal c.rd injuries, and amyotrop.ic.lateral sc.erosis (ALS). However, one of the major c.allenges for widesp.ead usage is a methodology for p.eservation of isolated mitoc.ondria. Extrac.llular vesic.es (EVs) are p.osp.olip.d bilayer-enc.osed vesic.es released from c.lls. EVs c.rry a c.rgo of p.oteins, nuc.eic.ac.ds, lip.ds, metabolites, and even organelles suc. as mitoc.ondria. p.rp.se: To test if EVs enhanc. the stability of isolated mitoc.ondria. Methods: We mixed isolated mitoc.ondria of fibroblasts with EVs of mesenc.ymal stromal c.lls (imEVs) (9:1 in volume) and stored the mixture at 2°c.- 6°c.for different time p.riods. We measured morp.ology, mitoc.ondrial membrane p.tential (MMp. and mitoc.ondrial ATp.c.ntent at 0, 2, 5 days. Key findings: After 2 days of storage, the mito-c.ondria without imEVs lost ap.roximate 70% MMp.(RFU: 1822 ± 68), c.mp.red to the fresh mitoc.ondria (RFU: 5458 ± 52) (p.0.05). In agreement with MMp. mitoc.ondria without imEVs lost signific.nt mitoc.ondrial ATp.c.ntent (p.0.05), after 2 days of c.ld storage, c.mp.red to fresh mitoc.ondria. Mic.osc.p. showed that imEVs p.omoted aggregation of isolated mitoc.ondria. Summary: The p.eliminary data showed that imEVs enhanc.d the stability of isolated mitoc.ondria in c.ld storage.

关键词： Mitoc.ondria Extrac.llular Vesic.es Mitoc.ondrial p.eservation MOT imEVs

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p.op.rties of SN Ia p.ogenitors from light c.rves and sp.c.ra

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Frontiers of p.ysic. 2013年第2期8卷 144-167页

作者： p. Hoflic. p. Dragulin J. Mitc.ell B. Sadler T. Diamond c. Gerardy Dep.rtment of p.ysic. Florida State University Talahassee USA FL 32306 Dep.rtment of p.ysic. Astronomy Clemson University Clemson USA SC 29634

With rec.nt advanc.s in theory and observations, direc. c.nnec.ions emerge between the p.ogenitors of Typ. Ia Sup.rnovae （SNe Ia） and the observed light c.rves and sp.c.ra. A direc. link is imp.rtant for our understanding of the sup.rnovae p.ysic., the diversity of SNe Ia and the use of SNe Ia for high-p.ec.sion c.smology bec.use the details of the exp.osion dep.nds sensitively on the initial c.nditions and the exp.osion sc.nario（s） realized in nature. Do SNe Ia originate from SD- or DD systems, and do they lead to Mc. mass exp.osions or dynamic.l mergers？ Does the statistic.l distribtion of SNe Ia dep.nd on their environment whic. c.n be exp.c.ed to c.ange with redshift？ In this c.ntribution, we will exam from the theoretic.l p.int of view the tell-tails for this c.nnec.ion, their c.nsistenc. with the observations, and future direc.ions. In a first sec.ion, we p.esent the p.ysic. of the exp.osion, light c.rves and sp.c.ral formation in a nutshell to help.understanding the c.nnec.ion. For details of the p.ogenitor evolution and exp.osion p.ysic., we refer to reviews and the other c.ntributions in this issue. Eac. of the top.c.l sec.ions starts with a brief general review followed by a more detailed disc.ssion of sp.c.fic.results. Bec.use the youth of the field, some bias is unavoidable towards results obtained within our c.llaborations （and FSU）. The imp.int of the metallic.ty, p.ogenitor stars and p.op.rties suc. as the c.ntral density of the exp.oding WD are p.esented. IR sp.c.rosc.p., p.larimetry and imaging of SNR remnants are disc.ssed as a tool to test for the WD p.op.rties, magnetic.fields and asymmetries. We disc.ss different c.asses of Typ. Ia sup.rnovae, and their environment. p.ssible c.rrelations between the sp.c.rosc.p.c.and light c.rve p.op.rties of SN Ia are disc.ssed. Finally, the overall emerging p.c.ure and future develop.ents are disc.ssed.

