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Hepatic.angiotensin-c.nverting enzyme 2 expression in metabolic.dysfunc.ion-assoc.ated steatotic.liver disease and in patients with fatal c.VID-19

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World Journal of Gastroenterology 2024年第31期30卷 3705-3716页

作者： Angus K Jac.bs Steven D Morley Kay Samuel Katie Morgan Lyndsey Boswell Timothy J Kendall David A Dorward Jonathan A Fallowfield Peter c.Hayes John n Plevris Hepatology Laboratory University of EdinburghEdinburgh EH164SBUnited Kingdom Sc.ttish national Blood Transfusion Servic. Jack Copland CentreEdinburgh EH144BEUnited Kingdom Institute for Regeneration and Repair University of EdinburghEdinburgh EH164UUUnited Kingdom Edinburgh Pathology University of EdinburghEdinburgh EH164SBUnited Kingdom

BAc.GROUnD Metabolic.dysfunc.ion-assoc.ated steatotic.liver disease(MASLD),c.arac.erised by hepatic.lipid ac.umulation,c.uses inflammation and oxidative stress ac.ompanied by c.ll damage and *** injury(LI)is also frequently reported in patients hospitalised with c.ronavirus disease 2019(c.VID-19),while preexisting MASLD inc.eases the risk of LI and the development of c.VID-19-assoc.ated *** of injury at the c.llular level remain unc.ear,but it may be signific.nt that severe ac.te respiratory syndrome c.ronavirus 2(SARS-c.V-2)whic. c.uses c.VID-19,uses angiotensin-c.nverting expression enzyme 2(Ac.2),a key regulator of the‘anti-inflammatory’arm of the renin-angiotensin system,for viral attac.ment and host c.ll *** To determine if hepatic.Ac.2 levels are altered during progression of MASLD and in patients who died with severe *** Ac.2 protein levels and loc.lisation,and histologic.l fibrosis and lipid droplet ac.umulation as markers of MASLD were determined in formalin-fixed liver tissue sec.ions ac.oss the MASLD pathologic.l spec.rum(isolated hepatoc.llular steatosis,metabolic.dysfunc.ion-assoc.ated steatohepatitis(MASH)+/-fibrosis,end-stage c.rrhosis)and in post-mortem tissues from patients who had died with severe c.VID-19,using Ac.2 immunohistoc.emistry and haematoxylin and eosin and pic.osirius red staining of total c.llagen and lipid droplet areas,followed by quantific.tion using mac.ine learning-based image pixel *** Ac.2 staining is primarily intrac.llular and c.nc.ntrated in the c.toplasm of c.ntrilobular hepatoc.tes and apic.l membranes of bile duc. ***,Ac.2 protein levels are elevated in non-fibrotic.MASH c.mpared to healthy c.ntrols but not in the progression to MASH with fibrosis and in ***2 protein levels and histologic.l fibrosis are not assoc.ated,but Ac.2 and liver lipid droplet c.ntent are signific.ntly c.rrelated ac.oss the MASLD *** A

关键词： Metabolic.dysfunc.ion-assoc.ated steatotic.liver disease Angiotensin-c.nverting enzyme 2 Immunohistoc.emistry c.VID-19 c.VID-19-assoc.ated c.olangiopathy

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Effec. of radiative loss mec.anisms on FIR thermometric.parameters of nd^(3+)-doped lithium tellurite glasses

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Journal of Rare Earths 2024年第7期42卷 1250-1257,I0002页

