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Are we giving biologics too much time? When should we stop treatment?

World Journal of Gastroenterology 2008年第36期14卷 5528-5531页

作者： Edouard Louis J Belaiche c reenaers Department of Gastroenterology cHU Liège and GIGA Research University of Liège Belgium

The optimal duration of biological treatment, particularly anti-TNF, in inflammatory bowel disease （IBD） is a very important question both for patients and physicians. There is no published evidence to clearly and definitely answer this question. However data on natural history of IBD, long term safety of biologics, immunosuppressors （IS） cessation and some preliminary studies on biologics cessation may help us to discuss this topic. The decision to stop a biological treatment is currently based on a compromise between the benefits and risks associated with the prolongation of this treatment. IBD, more particularly cD, are characterized by the development of complications and the need for recurrent hospitalizations and surgeries in approximately 2/3 of cases. In these patients potentially in need of biological treatments, it is probable that, as it has been demonstrated for IS, the longer a stable remission has be achieved under treatment, the lower the risk of relapse is alter treatment cessation. Further prospective studies should now aim at disclosing patient characteristics associated with a low risk of relapse to imple- ment this strategy.

关键词： Inflammatory bowel disease Immunosuppressors Biological treatment

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比利时南部基因5型丙型肝炎病毒患者:流行病学特征和治疗应答

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世界核心医学期刊文摘（胃肠病学分册） 2006年第5期2卷 14-14页

作者： Delwaide J. Gerard c. reenaers c. 李宏宇 Department of Hepato-Gastroenterology CHU Sart Tilman 4000 Liège Belgium Dr.

Data are scarce on patients infected with hepatitis c virus of genotype 5, due to the low prevalence of this genotype around the world. To better define the characteristics of these patients, we reviewed the files of 16 genotype 5 patients. Mean age was 38 ± 14. All patients were of European origin. Most of them (75% ) had been contaminated by transfusion within a short time period (between 1980 and 1991). There were no intravenous drug addicts. Seven patients received treatment. One patient did not respond to interferon (IFN) monotherapy. Of four patients treated with IFN and ribavirin, three became sustained viral responders. Two patients treated with pegylated IFN and ribavirin became sustained viral responders. In our region, genotype 5 patients seem to have been contaminated within a relatively short time period. Treatment with IFN or pegylated IFN and ribavirin gave a high rate (83% ) of sustained viral responses.

关键词：丙型肝炎病毒患者档案治疗应答部基因流行病学特征比利时聚乙二醇干扰素利巴韦林单一疗法病毒应答

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