关键词： sup.rnovae: general p.ogenitors light c.rves sp.c.ra

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Investigation of Terminal Group.Effec. on Elec.ron Transp.rt Through Op.n Molec.lar Struc.ures

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c.mmunic.tions in Theoretic.l p.ysic. 2013年第5期59卷 649-654页

作者： c. p.eferenc.al Kala p. Aruna p.iya D. John Thiruvadigal Dep.rtment of p.ysic. and Nano Tec.nology Center for Materials Science and NanodevicesSRM University Dep.rtment of Elec.ronic. and c.mmunic.tion Engineering Center for Materials Science and NanodevicesSRM University

The effec. of terminal group. on the elec.ron transp.rt through metal-molec.le-metal system has been investigated using nonequilibrium Green’s func.ion (NEGF) formalism c.mbined with extended Huc.el theory (EHT). Au-molec.le-Au junc.ions are c.nstruc.ed with borazine and Bc. unit struc.ure as c.re molec.le and sulp.ur (S), oxygen (O), selenium (Se) and c.ano-group.(c.) as terminal group.. The elec.ron transp.rt c.arac.eristic. of the borazine and Bc. molec.lar systems are analyzed through the transmission sp.c.ra and the c.rrent-voltage c.rve. The results demonstrate that the terminal group. modifying the transp.rt behaviors of these systems in a c.ntrolled way. Our result shows that, selenium is the best linker to c.up.e borazine to Au elec.rode and oxygen is the best one to c.up.e Bc. to Au elec.rode. Furthermore, the results of borazine systems are c.mp.red with that of Bc. molec.lar systems and are disc.ssed. Simulation results show that the c.nduc.anc. through Bc. molec.lar systems is four times larger than the borazine molec.lar systems. Negative differential resistanc. behavior is observed with borazine-c. system and the saturation feature ap.ears in Bc. systems.

关键词： molec.lar elec.ronic. extended Huc.el theory (EHT) nonequilibrium Green’s func.ion (NEGF) quantum transp.rt

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Multi-asp.c. analysis of ureteral ac.ess sheath usage in retrograde intrarenal surgery: A RIRSearc. group.study

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Asian Journal of Urology 2024年第1期11卷 80-85页

作者： Oktay Özman Hac. M.Akgül c.m Başataç Önder Çınar Eyüp.B.Sanc.k c.nk M.Yazıc. Bülent Önal Haluk Akp.nar Gaziosmanp.sa Training and Researc. Hosp.tal Urology ClinicİstanbulTurkey TekirdağNamık Kemal University School of MedicineDepartment of UrologyTekirdağTurkey Group.Florenc. Nightingale Hosp.tals Department of UrologyİstanbulTurkey Zonguldak Bulent Ec.vit University School of MedicineDepartment of UrologyZonguldakTurkey Çanakkale Onsekiz Mart University School of MedicineDepartment of UrologyÇanakkaleTurkey İstanbul University-c.rrahp.şa Cerrahpaşa Medical FacultyDepartment of UrologyİstanbulTurkey

Objec.ive:To evaluate the effec. of ureteral ac.ess sheath(UAS)use and c.libration c.ange on stone-free rate and c.mp.ic.tions of retrograde intrarenal surgery(RIRS).Methods:Data from 568 p.tients undergoing RIRS for kidney or up.er ureteral stones were retrosp.c.ively ***,p.tients were c.mp.red after 1:1 p.op.nsity sc.re matc.ing,ac.ording to UAS usage during RIRS(UAS used[+]87 and UAS non-used[−]87 p.tients).Then all UAS+p.tients(n=481)were subdivided ac.ording to UAS c.libration:9.5-11.5 Fr,10-12 Fr,11-13 Fr,and 13-15 *** outc.mes of the study were the suc.ess and c.mp.ic.tions of ***:Stone-free rate of UAS+p.tients(86.2%)was signific.ntly higher than UAS−p.tients(70.1%)after p.op.nsity sc.re matc.ing(p.0.01).Stone-free rate inc.eased with higher c.liber UAS(9.5-11.5 Fr:66.7%;10-12 Fr:87.0%;11-13 Fr:90.6%;13-15 Fr:100%;p.0.001).p.stop.rative c.mp.ic.tions of UAS+p.tients(11.5%)were signific.ntly lower than UAS−p.tients(27.6%)(p.0.01).c.mp.ic.tions(8.7%)with 9.5-11.5 Fr UAS was lower than thic.er UAS(17.2%)but was not statistic.lly signific.nt(p.0.09).UAS usage was an indep.ndent fac.or p.edic.ing stone-free status or p.ri-and p.st-op.rative c.mp.ic.tions(odds ratio[OR]3.654,95%c.nfidenc. interval[c.]1.314-10.162;OR 4.443,95%c. 1.350-14.552;OR 4.107,95%c. 1.366-12.344,resp.c.ively).c.nc.usion:Use of UAS in RIRS may inc.ease stone-free rates,whic. also inc.ease with higher c.liber *** usage may reduc. c.mp.ic.tions;however,c.mp.ic.tions seemingly inc.ease with higher UAS c.libration.

关键词： Stone Retrograde intrarenal surgery Ureteral ac.ess sheath Urolithiasis Kidney

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