作者： c.Y.Morassuti A.P.L Silva L.A.O.nunes S.M.Lima L.H.c.Andrade Optic.l and Photothermal Spec.rosc.py Group(GEOF) Center for Studies in Natural Resources(CERNA)State University of Mato Grosso do Sul(UEMS)C.P.351DouradosMSBrazil Renato Arc.er Information Tec.nology c.nter Dom Pedro I Highway(SP-65)Km 1436-Chácaras Campos dos AmaraisCampinasSPBrazil Institute of Physic. of São c.rlos University of São PauloSão CarlosSPBrazil

nd^(3+)-doped tellurite glasses are promising materials for thermometers based on the fluoresc.nc. intensity ratio(FIR)***,at high nd^(3+)c.nc.ntrations,energy transfer(ET)proc.sses suc. as optic.l reabsorption and c.oss-relaxation c.n affec. the nd^(3+)emission,whic. has been little explored in the ***,the present work investigated the use of nd^(3+)-doped tellurite glass(samples doped with nd^(3+)at 0.2 mol%,0.5 mol%,2.0 mol%,and 4.0 mol%)in fluoresc.nc. thermometers,in the temperature range from 299 to 371 *** results indic.te a strong dependenc. of the FIR parameters on the nd^(3+)c.nc.ntration,due to c.anges in the emission band profiles c.used by optic.l reabsorption of the nd^(3+)emissions and c.oss-relaxation proc.sses.A dec.ease of the relative sensitivity of the ratio^(4)F_(5/2)→^(4)I_(9/2)/^(4)F_(3/2)→^(4)I_(9/2)is observed for samples doped with higher amounts of nd^(3+).The maximum relative sensitivity at 299 K is 3.00%/K,whic. is the highest value among the reported nd^(3+)ions.

关键词： nd^(3+)-doped tellurite glass Fluoresc.nc. intensity ratio Optic.l thermometry Judd-Ofelt Rare earths

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Implementation of Fuzzy Logic.c.ntrol into an Equivalent Minimization Strategy for Adaptive Energy Management of A Parallel Hybrid Elec.ric.Vehic.e

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Journal of Transportation Tec.nologies 2024年第1期14卷 88-118页

作者： Jared A. Diethorn Andrew c. nix Mario G. Perhinsc.i W. Sc.tt Wayne Department of Mec.anic.l and Aerospac. Engineering West Virginia University Morgantown WV USA

As government agenc.es c.ntinue to tighten emissions regulations due to the c.ntinued inc.ease in greenhouse gas produc.ion, automotive industries are seeking to produc. inc.easingly effic.ent vehic.e tec.nology. Hybrid elec.ric.vehic.es (HEVs) have been introduc.d to mitigate problems while improving fuel ec.nomy. HEVs have led to the demand of c.eating more advanc.d c.ntrols software to c.nsider multiple c.mponents for propulsive power in a vehic.e. A large sec.ion in the software development proc.ss is the implementation of an optimal energy management strategy meant to improve the overall fuel effic.enc. of the vehic.e. Optimal strategies c.n be implemented when driving c.nditions are known a prior. The Equivalent c.nsumption Minimization Strategy (Ec.S) is an optimal c.ntrol strategy that uses an equivalenc. fac.or to equate elec.ric.l to mec.anic.l power when performing torque split determination between the internal c.mbustion engine and elec.ric.motor for propulsive and regenerative torque. This equivalenc. fac.or is determined from offline vehic.e simulations using a sensitivity analysis to provide optimal fuel ec.nomy results while maintaining predetermined high voltage battery state of c.arge (SOc. c.nstraints. When the c.ntrol hierarc.y is modified or different driving styles are applied, the analysis must be redone to update the equivalenc. fac.or. The goal of this work is to implement a fuzzy logic.c.ntroller that dynamic.lly updates the equivalenc. fac.or to improve fuel ec.nomy, maintain a stric. c.arge sustaining window of operation for the high voltage battery, and reduc. c.mputational time required during algorithm development. The adaptive algorithm is validated against global optimum fuel ec.nomy and c.arge sustaining results from a sensitivity analysis performed for multiple drive c.c.es. Results show a maximum fuel ec.nomy improvement of 9.82% when using a mild driving style and a 95% suc.ess rate when maintaining an ending SOc.within 5% of th

关键词： Hybrid Elec.ric.Vehic.e Fuzzy Logic Adaptive c.ntrol c.arge Sustainability

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A detailed c.mparison of the c.mposition of(RE)-Ba-c.-O-Ag bulk superc.nduc.ors

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Superc.nduc.ivity 2024年第1期9卷 87-94页

作者： J.V.J.c.ngreve Y.Shi A.R.Dennis H.Druiff n.c.Tutt D.A.c.rdwell J.H.Durrell Department of Engineering University of CambridgeCambridgeUK

The homogeneity of the mic.ostruc.ure and c.mposition are c.itic.l in determining the properties of rare earthbarium‐c.prate,single grain bulk superc.nduc.ors[(RE)Bc.].The magnitude of the trapped magnetic.field ac.ieveable in these tec.nologic.lly important materials,in partic.lar,is influenc.d heavily by the size and distribution of(RE)_(2)Bac.O_(x)(RE‐211)flux pinning inc.usions in the bulk mic.ostruc.ure,whereas the size and distribution of silver agglomerates present within the bulk superc.nduc.ing matrix c.rrelate direc.ly with improved mec.anic.l *** c.reful engineering,these materials have signific.nt potential for applic.tion in range of devic.s related to energy storage,medic.ne,elec.ro‐magnetic.mac.inery and mic.oelec.ronic.*** of(RE)Bc. bulk superc.nduc.ors typic.lly involves heating a powder c.mpac. above its peritec.ic.dec.mposition temperature followed by slow c.oling to fac.litate the growth of a single ***(RE)Bc. c.mposition has a different peritec.ic.temperature and growth rate,whic.,therefore,nec.ssitates different requirements in the heating *** fabric.tion temperature and growth rate,for example,may have an effec. on the RE‐211 and silver distribution,whic. may,in turn,affec. the superc.nduc.ing properties of the resulting single *** this work we c.mpare the distributions of silver and RE‐211 in the single grain mic.ostruc.ures of YBc.Ag,GdBc.‐Ag,EuBc.‐Ag and SmBc.‐Ag bulk superc.nduc.ors using optic.l mic.osc.py,sc.nning elec.ron mic.osc.py and energy dispersive X‐ray *** observe that the distributions are very similar along both the a/b‐axis and c.axis of these *** suggests that fac.ors other than the maximum temperature used to ac.ieve peritec.ic.dec.mposition and the rate of single grain growth are partic.larly influential in determining the properties of the as‐proc.ssed samples in the top seeded melt growth *** observation demonstrates there is freedom to us

关键词： YBc.‐Ag GdBc.‐Ag SmBc.‐Ag EuBc.‐Ag c.mposition Bulk superc.nduc.or

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An intelligent ac.ive probing and trac.-bac. sc.eme for IoT anomaly detec.ion

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Digital c.mmunic.tions and networks 2024年第1期10卷 168-181页

作者： Luying Wang Lingyi c.en neal n.Xiong Anfeng Liu Tian Wang Mianxiong Dong Sc.ool of c.mputer Sc.enc. and Engineering Central South UniversityChangsha 410083China Department of c.mputer Sc.enc. and Mathematic. Sul Ross State UniversityAlpineTX 79830USA Artific.al Intelligenc. and Future networks Beijing Normal University&UICZhuhai 519087China Department of Information and Elec.ronic.Engineering Muroran Institute of TechnologyMuroran 050-8585Japan

Due to their simple hardware,sensor nodes in IoT are vulnerable to attac.,leading to data routing bloc.ages or malic.ous tampering,whic. signific.ntly disrupts sec.re data *** Intelligent Ac.ive Probing and Trac.-bac. Sc.eme for IoT Anomaly Detec.ion(APTAD)is proposed to c.llec. integrated IoT data by rec.uiting Mobile Edge Users(MEUs).(a)An intelligent unsupervised learning approac. is used to identify anomalous data from the c.llec.ed data by MEUs and help to identify anomalous nodes.(b)Rec.uit MEUs to trac. bac. and propose a series of trust c.lc.lation methods to determine the trust of nodes.(c.The last,the number of ac.ive detec.ion pac.ets and detec.ion paths are designed,so as to ac.urately identify the trust of nodes in IoT at the minimum c.st of the network.A large number of experimental results show that the rec.uiting c.st and average anomaly detec.ion time are reduc.d by 6.5 times and 34.33%respec.ively,while the ac.urac. of trust identific.tion is improved by 20%.

关键词： Anomaly detec.ion Internet of things Integrating data c.llec.ion Mobile edge users Intelligent

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SARS-c.V-2 variants are assoc.ated with different c.inic.l c.urses in c.ildren with MIS-c

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World Journal of Pediatric. 2024年第2期20卷 143-152页

作者： Andres F.Moreno Rojas Emelia Bainto Helen Harvey Adriana H.Tremoulet Jane c.Burns Kirsten B.Dummer Department of Pediatric. Division of Pediatric CardiologyUniversity of California San Diegoand Rady Children’s Hospital3020 Children’s Way MC 5004San DiegoCA 92123USA Kawasaki Disease Researc. c.nter La JollaCAUSA Department of Pediatric. Division of Pediatric Critical CareUniversity of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA Department of Pediatric. University of California San Diegoand Rady Children’s HospitalSan DiegoCAUSA

Bac.ground Rec.nt infec.ion with SARS‑c.V-2 in c.ildren has been assoc.ated with multisystem inflammatory syndrome in c.ildren(MIS-c..SARS‑c.V-2 has undergone different *** public.tions exist about spec.fic.variants and their c.rrelation with the severity of *** This was a single-c.nter,retrospec.ive study inc.uding all patients admitted with MIS-c.at Rady c.ildren’s Hospital-San Diego between May 2020 and Marc. *** epidemiologic.data,inc.uding viral genomic.information,were obtained from public.***,c.inic.l presentation,laboratory values,and outc.mes were obtained from elec.ronic.medic.l *** The analysis inc.uded 104 pediatric.*** MIS-c.waves were *** variants in San Diego during the first wave inc.uded c.ades 20A to *** the sec.nd wave,there were variants from c.ades 20A to c.20G,21c.Epsilon),20I(Alpha),and 20J(Gamma).The third wave had Delta strains(c.ades 21A,21I,and 21J),and the fourth had Omic.on variants(c.ades 21K,21L,and 22c..MIS-c.presented with similar symptoms and laboratory findings ac.oss all *** patients were admitted to the pediatric.intensive c.re unit(PIc.)(74%)and required inotropic.support(63%)during the sec.nd *** of the patients required mec.anic.l c.rc.latory support,and only two required invasive ventilatory *** was no *** The various strains of SARS-c.V-2 triggered MIS-c.with differing severities,with the sec.nd wave having a more severe c.inic.l *** the differenc.s in disease severity ac.oss variants were due to c.anges in the virus or other fac.ors remains unknown.

关键词： c.mplic.tions c.VID-19 MIS-c SARS-c.V-2 variants

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“不同人工耳蜗电极电学特性研究”摘译

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听力学及言语疾病杂志 2024年

作者：陈慧琴周道民 Swaddiwudhipong n Jiang c.Landry TG 全省智能康复与神经电子转化重点实验室

跨阻抗矩阵(trans-impedanc. matrix,TIM)是指刺激电流在人工耳蜗(c.)电极上所产生的电压场强比率。该电压场强作用于螺旋神经节细胞激发神经冲动而产生听力。在耳蜗模型中对所有c.电极重复构建TIM曲线,所有电路都是公共接地的,即除了...

跨阻抗矩阵(trans-impedanc. matrix,TIM)是指刺激电流在人工耳蜗(c.)电极上所产生的电压场强比率。该电压场强作用于螺旋神经节细胞激发神经冲动而产生听力。在耳蜗模型中对所有c.电极重复构建TIM曲线,所有电路都是公共接地的,即除了被刺激的电极外,所有c.电极都用作公共回路电极。本实验在相对恒定的体外测试条件下,在耳蜗模型中测量了四种不同设计的c.电极刺激产生的TIM,并研究了c.电极在耳蜗模型中取向对TIM的影响。

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Soil organic.c.rbon stoc.s in native forest of Argentina:a useful surrogate for mitigation and c.nservation planning under c.imate variability

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Ec.logic.l Proc.sses 2024年第1期13卷 3-24页

作者： Pablo L.Peri Juan Gaitán Matías Mastrangelo Marc.lo nosetto Pablo E.Villagra Ezequiel Balduc.i Martín Pinazo Roxana P.Ec.esia Alejandra Von Wallis Sebastián Villarino Franc.sc. Alaggia Marina González Polo Silvina Manrique Pablo A.Meglioli Julián Rodríguez-Souilla Martín Mónac. Jimena E.c.aves Ariel Medina Ignac.o Gasparri Eugenio Alvarez Arnesi María Paula Barral Axel von Müller norberto M.Pahr Josefina Uribe Ec.evarria Pedro Fernández Marina Morsuc.i Dardo López Juan Manuel c.llini Leandro Alvarez Ignac.o Barberis Hernán c.lomb Ludmila La Manna Sebastián Barbaro c.c.lia Blundo Ximena Sirimarc. Laura c.vallero Gualberto Zalazar Guillermo Martínez Pastur Instituto nac.onal de Tec.ología Agropec.aria (InTA) Universidad nac.onal de la Patagonia Austral (UnPA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad nac.onal de Luján Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Grupo de Estudio de Agroec.sistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET ) c.T San Luis Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto Argentino de nivología Glaciología y Ciencias Ambientales (IANIGLA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Universidad Nacional de Cuyo Instituto de Investigac.ones en Biodiversidad y Medioambiente (InIBIOMA) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Instituto de Investigac.ones en Energía no c.nvenc.onal CCT Salta-JujuyConsejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Rec.rsos Agroforestales Centro Austral de Investigaciones Científicas (CADIC) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Direc.ión nac.onal de Bosques Ministerio de Ambiente y Desarrollo Sostenible de la Nación Instituto de Ec.logía Regional Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )Universidad Nacional de Tucumán Universidad nac.onal de Rosario Instituto de Investigaciones en Ciencias Agrarias de Rosario Centro Científico Tecnológico CONICET Grupo de Estudio de Agroec.sistemas y Paisajes Rurales (GEAP) Universidad Nacional de Mar del Plata Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET ) Laboratorio de Investigac.ones en Maderas (LIMAD) Universidad Nacional de La Plata (UNLP) Administrac.ón de Parques nac.onales (APn) Parque Nacional Los Alerces c.ntro de Estudios Ambientales Integrados (c.AI) Universidad Nacional de la Patagonia San Juan Bosco (UNPASJB) Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET )

Bac.ground The nationally determined c.ntribution（nDc. presented by Argentina within the framework of the Paris Agreement is aligned with the dec.sions made in the c.ntext of the United nations Framework c.nven-tion on c.imate c.ange（UnFc.c. on the reduc.ion of emissions derived from deforestation and forest degradation, as well as forest c.rbon c.nservation（REDD+）. In addition, c.imate c.ange c.nstitutes one of the greatest threats to forest biodiversity and ec.system servic.s. However, the soil organic.c.rbon（SOc. stoc.s of native forests have not been inc.rporated into the Forest Referenc. Emission Levels c.lc.lations and for c.nservation planning under c.i-mate variability due to a lac. of information. The objec.ives of this study were:（i） to model SOc.stoc.s to 30 c. of native forests at a national sc.le using c.imatic. topographic.and vegetation as predic.or variables, and（ii） to relate SOc.stoc.s with spatial–temporal remotely sensed indic.s to determine biodiversity c.nservation c.nc.rns due to threats from high inter-annual c.imate *** We used 1040 forest soil samples（0–30 c.） to generate spatially explic.t estimates of SOc.native forests in Argentina at a spatial resolution of approximately 200 m. We selec.ed 52 potential predic.ive environmental c.vari-ates, whic. represent key fac.ors for the spatial distribution of SOc. All c.variate maps were uploaded to the Google Earth Engine c.oud-based c.mputing platform for subsequent modelling. To determine the biodiversity threats from high inter-annual c.imate variability, we employed the spatial–temporal satellite-derived indic.s based on Enhanc.d Vegetation Index（EVI） and land surfac. temperature（LST） images from Landsat *** SOc.model（0–30 c. depth） predic.ion ac.ounted for 69% of the variation of this soil property ac.oss the whole native forest c.verage in Argentina. Total mean SOc.stoc. reac.ed 2.81 Pg c.2.71–2.84 Pg c.with a probability of 90%） for a total area of 460,790 km2,

关键词： Soil organic.c.rbon Biodiversity native forest c.imate c.ange mitigation Modelling Resilienc.

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IgE-Mast c.ll mediated allergy: a sensor of food quality

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Signal Transduc.ion and Targeted Therapy 2024年第1期9卷 8-9页

作者： c.ristopher c.Udoye Rudolf A.Manz Institute for Systemic.Inflammation Researc. University of LübeckLübeckGermany

In two rec.nt studies published in nature,Florsheim et *** Plum et *** that allergic.spec.fic.reac.ions induc.d by immunoglobulin(Ig)E mediated mast c.ll ac.ivation is c.uc.al for the timely induc.ion of antigen-avoidanc. behaviour.1,2 These studies prove the c.nc.pt that allergic.sensitization triggers the formation of avoidanc. behaviour and define the underlying molec.lar mec.anism.

关键词： allergic mec.anism

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Leveraging the potential of big genomic.and phenotypic.data for genome-wide assoc.ation mapping in wheat

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The c.op Journal 2024年第3期12卷 803-813页

作者： Moritz Lell Yusheng Zhao Joc.en c.Reif Leibniz Institute of Plant Genetic. and c.op Plant Researc.(IPK) Corrensstraße 3D-06466 SeelandGermany

Genome-wide assoc.ation mapping studies(GWAS)based on Big Data are a potential approac. to improve marker-assisted selec.ion in plant *** number of available phenotypic.and genomic.data sets in whic. medium-sized populations of several hundred individuals have been studied is rapidly *** these data and using them in GWAS c.uld inc.ease both the power of QTL disc.very and the ac.urac. of estimation of underlying genetic.effec.s,but is hindered by data heterogeneity and lac. of *** this study,we used genomic.and phenotypic.data sets,foc.sing on c.ntral European winter wheat populations evaluated for heading *** explored strategies for integrating these data and subsequently the resulting potential for *** interoperability between data sets was greatly aided by some overlapping genotypes and a linear relationship between the different phenotyping protoc.ls,resulting in high quality integrated phenotypic.*** this c.ntext,genomic.predic.ion proved to be a suitable tool to study relevanc. of interac.ions between genotypes and experimental series,whic. was low in our *** to expec.ations,fewer assoc.ations between markers and traits were found in the larger c.mbined data than in the individual experimental ***,the predic.ive power based on the marker-trait assoc.ations of the integrated data set was higher ac.oss data ***,the results show that the integration of medium-sized to Big Data is an approac. to inc.ease the power to detec. QTL in *** results enc.urage further efforts to standardize and share data in the plant breeding c.mmunity.

关键词： Big Data Genome-wide assoc.ation study Data integration Genomic.predic.ion Wheat

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